floating drug delivery system by shivani
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Microspheres are a potential approach for gastric retention as floating drug delivery systems. They can remain in the gastric region for extended periods, increasing gastric residence time and bioavailability while reducing dosing frequency. Literature reviews discuss preparation methods, characterization, advantages, and applications of microspheres for sustained drug release. One study prepared glibenclamide microspheres using non-aqueous emulsion solvent evaporation with magnesium stearate. The optimized formulation showed 11.5 hours of sustained drug release in vitro.
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FLOATING DRUG DELIVERY SYSTEM
This document discusses floating drug delivery systems (FDDS). It defines FDDS as systems that have sufficient buoyancy to float over gastric contents and remain in the stomach for a prolonged period of time. This results in increased gastric retention and better control of drug concentrations. The document covers the importance of FDDS, factors affecting performance, classifications, suitable drugs, evaluation tests, and examples of marketed products. It provides details on the preparation and functioning of various FDDS types including non-effervescent, effervescent, raft forming, and hollow microspheres.
floating dds
This document provides an overview of floating drug delivery systems. It begins with an introduction that describes how floating drug delivery systems can help modify gastric retention time and control drug release. It then discusses various factors that affect floating drug delivery systems and different mechanisms for achieving floatation. The document goes on to describe several types of non-effervescent and effervescent floating drug delivery systems that have been developed, including hydrodynamically balanced systems, hollow microspheres, alginate beads, and single-unit or multi-unit effervescent systems. It concludes by noting some applications and recent advances in floating drug delivery systems.
Floating Drug Delivery System(FDDS).pptx
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability of drugs with absorption windows in stomach or upper small intestine, unstable in the intestinal or colonic environment, and exhibit low solubility at high pH values. It is new drug delivery system maximize effectiveness and compliance.
Gastroretentive drug delivery system
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
Controlled drug delivery system
This document summarizes several controlled release oral drug delivery systems, including osmotic pressure controlled systems, hydrodynamically balanced systems, and pH-activated systems. Osmotic systems use a semipermeable membrane to control the rate of drug release based on osmotic pressure differences. Hydrodynamically balanced systems remain floating in the stomach for extended periods using gel polymers or effervescent components. pH-activated systems target drug delivery to specific regions of the GI tract based on pH-sensitive polymer coatings.
Floating drug delivery system review
This document discusses approaches for gastric retention drug delivery systems (GRDDS). It begins by introducing the benefits of controlled release drug delivery and factors that affect oral drug absorption. It then discusses needs for gastric retention like drugs that are absorbed in the upper GI tract or have a narrow absorption window. Approaches for gastric retention discussed include floating systems, bioadhesive systems, swelling/expanding systems, high density systems, and incorporating food agents to delay gastric emptying. Floating systems remain buoyant in the stomach without affecting emptying rate, while bioadhesive and swelling systems prolong gastric retention time.
Floating drug delivery system ppt
This document discusses floating drug delivery systems (FDDS). It begins with an introduction describing FDDS as low-density systems that remain buoyant in the stomach without affecting gastric emptying rate, resulting in increased gastric retention time. It then covers basic gastrointestinal tract physiology, approaches to prolonging gastric residence time including floating systems, and the mechanisms of floating systems. Some advantages include enhanced bioavailability and sustained drug delivery. Widely used polymers, preparation methods, classifications, evaluation tests, marketed products, and conclusions are also summarized.
Controlled Release Oral Drug Delivery System
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
Recommended
FLOATING DRUG DELIVERY SYSTEM
This document discusses floating drug delivery systems (FDDS). It defines FDDS as systems that have sufficient buoyancy to float over gastric contents and remain in the stomach for a prolonged period of time. This results in increased gastric retention and better control of drug concentrations. The document covers the importance of FDDS, factors affecting performance, classifications, suitable drugs, evaluation tests, and examples of marketed products. It provides details on the preparation and functioning of various FDDS types including non-effervescent, effervescent, raft forming, and hollow microspheres.
floating dds
This document provides an overview of floating drug delivery systems. It begins with an introduction that describes how floating drug delivery systems can help modify gastric retention time and control drug release. It then discusses various factors that affect floating drug delivery systems and different mechanisms for achieving floatation. The document goes on to describe several types of non-effervescent and effervescent floating drug delivery systems that have been developed, including hydrodynamically balanced systems, hollow microspheres, alginate beads, and single-unit or multi-unit effervescent systems. It concludes by noting some applications and recent advances in floating drug delivery systems.
Floating Drug Delivery System(FDDS).pptx
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability of drugs with absorption windows in stomach or upper small intestine, unstable in the intestinal or colonic environment, and exhibit low solubility at high pH values. It is new drug delivery system maximize effectiveness and compliance.
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This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
Controlled drug delivery system
This document summarizes several controlled release oral drug delivery systems, including osmotic pressure controlled systems, hydrodynamically balanced systems, and pH-activated systems. Osmotic systems use a semipermeable membrane to control the rate of drug release based on osmotic pressure differences. Hydrodynamically balanced systems remain floating in the stomach for extended periods using gel polymers or effervescent components. pH-activated systems target drug delivery to specific regions of the GI tract based on pH-sensitive polymer coatings.
