This document discusses the importance of calcium, vitamin D, and vitamin K2 for pregnancy nutrition. It notes that calcium is essential for fetal bone growth and development and helps reduce risks of pregnancy complications like preeclampsia. The recommended daily calcium intake increases during pregnancy. Vitamin D aids calcium absorption and vitamin K2 directs calcium to the bones. Together calcium, vitamin D and K2 support strong bones and healthy blood vessels in both mother and baby. Calcium deficiency during pregnancy can lead to issues like preeclampsia, while meeting calcium needs helps support the growth and health of both mother and fetus.
Calcium and Vitamin D Supplementation in PregnancySujoy Dasgupta
lectured delivered by Dr Sujoy Dasgupta in the CME on "High Risk Pregnancy" organized by the BOGS (Bengal Obettric snd Gynaecological Society) and Wanburry Pharma
This document provides an overview of calcium, including:
- Where calcium is stored in the body (mainly in bones)
- How calcium is absorbed from the diet and regulated in the body by hormones like PTH and vitamin D metabolites
- How calcium is reabsorbed and excreted by the kidneys, with most reabsorption occurring in the proximal tubule under control of PTH and vitamin D
- The primary forms of calcium supplements and factors affecting their absorption
During pregnancy and lactation, calcium requirements increase substantially to support the developing fetus and breastfeeding infant. The placenta transfers 200-300mg of calcium daily to the fetus during pregnancy, while breastmilk contains 280-400mg of calcium that is secreted daily during lactation. To meet these demands, women undergo physiological adaptations like increased intestinal calcium absorption facilitated by elevated vitamin D and intestinal calbindin levels. They also experience decreased urinary calcium excretion through effects of PTHrP and estrogen. These changes, along with calcium mobilization from maternal bones, enable women to direct calcium to the fetus and breastmilk. Low calcium intake can potentially impact fetal and infant growth and development as well as maternal bone health.
This slideshow is to educate people that the Best Calcium Supplement is actually Calmodulin (CaM), which is the trasporter and regulator for Calcium ions to go into the cells. Without CaM, calcium cannot be absorped into the cell which leads to calcium defiency. Serious calcium defiency will cause osteopenia and even osteoporosis. Too much of calcium causes calcification. Therefore, calcium needs to be regulated and balanced by Calmodulin.
This document discusses the role of calcium and vitamin D in reducing fracture risk. It notes that osteoporotic fractures are increasing with aging and are associated with morbidity, disability, and mortality. Adequate calcium and vitamin D intake helps maximize bone mineral density and prevents falls. The document reviews clinical trials on calcium and vitamin D supplementation for fracture prevention and concludes that daily supplementation of 800 IU of vitamin D and 1000 mg of calcium can effectively reduce fracture risk, especially in institutionalized elderly individuals. Compliance with long-term supplementation is important to maintain benefits.
The document discusses the importance of nutrition during pregnancy and lactation. It notes that the last two trimesters of pregnancy and first six months of lactation represent a critical period for an infant's growth and development. Inadequate maternal nutrition during this time can negatively impact both mother and fetus, leading to issues like low birth weight, prematurity, and impaired growth and development. Proper nutrition is essential to support the high demands of pregnancy, lactation, and the rapid growth and development of the fetus and infant.
