This document provides an overview of fluid therapy and electrolyte disturbances. It discusses the basic physiology of body fluids, including total body water content and distribution. It then covers various electrolyte abnormalities like hyponatremia, hypernatremia, hypokalemia, hyperkalemia, hypocalcemia, hypercalcemia, hypomagnesemia, and hypermagnesemia. It also addresses acid-base balance disturbances and different intravenous fluid options for fluid resuscitation and maintenance.
colloids with their properties and their benefits and disadvantages . indications for colloids. types of colloids and their effect on volume expansio.various studies done for colloids. body fluid compartments and distribution of total body water.
colloids with their properties and their benefits and disadvantages . indications for colloids. types of colloids and their effect on volume expansio.various studies done for colloids. body fluid compartments and distribution of total body water.
Acid base balance & ABG interpretation,Dept of anesthesiology,JJMMC,DavangereGopan Gopalakrisna Pillai
Acid base balance and ABG interpretation presented by Dr.Gopan.G,Post-Graduate student. Chairperson : Dr.Ravi.R,Professor, Department of Anaesthesiology & Critical care,JJMMC,Davangere.
Acid base balance & ABG interpretation,Dept of anesthesiology,JJMMC,DavangereGopan Gopalakrisna Pillai
Acid base balance and ABG interpretation presented by Dr.Gopan.G,Post-Graduate student. Chairperson : Dr.Ravi.R,Professor, Department of Anaesthesiology & Critical care,JJMMC,Davangere.
general presentation and management of Fluid & Electrolyte.pptxNatnael21
Discussion about physiology of fluid balance in human and clinical presentation and general management principles of major electrolyte abnormality like hypernatremia hyponatremia hyperkalemia and hypokalemia
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Fluid and electrolytes
1.
2. 1. Introduction
2. Basic physiology
3. Body fluid electrolytes disturbances
4. Parenteral fluid therapy
5. Basic principles
6. I.V. fluids
7. Methods of calculation of fluid transfusion rate
8. Fluid therapy in surgical patients
9. Volume resuscitation – end parameters & goals
10. Conclusion
11. References
Total body water
Distribution
Composition
Normal exchange of fluids
Salt intake & output
3. • Body is formed with solids & fluids.
• In human body water content is 45-75% of bodyweight.
• Importance :
1. In homeostasis
2. In transport Mechanism
3. In metabolic reactions
4. In maintenance of tissue texture
5. In temperature regulation
4.
5. • TBW varies with age, gender and body habitus .
• In adult males= 60-65% of body weight, average = 60%
• In adult female=45-50% of body weight, average = 50%
• In infant = 80% of body weight
• Obese patients have less TBW per Kg than lean body adult.
6. 1= Intracellular fluid (ICF)= 70% TBW or 30%(F) - 40% (M) BW
2= Extracellular fluid (ECF) = 30%TBW or 20% BW
Interstitial fluid = 7.5% of body weight ( 15%)
Intravascular fluid or plasma volume = 4% of body weight ( 5%)
Transcellular fluid = 3.5 % of body weight
Body compartment fluid
9. Osmolarity :
• It is fluid’s capability to create osmoticpressure.
• It is concentration of osmotically active substances in solution.
Osmolality :
• It is no. of particles / L of solution.
Tonicity :
• Way of expressing effective osmolarity.
10
Same effective osmolarity as body fluid Greater effective osmolarity than body fluid less effective osmolarity than body fluid
Cell in a
hypertonic
solution
Cell in a
hypotonic
solution
11. Water Gain route Average
Daily vol. (ml)
Minimum
(ml)
Maximum
(ml)
sensible Oral fluids 800 - 1500 0 1500/h
Solid food 500 – 700 0 1500
insensible Water of
oxidation
250 125 800
Water of
solution
0 0 500
Water loss route average
Daily vol. (ml)
Minimum
(ml)
Maximum
(ml)
sensible Urine 800 - 1500 500 1400 / h
Intestine 0 – 250 0 2500 / h
sweat 0 0 4000 / h
insensible Lungs 400
600 1500
Skin 500 - 1000
12. 13
Daily fluid replacement = 700 + urine output
Excess water loss
1. fever : 100 ml / degree fever / day
2. Tracheostomy (unhumidified air) : >1.5 L / day
13. Salt intake & output
• Daily salt intake varies 3-5 gm as NaCl
• Kidneys excretes excess salt: can vary from < 1 to > 200
mEq/day
• Volume and composition of various types of gastrointestinal
secretions
• Gastrointestinal losses usually are isotonic or slightly hypotonic
• Should replace by isotonic salt solution
16. Hypovolemia
• ECF volume deficit is most common fluid loss in surgical
patients, and aggravated by GeneralAnesthesia.