Floating drug delivery system review
This document discusses approaches for gastric retention drug delivery systems (GRDDS). It begins by introducing the benefits of controlled release drug delivery and factors that affect oral drug absorption. It then discusses needs for gastric retention like drugs that are absorbed in the upper GI tract or have a narrow absorption window. Approaches for gastric retention discussed include floating systems, bioadhesive systems, swelling/expanding systems, high density systems, and incorporating food agents to delay gastric emptying. Floating systems remain buoyant in the stomach without affecting emptying rate, while bioadhesive and swelling systems prolong gastric retention time.
Floating drug delivery system ppt
This document discusses floating drug delivery systems (FDDS). It begins with an introduction describing FDDS as low-density systems that remain buoyant in the stomach without affecting gastric emptying rate, resulting in increased gastric retention time. It then covers basic gastrointestinal tract physiology, approaches to prolonging gastric residence time including floating systems, and the mechanisms of floating systems. Some advantages include enhanced bioavailability and sustained drug delivery. Widely used polymers, preparation methods, classifications, evaluation tests, marketed products, and conclusions are also summarized.
Controlled Release Oral Drug Delivery System
Controlled Release Oral Drug Delivery System
Controlled drug delivery is one which delivers the drug at a predetermined rate, for locally or systemically, for a specified period of time.
Mucoadhesive drug delivery system Mali vv ppt
This document discusses mucoadhesive drug delivery systems (MDDS). It begins by defining MDDS as systems that use the bioadhesive properties of certain polymers to target and prolong the release of drugs at mucous membranes. It then covers the basics of mucous membranes and their structure, composition, and functions. The document discusses the need for MDDS to enhance drug absorption, prolong drug residence time, and target drug delivery. It also outlines the advantages and disadvantages of MDDS, various routes of administration, mechanisms of mucoadhesion, theories of mucoadhesion, mucoadhesive polymers, and methods of evaluating MDDS. In the end, it provides some applications of MDDS such as vaccine delivery, cancer
1 gastroretentive drug delivery systems
This document provides an overview of gastric retention drug delivery systems (GRDDS). It discusses the need for and advantages of GRDDS. The key approaches covered for achieving gastric retention include floating drug delivery systems, mucoadhesive systems, swellable systems, and high density systems. The document reviews gastrointestinal physiology and factors affecting gastric emptying. It also evaluates different GRDDS approaches and provides examples of commercial gastroretentive formulations. In conclusion, the document states that GRDDS are preferable for delivering drugs that need to be released in the gastric region.
Gastroretentive drug delivery System
This document discusses gastroretentive drug delivery systems. It begins by introducing the challenges of limited gastric residence time and rapid gastrointestinal transit for oral drug delivery. It then describes how gastroretentive delivery systems aim to retain the dosage form in the stomach to allow for controlled release of drugs that are absorbed in the upper GI tract. The document outlines various approaches to gastroretentive delivery including floating, gastroadhesive, high-density, and inflatable systems. It notes advantages like increased bioavailability and compliance through reduced dosing, as well as applications for drugs with absorption windows in the upper GI tract.
Hydrodynamically balanced systems
This document discusses approaches to controlled release oral drug delivery systems using hydrodynamically balanced systems. It describes various gastrointestinal anatomy and physiology factors that influence gastric retention time such as size, density, and food intake. Several mechanistic approaches to achieve prolonged gastric retention are outlined, including high-density systems, bioadhesive systems, swelling and expanding systems, magnetic systems, superporous hydrogels, and floating systems. Floating drug delivery systems that form rafts or generate gas are described as important approaches to obtain sufficient drug bioavailability through gastric retention.
Bio Adhesive Drug Delivery System
This document discusses mucoadhesion and bioadhesive drug delivery systems. It defines mucoadhesion as the ability of a material to adhere to a biological tissue for an extended period of time. There are several types of bioadhesive drug delivery systems depending on the route of administration, including buccal, sublingual, vaginal, rectal, nasal, ocular, and gastrointestinal systems. Mucoadhesion occurs through a complex mechanism involving theories such as electronic, wetting, diffusion, fracture, cohesive, adsorption, and mechanical theories. Key factors affecting mucoadhesion are polymer properties, environmental factors, and physiological factors.
formulation of Buccal Drug Delivery System.pptx
Prepare BY: Chrishmita
M.Pharmacy , 1st Year
Pharmaceutics Department
RR COLLEGE OF PHARMACY.
Thanks to PAWAN DHAMALA
floating drug delivery system
Among all diff. routes, oral has achieved more attention & quite successful.
This is due to fact that GI physiology provides more flexibility then other routes.