Role of Calcium in pregnancy DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Rashmi Jai...Lifecare Centre
ROLE OF CALCIUM IN PREGNANCY
FOCUS :
Daily requirement of calcium according to age
Calcium metabolism in pregnancy
Calcium requirement in pregnancy
Maternal benefits
Fetal benefits
Reduction in blood lead levels
Nutrition to improve calcium
Guidelines about dietary calcium intake / supplements in pregnancy
Calcium is essential for many physiological processes in the body. It makes up 1-1.5% of total body weight, with 99% located in bones and teeth. Dietary sources include dairy products, eggs, fish, and leafy greens. The recommended daily intake is 500 mg for adults and 1200 mg for children. Calcium is absorbed in the duodenum and jejunum through an active transport process requiring energy and carrier proteins. Homeostasis is maintained by calcitriol, parathyroid hormone, and calcitonin which regulate absorption from the intestine and resorption from bones. Imbalances can cause hypercalcemia with symptoms like confusion and arrhythmias, or hypocalcemia/
Calcium and Vitamin D Supplementation in PregnancySujoy Dasgupta
lectured delivered by Dr Sujoy Dasgupta in the CME on "High Risk Pregnancy" organized by the BOGS (Bengal Obettric snd Gynaecological Society) and Wanburry Pharma
This document provides an overview of calcium, including:
- Where calcium is stored in the body (mainly in bones)
- How calcium is absorbed from the diet and regulated in the body by hormones like PTH and vitamin D metabolites
- How calcium is reabsorbed and excreted by the kidneys, with most reabsorption occurring in the proximal tubule under control of PTH and vitamin D
- The primary forms of calcium supplements and factors affecting their absorption
During pregnancy and lactation, calcium requirements increase substantially to support the developing fetus and breastfeeding infant. The placenta transfers 200-300mg of calcium daily to the fetus during pregnancy, while breastmilk contains 280-400mg of calcium that is secreted daily during lactation. To meet these demands, women undergo physiological adaptations like increased intestinal calcium absorption facilitated by elevated vitamin D and intestinal calbindin levels. They also experience decreased urinary calcium excretion through effects of PTHrP and estrogen. These changes, along with calcium mobilization from maternal bones, enable women to direct calcium to the fetus and breastmilk. Low calcium intake can potentially impact fetal and infant growth and development as well as maternal bone health.
This slideshow is to educate people that the Best Calcium Supplement is actually Calmodulin (CaM), which is the trasporter and regulator for Calcium ions to go into the cells. Without CaM, calcium cannot be absorped into the cell which leads to calcium defiency. Serious calcium defiency will cause osteopenia and even osteoporosis. Too much of calcium causes calcification. Therefore, calcium needs to be regulated and balanced by Calmodulin.
This document discusses the role of calcium and vitamin D in reducing fracture risk. It notes that osteoporotic fractures are increasing with aging and are associated with morbidity, disability, and mortality. Adequate calcium and vitamin D intake helps maximize bone mineral density and prevents falls. The document reviews clinical trials on calcium and vitamin D supplementation for fracture prevention and concludes that daily supplementation of 800 IU of vitamin D and 1000 mg of calcium can effectively reduce fracture risk, especially in institutionalized elderly individuals. Compliance with long-term supplementation is important to maintain benefits.
The document discusses the importance of nutrition during pregnancy and lactation. It notes that the last two trimesters of pregnancy and first six months of lactation represent a critical period for an infant's growth and development. Inadequate maternal nutrition during this time can negatively impact both mother and fetus, leading to issues like low birth weight, prematurity, and impaired growth and development. Proper nutrition is essential to support the high demands of pregnancy, lactation, and the rapid growth and development of the fetus and infant.
Role of Calcium in pregnancy DR. SHARDA JAIN Dr. Jyoti Agarwal Dr. Rashmi Jai...Lifecare Centre
ROLE OF CALCIUM IN PREGNANCY
FOCUS :
Daily requirement of calcium according to age
Calcium metabolism in pregnancy
Calcium requirement in pregnancy
Maternal benefits
Fetal benefits
Reduction in blood lead levels
Nutrition to improve calcium
Guidelines about dietary calcium intake / supplements in pregnancy
Calcium is essential for many physiological processes in the body. It makes up 1-1.5% of total body weight, with 99% located in bones and teeth. Dietary sources include dairy products, eggs, fish, and leafy greens. The recommended daily intake is 500 mg for adults and 1200 mg for children. Calcium is absorbed in the duodenum and jejunum through an active transport process requiring energy and carrier proteins. Homeostasis is maintained by calcitriol, parathyroid hormone, and calcitonin which regulate absorption from the intestine and resorption from bones. Imbalances can cause hypercalcemia with symptoms like confusion and arrhythmias, or hypocalcemia/
Calcium is essential for life and health from birth to old age. It plays key roles in bone and teeth development, muscle function, blood clotting, and nerve signaling. Most calcium in the body is stored in bones and teeth. Calcium deficiency can cause over 100 diseases and symptoms vary by age. The document recommends daily calcium intake amounts and lists those who may need supplements. It describes different calcium supplement types and highlights the advantages of TIENS' amino acid chelated calcium supplements which have high absorption rates and no side effects.
