Now a days everybody wants evidence or proof for any purpose.so govt.of india introduces AYUSH research portal for the devalopment and taking awareness regarding ayurveda where it consists of clinical trial and pre-clinical trial data.
The main objective of present research investigation is to formulate
the sustained release tablet of Doxofylline using 32 factorial design.
Doxofylline, an anti-Asthmatic agent, belongs BCS class-III agent.
The SR tablets of Doxofylline were prepared employing different
concentrations of HPMC K100M and Chitosan in different
combinations by Direct Compression technique using 32 factorial
design. The concentration of Polymers, HPMC K100M and
Chitosan required to achieve the desired drug release was selected as
independent variables, X1 and X2 respectively whereas, time required
for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90%
(t90%) were selected as dependent variables. Totally nine formulations
were designed, Formulated and are evaluated for hardness, friability,
thickness, % drug content, In-vitro drug release. From the Results
it was concluded that all the formulation were found to be with
in the Pharmacopoeial limits and the In-vitro dissolution profiles
of all formulations were fitted in to different Kinetic models, the
statistical parameters like intercept, slope & regression coefficient
were calculated. Polynomial equations were developed for t10%,
t50%, t75%, t90%. Validity of developed polynomial equations were
verified by designing 2 check point formulations (C1, C2). According
to SUPAC guidelines the formulation (F4) containing combination
of 10% HPMC K100M and 15% Chitosan, is the most similar
formulation (similarity factor f2= 64.501, dissimilarity factor f1=
6.862 & No significant difference, t= 0.23001) to marketed product
(DOXOLIN). The selected formulation (F4) follows Zero order,
Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion anomalous Super Case-II Transport (n= 0.963).
In the present research work, the chewable tablets of ginger were prepared by wet granulation. Compression of chewable tablets was done by Karnavati lab scale tablet compression machine. The pre-compression parameters assessed for the granules produced include angle of repose, bulk and tapped density, Carr’s index, Housner’s ratio. Compressed tablets were evaluated for thickness, hardness, friability, disintegration time and dissolution time.
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...Dr. Anuj S Parihar
Oral mucositis (OM) is a common inflammatory complication among cancerous patients as an adverse effect of chemotherapy and radiotherapy. The aim of this study is to evaluate the healing effects of hydroalcoholic extract of Psidium
Guajava leaf on oral induced mucositis induced by 5-fluorouracil using histopathologic and tissue antioxidative markers assessment in male dark brown rats. In a prospective randomized double blind animal study, OM was induced in 64 male dark brown rats that allocated in 4 groups by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on once daily on days 3 and 4. Starting from day 12, gel base, topical form and 600 mg/kg dietry form of hydroalcoholic extract of Psidium Guajava leaf were administered per day. Pouch histopathology score, superoxide dismutase, glutathione peroxidase, total antioxidant capacity were evaluated on day 14 and 18. DPPH scavenging activity and total phenolic content also were measured. Histopathology scores of mucositis were lower in the systemic and topical treatment groups than the gel base and control groups (P<0.05). Higher activities of SOD, GPX and TAC were detected in the topical and systemic treatment groups in comparison to the others (P<0.05). The extract was rich in total phenolic content as antioxidant. The use of extract of Psidium Guajava leave may be associated with reduced intensity of OM, increased concentration of SOD, GPX and TAC on induced
OM in dark brown rats undergoing 5-FU consumption.
This document provides a detailed curriculum vitae for Dr. Dharmesh K. Golwala, including his educational background, work experience, publications, and professional affiliations. It outlines that he has a M. Pharm. and Ph.D. in Pharmaceutical Sciences and is currently the Principal and Associate Professor at C. U. Shah College of Pharmacy & Research in Surendranagar, Gujarat, India. He has over 12 years of experience in academia and the pharmaceutical industry and has authored numerous publications and presentations.
Acute and subchronic toxicity of mulberry fruitsEditya Apriliani
This document summarizes a study that investigated the acute and subchronic toxicity of mulberry fruits in rats. In the acute toxicity test, rats were given a single dose of 2000 mg/kg of mulberry fruit extract and observed for 14 days. No signs of toxicity or deaths were observed. In the subchronic toxicity test, rats were given oral doses of 2, 10, or 500 mg/kg/day of mulberry fruit extract for 90 days. Body weights, organ weights, hematological and clinical chemistry parameters were measured. No abnormalities were found except for some changes in BUN and glucose levels that were still within normal ranges. Histopathological examination also found no abnormalities. The results suggest mulberry fruits do not
Prokinetic effect of herbomineral unani formulation (dolabi) in diabetic ratsYounis I Munshi
This study investigated the prokinetic effects of the Unani herbomineral formulation Dolabi in diabetic rats. Diabetes was induced in rats by injecting streptozotocin. Dolabi treatment significantly increased gastric emptying and intestinal transit in diabetic rats compared to untreated diabetic rats. Dolabi also significantly decreased the EC50 of acetylcholine in the distal colon of diabetic rats, indicating improved smooth muscle response. In vitro, Dolabi showed potent antioxidant activity by scavenging stable DPPH free radicals. The results suggest Dolabi may exert its prokinetic effects by reducing oxidative stress in diabetes and could be useful for treating gastrointestinal impairments in diabetic patients.
The presentation is about the dose selection for laboratory animal toxicology drug testing, explaining staged and staggered approach of dose selection.
The main objective of present research investigation is to formulate
the sustained release tablet of Doxofylline using 32 factorial design.
Doxofylline, an anti-Asthmatic agent, belongs BCS class-III agent.
The SR tablets of Doxofylline were prepared employing different
concentrations of HPMC K100M and Chitosan in different
combinations by Direct Compression technique using 32 factorial
design. The concentration of Polymers, HPMC K100M and
Chitosan required to achieve the desired drug release was selected as
independent variables, X1 and X2 respectively whereas, time required
for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90%
(t90%) were selected as dependent variables. Totally nine formulations
were designed, Formulated and are evaluated for hardness, friability,
thickness, % drug content, In-vitro drug release. From the Results
it was concluded that all the formulation were found to be with
in the Pharmacopoeial limits and the In-vitro dissolution profiles
of all formulations were fitted in to different Kinetic models, the
statistical parameters like intercept, slope & regression coefficient
were calculated. Polynomial equations were developed for t10%,
t50%, t75%, t90%. Validity of developed polynomial equations were
verified by designing 2 check point formulations (C1, C2). According
to SUPAC guidelines the formulation (F4) containing combination
of 10% HPMC K100M and 15% Chitosan, is the most similar
formulation (similarity factor f2= 64.501, dissimilarity factor f1=
6.862 & No significant difference, t= 0.23001) to marketed product
(DOXOLIN). The selected formulation (F4) follows Zero order,
Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion anomalous Super Case-II Transport (n= 0.963).
In the present research work, the chewable tablets of ginger were prepared by wet granulation. Compression of chewable tablets was done by Karnavati lab scale tablet compression machine. The pre-compression parameters assessed for the granules produced include angle of repose, bulk and tapped density, Carr’s index, Housner’s ratio. Compressed tablets were evaluated for thickness, hardness, friability, disintegration time and dissolution time.
