Escitalopram is a selective serotonin reuptake inhibitor (SSRI) used to treat mood disorders like depression and anxiety disorders like generalized anxiety disorder. It works by inhibiting the reuptake of the neurotransmitter serotonin in the brain. Unlike other SSRIs, escitalopram binds to both the primary and allosteric sites of the serotonin transporter, resulting in a stronger and longer-lasting inhibition of serotonin reuptake. The usual starting dose for depression is 10 mg per day, while for panic disorder it is 5 mg for the first week then increasing to 10 mg. Maximum effectiveness may take 2-4 weeks for depression or up to 3 months for panic disorder.
This training was provided by Standpharm Pakistan Ltd for the launch of our product Escilam.
this Training program will help you to understand the Nervous system, Neurotransmission, Neurotransmitters, and Escitalopram
I hope my this training will help other learners of nervous system neurotransmission neurons and escitalopram
This training was provided by Standpharm Pakistan Ltd for the launch of our product Escilam.
this Training program will help you to understand the Nervous system, Neurotransmission, Neurotransmitters, and Escitalopram
I hope my this training will help other learners of nervous system neurotransmission neurons and escitalopram
antipsychotics history, managment of psychosis,side effect of antipsychotics, mechanism of antipsychotics, atypical antipsychotics,2nd generation antipsychotics.
antipsychotics history, managment of psychosis,side effect of antipsychotics, mechanism of antipsychotics, atypical antipsychotics,2nd generation antipsychotics.
Wimmics seminar--drug interaction knowledge base, micropublication, open anno...jodischneider
Presentation to the INRIA WIMMICS research group 2014-10-17 about our LISC paper: Using the micropublication ontology and the Open Annotation Data Model to represent evidence within a drug-drug interaction knowledge base:
http://jodischneider.com/pubs/lisc2014.pdf
http://wimmics.inria.fr/seminars
Generic Quetiapine Fumarate Tablets (Qutipin) are used for the treatment of schizophrenia. They are also used for the acute treatment and maintenence treatment of bipolar I disorder.
How GPs and mental health practitioners should work togetherKris Van den Broeck
In this slideshow, we first present a literature study, showing that guidelines on the treatment of major depressive disorder (MDD) only provide little information about how to organise collaborative care. An additional Pubmed search, however, may be inspirational for who would like to improve collaboration amongst caregivers regarding the care for severely depressed patients. A second (qualitative) study presented in this presentation outlines how collaborative care amongst general practitioners (GPs) and mental health care practitioners is organised today in Belgium and what can be improved according to practitioners in favour of severely depressed patients.
TREATMENT RESISTANT DEPRESSION IS A AREA THAT IS NOT EXPLORED MUCH, BUT IT REALLY NEEDS LOT OF ATTENTION AS IT IS ONE OF THE MOST COMMON OBSTACLE IN ACHIEVING COMPLETE REMISSION IN DEPRESSION
Clinical Practice Guideline of Major Depressive Disorder
for General Practitioner : CPG-MDD-GP
แนวทางการจัดการโรคซึมเศร้า
สำหรับแพทย์เวชปฏิบัติทั่วไปในสถานบริการระดับปฐมภูมิและทุติยภูม
http://www.thaidepression.com/www/news54/CPG-MDD-GP.pdf
Problems regarding neurology increasing at an alarming rate. If you are suffering from any nervous problem, Please go through Shuddhi Ayurveda for Nervous System Natural Remedies or contact us at 7398673986.
obsessive-compulsive disorder is a mental disorder whose main symptoms include obsessions and compulsions, driving the person to engage in unwanted, often-times distress behaviors or thoughts. The obsessions are usually related to a sense of harm, risk or injury. The common Obsessions include concern about contamination, doubt, fear of loss or letting go, fear of physically injuring someone.It’s treatment is done through a combination of psychiatric medications and psychotherapy.
Obsessive-Compulsive Disorder (OCD) is a common, chronic and long-lasting disorder in which a person has uncontrollable, reoccurring thoughts (obsessions) and behaviors (compulsions) that he or she feels the urge to repeat over and over.
An obsession is defined as an idea, impulse, or image which intrude into the conscious aware repeatedly.
Depression is a mental disorder and has become most common in recent years. This slide or presentation deals with all types of aetiologies of depression, theories that are involved in development of depression, pathophysiology of drepression, various classes anti-depressant their pharmacology with the adverse events or effects. This also gives a brief note on difference between depression and sadness.
Mechanism of Action:
Loratadine: Loratadine is a antihistamine, which binds with H1-receptors present in periphery and inhibit secretion of histamine.
Montelukast: It is a leukotriene receptor antagonist, stop release of LTD-4 in air way. These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms
Mechanism Of Action:
Loratadine: Loratadine is a antihistamine, which binds with H1-receptors present in periphery and inhibit secretion of histamine.
Montelukast: It is a leukotriene receptor antagonist, stop release of LTD-4 in air way. These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.
Esdom is a combination of esomeprazole and domperidone. esomeprazole inhibits the H + /K + - AT Pase enzyme(proton pump inhibitor), which is responsible for gastric acid secretion in the parietal cells of the stomach and irreversibly block the final step of acid secretion. It increases motility of GI tract by inhibiting the action of dopamine and fastens gastric emptying. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptor.
Esomeprazole 40mg, Domperidone -SR 30mg.