HYPERHOMOCYSTIENEMIA IN PREGNANCY AND LACTATION AND ROLE OF VITAMIN B12, D3 A...DR SHASHWAT JANI
This document discusses hyperhomocysteinemia in pregnancy and lactation. It begins with an introduction to vitamin B12, its importance in pregnancy and lactation, and sources of vitamin B12. It then discusses homocysteine, hyperhomocysteinemia, and the epidemiology of hyperhomocysteinemia in India. The document outlines the links between hyperhomocysteinemia and various pregnancy complications as well as the roles of folate, vitamin B12, and methylcobalamin in pregnancy outcomes. It emphasizes that vitamin B12 deficiency is more common than folate deficiency among pregnant women in India. Throughout, it provides evidence from various studies on the effects of vitamin B12 supplementation on mothers,
Calcium is essential for building strong bones and maintaining bone density as we age. Our bones absorb most calcium during childhood and adolescence, so it is important to consume adequate calcium from foods like dairy, soy, leafy greens and fortified foods starting at a young age. Not getting enough calcium can lead to osteoporosis, a disease where bones become brittle and prone to breaking. In addition to calcium, vitamin D is needed to help the body absorb calcium from foods. The document provides recommendations for daily calcium and vitamin D intake at different life stages to support bone health.
Slide set that accompanied a public lecture on Nutrients and Bone Health held in London September 2011. The lecture focused on the importance of diet and lifestyle in maintaining healthy bone and preventing osteoporosis. Aspects of diagnosis are reviewed and the use of bone markers to indicate bone turnover are discussed in relation to monitoring the response to treatment.
This document discusses vitamin D deficiency in India. It provides the following key points:
1. More than 80% of adults in India do not get enough vitamin D, despite India's sunny climate, due to factors like skin pigmentation and low dietary intake.
2. The most common disorders caused by vitamin D deficiency in India are osteomalacia and rickets, which are bone diseases characterized by softening of the bones.
3. Good food sources of vitamin D include cod liver oil, fatty fish like salmon and tuna, and fortified foods like milk, cereal and orange juice. However, dietary intake of vitamin D is still low for most Indians.
Calcium is essential for bone health, muscle function, and other bodily processes. A lack of calcium can lead to osteoporosis, rickets, hypertension during pregnancy, and other disorders. Supplementation with calcium and vitamin D can help prevent pregnancy complications like preeclampsia and preterm labor by supporting fetal bone development and reducing blood pressure. Maintaining adequate calcium intake is important for overall health.
Calcium is essential for bone health, especially in infants. Breastfeeding provides optimal calcium, but lactating mothers can experience bone loss. The document presents a brand plan for a calcium supplement called MotherCal, positioned for lactating mothers. It highlights that MotherCal contains calcium citrate, which is better absorbed than carbonate, and also includes phosphate and vitamin D for bone health. Statistics show low rates of exclusive breastfeeding in India and need to support lactating mothers' bone health. The plan includes promotional materials to educate about breastfeeding and launch MotherCal.
This presentation discusses the calcium and vitamin D supplement Caldolin. It contains calcium carbonate which maintains calcium homeostasis and helps form bone mass. It also contains vitamin D3 which ensures calcium absorption, decreases bone resorption, and promotes bone mineralization. Caldolin is recommended as a dietary supplement for those with inadequate calcium intake, including during pregnancy, lactation, menopause, and for the aged. It can also treat calcium deficiency states like osteoporosis, osteomalacia, and rickets. The presentation provides dosage instructions and notes possible side effects like constipation or diarrhea. It concludes with market information on leading calcium supplements in Bangladesh.
Vitamin D is synthesized in the skin upon exposure to sunlight and is hydroxylated sequentially in the liver and kidneys to produce the active form of vitamin D. It regulates calcium and phosphate levels in the blood and promotes bone health by enhancing intestinal calcium absorption and stimulating bone mineralization. Vitamin D supplements in the form of cholecalciferol tablets or sachets are used to treat osteoporosis and fractures by helping to maintain calcium levels and supporting bone mineral density and structure.
This document provides an overview of calcium metabolism and disorders. It discusses:
1. The essential biochemical functions of calcium in muscle contraction, nerve impulse transmission, hormone secretion, and enzyme activation.
2. How calcium levels are tightly regulated by parathyroid hormone, calcitriol (vitamin D), and calcitonin through effects on intestinal absorption, renal excretion, and bone resorption.