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...Dr. Anuj S Parihar
Oral mucositis (OM) is a common inflammatory complication among cancerous patients as an adverse effect of chemotherapy and radiotherapy. The aim of this study is to evaluate the healing effects of hydroalcoholic extract of Psidium
Guajava leaf on oral induced mucositis induced by 5-fluorouracil using histopathologic and tissue antioxidative markers assessment in male dark brown rats. In a prospective randomized double blind animal study, OM was induced in 64 male dark brown rats that allocated in 4 groups by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. The cheek pouch was scratched with a sterile needle on once daily on days 3 and 4. Starting from day 12, gel base, topical form and 600 mg/kg dietry form of hydroalcoholic extract of Psidium Guajava leaf were administered per day. Pouch histopathology score, superoxide dismutase, glutathione peroxidase, total antioxidant capacity were evaluated on day 14 and 18. DPPH scavenging activity and total phenolic content also were measured. Histopathology scores of mucositis were lower in the systemic and topical treatment groups than the gel base and control groups (P<0.05). Higher activities of SOD, GPX and TAC were detected in the topical and systemic treatment groups in comparison to the others (P<0.05). The extract was rich in total phenolic content as antioxidant. The use of extract of Psidium Guajava leave may be associated with reduced intensity of OM, increased concentration of SOD, GPX and TAC on induced
OM in dark brown rats undergoing 5-FU consumption.
This document provides a detailed curriculum vitae for Dr. Dharmesh K. Golwala, including his educational background, work experience, publications, and professional affiliations. It outlines that he has a M. Pharm. and Ph.D. in Pharmaceutical Sciences and is currently the Principal and Associate Professor at C. U. Shah College of Pharmacy & Research in Surendranagar, Gujarat, India. He has over 12 years of experience in academia and the pharmaceutical industry and has authored numerous publications and presentations.
Acute and subchronic toxicity of mulberry fruitsEditya Apriliani
This document summarizes a study that investigated the acute and subchronic toxicity of mulberry fruits in rats. In the acute toxicity test, rats were given a single dose of 2000 mg/kg of mulberry fruit extract and observed for 14 days. No signs of toxicity or deaths were observed. In the subchronic toxicity test, rats were given oral doses of 2, 10, or 500 mg/kg/day of mulberry fruit extract for 90 days. Body weights, organ weights, hematological and clinical chemistry parameters were measured. No abnormalities were found except for some changes in BUN and glucose levels that were still within normal ranges. Histopathological examination also found no abnormalities. The results suggest mulberry fruits do not
Prokinetic effect of herbomineral unani formulation (dolabi) in diabetic ratsYounis I Munshi
This study investigated the prokinetic effects of the Unani herbomineral formulation Dolabi in diabetic rats. Diabetes was induced in rats by injecting streptozotocin. Dolabi treatment significantly increased gastric emptying and intestinal transit in diabetic rats compared to untreated diabetic rats. Dolabi also significantly decreased the EC50 of acetylcholine in the distal colon of diabetic rats, indicating improved smooth muscle response. In vitro, Dolabi showed potent antioxidant activity by scavenging stable DPPH free radicals. The results suggest Dolabi may exert its prokinetic effects by reducing oxidative stress in diabetes and could be useful for treating gastrointestinal impairments in diabetic patients.
The presentation is about the dose selection for laboratory animal toxicology drug testing, explaining staged and staggered approach of dose selection.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
INFLUENCE OF AYURVEDIC ANTIDIABETIC AGENT ON THE PHARMACODYNAMICS OF GLIMEPIRIDEJing Zang
The present study is planned to explore the influence of ayurvedic antidibetic drug Madhumehari on the pharmacodynamics of glimepiride. Wistar albino rats of either sex were induced diabetes with alloxan and were used. The study was done in two phases, acute phase and chronic phase. In acute phase the diabetic rats were divided into six groups each consisting of 6. The diabetic control (Group-I) was treated with 0.5%W/V CMC suspension orally. To the diabetic group II, III and IV glimepiride 4mg/kg body wt, madhumehari 100mg/kg body wt. and madhumehari 200mg/kg body wt. were administered orally respectively. Groups V and VI were given orally the combination of glimepiride 4mg/kg body wt + madhumehari 100mg/kg body wt and glimepiride 4mg/kg body wt + madhumehari 200mg/kg body wt. In chronic study the protocol was similar to that of acute study but treatment was given for 7 days. Blood samples were collected from retro orbital plexus at predetermined time intervals for serum glucose level estimation after the oral dosing of glimepiride. The combination of glimepiride + madhumehari has shown antidiabetic activity at 3rd hour. Glimepiride when administered along with madhumehari 100 & 200mg orally the fall in serum glucose level was found to be more significant when compared with the per se treatment of glimepiride, madhumehari 100 & 200mg in both acute and chronic studies. From the above study it may be concluded that there is additive type of Pharmacodynamic interaction is possible between glimepiride and madhumehari.
This research article studied the antidiabetic and antihyperlipidemic effects of Piper longum root aqueous extract (PlrAqe) in streptozotocin-induced diabetic rats. In short term studies, PlrAqe at 200 mg/kg body weight significantly reduced fasting blood glucose levels in diabetic rats over 6 hours. In long term studies over 30 days, PlrAqe treatment normalized fasting blood glucose and lipid profiles and protected liver and kidney functions in diabetic rats. The results suggest that PlrAqe is effective in managing hyperglycemia and diabetes complications, and may be a potential source for new oral anti-diabetic agents.
Abstract:
Hyperlipidemia is a major risk factor in the
initiation and progression of atherosclerotic lesions,
conditions such as coronary heart disease, ischemic
cerebrovascular disease and peripheral vascular
disease. This leads to high mortality and morbidity
rate in developed countries. This is mainly due to
altered lipoprotein metabolism. Standard treatments
for Hyperlipidemia & dyslipidemia with statins and
with the other available agents have adverse effects.
Thus, there is more need for development of newer
pharmacological agents which are more efficient in
lowering LDL Cholesterol and Triglycerides. The
hypolipidemic activity of Nathaichoori Chooranam
was studied on high fat diet induced
hyperlipidemic rats. Hyperlipidemia in experimental
rats was evidenced by an enhancement in the levels
of Cholesterols, Triglycerides, LDL and VLDL.
The trial drug showed significant hypolipidemic
effect by lowering the serum levels of biochemical
parameters, such as significant reduction in the level
of serum Cholesterol, TGL, LDL, VLDL and
increase in HDL level which was similar to the
standard drug atorvastatin. So, it is concluded that
the Nathaichoori chooranam can be used in the
treatment of Hyperlipidemia and Obesity.
This document summarizes the development and evaluation of taste masked tablets of drotoverine using solid dispersion technique. Drotoverine has an unpleasant bitter taste and poor aqueous solubility, resulting in incomplete absorption. Solid dispersion with carriers like urea and mannitol was used to mask the bitter taste and improve dissolution. Tablets were prepared by direct compression and evaluated for properties like hardness, friability and disintegration time. Fourier transform infrared spectroscopy and scanning electron microscopy showed no interaction between drug and carriers. Tablets using solid dispersion exhibited faster disintegration and complete taste masking. Dissolution studies also showed improved dissolution profile. Human volunteers rated the taste as tasteless. The formulated tablets thus demonstrated successful masking of bitter taste and improved
1) Fenugreek seeds contain antioxidants like flavonoids that may lower blood pressure. This study examined if fenugreek could help reduce blood pressure in those with prehypertension when used as an adjunct to the NCEP step 1 diet.