• Most common causes of ECF volume deficit are: GI losses
from vomiting, nasogastric suction, diarrhoea, and fistular
drainage
• Other common causes: soft-tissue injuries and
infections, peritonitis, obstruction and burns.
18. Hypervolemia
• Iatrogenic or Secondary to renal
insufficiency, cirrhosis, or CHF.
Signs
• CNS: none
• CVS: elevated JVP, venous
distension – pulmonary edema, S3,
• Respiratory : shortness of breath even
in rest.
• GI: edema of bowel
• Tissue: pitting edema –
anasarca, ascites, weight gain
Clinical Diagnosis
• Electrolytes imbalance
• Decreased specific gravity
• Decreased hematocrit
• Cholesterol
• Liver enzymes
• Bilirubin
• Creatinin clearance
19. Management of Hypervolemia:
• Prevention is the best way
• Guide fluid therapy with CVP level or
pulmonary wedge pressure
• Diuretics
• Increase oncotic pressure: FFP or
albumin infusion (may followed by diuretics)
• Dialysis
21. Hyponatremia
• Na+ is the most abundant positive ion of ECF compartment
and is critical in determining the ECF and ICF osmolality.
• Normal amount 135-145 mEq/l.
Signs & symptoms
• Sign & symptoms : <120 mEq/l.
• CNS:
confusion, lethargy, stupor,headache,
seizure, coma
• GI: nausea, vomiting
26. Potassium Abnormalities
• Normal daily dietary intake of K+ is approx. 50 to 100 mEq/day,
& The normal range of serum potassium: 3.5-5.1 meq/L.
• Majority of K+ is excreted in the urine (0-700 meq/day).
• 98% of the potassium in the body is located in ICF at 150
mEq/L and it is the major cation of intracellular water.
• Intracellular K+ is released into the extracellular space in
response to severe injury or surgical stress, acidosis, and the
catabolic state.
• K+ has an important role in the regulation of acid-base balance.
27. Hypokalemia
Etiology :
• Inadequate intake
• Dietary, potassium-free intravenous fluids,potassium-deficient
• Total parenteral nutrition
• Excessive potassium excretion
• Hyperaldosteronism
• Medications
• Gastrointestinal losses
• Direct loss of potassium from gastrointestinal fluid (diarrhea),(gastric
fluid, either as vomiting or high nasogastric output)
• Renal loss of potassium
• Intracellular-shift (metabolic alkalosis or insulin therapy)
• Potassium decrease by 0.3 meq/L for every 0.1 increase in pH above normal
Serum K+ < 3.5 mEq/L
28. Treatment :
• KCl 10 mEq/L/hr IV - pripherally
• KC1 20 mEq/L/hr IV - centrally
Body system Signs & symptoms
Gastrointestinal Paralytic Ileus, constipation
Neuromuscular Decreased reflexes, fatigue, weakness, paralysis,
rhabdomyolysis, hyporeflexia
Cardiovascular U-waves
T-wave flattening
ST-segment changes
Arrhythmias
Tissue Dry sticky mucous membranes, red swollen tongue,
decreased saliva and tears
Renal Polyuria & polydypsia
30. Body system Signs & symptoms
Gastrointestinal Nausea/vomiting ,colic diarrhea
Neuromuscular weakness, paralysis, respiratory failure
Cardiovascular Arrhythmia, arrest
ECG changes Peaked T waves (early change)
Flattened P wave
Prolonged PR interval (first-degree block)
Widened QRS complex
Sine wave formation
Ventricular fibrillation
Treatment of hyperkalemia
31. Calcium Abnormalities
• Majority of the 1000 to 1200g of calcium in the average-sized adultis
found in the bone .
• Normal daily intake of calcium is 1 to 3 gm.