3. Common calcium metabolism disorders like hypercalcemia and hypocalcemia, their causes, symptoms, and treatment. Primary hyperparathyroidism is the most common cause of hypercalcemia.
This document discusses calcium, including its history, functions, absorption, metabolism, and sources. It provides the following key points:
- Calcium is essential for bone formation, muscle and nerve function, and plays a role in many biochemical reactions in the body.
- It is absorbed in the small intestine through both passive and active transport, and its levels are regulated by parathyroid hormone, vitamin D, and calcitonin.
- Good dietary sources include dairy products like milk and cheese, as well as green leafy vegetables. Calcium supplements may be recommended for some groups.
- Disorders can include osteoporosis, rickets, and hypocalcemia or hypercalcemia if levels
Vitamin D is an essential vitamin that must be metabolized to become biologically active. It plays an important role in calcium homeostasis, bone and muscle health, immune function, and the regulation of cell growth. The best indicator of vitamin D status is the measurement of 25-hydroxyvitamin D in the blood, as it reflects vitamin D from dietary intake and sunlight exposure. Low vitamin D levels have been associated with increased risk of various chronic diseases. Vitamin D deficiency can lead to impaired bone mineralization and increased fracture risk.
The document summarizes key information about calcium and phosphorus metabolism. It discusses their daily requirements, distribution in the body, dietary sources, functions, factors controlling absorption such as vitamin D, parathyroid hormone, and calcitonin. It also outlines hormonal control of calcium and phosphorus metabolism and clinical importance of hypo- and hypercalcemia and hyperphosphatemia. The objectives are to understand the role of calcium and phosphorus in the body and factors influencing their metabolism.
Vitamin D is a fat-soluble vitamin that is important for bone and muscle health. It is synthesized in the skin upon exposure to sunlight or obtained from dietary sources. The liver and kidneys work to activate vitamin D before it can be used by the body. Vitamin D deficiency can lead to rickets in children and osteomalacia or osteoporosis in adults and is associated with increased risk of various diseases. Treatment of deficiency involves obtaining more vitamin D through diet, supplements, or sunlight exposure.
About two out of three Americans do not meet the Recommended Daily Allowance for calcium, which partly explains why osteoporosis or osteopenia (inadequate bone density) affects the majority of post-menopausal women and is increasingly common in men. For that reason, next to multivitamins, calcium pills are the most commonly consumed daily over-the-counter supplement.
Unfortunately, recent studies suggest that traditional mono-nutrient calcium supplements might increase risk of heart issues by accelerating calcified plaque build-up in your coronary arteries. In this webinar Dr. James O'Keefe will teach you how to optimize bone strength, while at the same time promoting heart health through proper calcium consumption.
This document discusses vitamin D, including its forms, functions, metabolism, and deficiency/toxicity. Some key points:
- Vitamin D exists in two forms, D2 and D3. D3 is produced in the skin upon sun exposure and converted to its active form in the liver and kidneys.
- Its active form, calcitriol, regulates calcium and phosphorus levels by increasing their absorption in the intestine and reabsorption in kidneys. It also mobilizes calcium from bones.
- Deficiency causes rickets in children and osteomalacia in adults due to impaired bone mineralization. Toxicity leads to hypercalcemia which can damage soft tissues like kidneys.
Calcium in PG Doctors presentation.pptxTanvirIslam94
Calcium needs increase during pregnancy and lactation to support fetal and infant development. During pregnancy, 200-300 mg of calcium is transferred daily via the placenta to the fetus or excreted in breastmilk. To meet these demands, women experience increased intestinal calcium absorption, decreased urinary calcium excretion, and increased bone calcium turnover. Calcium supplementation in pregnancy has been shown to reduce risks of preeclampsia and gestational hypertension by around 40%. Adequate calcium intake during pregnancy and lactation supports healthy bone development in both mother and child.
The document discusses nutrition requirements during pregnancy and lactation. It notes that nutritional needs increase tremendously during these periods as the mother must nourish herself as well as the growing fetus or breastfeeding infant. Specifically, it outlines how energy, protein, calcium, iron, vitamin and mineral needs escalate. Meeting these heightened requirements is important for limiting complications and supporting healthy fetal development and birth outcomes. Inadequate nutrition can endanger both mother and baby. The document also covers some potential issues like gestational diabetes, birth defects, and challenges that can arise during delivery or for the newborn.