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The document discusses bioadhesion and mucoadhesion. It defines bioadhesion as materials adhering to biological tissues for extended periods via interfacial forces. Mucoadhesion specifically refers to adhesion between materials and mucosal surfaces. Mucoadhesive drug delivery systems can prolong drug release at application sites, improving therapeutic outcomes. Ideal mucoadhesive polymers rapidly adhere to mucosal layers without interfering with drug release, are biodegradable and non-toxic, and enhance drug penetration at delivery sites. The mechanisms of bioadhesion involve wetting, swelling, interpenetration and entanglement of polymer chains followed by secondary bonding formations. Key factors influencing bioadhesion are discussed.
Gastro retentive drug delivery system
Gastro Retentive Drug Delivery system is a Novel drug delivery system which is more used to retain the drug for a longer period of time in the body and also to increase the GI transit time.
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EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
This document summarizes the evaluation of transdermal drug delivery systems. It discusses various physicochemical evaluation methods like thickness, drug content, moisture content testing. It also describes in-vitro evaluation methods like drug release studies using models like Higuchi and Peppas. In-vitro skin permeation studies are also briefly mentioned. The document provides an overview of the evaluation process for transdermal drug delivery systems.
Orodispersible tablets
This document provides an overview of orodispersible tablets. It discusses their history, formulation strategies, evaluation parameters and benefits over conventional tablets. Orodispersible tablets are designed to dissolve rapidly in the mouth without water. They were developed to help patients like children, elderly and those with swallowing difficulties. The key ingredients are superdisintegrants which cause the tablet to break apart quickly. Evaluation tests include hardness, friability, wetting time and in vitro dissolution studies. Orodispersible tablets offer ease of administration, accurate dosing and enhanced bioavailability compared to other dosage forms.
Oral & dissolution controlled release system
This document summarizes a seminar on oral controlled drug delivery systems presented by Sonam M. Gandhi. It discusses advantages and disadvantages of controlled delivery systems. Key types discussed include dissolution controlled, diffusion controlled, and combined dissolution/diffusion controlled systems using coatings or matrices. Other methods covered are ion exchange resins, pH dependent formulations, osmotic pressure controlled systems, and hydrodynamically balanced systems. Specific examples and equations are provided to explain the drug release mechanisms and rate determinations for several of these approaches.
Gastroretentive drug delivery system by mali vv
This document provides an overview of gastro-retentive drug delivery systems (GRDDS). It defines GRDDS as a drug delivery system that can retain a dosage form in the stomach for an extended period of time to slowly release medication. The document discusses the anatomy of the stomach and factors controlling gastric retention. It also outlines several approaches for GRDDS, including floating drug delivery systems, bioadhesive/mucoadhesive systems, and expandable/swellable systems. The advantages and applications of GRDDS are noted.
Buccal Drug Delivery System
This document discusses methods of formulating and evaluating buccal drug delivery systems. It describes the basic structure and designs of buccal dosage forms as being matrix or reservoir types. The key components are outlined as the drug substance, bioadhesive polymers, backing membrane, and permeation enhancers. Various formulation methods are provided for solid, semi-solid and liquid buccal dosage forms including tablets, patches, films, gels and sprays. Evaluation methods are also summarized such as weight variation, thickness, friability, hardness, and in-vitro swelling studies.
Feedback regulated drug delivery system
This document discusses feedback regulated drug delivery systems, which release drugs in response to physiological triggers. It provides 3 examples: 1) Bio-erosion regulated systems where an enzyme triggers polymer degradation and drug release, 2) Bio-responsive systems where a membrane permeability is controlled by biochemical triggers, and 3) Self-regulated systems using reversible binding to competitively release drugs. One approach discussed uses a cationic hydrogel to release an opioid overdose antidote in response to rising carbon dioxide levels from opioid use. Feedback systems aim to better match drug release to physiological needs compared to traditional delivery.
Fdds new
This document provides an overview of floating drug delivery systems (FDDS). It defines FDDS as systems that can remain in the gastric region for several hours, prolonging the gastric residence time of drugs. The document classifies FDDS into two main types - effervescent systems that use gas formation and non-effervescent systems that use swelling polymers. It lists advantages such as improved drug absorption and controlled delivery. The document also summarizes some research articles on developing FDDS for various drugs.
Rate controlled drug delivery system
This document discusses different types of rate controlled drug delivery systems. It begins by introducing controlled release drug delivery and distinguishing it from sustained release. It then classifies controlled release systems into three main categories: rate programmed, activation modulated, and feedback regulated systems. Within each category it describes several examples of systems, identifying how drug release is controlled in each case. Key factors that can affect controlled release are also listed. The document aims to provide an overview of controlled drug delivery technologies with classifications and examples.
MUCOADHESIIVE DRUG DELIVERY SYSTEM
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Mucoadhesive dds buccal & nasal
This document discusses mucoadhesive drug delivery systems. It begins by defining bioadhesion and mucoadhesion, noting that mucoadhesion involves the attachment of a drug carrier to a mucosal surface like epithelial tissue. It then covers the concept of mucoadhesion in more detail and discusses the advantages and disadvantages of mucoadhesive drug delivery. Some key advantages include avoiding first pass metabolism, targeting drug delivery, and allowing delivery of drugs that are unstable in the stomach or intestines. The document also discusses the formulation design of mucoadhesive drug delivery systems.