• Normal serum level = 8.8-10.5 mg/dl
• Albumin Bound = 40-60%
• Ionized portion (1.2 mg/dl) is responsible for neuromuscularstability
• Most is excreted via the GI tract
Corrected calcium = 4 – albumin x 0.8 + serum calcium
33. Hypocalcemia S/S Hypercalcemia S/S
1. Hypotension
2. Anxiety
3. Psychosis
4. Paresthesia
5. Laryngeal spasm
6. Numbness and tingling of the
circumoral region and the tips of the
fingers and toes
7. tetany with carpopedal spasm,
convulsions (with severe deficit),
8. Chvosteck & trousseau’s signs
1. Hypertension
2. Bradycardia
3. Constipation
4. Anorexia
5. nausea, vomiting
6. Nephrolithiasis
7. Pain
8. Psychosis
9. Pruritis
10. weight loss, thirst, polydipsia,and
polyuria
11. easy fatigue, weakness, stupor,and
coma
Treatment :
IV calcium for acute -1gm in D5 or NS
Oral calcium and vitamin D for chronic
34. Magnesium Abnormalities
• Total body content of magnesium 2000 mEq, about half of which is
incorporated in bone.
• Normal daily dietary intake of magnesium is approximately 240 mg
• Normal serum level = 1.5- 2.4 mg/dl
• Deficiency causes impaired repletion of Na+ & Ca 2+
35. Hypomagnesemia
• causes:
– starvation, malabsorption syndromes, GI losses, prolonged
IV or TPN with magnesium-free solutions
• signs & symptoms:
– similar to those of calcium deficiency
36. Hypermagnesemia
• Symptomatic hypermagnesemia, although rare, is most
commonly seen with severe renal insufficiency
• signs & symptoms:
CNS: lethargy and weakness with progressive loss of DTR’s –
somnolence, coma, death
CVS: increased P-R interval, widened QRS complex, and
elevated T waves (resemble hyperkalemia) – cardiac arrest
37. Basic principle
Should have knowledge of
1. Etiology of fluid deficit
2. Type of electrolyte deficit
3. Associated illness
4. Clinical status
Rationale
1. When to give or avoid
2. Which fluid
3. How much
4. Drop rate
5. Contraindication of specific fluid
6. How to correct the imbalance
7. How & when to use specific fluids
38. • Oral route is always preferred.
• Intravenous therapy should be started in criticalsituations.
indications
Oral intake is not possible
Severe vomiting, diarrhoea,
Dehydration & shock
hypoglycemia
Vehicle for some medication contraindications
Nutrition Ability to take oral fluid
Treatment of critical problems
(poisoning)
Avoid in CHF & volume overload
39. Advantages
Acute, controlled, predictable way
Immediate response
Prompt correction
Disadvantages
Require strict asepsis
Skilled supervision
Improper selection of fluid - dangerous
Improper volume – life threatening
Improper technique - complications
complications
Local : hematoma, infusion phlebitis, infiltration
Systemic : circulation overload, rigors, septicemia, air embolism
Others : fluid contamination, I.V. set & catheter problem
Human error
40. • Para = other than , enteron (Gk) = intestine
• Ways to approach i.v. route –
venepuncture venesection
41. Median
cubital vein
Long
Saphenous
vein
In obese, female & infants
Risk of
thrombophlebitis &
pulmonary
embolism
Rare in infants / children
1. Cephalic vein in deltopectoral
groove
2. Subclavian vein
3. Internal jugular vein
4. External jugular vein
Neonates /
small children
42. I.V. fluids
Based on use
Maintenance fluids Replacement fluids Special fluids
5% D NS, Inj. Sod.bicarbonate,
5% D with 0.45% NaCl DNS, mannitol,
RL, NS 1.6%, 3%, 5%
ISOLYTE -G, Inj. KCl
ISOLYTE-E, 25% Dextrose
ISOLYTE-M,
ISOLYTE-P
43. I.V. fluids
Based on property
Crystalloids
(solution of large molecules)
Colloids
(solution of electrolytes)
Life saving
RL 5% Albumin
NS 25% Albumin
DNS 10% Pentastarch
D-5% 10% Dextran -40
ISOLYTES 6% Dextran -70
10% Hetastarch
44. 5 % dextrose
Composition : Glucose 50 gms
Pharmacological basis :
Corrects dehydration and supplies energy( 170Kcal/L)
Indications :
• Prevention and treatment of dehydration
• Pre and post op fluid replacement
• IV administration of various drugs
• Prevention of ketosis in starvation, vomiting,diarrhea
• Adequate glucose infusion protects liver againsttoxic
substances
• Correction of hypernatremia
45. Contra indications
• Cerebral edema, neuro surgical procedures
• Acute ischaemic stroke
