This document outlines a seminar on evidence-based nursing practice. It defines evidence-based practice as using the best available research evidence, clinical expertise, and patient values to guide nursing care. The five steps of evidence-based practice are described as formulating questions, searching literature, critically analyzing evidence, implementing useful findings, and evaluating changes. Barriers to evidence-based practice include lack of skills, support, time and access to research. Clinical nurse educators and administrators can promote evidence-based practice through role modeling, education and creating supportive environments for nursing research.