Floating drug delivery systems
This document summarizes floating drug delivery systems (FDDS), which are designed to remain in the stomach for a prolonged period of time. The document begins by describing gastric physiology and emptying processes. It then classifies and describes different types of FDDS, including single and multiple unit systems that are effervescent (gas-generating) or non-effervescent. Effervescent systems use carbon dioxide to float, while non-effervescent systems swell upon contact with gastric fluid. The document also discusses evaluation methods and applications of FDDS to improve drug bioavailability.
Bilayer Floating Tablet Technology: An Overview
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Mucoadhesive drug delivery system Mali vv ppt
This document discusses mucoadhesive drug delivery systems (MDDS). It begins by defining MDDS as systems that use the bioadhesive properties of certain polymers to target and prolong the release of drugs at mucous membranes. It then covers the basics of mucous membranes and their structure, composition, and functions. The document discusses the need for MDDS to enhance drug absorption, prolong drug residence time, and target drug delivery. It also outlines the advantages and disadvantages of MDDS, various routes of administration, mechanisms of mucoadhesion, theories of mucoadhesion, mucoadhesive polymers, and methods of evaluating MDDS. In the end, it provides some applications of MDDS such as vaccine delivery, cancer
1 gastroretentive drug delivery systems
This document provides an overview of gastric retention drug delivery systems (GRDDS). It discusses the need for and advantages of GRDDS. The key approaches covered for achieving gastric retention include floating drug delivery systems, mucoadhesive systems, swellable systems, and high density systems. The document reviews gastrointestinal physiology and factors affecting gastric emptying. It also evaluates different GRDDS approaches and provides examples of commercial gastroretentive formulations. In conclusion, the document states that GRDDS are preferable for delivering drugs that need to be released in the gastric region.
Gastroretentive drug delivery System
This document discusses gastroretentive drug delivery systems. It begins by introducing the challenges of limited gastric residence time and rapid gastrointestinal transit for oral drug delivery. It then describes how gastroretentive delivery systems aim to retain the dosage form in the stomach to allow for controlled release of drugs that are absorbed in the upper GI tract. The document outlines various approaches to gastroretentive delivery including floating, gastroadhesive, high-density, and inflatable systems. It notes advantages like increased bioavailability and compliance through reduced dosing, as well as applications for drugs with absorption windows in the upper GI tract.
Hydrodynamically balanced systems
This document discusses approaches to controlled release oral drug delivery systems using hydrodynamically balanced systems. It describes various gastrointestinal anatomy and physiology factors that influence gastric retention time such as size, density, and food intake. Several mechanistic approaches to achieve prolonged gastric retention are outlined, including high-density systems, bioadhesive systems, swelling and expanding systems, magnetic systems, superporous hydrogels, and floating systems. Floating drug delivery systems that form rafts or generate gas are described as important approaches to obtain sufficient drug bioavailability through gastric retention.
Bio Adhesive Drug Delivery System
This document discusses mucoadhesion and bioadhesive drug delivery systems. It defines mucoadhesion as the ability of a material to adhere to a biological tissue for an extended period of time. There are several types of bioadhesive drug delivery systems depending on the route of administration, including buccal, sublingual, vaginal, rectal, nasal, ocular, and gastrointestinal systems. Mucoadhesion occurs through a complex mechanism involving theories such as electronic, wetting, diffusion, fracture, cohesive, adsorption, and mechanical theories. Key factors affecting mucoadhesion are polymer properties, environmental factors, and physiological factors.
formulation of Buccal Drug Delivery System.pptx
Prepare BY: Chrishmita
M.Pharmacy , 1st Year
Pharmaceutics Department
RR COLLEGE OF PHARMACY.
Thanks to PAWAN DHAMALA
floating drug delivery system
Among all diff. routes, oral has achieved more attention & quite successful.
This is due to fact that GI physiology provides more flexibility then other routes.
Bioadhesive drug delivery system
The document discusses bioadhesion and mucoadhesion. It defines bioadhesion as materials adhering to biological tissues for extended periods via interfacial forces. Mucoadhesion specifically refers to adhesion between materials and mucosal surfaces. Mucoadhesive drug delivery systems can prolong drug release at application sites, improving therapeutic outcomes. Ideal mucoadhesive polymers rapidly adhere to mucosal layers without interfering with drug release, are biodegradable and non-toxic, and enhance drug penetration at delivery sites. The mechanisms of bioadhesion involve wetting, swelling, interpenetration and entanglement of polymer chains followed by secondary bonding formations. Key factors influencing bioadhesion are discussed.
Gastro retentive drug delivery system
Gastro Retentive Drug Delivery system is a Novel drug delivery system which is more used to retain the drug for a longer period of time in the body and also to increase the GI transit time.
permeation enhancers by Hemant Chalaune ist M pharm
This document discusses skin as a drug delivery route and permeation enhancers. It begins with an overview of skin structure and properties that create a barrier to drug delivery. It then discusses permeation enhancers, classifying them as chemical or physical and describing examples from each class. The document explains several specific permeation enhancers in depth, including their proposed mechanisms of action, such as disrupting lipid packing or increasing hydration. It concludes that permeation enhancers are crucial components for improving drug bioavailability through the skin.
EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEMS
This document summarizes the evaluation of transdermal drug delivery systems. It discusses various physicochemical evaluation methods like thickness, drug content, moisture content testing. It also describes in-vitro evaluation methods like drug release studies using models like Higuchi and Peppas. In-vitro skin permeation studies are also briefly mentioned. The document provides an overview of the evaluation process for transdermal drug delivery systems.
Orodispersible tablets
This document provides an overview of orodispersible tablets. It discusses their history, formulation strategies, evaluation parameters and benefits over conventional tablets. Orodispersible tablets are designed to dissolve rapidly in the mouth without water. They were developed to help patients like children, elderly and those with swallowing difficulties. The key ingredients are superdisintegrants which cause the tablet to break apart quickly. Evaluation tests include hardness, friability, wetting time and in vitro dissolution studies. Orodispersible tablets offer ease of administration, accurate dosing and enhanced bioavailability compared to other dosage forms.
Oral & dissolution controlled release system
This document summarizes a seminar on oral controlled drug delivery systems presented by Sonam M. Gandhi. It discusses advantages and disadvantages of controlled delivery systems. Key types discussed include dissolution controlled, diffusion controlled, and combined dissolution/diffusion controlled systems using coatings or matrices. Other methods covered are ion exchange resins, pH dependent formulations, osmotic pressure controlled systems, and hydrodynamically balanced systems. Specific examples and equations are provided to explain the drug release mechanisms and rate determinations for several of these approaches.
Gastroretentive drug delivery system by mali vv
This document provides an overview of gastro-retentive drug delivery systems (GRDDS). It defines GRDDS as a drug delivery system that can retain a dosage form in the stomach for an extended period of time to slowly release medication. The document discusses the anatomy of the stomach and factors controlling gastric retention. It also outlines several approaches for GRDDS, including floating drug delivery systems, bioadhesive/mucoadhesive systems, and expandable/swellable systems. The advantages and applications of GRDDS are noted.
Buccal Drug Delivery System
This document discusses methods of formulating and evaluating buccal drug delivery systems. It describes the basic structure and designs of buccal dosage forms as being matrix or reservoir types. The key components are outlined as the drug substance, bioadhesive polymers, backing membrane, and permeation enhancers. Various formulation methods are provided for solid, semi-solid and liquid buccal dosage forms including tablets, patches, films, gels and sprays. Evaluation methods are also summarized such as weight variation, thickness, friability, hardness, and in-vitro swelling studies.
Feedback regulated drug delivery system
This document discusses feedback regulated drug delivery systems, which release drugs in response to physiological triggers. It provides 3 examples: 1) Bio-erosion regulated systems where an enzyme triggers polymer degradation and drug release, 2) Bio-responsive systems where a membrane permeability is controlled by biochemical triggers, and 3) Self-regulated systems using reversible binding to competitively release drugs. One approach discussed uses a cationic hydrogel to release an opioid overdose antidote in response to rising carbon dioxide levels from opioid use. Feedback systems aim to better match drug release to physiological needs compared to traditional delivery.
Fdds new
This document provides an overview of floating drug delivery systems (FDDS). It defines FDDS as systems that can remain in the gastric region for several hours, prolonging the gastric residence time of drugs. The document classifies FDDS into two main types - effervescent systems that use gas formation and non-effervescent systems that use swelling polymers. It lists advantages such as improved drug absorption and controlled delivery. The document also summarizes some research articles on developing FDDS for various drugs.
Rate controlled drug delivery system
This document discusses different types of rate controlled drug delivery systems. It begins by introducing controlled release drug delivery and distinguishing it from sustained release. It then classifies controlled release systems into three main categories: rate programmed, activation modulated, and feedback regulated systems. Within each category it describes several examples of systems, identifying how drug release is controlled in each case. Key factors that can affect controlled release are also listed. The document aims to provide an overview of controlled drug delivery technologies with classifications and examples.
MUCOADHESIIVE DRUG DELIVERY SYSTEM
Mucoadhesive drug delivery systems aim to increase drug bioavailability by keeping formulations in close contact with mucus membranes. There are three main stages of mucoadhesion: wetting and swelling, interpenetration of polymer chains with the mucus layer, and formation of chemical bonds. Several theories explain mucoadhesion, including electronic, adsorption, wetting, diffusion, and fracture theories. Key factors affecting mucoadhesion are related to the polymer properties, such as molecular weight, concentration, flexibility, and spatial conformation, as well as environmental and physiological factors. Mucoadhesive systems can provide benefits like prolonged drug residence at the site of action and increased drug absorption.
Mucoadhesive dds buccal & nasal
This document discusses mucoadhesive drug delivery systems. It begins by defining bioadhesion and mucoadhesion, noting that mucoadhesion involves the attachment of a drug carrier to a mucosal surface like epithelial tissue. It then covers the concept of mucoadhesion in more detail and discusses the advantages and disadvantages of mucoadhesive drug delivery. Some key advantages include avoiding first pass metabolism, targeting drug delivery, and allowing delivery of drugs that are unstable in the stomach or intestines. The document also discusses the formulation design of mucoadhesive drug delivery systems.
