This document outlines a student project to develop a gastroretentive floating tablet of the antihypertensive drug propranolol hydrochloride using polymers like HPMC and HPC to increase its residence time in the stomach and bioavailability. The objectives are to study the drug's bioavailability, residence time in stomach, dosing frequency, and absorption window. Materials include propranolol HCl and polymers. Tablets will be formulated by direct compression and evaluated for properties, in vitro drug release kinetics, and in vivo gastrointestinal residence time. The literature review covers gastroretentive drug delivery systems and previous work formulating propranolol HCl tablets.

1. GUIDE NAME
Ms. ATKORE V.T.
Asst. Professor
GASTRO RETENTIVE DRUG
DELIVERY SYSTEM
PRESENTED BY
JADHAV VIJAY CHANDOJI
B PHARM FINAL YEAR

2. CONTENTS
ABSTRACT
INTRODUCTION
LITERATURE REVIEW
AIM & OBJECTIVES
PLAN OF WORK
REFERENCES

3. ABSTRACT
 The objective of present study was to develope gastro retentive drug delivery
system for anti-hypertensive drug propranolol hydrochloride.
 The biggest problem in oral drug delivery is low and erotic drug bioavailability, so
to increase bioavailability of drug it should be retain in stomach was investigated.
 Hydroxy propyl methyl cellulose (HPMC), Hydroxy propyl cellulose (HPC),
Xanthum gum was evaluated for their gel forming abilities as polymer .
 Propranolol has extensive first pass metabolism so their bioavailability is
low.Therefore to increase bioavailability it was decided to formulate floating tablet of
propranolol so that it remains in upper part of GIT for longer time.
 Evaluate the physical properties, in-vitro release and in-vivo behavior of
propranolol drug. Floating tablet was formulated with HPMC & HPC Polymer to
enhance the retention of the drug into stomach to enhance release thus bioavailability
increase.
 For making the tablet which retain in upper GI Tract it should be float on the gastric
juices so to make it float it should be low in density.

4. • Oral drug delivery has most widely used routes of administration among all the routes
of administration among all the routes , It is most convenient and extensively used.
• GRDDS : It is the control release drug delivery system possessing the ability of being
retained in stomach and release drug over extended period of time.
• They can help in optimizing oral controlled drug delivery of drugs having absorption
window continuously release drugs for prolong period of time,
Thus ensure optimal bioavailability.
• Gastric emptying occur during fasting as well as fed state.
• Gastric emptying studies revealed that orally administered controlled release dosage
form have two complications
- Short gastric residence time
- Unpredictable gastric emptying time

5. • GRDDS as novel approach aim to address these limitations by facilitating prolonged
drug retention in stomach thereby enhancing drug absorption and bioavailability.
This retention is achieved through various mechanisms such as Buoyancy, swelling,
mucoadhesion or other innovative stratergies.
APPLICATIONS
1. Local action in stomach
2. Drug unstable in upper part of GIT
3. Insoluble in intestinal fluid
4. Drug with variable bioavailability
5. Drug with site specific absorption in window

6. 1) Alexander streubel et.al. : Review of Gastro retentive drug delivery system.
This article gives an overview of parameter affecting gastric emptying in humans and
help to design pharmaceutical dosage form with prolong gastric residence time , in
particular floating drug delivery system are discussed. (2006)
2) Swati S.Jagdale, Amit J.Agnekar, SudhirV.Pandya, Bhanudas S.Kuchekar
et.al.:Formulation and evaluation of GRDDS of propranolol HCL.(2009)
This article gives detail information about the formulation of propranolol hydrochloride
tablet for antihypertension which release the drug for longer time and improve
bioavailability of the drug.it also give an idea about the polymers which can be used to
retain the drug in stomach for longer time
3) Nirav Patel, C.Nagesh, S.Chandrashekhar, Patel Jinal, Jani Devdatt et.al.:
Floating drug delivery system ; An innovative acceptable approach in GRDDS.(2009)
This review summarize the in-vitro techniques, in-vivo studies to evaluate the
performance and application of floating systems.

7. AIM : To Study on development of Gastro retentive floating Tablet of Propranolol
HCL
OBJECTIVES : A] Study The Bioavailability Of Drug
B] Study Of Residence Time In Stomach
C] Study Of Dosing Frequency Of Drug
D] Study Of Absorption Window

8. MATERIALS : Propranolol Hydrochloride (API)
HPMC,HPC, Xanthum Gum, Sodium Alginate. (POLYMER)
METHODS : Review on
1) Formulation
o Direct Compression Method
2) Evaluation Tests
o Evaluation Of Powder Blend
o In-Vivo Buoyancy Study
- Lag time for floating tablet
- Matrix Integrity
- Swelling Index
o In-Vivo Drug Release
o Kinetic Modelling Of Drug Release
o In-Vivo Evaluation Of GIT Residential Time

9. 1) Singh B.N., Kim KH, Floating Drug Delivery System ; An Approach To Oral
Controlled Drug Delivery Via Gastric Retention
2) K.D.Tripathi , Antihypersensitive Drugs ; Essential Of Medical Pharmacology
3) Davis S.S. Formulation Stratergies For Absorption Window
4) Matharv A.S., Motto M.G. , Patel M.R. , et.al. Evaluation Of HPMC Matrix
System As Floating Gastro Retentive Drug Delivery System
5) Robinson J.R, Lee V.H.L. Controlled drug delivery : fundamentals and
applications 2nd edition.