2) 51 subjects with prehypertension were randomized to receive either fenugreek seed powder or a placebo daily for 12 weeks in addition to the NCEP diet.
3) At the end of the study, systolic and diastolic blood pressures were significantly reduced from baseline in the fenugreek group but not the placebo group, suggesting fenugreek seeds may help lower blood pressure when used along with the NCEP diet.
The document evaluates the analgesic and anti-inflammatory activities of Karuvilanchi ver chooranam (KVC), the root powder of Smilax zeylanica, in rodent models. The results showed that KVC significantly increased the reaction time in hot plate test and inhibited acetic acid-induced writhing responses in mice, indicating its analgesic effects. KVC also significantly reduced formalin-induced paw edema in rats and cotton pellet-induced granuloma formation, demonstrating its anti-inflammatory properties. The study confirms the traditional use of KVC for pain and inflammation management.
This document provides a biography and resume for Dr. Rahul A. Hajare, a researcher in biologics development and protein chemistry. It summarizes his educational background, areas of research interest, research experience, awards, publications, projects, and academic appointments. Some key details include that he received a Ph.D. in 2012 from Vinayaka Mission University and has over 52 publications. His research focuses on areas like biologics development, protein chemistry, molecular biology, and drug discovery. He has worked on projects related to HIV inhibition and anticancer activity.
Efficacy and safety of human placental extract solution on fatigue (http://pl...Swapan Das
From:http://placentrex.blogspot.com/
For the readers of Human Placental Extract (HPE) Blog blog we have come up with the following study recently conducted by a Korean team on the efficacy and safety of Human Placental Extract solution on fatigue. Fatigue is a common symptom, but only a few effective treatments are available. This study was supported by a grant from Unimed Pharm., INC. and was conducted at the requests of the Korea Food and Drug Administration (KFDA).
http://placentrex.blogspot.com/2011/09/kfda-requests-for-study-of-hpes-role-on.html
This document describes a study that evaluated the anti-diabetic effects of an Ayurvedic herbo-mineral formulation called Trushanadi loha. The formulation contains 14 plant and mineral ingredients. An aqueous extract was tested in rats. Blood glucose levels were measured. The extract produced a 40% reduction in blood glucose levels in normal rats, demonstrating significant anti-diabetic activity. The formulation was also found to be non-toxic in acute oral toxicity tests in rats at doses up to 5,000 mg/kg. Overall, the study provides evidence that Trushanadi loha has anti-diabetic properties and a safe toxicity profile.
This research paper evaluated the hepatoprotective activity of Tephrosia purpurea Linn stem. The stem was extracted with methanol and subjected to phytochemical screening which revealed the presence of flavonoids, phytosterols, alkaloids and proteins. An acute toxicity study found the extract was safe up to a dose of 2000 mg/kg. Hepatoprotective activity was evaluated against CCl4-induced hepatotoxicity in rats. Biochemical parameters (SGPT, SGOT, ALP, bilirubin) were assessed. The methanol extract reduced these serum levels and exhibited dose-dependent hepatoprotective activity comparable to the standard drug silymarin. Phytoc
This document provides a bio-data or curriculum vitae for Prof. Yamini Bhusan Tripathi. It lists his personal details including name, date of birth, education, positions held, research experience, publications, projects, awards, patents, books, and training. It shows that he is a professor of medicinal chemistry with over 36 years of teaching and research experience, having published over 129 papers and authored or edited several books and book chapters in his field.
This study compared the pharmacokinetics of a single 60 mg/kg dose of azithromycin extended-release oral suspension to a single 30 mg/kg dose of azithromycin immediate-release oral suspension in children aged 6 months to 6 years with acute otitis media. The study found that the 60 mg/kg extended-release dose provided similar or greater systemic exposure of azithromycin compared to the 30 mg/kg immediate-release dose, as the adjusted geometric mean ratio of the area under the concentration-time curve from time 0 to 72 hours post-dose was 157.98% with a lower 90% confidence interval boundary above the predetermined threshold of 80%. Extended-release resulted in lower concentrations
Indian journal of research in pharmacy and biotechnology 4debjit bhowmik
This document discusses the controversial role of antipsychotics in the treatment of Alzheimer's disease. While atypical antipsychotics can effectively treat psychotic symptoms and behavioral issues in the short term, several placebo-controlled studies have found they nearly double the risk of death over 2-3 years due to adverse events like infections. The FDA issued a black box warning about this increased mortality risk. Currently, the only FDA-approved medications target cognitive symptoms, but they also have significant side effects. More research is needed to develop safer alternatives for managing behavioral and psychological symptoms in Alzheimer's patients. Non-pharmacological interventions should be the primary treatment approach.
Hepatoprotective Potential of Tephrosia purpurea in Thioacetamide-Induced Hep...BRNSS Publication Hub
Background: Hepatotoxicity ultimately leads to liver failure. Conventional treatment options for hepatotoxicity are limited and not safe. Aim: The present work has been designed to evaluate the hepatoprotective effects of ethanolic extract of the root of Tephrosia purpurea (Linn.) against thioacetamide-induced hepatotoxicity in experimental Wistar albino rats. Materials and Methods: The plant roots, T. purpurea, were collected from the local area of Jodhpur, Rajasthan, and verification was done by Botanical Survey of India (BSI), Jodhpur, Rajasthan, and a herbarium specimen was deposited in BSI with No. LMC/PM/PD-001. All other reagents and chemicals were of suitable analytical grade and were used as received. Results: On the basis of statistical analysis, both the doses (200 and 400 mg/kg b.wt) of the ethanolic extract of T. purpurea root shown significant hepatoprotective activity compare to negative control. The dose of 400 mg/kg b.wt showed better reduction in serum enzyme level compare to 200 mg/kg b.wt dose of the ethanolic extract of T. purpurea root. Results were determined by one-way analysis of variance (ANOVA non-parametric) followed by Dunnett’s test with P < 0.01 considered statistically significant. Conclusion: Based on the results obtained, it may be concluded that the ethanolic extract of T. purpurea root has a significant protective effect on liver injuries.
The document discusses general considerations for conducting bioavailability and bioequivalence studies for orally administered drugs, including the regulatory objectives, methods used to evaluate bioavailability and demonstrate bioequivalence, and special topics like food effect and long half-life drugs. It provides background on key concepts like bioavailability, bioequivalence and their regulatory definitions as well as guidance on study design and requirements for different types of drug products and changes.
The goal of reverse pharmacology is to utilize disease pathology in order to identify specific and targetable elements that novel compounds can be modeled from.
