Gene regulation in prokaryotes occurs through operons, clusters of genes that are expressed together. The lac and trp operons are examples of inducible and repressible operons, respectively. The lac operon is induced by the presence of lactose and involves both positive and negative control. It is negatively controlled by the lac repressor binding to the operator, but activated by the catabolite activator protein. The trp operon is repressed by the binding of tryptophan to the trp repressor, preventing transcription. It also uses attenuation, where mRNA folding terminates transcription at high tryptophan levels. Operons regulate metabolic pathways through induction or repression in response to environmental conditions.