Esomeprazole and Domperidone, it is most commonly used to treat or prevent conditions, such as: heartburn, ulcers, Gastritis and GERD. Side effects may include: nausea, dizziness, stomach pain and flatulence.
Analgesics continue to be the mainstay of therapy in osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role, particularly where there is a significant inflammatory component to the osteoarthritis. Piroxicam-beta-cyclodextrin (PBC) is a new formulation in which piroxicam has been complexed with beta-cyclodextrin, a cyclic oligosaccharide. This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action. PBC, like piroxicam, is administered once daily. PBC has been used in the treatment of osteoarthritis. In comparison with piroxicam, PBC showed a more rapid analgesic-anti-inflammatory action after the first administration in patients with active osteoarthritis. Subsequent evaluations at the second, fifth and last day of treatment demonstrated a comparable efficacy of the two drugs. The efficacy and tolerability of PBC was compared with other NSAIDs given intramuscularly, such as diclofenac and ketoprofen. The three compounds provided marked pain relief within thirty minutes and this increased progressively until the third to fourth hour. The efficacy of oral PBC was comparable to that of intramuscular diclofenac or ketoprofen. In comparison with metamisole PBC achieved a more rapid and sustained reduction in pain intensity during the first twelve hours of treatment. This rapid and marked reduction in pain intensity with PBC was also observed in patients with low-back pain when compared with etodolac. In view of its efficacy, tolerability and rapid onset of action, piroxicam-beta-cyclodextrin appears to be an useful analgesic and a prominent progress in the treatment of acute rheumatic pain.
ref: https://www.ncbi.nlm.nih.gov/pubmed/7805703
levofloxacin plus metronidazole combination.
A once-daily regimen of levofloxacin plus metronidazole looks promising for the treatment of intra-abdominal infections.
Nutrition for pregnant and lactating ladiesNadia Qayyum
Nutrients:
A nutrient is a chemical substance in food that helps maintain the body. Some provide energy. All help build cells and tissues, regulate bodily processes such as breathing. No single food supplies all the nutrients the body needs to function.
Ferrous Bisglycinate is chelated iron form, in which iron is chelated with two amino acids.
Small, stable molecule with no ionic charge
Does not react with other nutrients
Bioavailable (easily absorbed)
Safe
Less gastric upset
Folic acid and vitamin B9, is one of the B vitamins.The recommended daily intake level of folate is 400 micrograms from foods or dietary supplements.Folic acid is used to treat anemia caused by folic acid deficiency.It is also used as a supplement by women during pregnancy to prevent neural tube defects (NTDs) in the baby.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
3. Nervous System
• The nervous system is the part of an
animal's body that coordinates its
voluntary and involuntary actions and
transmits signals between different parts
of its body.
• Voluntary action: That automatically occur
in your body.
• Involuntary action: Action that occur
because of your choice.
2/22/2017 3
6. Neurotransmitters
• Neurotransmitters are
endogenous chemicals that
transmit signals across a
synapse from one neuron
(brain cell) to another 'target'
neuron.
• Synapse: In the nervous
system, a synapse is a
structure that permits a
neuron (or nerve cell) to pass
an electrical or chemical
signal to another cell (neural
or otherwise).
2/22/2017 6
Synapse
7. There are some criteria for identifying
neurotransmitters:
• The chemical must be synthesized in the neuron
or otherwise be present in it.
• When the neuron is active, the chemical must be
released and produce a response in some target.
• The same response must be obtained when the
chemical is experimentally placed on the target.
• A mechanism must exist for removing the
chemical from its site of activation after its work is
done.
• Carry messages between neurons.
• Example: Adrenaline, Noradrenalin, Serotonin,
Acetylcholine.2/22/2017 7
10. Selective Serotonin Reuptake
inhibitor
Mechanism Of Action:
• Escitalopram:
• Unlike other SSRIs Escitalopram binds with both
sites of Serotonin transporter i.e. Primary and
Allosteric site while other SSRIs and SNRI bind
only with primary site. In this way Escitalopram
binding with SERT is more strong.
2/22/2017 10
12. 2/22/2017 12
By binding with allosteric site Escitalopram makes changing in structure of
primary site, which makes binding of escitalopram more strong at primary site
so less amount of serotonin is reuptake.
13. Indications:
• Depression: Depression is a mood disorder that causes a persistent feeling
of sadness and loss of interest.
• Anxiety disorder: An anxiety disorder is a serious mental illness. For people
with anxiety disorders, worry and fear are constant and overwhelming, and
can be crippling.
• GAD: Generalized Anxiety Disorder, GAD, is an anxiety disorder
characterized by chronic anxiety, exaggerated worry and tension,even when
there is no or little tension really exist in their lives.
• Phobic States: Persistent fear of social or performance situations.
• Panic disorder: People with this condition have feelings of terror that strike
suddenly and repeatedly with no warning.
• OCD: (Obsessive–compulsive disorder )Recurrent & persistent thoughts,
impulses or images…..intrusive and inappropriate.
2/22/2017 13
14. Dose
• Escitalopram is indicated in the treatment of depressive episodes,
panic disorder.
With depressive episodes, the usual dose is 10 mg per day taken at
once with or without food. The antidepressant response is generally
reached after 2 to 4 weeks. After the disappearance of the
symptoms is a need for further treatment for at least 6 months.
In panic disorder with or without agoraphobia the amount of the
initial dose is 5 mg per day during the first week after which the dose
is increased to 10 mg per day. Maximum effectiveness is reached
after about 3 months.
Thank You
2/22/2017 14