This study evaluated the safety and anti-diabetic effects of a polyherbal phytocomposite (PHC) created from the leaves of Ficus benghalensis, Syzygium cumini, and Ocimum sanctum. In acute toxicity tests, the PHC showed no adverse effects at doses up to 7.5g/kg and the median lethal dose was determined to be 20.25g/kg. In sub-chronic toxicity tests, the PHC at doses up to 750mg/kg caused some changes in organ weights and blood biomarkers but no mortality. The PHC significantly lowered blood glucose and lipids in diabetic rats, performing better than the individual plant extracts and metformin. The PHC
This document provides a summary of the qualifications and experience of Dr. GURFATEH SINGH, including his education, work experience, research experience, technical skills, academic achievements, publications, and extracurricular activities. He has over 15 years of experience working as an Assistant Professor and has supervised over 45 students. He has received several awards for his research and publications in the fields of pharmacology and cardiovascular disease.
This document describes a study that evaluated the pharmacological effects of Terminalia chebula fruit extracts against neurodegenerative disorders in rodents. The study involved extracting Terminalia chebula fruits with polar and non-polar solvents, conducting preliminary phytochemical analysis, and screening the extracts for anti-parkinsonism and memory-enhancing effects. For anti-parkinsonism activity, the extracts were tested in a haloperidol-induced catatonia model in rats, while for memory effects the extracts were evaluated in ethanol-induced cognitive impairment and diazepam-induced amnesia models. The results of the study were discussed and compared to control groups.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
INFLUENCE OF AYURVEDIC ANTIDIABETIC AGENT ON THE PHARMACODYNAMICS OF GLIMEPIRIDEJing Zang
The present study is planned to explore the influence of ayurvedic antidibetic drug Madhumehari on the pharmacodynamics of glimepiride. Wistar albino rats of either sex were induced diabetes with alloxan and were used. The study was done in two phases, acute phase and chronic phase. In acute phase the diabetic rats were divided into six groups each consisting of 6. The diabetic control (Group-I) was treated with 0.5%W/V CMC suspension orally. To the diabetic group II, III and IV glimepiride 4mg/kg body wt, madhumehari 100mg/kg body wt. and madhumehari 200mg/kg body wt. were administered orally respectively. Groups V and VI were given orally the combination of glimepiride 4mg/kg body wt + madhumehari 100mg/kg body wt and glimepiride 4mg/kg body wt + madhumehari 200mg/kg body wt. In chronic study the protocol was similar to that of acute study but treatment was given for 7 days. Blood samples were collected from retro orbital plexus at predetermined time intervals for serum glucose level estimation after the oral dosing of glimepiride. The combination of glimepiride + madhumehari has shown antidiabetic activity at 3rd hour. Glimepiride when administered along with madhumehari 100 & 200mg orally the fall in serum glucose level was found to be more significant when compared with the per se treatment of glimepiride, madhumehari 100 & 200mg in both acute and chronic studies. From the above study it may be concluded that there is additive type of Pharmacodynamic interaction is possible between glimepiride and madhumehari.
This research article studied the antidiabetic and antihyperlipidemic effects of Piper longum root aqueous extract (PlrAqe) in streptozotocin-induced diabetic rats. In short term studies, PlrAqe at 200 mg/kg body weight significantly reduced fasting blood glucose levels in diabetic rats over 6 hours. In long term studies over 30 days, PlrAqe treatment normalized fasting blood glucose and lipid profiles and protected liver and kidney functions in diabetic rats. The results suggest that PlrAqe is effective in managing hyperglycemia and diabetes complications, and may be a potential source for new oral anti-diabetic agents.
Abstract:
Hyperlipidemia is a major risk factor in the
initiation and progression of atherosclerotic lesions,
conditions such as coronary heart disease, ischemic
cerebrovascular disease and peripheral vascular
disease. This leads to high mortality and morbidity
rate in developed countries. This is mainly due to
altered lipoprotein metabolism. Standard treatments
for Hyperlipidemia & dyslipidemia with statins and
with the other available agents have adverse effects.
Thus, there is more need for development of newer
pharmacological agents which are more efficient in
lowering LDL Cholesterol and Triglycerides. The
hypolipidemic activity of Nathaichoori Chooranam
was studied on high fat diet induced
hyperlipidemic rats. Hyperlipidemia in experimental
rats was evidenced by an enhancement in the levels
of Cholesterols, Triglycerides, LDL and VLDL.
The trial drug showed significant hypolipidemic
effect by lowering the serum levels of biochemical
parameters, such as significant reduction in the level
of serum Cholesterol, TGL, LDL, VLDL and
increase in HDL level which was similar to the
standard drug atorvastatin. So, it is concluded that
the Nathaichoori chooranam can be used in the
treatment of Hyperlipidemia and Obesity.
This document summarizes the development and evaluation of taste masked tablets of drotoverine using solid dispersion technique. Drotoverine has an unpleasant bitter taste and poor aqueous solubility, resulting in incomplete absorption. Solid dispersion with carriers like urea and mannitol was used to mask the bitter taste and improve dissolution. Tablets were prepared by direct compression and evaluated for properties like hardness, friability and disintegration time. Fourier transform infrared spectroscopy and scanning electron microscopy showed no interaction between drug and carriers. Tablets using solid dispersion exhibited faster disintegration and complete taste masking. Dissolution studies also showed improved dissolution profile. Human volunteers rated the taste as tasteless. The formulated tablets thus demonstrated successful masking of bitter taste and improved
1) Fenugreek seeds contain antioxidants like flavonoids that may lower blood pressure. This study examined if fenugreek could help reduce blood pressure in those with prehypertension when used as an adjunct to the NCEP step 1 diet.
2) 51 subjects with prehypertension were randomized to receive either fenugreek seed powder or a placebo daily for 12 weeks in addition to the NCEP diet.
3) At the end of the study, systolic and diastolic blood pressures were significantly reduced from baseline in the fenugreek group but not the placebo group, suggesting fenugreek seeds may help lower blood pressure when used along with the NCEP diet.
The document evaluates the analgesic and anti-inflammatory activities of Karuvilanchi ver chooranam (KVC), the root powder of Smilax zeylanica, in rodent models. The results showed that KVC significantly increased the reaction time in hot plate test and inhibited acetic acid-induced writhing responses in mice, indicating its analgesic effects. KVC also significantly reduced formalin-induced paw edema in rats and cotton pellet-induced granuloma formation, demonstrating its anti-inflammatory properties. The study confirms the traditional use of KVC for pain and inflammation management.
This document provides a biography and resume for Dr. Rahul A. Hajare, a researcher in biologics development and protein chemistry. It summarizes his educational background, areas of research interest, research experience, awards, publications, projects, and academic appointments. Some key details include that he received a Ph.D. in 2012 from Vinayaka Mission University and has over 52 publications. His research focuses on areas like biologics development, protein chemistry, molecular biology, and drug discovery. He has worked on projects related to HIV inhibition and anticancer activity.
Efficacy and safety of human placental extract solution on fatigue (http://pl...Swapan Das
From:http://placentrex.blogspot.com/
For the readers of Human Placental Extract (HPE) Blog blog we have come up with the following study recently conducted by a Korean team on the efficacy and safety of Human Placental Extract solution on fatigue. Fatigue is a common symptom, but only a few effective treatments are available. This study was supported by a grant from Unimed Pharm., INC. and was conducted at the requests of the Korea Food and Drug Administration (KFDA).
http://placentrex.blogspot.com/2011/09/kfda-requests-for-study-of-hpes-role-on.html
This document describes a study that evaluated the anti-diabetic effects of an Ayurvedic herbo-mineral formulation called Trushanadi loha. The formulation contains 14 plant and mineral ingredients. An aqueous extract was tested in rats. Blood glucose levels were measured. The extract produced a 40% reduction in blood glucose levels in normal rats, demonstrating significant anti-diabetic activity. The formulation was also found to be non-toxic in acute oral toxicity tests in rats at doses up to 5,000 mg/kg. Overall, the study provides evidence that Trushanadi loha has anti-diabetic properties and a safe toxicity profile.
