This document provides guidance on conducting a general clinical examination (GCE). It defines a GCE as the direct observation and examination of a patient using inspection, palpation, percussion and auscultation. The objectives and significance of a GCE are explained, which is to gather clinical signs, analyze them, make diagnoses or differential diagnoses, and guide further testing and treatment. Steps for systematically conducting a GCE are outlined, including preparing the patient, examining different body regions like the head, neck, hands, lymph nodes and feet.