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permeation enhancers by Hemant Chalaune ist M pharm
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Floating drug delivery systems
This document summarizes floating drug delivery systems (FDDS), which are designed to remain in the stomach for a prolonged period of time. The document begins by describing gastric physiology and emptying processes. It then classifies and describes different types of FDDS, including single and multiple unit systems that are effervescent (gas-generating) or non-effervescent. Effervescent systems use carbon dioxide to float, while non-effervescent systems swell upon contact with gastric fluid. The document also discusses evaluation methods and applications of FDDS to improve drug bioavailability.
Bilayer Floating Tablet Technology: An Overview
Bilayer floating tablet technology provides a means to separate incompatible drugs and control drug release profiles. It utilizes lower density to allow tablets to float in the stomach for prolonged periods, increasing bioavailability and allowing for sustained delivery of drugs that are absorbed in the stomach. Evaluation tests examine properties like floating lag time and dissolution rates in vitro and gastric retention in vivo. Several commercial bilayer floating tablet products are available.
Floating microspheres: Research article
Gastric emptying is a complex process, one that is highly variable and makes in vivo performance of drug delivery systems uncertain. A controlled drug delivery system with prolonged residence time in the stomach can be great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastrointestinal (GI) transit time and to the non-uniformity of drug absorption throughout the alimentary canal. Floating drug delivery systems are useful in such applications. Floating microspheres have been gaining attention due to the uniform distribution of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. The present research briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. Floating microsphere were prepared by solvent evapouration method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. The shape and surface morphology of the microspheres were characterised by differential scanning calorimetry and scanning electron microscopy.
01_IJPBA_1770_19.pdf
This document provides an overview of floating drug delivery systems (FDDS). FDDS are low-density drug delivery systems that remain buoyant in the stomach without affecting gastric emptying rate, resulting in increased gastric retention time and better control of drug concentrations. FDDS are useful for drugs that need to be absorbed in the stomach or have a narrow absorption window in the upper gastrointestinal tract. The document discusses the advantages and disadvantages of FDDS, examples of commercially available FDDS formulations, and different types of FDDS including effervescent systems that use gas-generating agents and non-effervescent systems. It concludes that FDDS can enhance bioavailability for certain drugs but may not be suitable for all drugs depending on factors like
01_IJPBA_1770_19.pdf
This document provides an overview of floating drug delivery systems (FDDS). FDDS are low-density drug delivery systems that remain buoyant in the stomach without affecting gastric emptying rate, resulting in increased gastric retention time and better control of drug concentrations. There are two main types of FDDS - effervescent systems that use gas-generating agents to reduce density, and non-effervescent systems that rely on gel-forming or swellable polymers. FDDS can improve drug absorption for drugs that need to be absorbed in the stomach or have a narrow absorption window in the small intestine. Several commercially available FDDS products and patents are described. Factors like dosage form size and shape, gender, posture, and age
Floating Drug Delivery System: An Outlook
Floating drug delivery approach uses low-density systems that have sufficient buoyancy to flow over the
gastric contents and remains buoyant in the stomach without affecting the stomachic emptying rate for a
chronic period of time. This result is increased gastric retention time and better control of the fluctuations
in plasma drug concentration with a low risk of toxicity. Drugs, which are locally active in the stomach,
drugs having narrow absorption window and unstable in the intestine, and colonic environment, are the
potential drug candidates. The approach not only improves drug absorption but also minimizes the mucosal
irritation of drugs. As the approach requires a high fluid level in the stomach to float and work efficiently,
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granules, powders, capsules, tablets, laminated films, and hollow microspheres and few formulations have
been commercialized in the market at the present time. This review gives an overview of the approach of
floating drug delivery at present with sequential demystification thus enabling a greater understanding of
their role in medicine and drug delivery
01_IJPBA_1770_19.pdf
This document provides an overview of floating drug delivery systems (FDDS). FDDS are low-density drug delivery systems that remain buoyant in the stomach without affecting gastric emptying rate, resulting in increased gastric retention time and better control of drug concentrations. There are two main types of FDDS - effervescent systems that use gas-generating agents to reduce density, and non-effervescent systems that rely on gel-forming or swellable polymers. FDDS can improve drug absorption for drugs that need to be absorbed in the stomach or have a narrow absorption window in the small intestine. Several commercially available FDDS products and patents are described. Factors like dosage form size and shape, gender, posture, and age
M.Pham project presentation phase 2
The document discusses the formulation and evaluation of an artemether sustained release floating bilayer tablet. It aims to develop a floating drug delivery system for artemether to increase its gastric residence time and provide sustained release to ensure optimal drug levels in the blood and minimize side effects. The document provides background on floating drug delivery systems and reviews previous literature on developing such systems for other drugs. It then gives information on the drug artemether and outlines the objectives and methodology that will be used in the study.