This research paper evaluated the hepatoprotective activity of Tephrosia purpurea Linn stem. The stem was extracted with methanol and subjected to phytochemical screening which revealed the presence of flavonoids, phytosterols, alkaloids and proteins. An acute toxicity study found the extract was safe up to a dose of 2000 mg/kg. Hepatoprotective activity was evaluated against CCl4-induced hepatotoxicity in rats. Biochemical parameters (SGPT, SGOT, ALP, bilirubin) were assessed. The methanol extract reduced these serum levels and exhibited dose-dependent hepatoprotective activity comparable to the standard drug silymarin. Phytoc
This document provides a bio-data or curriculum vitae for Prof. Yamini Bhusan Tripathi. It lists his personal details including name, date of birth, education, positions held, research experience, publications, projects, awards, patents, books, and training. It shows that he is a professor of medicinal chemistry with over 36 years of teaching and research experience, having published over 129 papers and authored or edited several books and book chapters in his field.
This study compared the pharmacokinetics of a single 60 mg/kg dose of azithromycin extended-release oral suspension to a single 30 mg/kg dose of azithromycin immediate-release oral suspension in children aged 6 months to 6 years with acute otitis media. The study found that the 60 mg/kg extended-release dose provided similar or greater systemic exposure of azithromycin compared to the 30 mg/kg immediate-release dose, as the adjusted geometric mean ratio of the area under the concentration-time curve from time 0 to 72 hours post-dose was 157.98% with a lower 90% confidence interval boundary above the predetermined threshold of 80%. Extended-release resulted in lower concentrations
Indian journal of research in pharmacy and biotechnology 4debjit bhowmik
This document discusses the controversial role of antipsychotics in the treatment of Alzheimer's disease. While atypical antipsychotics can effectively treat psychotic symptoms and behavioral issues in the short term, several placebo-controlled studies have found they nearly double the risk of death over 2-3 years due to adverse events like infections. The FDA issued a black box warning about this increased mortality risk. Currently, the only FDA-approved medications target cognitive symptoms, but they also have significant side effects. More research is needed to develop safer alternatives for managing behavioral and psychological symptoms in Alzheimer's patients. Non-pharmacological interventions should be the primary treatment approach.
Hepatoprotective Potential of Tephrosia purpurea in Thioacetamide-Induced Hep...BRNSS Publication Hub
Background: Hepatotoxicity ultimately leads to liver failure. Conventional treatment options for hepatotoxicity are limited and not safe. Aim: The present work has been designed to evaluate the hepatoprotective effects of ethanolic extract of the root of Tephrosia purpurea (Linn.) against thioacetamide-induced hepatotoxicity in experimental Wistar albino rats. Materials and Methods: The plant roots, T. purpurea, were collected from the local area of Jodhpur, Rajasthan, and verification was done by Botanical Survey of India (BSI), Jodhpur, Rajasthan, and a herbarium specimen was deposited in BSI with No. LMC/PM/PD-001. All other reagents and chemicals were of suitable analytical grade and were used as received. Results: On the basis of statistical analysis, both the doses (200 and 400 mg/kg b.wt) of the ethanolic extract of T. purpurea root shown significant hepatoprotective activity compare to negative control. The dose of 400 mg/kg b.wt showed better reduction in serum enzyme level compare to 200 mg/kg b.wt dose of the ethanolic extract of T. purpurea root. Results were determined by one-way analysis of variance (ANOVA non-parametric) followed by Dunnett’s test with P < 0.01 considered statistically significant. Conclusion: Based on the results obtained, it may be concluded that the ethanolic extract of T. purpurea root has a significant protective effect on liver injuries.
The document discusses general considerations for conducting bioavailability and bioequivalence studies for orally administered drugs, including the regulatory objectives, methods used to evaluate bioavailability and demonstrate bioequivalence, and special topics like food effect and long half-life drugs. It provides background on key concepts like bioavailability, bioequivalence and their regulatory definitions as well as guidance on study design and requirements for different types of drug products and changes.
The goal of reverse pharmacology is to utilize disease pathology in order to identify specific and targetable elements that novel compounds can be modeled from.
This study evaluated the safety and anti-diabetic effects of a polyherbal phytocomposite (PHC) created from the leaves of Ficus benghalensis, Syzygium cumini, and Ocimum sanctum. In acute toxicity tests, the PHC showed no adverse effects at doses up to 7.5g/kg and the median lethal dose was determined to be 20.25g/kg. In sub-chronic toxicity tests, the PHC at doses up to 750mg/kg caused some changes in organ weights and blood biomarkers but no mortality. The PHC significantly lowered blood glucose and lipids in diabetic rats, performing better than the individual plant extracts and metformin. The PHC
This document provides a summary of the qualifications and experience of Dr. GURFATEH SINGH, including his education, work experience, research experience, technical skills, academic achievements, publications, and extracurricular activities. He has over 15 years of experience working as an Assistant Professor and has supervised over 45 students. He has received several awards for his research and publications in the fields of pharmacology and cardiovascular disease.
This document describes a study that evaluated the pharmacological effects of Terminalia chebula fruit extracts against neurodegenerative disorders in rodents. The study involved extracting Terminalia chebula fruits with polar and non-polar solvents, conducting preliminary phytochemical analysis, and screening the extracts for anti-parkinsonism and memory-enhancing effects. For anti-parkinsonism activity, the extracts were tested in a haloperidol-induced catatonia model in rats, while for memory effects the extracts were evaluated in ethanol-induced cognitive impairment and diazepam-induced amnesia models. The results of the study were discussed and compared to control groups.
A Textbook of Clinical-Pharmacy, Essential concepts and skillsFeroze Fathima
This document provides an overview of the textbook "A Textbook of Clinical Pharmacy Practice: Essential Concepts and Skills". The textbook is in its second edition and aims to teach the essential concepts and skills of clinical pharmacy practice. It contains 30 chapters contributed by experts in clinical pharmacy from India and other countries. The chapters cover topics such as community and hospital pharmacy practice, communication skills, medication adherence, pharmacovigilance, clinical skills like ward rounds and medication reviews, and specialized topics such as geriatric pharmacy and pharmacoeconomics. The textbook is intended to support the teaching of clinical pharmacy to pharmacy students and practicing pharmacists.
Globalization is happening now and we must be aware of it. Standardization is important for traditional Indian systems of medicine (ISM) like Ayurveda to ensure safety and efficacy. This includes standardizing education, manufacturing practices, research methods, and regulations. National institutes and universities provide Ayurveda education following standardized syllabi. Quality control measures are in place for herb cultivation, product development, and testing to meet global standards. Collaborative research is conducted between ISM institutions and other organizations. Standardization helps mainstream ISM while protecting traditional knowledge and making the most of available resources and talent for the health of all.
