The document summarizes the principles and practice of environmental safety assessment for transgenic plants. It discusses evaluating the stability of genetic modifications, potential for gene transfer to related and unrelated organisms, weediness potential, and effects on non-target organisms. It provides details on Monsanto's MON 810 Bt corn, including the genetic elements inserted, molecular characterization of the inserted DNA, expression of the Cry1Ab protein, and laboratory and field studies finding no adverse effects on non-target and beneficial organisms except certain lepidopteran pests. It emphasizes the importance of insect resistance management plans to prolong the effectiveness of Bt toxins in crops.