• Hypovolemic shock
• Hyponatremia , water intoxication
• Same iv line blood transfusion – hemolysis , clumping occurs
• Uncontrolled DM , severe hyperglycemia
Rate of adminstration – 0.5 gm/kgBW/hr or 666ml/hr 5 % D or 333ml/hr
10 %D
46. INVERTED SUGAR SOLUTION
Composition : inverted sugar 100 gms
Pharmacological basis :
half dextrose + half fructose
Indications :
• Prevention and treatment of dehydration (specially pregnancy)
• Liver diseases (prevents glycogen depletion)
Adverse effects :
1. Lactic acidosis
2. Hyperurecemia
3. hypophosphatemia
Contra indications
• hereditory fructose intolerance
• Caution in renal & hepatic impairment
• >25gm fructose should be avoided
• more expansive
47. Isotonic saline(0.9 % NS)
• Composition : Na+ 154 mEq, Cl- 154 meq
• Pharmacological basis : provide major ECF electrolytes..
corrects both water and electrolyte deficit.
increase the iv volume substantially
Contra indications
• Avoid in pre eclamptic patients, CHF, renal disease and cirrhosis
• Dehydration with severe hypokalemia – deficit of ICF potassium
• Large volume may lead to hyperchloremic acidosis.
48. Indications
• Water and salt depletion – diarrhoea, vomiting, excessive diuresis
• Hypovolemic shock
• Alkalosis with dehydration
• Severe salt depletion and hyponatremia
• Initial fluid therapy in DKA
• Hypercalcemia
• Fluid challenge in prerenal ARF
• Irrigation – washing of body fluids
• Vehicle for certain drugs
49. DNS
Pharmacological basis :
• Supply major EC electrolytes, energy and fluid to correct dehydration
Indications :
• Conditions with salt depletion ,hypovolemia
• Correction of vomiting or NGT aspiration induced alkalosis and hypochloremia
• Compatible with blood transfusion
Contra indications :
• Anasarca – cardiac, hepatic or renal
• Severe hypovolemic shock (osmotic diuresis)
• >25gm/hr should be avoided
50. DNS with
half strength saline
Pharmacological basis :
• Supply major EC electrolytes, energy and fluid to correct dehydration
• more water with less salt.
Indications :
• paediatric & very elderly
• Maintenance fluid in early post operativeperiods
• Treatment of hypernatremia
• Compatible with blood transfusion
Contra indications :
• hyponatremia
• Severe dehydration
51. Ringer’s
lactate
Pharmacological basis :
• Most physiological fluid , rapidly expand s iv volume..
• Lactate metabolised in liver to bicarbonate providing buffering capacity
• Acetate instead of lactate advantageous in severe shock.
52. Indications
• Correction in severe hypovolemia
• Replacing fluid in post op patients, burns
• Diarrhoea induced hypokalemic metabolic acidosis
• Fluid of choice in diarrhoea induced dehydration inpaediatrics
• DKA , provides water, correct metabolic acidosis and suppliespotassium
• Maintaining normal ECF fluid and electrolyte balance
Contra indications
• Liver disease, severe hypoxia and shock
• Severe CHF , lactic acidosis takes place
• Addison’s disease
• Vomiting or NGT induced alkalosis
• Simultaneous infusion of RL and blood
• Certain drugs – amphotericin, thiopental, ampicillin,
doxycycline
54. Isolyte G :
• Vomiting or NGT induced hypochloremic, hypokalemic metabolic alkalosis
• NH4 gets converted to H+ and urea in liver
• Treatment of metabolic alkalosis
• Contraindications : Hepatic failure, renal failure, metabolicacidosis
Isolyte M
• Richest source of potassium (35 mEq)
• Ideal fluid for maintenance
• Correction of hypokalemia
• Contraindications : Renal failure, burns,adrenocortical insufficiency
55. Isolyte P
• Maintenance fluid for children – as they require less electrolytes and more
water
• Excessive water loss or inability to concentrate urine
• Contraindications : hyponatremia, renal failure
Isolyte E
• Extracellular replacement solution, additional K and acetate(47mEq)
• Only iv fluid to correct Mg deficiency
• Treatment of diarrhoea, metabolic acidosis
• Contraindications – metabolic alkalosis
56. • Extravascular accumulation in skin, connective tissue , lungs and kidney
• Inhibition of GI motility
• Delayed healing of anastomosis
• Large volume ,rapid infusion crystalloids causes hypercoagulability..