This document is a curriculum vitae for Dr. Rajesh Yadav that provides details about his educational qualifications and professional experience. It summarizes that he has a Ph.D. in Pharmaceutical Sciences, has over 13 years of teaching experience as a lecturer and professor, and 5.5 years of research experience. He has published over 25 research papers and presented in several national and international conferences.
Rajesh Kumar Suman has extensive experience in preclinical research including extraction of medicinal plants, animal handling for procedures like injections and blood collection, and conducting drug utilization research. He holds a PhD in Medical Pharmacology from MGM Institute of Health Sciences and has published several research papers and book chapters. His objective is to achieve a challenging career where he can utilize his skills in research.
Srinivas Maddi CV _ Prinicipal scientist_ DMPK_ 2015Srinivas Maddi
This cover letter summarizes an applicant's 8+ years of experience in drug metabolism, pharmacokinetics, and preclinical formulation research. They established a DMPK lab and led due diligence programs that resulted in out-licensing of new chemical entities. The applicant has expertise in designing and interpreting in vitro and in vivo pharmacokinetic studies for small molecules and experience with PK-PD modeling.
To perform to my best ability in the field of pharmaceutical education and research in all personal and professional activities and get involved in the growth of the organization in a very responsible and honest way.
This document outlines the formulation and evaluation of an herbal emulgel containing Terminalia chebula for the treatment of rheumatoid arthritis. Key points:
1. An emulgel was developed to improve delivery of hydrophilic herbal extracts through the skin using a stable dual drug release system.
2. The emulgel was prepared using a gel base incorporated with an herbal oil-in-water emulsion containing Terminalia chebula extract.
3. Evaluation tests showed the emulgel had desirable physical properties and released the herbal extract in vitro over an extended period, indicating its potential for transdermal delivery in rheumatoid arthritis treatment.
The document summarizes the pharmacognostic and phytochemical evaluation of the leaf and stem of Euphorbia hirta. Macroscopic and microscopic analysis revealed characteristic features of the leaf such as elliptic or oblong shape, faintly toothed margins, and presence of anomocytic stomata. Microscopic analysis of the stem showed small epidermal cells with papillate outer walls and vascular tissue comprising xylem and phloem. Phytochemical screening indicated the presence of steroids, carbohydrates, flavonoids, proteins, alkaloids and saponins. The results provide standardized information that can help in the identification and quality control of E. hirta materials.
Development and Evaluation of Enteric Coated Herbal Drug Delivery System for ...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Ayurveda shows a way forward to drug discoverysaumyagulati4
drug discovery in Ayurveda.
Is there is a need for Stepwise drug discovery in Ayurveda?
i:e from in-vitro to Clinical.
or Clinical to laboratory research in Ayurveda.
Usefulness of Rare and Lesser Known Medicine Gaultheria Procumbens A Clinical...ijtsrd
Background Homoeopathic medicines known for its utility in wider spectrum of pathological conditions. Homoeopathic Science adds new medicines in the system through drug proving and explores additional features of already existed medicines through clinical verification. Gaultheria Procumbens is among those medicines having broader application but lesser known due to limited Clinical Experience with the medicine. Clinical verification of this Medicine will explores many new insights in its healing power and ultimately its utility in day to day practice. Aims The Main Objective was to study to verify the Clinical Utility of Rare and Lesser Known Medicine Gaultheria Procumbens. Another important objective is to prepare a Remedy Profile of Gaultheria Procumbens from clinical verified Symptoms during study. With research question, Will the verification of rare and lesser known medicine Gaultheria Procumbens helpful in Homoeopathic Practice Setting and Design The study was Prospective Analytical and Interventional Clinical Verification study. A clinical study had been conducted in which total 30 experimental samples were Purposively selected from the 3 project sites, Smt. S. I. Patel Ipcowala Homoeopathic Hospital, Amul Dairy Road, Anand and Rural as well as O.P.D. centers situated at Dharmaj, Napad and Anand Agriculture university Health centre.Materials and Methods 30 samples were selected through Purposive Sampling method with fulfillment of inclusion and exclusion criteria. Data collection was done with the Personal Interview Method According to guidelines given in Organon of medicine, book by Dr. Hahnemann. Remedy Profile of Gaultheria Procumbens from available data during Review of Literature with specially Prepared Case Performa and Scoring systems were selected as tools for data collection. Potency Selection, Repetition and Follow ups were decided according to need of particular case. Statistical Analysis Paired t test was done in Microsoft Excel using Pre Treatment and Post Treatment Score from Subjective Scoring System MYMOP Measure Yourself Medical Outcome Profile .Result Most of the cases 11 36.67 were seen in the age group 51 60 that suggest this age group have more Prevalence of the diseases affect the Locomotor system during this era and Female sex having slightly more Predominance than Male sex. Most of cases in this study with Acute phase or Acute Excerbations of Chronic than the Chronic one. Other variables like potency and diagnosis were also observed.Conclusion This study helps to verify the medicine Gaultheria Procumbens and Explore its utility in Practical Homeopathy. Some characteristic symptoms as well as sphere of action were also found during this study which will be helpful in prescribing as well as studying the medicine Gaultheria Procumbens. This Primary research will be a good base for further research with Gaultheria Procumbens. Dr. Jalpa P. Atri "Usefulness of Rare and Lesser Known Medicine Gaultheria Procumbens: A Clinic
A Systematic Review and Meta-Analysis of Plant cell technology for Production...Pubrica
Plant cell technology is an important strategy for the production of plant-based drugs. It has several advantages such as high accuracy, repeatability, and productivity; this technology can be used instead of whole herbs.
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Phytochemical screening and evaluation of aphrodisiac and antihyperlipidemic ...Srota Dawn
This document discusses a dissertation submitted to Vels University in partial fulfillment of the requirements for a Master of Pharmacy degree. The dissertation involves phytochemical screening and evaluation of the aphrodisiac and antihyperlipidemic activities of a polyherbal extract containing Daucus carota sativus seeds, Musa paradisiaca sapientum stem, and Cucumis melo peel. It provides background on the plants and certificates from the dissertation guide and university directors.
Stress testing involves subjecting drug substances and products to conditions beyond typical accelerated testing to induce degradation. This helps identify degradation products and establish degradation pathways. Stress testing is performed during development and manufacturing to validate stability-indicating analytical methods. Methods may involve exposure to heat, humidity, acids, bases, oxidation or light. Identification and characterization of degradation products is important for regulatory approval and safety evaluation.
This document discusses methods for determining pesticide residues in medicinal plant materials. It covers the qualitative and quantitative determination of organochlorine pesticides through extraction, clean-up, and gas chromatography analysis. It also describes the determination of phosphates using a spectrophotometric method and provides recommendations for determining specific pesticide residues, including using reference substances, checking for linear relationships, and storing reference solutions properly.
This document describes two limit test methods for determining the amount of lead in herbal medicine extracts.
Method 1 involves igniting a sample to ash, dissolving the residue, and comparing the color of the test solution to a control solution containing a known amount of lead after adding sodium sulfide. Method 2 involves heat-treating a sample, performing an atomic absorption spectrophotometry analysis using the standard addition method, and ensuring the absorbance of the test solution does not exceed the standard solution. Both methods are used to test if the amount of lead is below specified limits.