Formulation and Evaluation of Gastroretentive Drug Delivery System of Repagli...
Formulation and Evaluation of Gastroretentive Drug Delivery System of Repagli...BRNSSPublicationHubI
This document discusses the formulation and evaluation of a gastroretentive drug delivery system for repaglinide. It begins with an introduction that outlines the advantages of novel drug delivery systems and gastroretentive formulations. It then provides details on the materials and methods used, including the preformulation, formulation, characterization, and evaluation of floating microspheres loaded with repaglinide. The goals of the research were to develop a gastroretentive delivery system for repaglinide to achieve prolonged gastric retention and controlled drug release in the stomach.colon specific drug delivery system
This document presents a project seminar presentation for a Bachelor of Pharmacy degree. It discusses targeted drug delivery systems, with a focus on colon targeted drug delivery. It provides background on the anatomy and physiology of the colon, factors affecting drug absorption in the colon, and various approaches to colon targeted drug delivery including pH dependent, time dependent, bacteria dependent and matrix tablet approaches. It also provides details of the drug sulfasalazine and presents the aim, objectives and plan of work for a research project on the formulation of colon-specific matrix tablets of 5-Amino Salicylic Acid.
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review Report
This document discusses microspheres as a drug delivery system for targeted colon delivery. It begins with an introduction to colon targeted drug delivery and reasons for targeting the colon. It then discusses microspheres in more detail, including definitions and types such as bioadhesive, magnetic, floating, and polymeric microspheres. Methods for preparing microspheres and their advantages are summarized. The document concludes with some limitations of microsphere drug delivery systems.
GASTRO RETENTIVE DRUG DELIVERY SYSTEM PPT PDF.pdf
This document outlines a student project to develop a gastroretentive floating tablet of the antihypertensive drug propranolol hydrochloride using polymers like HPMC and HPC to increase its residence time in the stomach and bioavailability. The objectives are to study the drug's bioavailability, residence time in stomach, dosing frequency, and absorption window. Materials include propranolol HCl and polymers. Tablets will be formulated by direct compression and evaluated for properties, in vitro drug release kinetics, and in vivo gastrointestinal residence time. The literature review covers gastroretentive drug delivery systems and previous work formulating propranolol HCl tablets.
patrial
The document provides an overview of oral controlled release drug delivery systems. It discusses the anatomy and physiology related to oral drug administration. Some key advantages of controlled release oral dosage forms are enhanced bioavailability, reduced dosing frequency, and more consistent drug levels in the body. The document also covers various mechanisms for controlled release, including osmotic pumps, floating systems, and coating technologies. It provides examples of commercially available controlled release drugs and classifications of these systems.
1557 full
The document describes a study that formulated and evaluated polymeric nanoparticles containing the antiviral drug acyclovir for prolonged retention in the stomach. Nanoparticles were prepared using different hydrophilic polymers including bovine serum albumin, chitosan, and gelatin. The nanoparticles were characterized for properties such as particle size, zeta potential, drug loading efficiency, and drug release. Nanoparticles prepared with chitosan in a 1:1 ratio with acyclovir showed a particle size of 312.04 nm, zeta potential of 33.2 mV, drug loading efficiency of 17.54%, and entrapment efficiency of 73.4%, indicating they may be suitable for gastric retention delivery of acyclovir.
Formulation and evaluation of rosiglitazone nanosuspension
The main aim of this study is to formulate and evaluate Rosiglitazone Nano suspension. Nano suspensions are colloidal dispersion of Nano sized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1micro meter in size. Rosiglitazone is an oral rapid and short –acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enter hepatic circulation. Rosiglitazone Nano suspension was prepared by precipitation technique. After preparation of Nano suspension various characterization studies were done such as drug content, %yield, FTIR, DSC, TEM, and Invitro drug release.PVPK30,polaxomer are used as stabilizers. From the dissolution study F4 formulation which containts PVPK30 as stabilizer was considered as optimized formulation. It showed maximum drug release at 30min.FTIR and DSC studies revealed that good stability in dispersion.
Gastroretentive Drug Delivery System -> by Mohit kumar
Contents
INTRODUCTION
WHAT IS GRDDS ?
NEED FOR GRDDS…?
POTENTIAL DRUG CANDIDATES
DRUGS THAT ARE UNSUITABLE FOR GASTRORETENTIVE DRUG DELIVERY SYSTEMS
FACTORS AFFECTING THE GASTRORETENTIVE SYSTEM.
ADVANTAGES OF GRDDS
DISADVANTAGES OF GRDDS
APPROACHES TO EXTEND GI TRANSIT
INTRODUCTION
Oral route has been the most convenient and accepted route of drug delivery.
Gastroretentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs.
WHAT IS GRDDS ?
Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects.
NEED FOR GRDDS…?
Oral drug delivery system, sustained drug delivery systems, these drug delivery systems suffer from mainly two adversities:
Short gastric retention time(GRT) and
Unpredictable short gastric emptying time (GET)
which can result in incomplete drug release from the dosage form in the absorption zone (stomach or upper part of small intestine) leading to diminished efficacy of administered dose.