Calcium is essential for life and health from birth to old age. It plays key roles in bone and teeth development, muscle function, blood clotting, and nerve signaling. Most calcium in the body is stored in bones and teeth. Calcium deficiency can cause over 100 diseases and symptoms vary by age. The document recommends daily calcium intake amounts and lists those who may need supplements. It describes different calcium supplement types and highlights the advantages of TIENS' amino acid chelated calcium supplements which have high absorption rates and no side effects.
HYPERHOMOCYSTIENEMIA IN PREGNANCY AND LACTATION AND ROLE OF VITAMIN B12, D3 A...DR SHASHWAT JANI
This document discusses hyperhomocysteinemia in pregnancy and lactation. It begins with an introduction to vitamin B12, its importance in pregnancy and lactation, and sources of vitamin B12. It then discusses homocysteine, hyperhomocysteinemia, and the epidemiology of hyperhomocysteinemia in India. The document outlines the links between hyperhomocysteinemia and various pregnancy complications as well as the roles of folate, vitamin B12, and methylcobalamin in pregnancy outcomes. It emphasizes that vitamin B12 deficiency is more common than folate deficiency among pregnant women in India. Throughout, it provides evidence from various studies on the effects of vitamin B12 supplementation on mothers,
Calcium is essential for building strong bones and maintaining bone density as we age. Our bones absorb most calcium during childhood and adolescence, so it is important to consume adequate calcium from foods like dairy, soy, leafy greens and fortified foods starting at a young age. Not getting enough calcium can lead to osteoporosis, a disease where bones become brittle and prone to breaking. In addition to calcium, vitamin D is needed to help the body absorb calcium from foods. The document provides recommendations for daily calcium and vitamin D intake at different life stages to support bone health.
Slide set that accompanied a public lecture on Nutrients and Bone Health held in London September 2011. The lecture focused on the importance of diet and lifestyle in maintaining healthy bone and preventing osteoporosis. Aspects of diagnosis are reviewed and the use of bone markers to indicate bone turnover are discussed in relation to monitoring the response to treatment.
This document discusses vitamin D deficiency in India. It provides the following key points:
1. More than 80% of adults in India do not get enough vitamin D, despite India's sunny climate, due to factors like skin pigmentation and low dietary intake.
2. The most common disorders caused by vitamin D deficiency in India are osteomalacia and rickets, which are bone diseases characterized by softening of the bones.
3. Good food sources of vitamin D include cod liver oil, fatty fish like salmon and tuna, and fortified foods like milk, cereal and orange juice. However, dietary intake of vitamin D is still low for most Indians.
Calcium is essential for bone health, muscle function, and other bodily processes. A lack of calcium can lead to osteoporosis, rickets, hypertension during pregnancy, and other disorders. Supplementation with calcium and vitamin D can help prevent pregnancy complications like preeclampsia and preterm labor by supporting fetal bone development and reducing blood pressure. Maintaining adequate calcium intake is important for overall health.
Calcium is essential for bone health, especially in infants. Breastfeeding provides optimal calcium, but lactating mothers can experience bone loss. The document presents a brand plan for a calcium supplement called MotherCal, positioned for lactating mothers. It highlights that MotherCal contains calcium citrate, which is better absorbed than carbonate, and also includes phosphate and vitamin D for bone health. Statistics show low rates of exclusive breastfeeding in India and need to support lactating mothers' bone health. The plan includes promotional materials to educate about breastfeeding and launch MotherCal.
This presentation discusses the calcium and vitamin D supplement Caldolin. It contains calcium carbonate which maintains calcium homeostasis and helps form bone mass. It also contains vitamin D3 which ensures calcium absorption, decreases bone resorption, and promotes bone mineralization. Caldolin is recommended as a dietary supplement for those with inadequate calcium intake, including during pregnancy, lactation, menopause, and for the aged. It can also treat calcium deficiency states like osteoporosis, osteomalacia, and rickets. The presentation provides dosage instructions and notes possible side effects like constipation or diarrhea. It concludes with market information on leading calcium supplements in Bangladesh.