Ruttmann TG, James MF. Effects on coagulation
due to intravenous crystalloid or colloid in
patients undergoing vascular surgery.
Br J Anesth 2002 ; 89 : 999 - 1003
58. Colloids
Colloids : large molecular wt substances that largely remains in
the intravascular compartment thereby generating oncotic
pressure
• 3 times more potent
• 1 ml blood loss = 1ml colloid = 3ml crystalloids
60. Type of fluid Effective plasma
volume
expansion/100ml
duration
5% albumin 70 – 130 ml 16 hrs
25% albumin 400 – 500 ml 16 hrs
6% hetastarch 100 – 130 ml 24 hrs
10% pentastarch 150 ml 8 hrs
10% dextran 40 100 – 150 ml 6 hrs
6% dextran 70 80 ml 12 hrs
61. Albumin
• Maintain plasma oncotic pressure – 75-80 %
• Heat treated preparation of albumin – 5%, 20% and 25%
commercially available
Pharmacalogical basis :
• 5% albumin – COP of 20 mmHg
• 25% albumin – COP of 70mmHg ,expands plasma volume to 4-5
times the volume infused within 4-5 min.
Rate of infusion :
• Adults – initial infusion of 25 gm
• 1 to 2 ml/min – 5% albumin
• 1 ml/min - 25% albumin
62. Indications :
• Plasma volume expansion in acute hypovolemic shock, burns, severe
hypoalbuminemia
• Hypo proteinemia – liver disease, Diuretic resistant in nephroticsyndrome
• Oligourea
• In therapeutic plasmapheresis , as an exchange fluid
Contra indications :
• Severe anaemia, cardiac failure
• Hypersensitive reaction
63. Dextran
• Dextran are glucose polymers produced by bacteria (leuconostoc
mesenteroides)
2 forms : dextran 70(MW 70,000) and dextran40(40,000)
Pharmacological basis :
• Effectively expand iv volume, but not suitable for bloodtransfusion.
• Dextran 40 as 10% sol greater expansion , short duration( 6hrs) – rapidrenal
excretion
• Anti thrombotic , inhibits plateletaggregation
• Improves micro circulatory flow as preventing thromboimbolism.
64. Indications :
• Hypovolemia correction
• Prophylaxis of DVT and post operative thromboembolism
• Improves blood flow and micro circulation in threatenedvascular
gangrene
• Myocardial ischemia, cerebral ischemia as maintaining vascular
graft patency
Adverse effects
• Acute renal failure
• Interfere with blood grouping and crossmatching
• Hypersensitivity reaction
65. Precautions/CI :
• Severe oligo-anuria
• CHF, circulatory overload
• Bleeding disorders like thrombocytopenia.
• Severe dehydration
• Anticoagulant effect of heparin enhanced
• Hypersensitive to dextran
Administration :
• Adult patient in shock – rapid 500 ml iv infusion
• First 24 hrs – dose should not exceed20ml/kg
• Next 5 days – 10 ml/kg/ day
66. Gelatin polymers( haemaccel)
• 500 ml Sterile, pyrogen free 3.5 % solution
• Polymer of degraded gelatin with electrolytes
• 2 types
• Succinylated gelatin (modified fluid gelatin)
• Urea cross linked gelatin ( polygeline)
Composition : Na 145 mEq, Cl 145 mEq, Ca 12.5 mEq,
potassium 5.1 mEq
Indications :
• Rapid plasma volume expansion in hypovolemia
• Volume pre loading in general anesthesia
• Priming of heart lung machines
67. Advantages :
• Does not interfere with coagulation, bloodgrouping
• Remains in blood for 4 to 5 hrs
• Infusion of 1000ml expands plasma volume by 50%
Side effects :
• Hypersensitivity reaction
• Bronchospasm, hypotension
• Should not be mixed with citrated blood
68. Hydroxyethyl starch
Hetastarch :
• It is composed of more than 90% esterified amylopectine.
