The Pulsar Virtual Summit North America 2021 featured discussions on achieving exactly-once semantics in transactional messaging using Apache Pulsar, focusing on features such as idempotent producers and guaranteed message deduplication. It introduced the concept of transactions which allow for atomic writes and acknowledgments across multiple topic partitions, ensuring that all operations succeed or fail as a unit. The summit highlighted ongoing developments and support for transactions in various programming languages and integrations with other systems.