Vitamin D is synthesized in the skin upon exposure to sunlight and is hydroxylated sequentially in the liver and kidneys to produce the active form of vitamin D. It regulates calcium and phosphate levels in the blood and promotes bone health by enhancing intestinal calcium absorption and stimulating bone mineralization. Vitamin D supplements in the form of cholecalciferol tablets or sachets are used to treat osteoporosis and fractures by helping to maintain calcium levels and supporting bone mineral density and structure.
This document provides an overview of calcium metabolism and disorders. It discusses:
1. The essential biochemical functions of calcium in muscle contraction, nerve impulse transmission, hormone secretion, and enzyme activation.
2. How calcium levels are tightly regulated by parathyroid hormone, calcitriol (vitamin D), and calcitonin through effects on intestinal absorption, renal excretion, and bone resorption.
3. Common calcium metabolism disorders like hypercalcemia and hypocalcemia, their causes, symptoms, and treatment. Primary hyperparathyroidism is the most common cause of hypercalcemia.
This document discusses calcium, including its history, functions, absorption, metabolism, and sources. It provides the following key points:
- Calcium is essential for bone formation, muscle and nerve function, and plays a role in many biochemical reactions in the body.
- It is absorbed in the small intestine through both passive and active transport, and its levels are regulated by parathyroid hormone, vitamin D, and calcitonin.
- Good dietary sources include dairy products like milk and cheese, as well as green leafy vegetables. Calcium supplements may be recommended for some groups.
- Disorders can include osteoporosis, rickets, and hypocalcemia or hypercalcemia if levels
Vitamin D is an essential vitamin that must be metabolized to become biologically active. It plays an important role in calcium homeostasis, bone and muscle health, immune function, and the regulation of cell growth. The best indicator of vitamin D status is the measurement of 25-hydroxyvitamin D in the blood, as it reflects vitamin D from dietary intake and sunlight exposure. Low vitamin D levels have been associated with increased risk of various chronic diseases. Vitamin D deficiency can lead to impaired bone mineralization and increased fracture risk.
The document summarizes key information about calcium and phosphorus metabolism. It discusses their daily requirements, distribution in the body, dietary sources, functions, factors controlling absorption such as vitamin D, parathyroid hormone, and calcitonin. It also outlines hormonal control of calcium and phosphorus metabolism and clinical importance of hypo- and hypercalcemia and hyperphosphatemia. The objectives are to understand the role of calcium and phosphorus in the body and factors influencing their metabolism.
Vitamin D is a fat-soluble vitamin that is important for bone and muscle health. It is synthesized in the skin upon exposure to sunlight or obtained from dietary sources. The liver and kidneys work to activate vitamin D before it can be used by the body. Vitamin D deficiency can lead to rickets in children and osteomalacia or osteoporosis in adults and is associated with increased risk of various diseases. Treatment of deficiency involves obtaining more vitamin D through diet, supplements, or sunlight exposure.
About two out of three Americans do not meet the Recommended Daily Allowance for calcium, which partly explains why osteoporosis or osteopenia (inadequate bone density) affects the majority of post-menopausal women and is increasingly common in men. For that reason, next to multivitamins, calcium pills are the most commonly consumed daily over-the-counter supplement.
Unfortunately, recent studies suggest that traditional mono-nutrient calcium supplements might increase risk of heart issues by accelerating calcified plaque build-up in your coronary arteries. In this webinar Dr. James O'Keefe will teach you how to optimize bone strength, while at the same time promoting heart health through proper calcium consumption.
This document discusses vitamin D, including its forms, functions, metabolism, and deficiency/toxicity. Some key points:
- Vitamin D exists in two forms, D2 and D3. D3 is produced in the skin upon sun exposure and converted to its active form in the liver and kidneys.
- Its active form, calcitriol, regulates calcium and phosphorus levels by increasing their absorption in the intestine and reabsorption in kidneys. It also mobilizes calcium from bones.
- Deficiency causes rickets in children and osteomalacia in adults due to impaired bone mineralization. Toxicity leads to hypercalcemia which can damage soft tissues like kidneys.
Calcium in PG Doctors presentation.pptxTanvirIslam94
Calcium needs increase during pregnancy and lactation to support fetal and infant development. During pregnancy, 200-300 mg of calcium is transferred daily via the placenta to the fetus or excreted in breastmilk. To meet these demands, women experience increased intestinal calcium absorption, decreased urinary calcium excretion, and increased bone calcium turnover. Calcium supplementation in pregnancy has been shown to reduce risks of preeclampsia and gestational hypertension by around 40%. Adequate calcium intake during pregnancy and lactation supports healthy bone development in both mother and child.