1) Three ayurvedic publications on herbal medicines for obesity were systematically reviewed. Ephedra and caffeine were found to reduce body weight and fat over 12 weeks without serious side effects.
2) Several herbal supplements including Cissus quadrangularis, ephedra and caffeine, and extracts of ginger and other plants were found to reduce body weight, fat levels, and waist circumference in human studies on obesity.
3) Terminalia arjuna bark powder was found to have antioxidant effects comparable to vitamin E and significantly reduced cholesterol levels in patients with coronary heart disease.
This document discusses validation parameters for analytical methods according to the International Council for Harmonisation guidelines. It lists accuracy, precision (repeatability, intermediate precision), specificity, detection limit, quantitation limit, linearity, range, and robustness as key validation characteristics that should be considered. It provides definitions and details for each validation characteristic. Revalidation may be necessary if there are changes in the drug substance synthesis, product composition, or analytical procedure.
The document summarizes key aspects of the Wildlife Protection Act of 1972 in India. Some key points:
- The Act was enacted to effectively protect wildlife in India and control poaching, smuggling, and illegal trade of wildlife.
- Authorities like the Director of Wildlife Preservation, Chief Wildlife Wardens, and Wildlife Wardens were established to administer the Act.
- A Wildlife Advisory Board was constituted at the state level to advise on wildlife protection and conservation matters.
- Hunting of wild animals is prohibited, with penalties prescribed for offences. National Parks and Sanctuaries can be established for protection of wildlife.
- Subsequent amendments have strengthened the Act by prescribing higher fines and imprisonment
This document summarizes analytical profiles of the plant Carissa carandas Linn, including its botanical description, phytochemical analysis, and isolation of compounds. Key points include:
- Carissone and scopoletin were isolated from root extracts and found to have anti-inflammatory activity.
- HPLC, NMR, and mass spectroscopy were used to analyze marker compounds. HPLC showed retention times for carissone, oleonolic acid, stigmasterol, and scopoleetin.
- NMR analysis supported the identification of carissone. 13C NMR showed signals for a keto group and hydroxyl group in carissone.
- Several therapeutic activities of C
This document summarizes research on the properties and health benefits of five different plants, including almonds and walnuts. It describes chemical compositions, pharmacological actions, and clinical studies showing benefits such as lowering cholesterol, blood pressure, and risk of heart disease. Multiple papers discuss antioxidants and anti-inflammatory compounds in each plant that may help prevent cancer, diabetes, and neurodegenerative diseases.
it is related to that of ayurvedic and traditional ealth scciences ,deals with its global market ,importance some examples reffered from internet sources.
it will discusses about pathophysiolgy,of anxiety and depression and SAR as well pharmacology of antidepressants and anxiolytics from standard books as a references as i mentioned
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
1. Assignment-3
Collection of Research data
done on Ayurvedic Herbal
medicines
Presented to:
DR., S. M .TRIPATHI
(MD)
Presented by:
D. Gnana bhaskar
Reg no:16TMM2364
MS(Pharm)2nd SEM
2. Comparative clinical evaluation of herbal formulation with
multivitamin formulation for learning and memory enhancement
Jigna Shah *1, Ramesh Goyal 2
1 Shri Sarvajanik Pharmacy College, near arvind baug, Mehsana, Gujarat, India. 2 The
Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
Vol.3 Issue 1, January-March 2010 ISSN 0974-2441, Asian Journal of Pharmaceutical and Clinical Research
Data suggest that both PHF and MV supplementation improves learning
and memory as compared to placebo in healthy young subjects. PHF
appears to be more active than MV. Both the drugs might be enhancing
learning and memory due to their antioxidant property or by contributing
to the production of important brain neurotransmitters such as
acetylcholine, adrenal hormones, steroids and cortisone or by
maintaining adequate levels of various micronutrients, which ultimately
affect mental functions and enhance learning abilities.
PHF (Tonix Healthcare, Ahmedabad, India)
and MV (Ami Healthcare, Ahmedabad, India).
PHF is polyherbal formulation containing
ashwagandha, jatamansi, sarpagandha,
shankhpushpi, shatavari, amalki, kauch bij
extract, khurasani ajmo, shilajit, mukta shukhti
pishti and praval pishti. MV is vitamin B
complex capsule containing vitamin B1 (10
mg), vitamin B2 (10 mg), vitamin B6 (3 mg),
vitamin B12 (15 µg), niacinamide (100 mg),
calcium pantothenate (50 mg) and folic acid
(1.5 mg), ascorbic acid (150 mg), biotin (100
µg).
About the formulation Conclusion
3. “Vasuliv Syrup
Extract of Glycyrrhiza glabra (Yashtimadhu) root 6,
Phyllanthus niruri (Bhumyamalaki) whole plant 7,
Boerhaavia diffusa (Punarnava) root 8, Eclipta alba
(Bhringraj) whole plant 9, Terminalia belerica (Bibhitaki)
fruit 10, Terminalia chebula (Haritaki) fruit 11, Picrorhiza
kurroa (Kutaki) root 12, Tephrosia purpurea (Sharpunkh)
whole plant 13, Cichorium intybus (Kasni) seed 14 and
Andrographis paniculata (Kalmegh) aerial
Pharmacological investigation of Polyherbal formulation on Carbon
tetrachloride (CCl4)-induced liver damage in wistar rats Vasuliv Syrup
1Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., 896/A, G.I.D.C., Makarpura, Vadodara – 390 010, Gujarat,
India.
2Department of Pharmacognosy and Phytochemistry, Shri B. M. Shah College of Pharmaceutical Education and Research,
Dhansura road, College campus, Modasa – 383 315, Gujarat, India.
Hardik Soni1*, Priyanka Desai2, Natvarlal Patel2 and Ghanshyam Patel1
www.ssjournals.com ISSN: 2277-3312 Journal DOI:10.7439/ijpr
International Journal of Pharmacological Research
Conclusion
On the basis of study data, it can be concluded that Polyherbal
formulation (Vasuliv Syrup) has promising hepatoprotective
activity against CCl4-induced liver damage. It can be employed
as safe and effective treatment for hepato-toxicity or liver
damage.
About the formulation Conclusion
4. Safety evaluation of mercury based Ayurvedic formulation
(Sidh Makardhwaj) on brain cerebrum, liver & kidney in rats
Indian J Med Res 139, April 2014, pp 610-618
Department of Pharmacology, All India Institute of Medical Sciences & *Department of AYUSH, Ministry of Health & Family Welfare,
Government of India, New Delhi, India.
Gajendra Kumar, Amita Srivastava, Surinder Kumar Sharma* & Yogendra
Kumar Gupta
Sidh Makardhwaj is a popular Kupipakwa rasayan,
prepared with swarna (gold), parada (mercury), gandhaka
(sulphur) in a specific ratio (1:8:24) mentioned in Ayurvedic
Formulary of India1. It has been used in the Indian Systems of
Medicine for centuries with claimed efficacy and safety for the
treatment of rheumatoid arthritis, neurological disorders, as a
rasayana for vigour and longevity of .life. It is prepared by a
specific process of constant heating for more than 24 h converting
it in a stable compound (mercury sulphide).