• Esterification retards degradation leading to longer plasma expansion
• 6% starch - MW 4,50,000
Pharmacological basis :
• Osmolality – 310 mosm/L
• Higher colloidal osmotic pressure
• LMW substances excreted in urine in 24 hrs
69. Advantages :
• Non antigenic
• Does not interfere with blood grouping
• Greater plasma volume expansion
• Preserve intestinal micro vascular perfusion in endotoxaemia
• Duration – 24 hrs
Disadvantages :
• Increase in S amylase concentration upto 5 days after
discontinuation
• Affects coagulation by prolonging PTT, PT and bleeding time
by lowering fibrinogen
• Decrease platelet aggregation , VWF , factorVIII
70. Contra indications :
• Bleeding disorders , CHF
• Impaired renal function
Administration :
• Adult dose 6% solution – 500ml to 1 lit
• Total daily dose should not exceed 20ml/kg
71. Pentastarch :
• LMW derivative (2,64,000) 3%, 6% and 10% solution
• Lower degree of esterification
• Lesser effect on coagulation
• 10% solution can increase plasma volume 1.5 times of infused volume
72. Special fluids
• Inj KCl 10 ml amp – 20mEq
• 25%D (25 ml amp or 100 ml infusion bottle)– in hypoglycemic shock
• Inj. Sodium bicarbonate (25 ml amp. 22.5mEq Na+ & 22.5mEq HCO3-)
dose = 10-15 mEq/L : in metabolic acidosis
• Mannitol 10% & 20% : osmotic diuretic
73. Goals
• Maintenance of normovolemia and hemodynamic stability
• Acceptable plasma colloid osmotic pressure
• Correction of electrolyte imbalance
• Correction of acid base imbalance
• Adequate urine output( 0.5 to 1 ml/kg/hr)
74. Crystalloids or colloids…???
• Crystalloids – recommended as the initial fluid of
choice in resuscitating patients from hemorrhagic
shock
Svensen C, Ponzer S… Volume kinetics of Ringer solution after surgery for hip
fracture. Canadian journal of anesthesia 1999 ; 46 : 133 - 141
• COCHRANE Collaboration in critically ill patients –
“ No evidence from RCT that resuscitation with colloids
reduces the risk of death, compared with crystalloids in
patients with trauma or burns after surgery”
Roberts I, Alderson P, Bunn F et al : Colloids versus crystalloids for fluid
resuscitation in critically ill patients.. Cochrane Database Syst Rev(4) : CD
000567, 2004
75. Goal : the oxygen carrying capacity of blood.
Indications
1. Hb <6 gm% (normal =10 gm%)
2. age
3. Medical status
4. Major surgical procedure
5. Anticipation of ongoing blood loss
>100ml/min
6. Acute blood loss > 40% (2L crystalloid 3:1---
colloid 1:1 )
76. • AMERICAN COLLEGE OF SURGEONS (2001),
• Classification of acute hemorrhage
Committee on Trauma. Advanced Trauma Life Support Student
manual. 6th ed. Chicago. American College of Surgeons. 2001: 87-107.
77. • Transfusion with whole blood is indicated very rarely.
• Advantages :
1. Preservation of remaining whole blood components
2. Longer storage
3. Decreases the risk of transfusion reaction
78.
79.
80.
81. Holiday Segar Method
4 ml/kg/hr = 4x10/hr = 40 ml/hr
2ml/kg/hr = 2x20/hr = 40 ml/hr
So, for > 20 kg patient = body wt + 40 ml
Eg. For 70 kg. pt = 70+40 = 110 ml
82. Fluid therapy in
surgical patients
• Fluid and electrolyte management are paramount to the care of the surgical
patient. Changes in both fluid volume and electrolyte composition occur
preoperatively, intraoperatively, and post operatively, as well as in response
to trauma and sepsis.
• Proper fluid & electrolyte state is helpful in reducing morbidity & mortality
in certain surgical procedures, hence it is important.
83. 1. Acute stress : sympathetic stimuli, tachycardia & vasoconstriction.