To formulate a site-specific orally administered controlled release dosage form, it is desirable to achieve a prolong gastric residence time by the drug delivery.
Prolonged gastric retention time (GRT) in the stomach could be advantageous for local action e.g. treatment of peptic ulcer, etc.
POTENTIAL DRUG CANDIDATES FOR GASTRORETENTIVE DRUG DELIVERY SYSTEMS
Drugs that disturb normal colonic microbes e.g. antibiotics against Helicobacter pylori.
Drugs that degrade in the colon. e.g. Ranitidine, Metformin HCl.
Drugs which are absorbed rapidly from the GI tract. e.g. Metronidazole, tetracycline.
Drugs with a narrow window of absorption e.g. Cyclosporine, Methotrexate, Levodopa, etc.
Drugs that are poorly soluble at alkaline pH e.g. Furosemide, Diazepam, Verapamil, etc.
Drugs that are primarily absorbed in the stomach e.g. Amoxicillin.
Drugs acting locally in the stomach(active in stomach) e.g. Antacids and drugs for H. Pylori viz., Misoprostol
DRUGS THAT ARE UNSUITABLE FOR GASTRORETENTIVE DRUG DELIVERY SYSTEMS
Drugs that have very limited acid solubility phenytoin etc.
Drugs that suffer instability in the gastric environment e.g. erythromycin etc.
Drugs intended for selective release in the colon e.g. 5-amino salicylic acid and corticosteroids etc.
FACTORS AFFECTING THE GASTRORETENTIVE SYSTEM.
Density
Size
Shape of dosage form
Single or multiple unit formulation
Fed or unfed state.
Advantages of GRDDS
Increase in bioavailability and curative efficiency of drugs and economic usage of dosage.
Minimised factor of risk in resistance in antibiotics owing to stabilised therapeutic levels over prolonged periods removing fluctuations.
Formulation Development and Evaluation of Gastro Retentive Drug Delivery Syst...
Formulation Development and Evaluation of Gastro Retentive Drug Delivery Syst...Dr. Raghavendra Kumar Gunda
In recent years many advancement has been made in research and development of Oral Drug Delivery System. Concept of Novel Drug Delivery System arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations.
Purpose of this review is to compile the recent literature with special focus on Gastro Retentive Drug Delivery Systems to give an update
on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Various approaches are currently used including Gastro Retentive Floating Drug Delivery Systems(GRFDDS),swelling and expanding system, polymeric bioadhesive systems, modifiedshape
systems, high density system and other delayed gastric emptying devices. These systems are very helpful to different problem solve during the formulation of different dosage form. The present work also focuses on the polymers used in floating drug delivery systems
mostly from natural origin. Floating drug delivery systems are less dense than gastric fluids; hence remain buoyant in the upper GIT for a
prolonged period, releasing the drug at the desired/ predeterminedrate. This review article focuses on the recent technological development in floating drug delivery systems with special emphasis on the principal mechanism of floatation and advantages of achieving gastric
retention, brief collection on various polymers employed for floating drug delivery systems etc. In addition this review also summarizes the In –Vitro and In -Vivo studies to evaluate their performance and also their future potential.FORMULATION DEVELOPMENT AND EVALUATION OF CARVEDILOL PHOSPHATE GASTRO RETENTI...
FORMULATION DEVELOPMENT AND EVALUATION OF CARVEDILOL PHOSPHATE GASTRO RETENTI...Dr. Raghavendra Kumar Gunda
This document describes the development and evaluation of carvedilol phosphate gastroretentive floating tablets using a 32 factorial design. Carvedilol phosphate is a drug that belongs to BCS Class II and is indicated for hypertension and heart failure. Floating tablets were prepared using varying concentrations of guar gum and sodium bicarbonate as polymers to control the release of the water soluble drug. Nine formulations were designed and evaluated for properties like drug content, floating lag time, and in vitro drug release using kinetic models. The results showed that all formulations met pharmacopeial standards and formulation F8 containing 25% guar gum and 3.75% sodium bicarbonate best matched the marketed product with respect to drug release.Crps 4
. Recent Advances in Mucoadhesive Buccal Drug Delivery Systems and Its Marketed Scope and
Opportunities
K.P.Sampath Kumar ,DebjitBhowmik .AmitsankarDutta, Shravan Paswan, Lokesh Deb
Critical Review in Pharmaceutical Sciences 2012, 1(1):83-98.
Floating Drug Delivery System: An Editorial Note
Open access plays a pivotal role in propagating scientific information globally. It is completely user friendly and is open for all to access easily. Its salient features are, that it covers 50 worlds’s leading languages and have the facility of audio versions too. It invites every individual to share as well as explore scientific knowledge and research in the field of pharmaceutical sciences. It enhances scientific skills of the authors, readers, reviewers, editors and advisors by providing scientific credits. On whole it encourages each and everyone and attracts all towards the majestic world of science.
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Gastroretentive Drug Delivery System -> by Mohit kumar
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Formulation Development and Evaluation of Gastro Retentive Drug Delivery Syst...
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