The findings of the present study suggest that Sidh
Makardhwaj upto five times the equivalent human
dose administered for 28 days did not show any
toxicological effects on rat brain cerebrum, liver
and kidney
About the formulation Conclusion
6. Preliminary pharmacological evaluation of an
Ayurvedic formulation Dasamularista
Sultana Rajia*, M Shahabuddin Kabir Choudhuri, Mafruhi Sattar and Masum
Shahriar
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
Oriental Pharmacy and Experimental Medicine 2006 6(3), 208-214
The results suggest Dasamularista reduced the intestinal
motility in our experimental models and have antidiarrhoeal
effect. Dasamularista did not alter the acetic acid induced
abdominal writhing,but the significant reduction on the onset
of sleeping time and increased duration of sleep indicates the
formulation may have effect on the central nervous system.
Further studies are suggested with individual ingredients and
as a formulation.
About the formulation Conclusion
7. Pharmacognostic evaluation of an ayurvedic
formulation Eladi Gutika
Sunita Shailajan, Sasikumar Menon1, Manasi Yeragi, Vishakha Kelkar
Herbal Research Lab, Ramnarain Ruia College, Matunga, 1Therapeutic Drug Monitoring Laboratory, Sion,
Mumbai, India
DOI:10.4103/0973-8258.94352, International Journal of Green Pharmacy(302-306), Int J
Green Pharm 2011;5:302-6.
Eladi Gutika (EG), is an Ayurvedic polyherbal formulation of
seven ingredients namelyEla (Ellettaria cardamomum),Tejpatra
(Cinnamomumtamala),Tvak(Cinnamomumverum),Pippali(Piperl
ongum),Madhuka(Glycirrhizaglabra),Kharjura,(Phoenixsylvestri
s),Mrdvika (Vitisvinifera), Sita (Sugar) and Madhu (Honey). It is
prescribed for the treatment of cough and asthma. Due to lack of
modern pharmacopoeial standards laid down and followed for
processing of EG, the medicine may not have desired quality and
batch to batch consistency. Hence, there is a need for
standardization of EG using modern bioanalytical tools
Values and the results of such reproducible modern techniques
can make the traditional medicines more acceptable in the local
and global market. Thus, rationally designed, carefully
standardised, synergistic traditional herbal formulations and
botanical drug products with robust scientific evidence can also
be alternative to modern medicin
About the formulation Conclusion
8. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
Volume 4, Issue 05, 708-715. Research Article ISSN 2278 – 4357 ,,.
PHARMACOLOGICAL EVALUATION AND DEVELOPMENT OF AN ANTIULCER POLYHERBAL
FORMULATION
Mohammed Sajid, UtkarshaPagdhare* and Vasanti Suvarna
Department of Pharmaceutical Chemistry, S.V.K.M’S, Dr. Bhanuben Nanavati College
of Pharmacy, Mithibhai College Campus, V.M. Road. Vile Parle- (W),
Mumbai - 400 056, India.
(PHF) containing the extracts of
amla(Emblicaofficinalis) fruitsandtulsi(Ocimum
sanctum) leaves, andneem(Azadirachtaindica)
The phytochemical screening of
Embilicaofficinalis,Azadirachtaindica and Ocimum
sanctumextracts,showed presence of
alkaloids,tannins,glycosides and absence of
proteins.The mixture of extracts showed significant
reduction in ulcer index and showed significant ulcer
protectionin ethanol induced ulcer model
About the formulation Conclusion
9. Evaluation of Ayurvedic compound formulations III- Laghugangadhar Churna
Anshu Rathi*, Vartika Rai, Sayyada Khatoon, Subha Rastogi, Ajay
Kumar Singh Rawat, Shanta Mehrotra & M M Pandey
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow 226 001, Uttar Pradesh
Indian Journal of Traditional Knowledge Vol. 9 (3), July 2010, pp. 576-580
Lagugangadhar Churna (LGC), a common
compound preparation used for treatment of
diarrhoea and dysentery. This compound
preparation is composed of six medicinal plant
ingredients like exudates of S. malabarica, rhizome
of C. rotundus, stem bark of S. racemosa, flower of
W. fruticosa, fruit pulp of A. marmelos and seeds
of H. antidysenterica.
The development of pharmacopoeial standards of
Laghugangadhar Churna was based on outcome of microscopical,
physicochemical and HPTLC finger print profiles. The results
were found to be highly accurate, quick and reliable for routine
monitoring based on quality control of raw material, processed
powder and compound preparations. The ingredients C. rotundus
and H. antidysenterica are also used in other compound
formulations like Ashwagandhadi churna, Katphaladi churna and
Palashbijadi churna and these preparations can also be
standardized by similar protocols. With the growing demand of
herbal drugs in the herbal drug market, it is suggested that this
standardization tool will help in maintaining the quality and batch
to batch consistency of many important Ayurvedic preparations
including Laghugangadhar Churna
About the formulation Conclusion
10. Evaluation of stability study of Ayurvedic formulation – Rasayana Churna
Biswajyoti Patgiri, Hardik Soni*, Surendra Bhatt
Journal of Pharmacognosy and Phytochemistry 2014; 2 (5): 126-130
Department of Rasashastra &
Bhaishajya Kalpana, Institute forPost Graduate Teaching and Researchin Ayurveda (IPGT&RA), GujaratAyurved University,
Jamnagar – 361008, Gujarat, India.
Rasayana Churna is a traditional Ayurvedic
formulation, which comprises dried powders of three
well known rejuvenating drugs viz. dried stem of
Guduchi (Tinospora cordifolia Miers.), dried fruit of
Gokshur (Tribulus terrestris Linn.) and dried
pericarp of Amalaki (Emblica officinalis Gaertn.) in
equal proportion
The present investigation supports that the Rasayana Churna was
suitable at accelerated condition up to 6 month storage. it can be
extrapolated that shelf life of Rasayana Churna is 25.12 months
(2.09 years) for countries which comes under climatic zone I & II
and 16.60 months (1.38 years) for countries which comes under
climatic zone III & IV. Real time stability data of Rasayana Churna
showed very good stability up to 1 year.
About the formulation Conclusion
11. FORMULATION AND EVALUATION OF CHURNA FOR DIGESTIVE PROPERTY
D. Chamundeeswari a , P. Kanimozhi a, Vasanthkumar a,
C.Umamaheswara Reddy a
Sri Ramachandra Journal of Medicine Nov. 2007,(39-43)
Department of Pharmacognosy Sri Ramachandra College of Pharmacy Sri Ramachandra University,
Porur, Chennai – 600 116 Sri Ramachandra College of Pharmacy
The raw materials such as rhizomes of Zingiber
officinale (2 parts), fruits of Foeniculum vulgarae (2
parts), barks of Cinnamomum zeylanicum (1 part)
and fruits of Trachyspermum ammi (1 part) were
used for the preparation of the formulation
The physical parameters evaluated confirm the standard
of the formulated churna. The invitro study of enzymatic
activity carried out by above methods brings out the fact
that the formulated churna possess the property of digesting
starch, lipids and proteins similar to that of marketed
formulation GASTRAP.
About the formulation Conclusion