2. Stress : corticosteroids secretion (up to 48 hrs)
Na+ retention, K+ depletion Intracellular K+ depletion hyperkalemia
3. Stress : ADH (up to 2-3 post op days) water retention
Requirement of maintenance fluid is less on1st post op day.
4. NPO require consideration & replacement.
5. Pre, intra & post operative blood / fluid loss require consideration&
replacement.
84. 6. Hypovolemia should be corrected preoperatively hypotension intraoperatively
7. Surgical stress / direct damage to kidney, brain, lungs, skin, GIT shouldbe
considered as they play important role in fluid & electrolytebalance.
85. Preoperative fluid therapy
• Very important for better outcome in surgical patients.
• 3 parameter are important
1. Correction of hypovolemia (GA diminishes the compensatory reflexes )
2. Correction of anemia (48 hours prior to surgery)
3. Correction of other disorders (eg. hypo & hyperkalemia)
86. Intraoperative fluid therapy
• Volume to be replaced –
1. Correction of fluid deficit due to starvation:
2. Maintenance volume for intraop period :
Duration of starvation (in hr) x 2 ml / kg ; 5% D
Duration of surgery (in hr) x 2 ml / kg ; 5% D
3. Correction of intra op loss :
a. Suction container
b. Surgical sponge
c. Third space
Blood loss =3/1 with crystalloid
Blood / blood products if indicated
•
•
• Decrease in Hb by 2gm% can be tolerated by patient with pre op Hb = 10gm%
Type of trauma Requirement of
fluid
Least trauma nil
Minimal trauma 4 ml /kg / hr
Moderate trauma 6 ml /kg / hr
severetrauma 10 ml /kg / hr
87. Postoperative fluid therapy
1. First 24 hrs of surgery (total = 2L)
2. 2nd post op day (total = 3L)
3. 3rd post op day (total = 3 L)
2L 5% D or 1.5 L 5% D + 500ml 0.9% NS
2L 5% D + 1L 0.9% NS
2L 5% D + 1L 0.9% NS + 40-60 mEq K+ / day
88. End parameters Goals
1. Achieve primary goal (0xygen supply)
2. Good level of Hb% & cardiac output
3. Test for –
ABG
CVP
Pulmonary pressure
BP
heart rate
Urine output > 1ml/kg/hr
1. CVP = 15 mmHg
2. Pulmonary capillary wedge pressure
10-12 mmHg
3. Cardiac index >3L/min/sq meter
4. Oxygen uptake >100 ml /min/sq meter
5. Blood lactate < 4 mmol/l
6. Basic deficit
89. • ‘Fluid therapy should
be directed not only to
effective volume
expansion of a leaky
circulation but also to
micro vascular
protection’.
90. BOOKS
1. H E L E N G I A N N A K O P O U L O S , LEE C A R R A S C O , J ASON
A L A B A K O F F , P E T E R D . Q U I N N . F L U I D AND E L E C T R O L Y T E M A N A G E
M E N T AND B L O O D P R O D U C T U S A G E . O R A L M A X I L L O F A C I A L S U R
G C L I N N AM 18 ( 2 0 0 6 ) 7 – 17 .
2. GYTO N & HALL TE XTB O O K O F M E D I CAL PHYS I O LO GY, 1 0 TH
E D ITI O N .
3. S E M B U L I N G A M K. S E M B U L I N G A M P R E M A . K S E M B U L I N G A M
- E S S E N T I A L S O F M E D I C A L P H Y S I O L O G Y , 6 T H E D I T I O N
4. C O N C I S E T E X T B O O K O F S U R G E R Y – D A S S . 3 RD ED
References
91. Others
Ruttmann TG, James MF. Effects on coagulation due to
intravenous cry stalloid or colloid in patients undergoing v
ascular surgery. Br J Anesth 2002 ; 89 : 999 – 1003.
Svensen C, Ponzer S. Volume kinetics of Ringer solution after sur
gery for hip fracture. Canadian journal of anesthesia 1999
; 4 6 : 1 3 3 – 141.
Roberts I, Alderson P, Bunn F et al : Colloids versus
cry stalloids for fluid resuscitation in critically ill patients.. C
ochrane Database Syst Rev(4) : CD 000567, 2004
C ommittee on Trauma. Advanc ed Trauma Life Support St
u d e n t ma n ual. 6th ed. Chicago. American College of Surg
eons. 2001: 87 -107
References