The document discusses nutrition requirements during pregnancy and lactation. It notes that nutritional needs increase tremendously during these periods as the mother must nourish herself as well as the growing fetus or breastfeeding infant. Specifically, it outlines how energy, protein, calcium, iron, vitamin and mineral needs escalate. Meeting these heightened requirements is important for limiting complications and supporting healthy fetal development and birth outcomes. Inadequate nutrition can endanger both mother and baby. The document also covers some potential issues like gestational diabetes, birth defects, and challenges that can arise during delivery or for the newborn.
Nutrition requirements increases tremendously during pregnancy and lactation as the expectant or nursing mother not only has to nourish herself but also growing foetus and the infant who is being breast fed
This document discusses maternal nutrition during pregnancy and lactation. It defines key terms and identifies the nutritional needs and requirements that increase during these stages, including additional daily calories, protein, iron, calcium and other vitamins and minerals. The document also discusses nutritional risk factors during pregnancy like iron deficiency anemia, which has a high prevalence in Pakistan. Maintaining good nutrition is important for both maternal and infant health.
Nutrition during pregnancy and lactation is critical. During pregnancy, a woman's nutritional needs increase significantly to support the growth of the fetus and development of maternal tissues. Key nutrients in higher demand include calories, protein, iron, calcium, folic acid, iodine, vitamins A, C, D, B6, B12, and long-chain omega-3 fatty acids. Inadequate nutrition during pregnancy can harm both mother and baby. During lactation, extra nutrients are needed to nourish the infant through breastmilk production. Lactating mothers have higher requirements for calories, protein, calcium, iron, vitamins A and B6. Meeting these nutritional needs is important for the health of both mother and child.
Nutrition requirements increase tremendously during pregnancy and lactation as the expectant or nursing mother must nourish herself and her growing fetus or breastfeeding infant. During pregnancy, a woman's basal metabolic rate and gastrointestinal changes increase her total energy needs by 300 calories in the second and third trimesters. Inadequate nutrition during pregnancy increases risks for both mother and baby, including complications during labor and low birthweight. Nutritional needs are also increased during lactation to support milk production and the infant's needs. Adequate intake of proteins, vitamins, minerals and fluids is important for both mother and baby's health during these periods.
This document discusses the importance of maternal nutrition for fetal development and lifelong health outcomes. It defines an optimum fetus and lists the benefits of achieving this. Key factors that influence fetal growth such as gestational age, maternal weight gain, and nutrition are examined. The link between maternal nutrition and fetal status is established through evidence from wartime famines. The roles of specific nutrients including iron, calcium, magnesium, vitamin D, folate, antioxidants, and omega-3s are outlined. Food-borne infections and the ideal diet for pregnant women are also addressed.
The document discusses maternal nutrition during pregnancy. It notes that pregnancy causes physiological changes in women to accommodate the fetus, including hormonal changes, weight gain, breast growth, increased blood volume, and fluid retention. Nutritional needs increase during the second and third trimesters to support fetal growth. Inadequate nutrition can lead to complications like preterm birth and low birth weight. Key nutrients that increase in recommended intake include calories, protein, fatty acids, fiber, vitamins A, C, D, B vitamins, iron, calcium and folate. Ensuring good prenatal nutrition promotes healthy pregnancy and birth outcomes.
This document discusses maternal nutrition during pregnancy. It notes that maternal nutrition focuses on a woman's nutritional status as it relates to bearing and nurturing children. During pregnancy, women experience numerous physiological changes including hormonal changes, weight gain, breast size growth, cardiovascular changes, and changes in body fluids. Inadequate nutrition during pregnancy can increase health risks for both mother and baby, including complications during labor, premature birth, and nutritional deficiencies in infants. The needs for vitamins, minerals, proteins and other nutrients increase during pregnancy to support fetal growth and development as well as maternal tissue growth. Poor maternal nutrition can negatively impact fetal development and increase health risks later in life. Supplementation with iron and folic acid is especially important during pregnancy
The document discusses nutrition requirements during pregnancy and lactation. It recommends increased calorie, protein, vitamin and mineral intake during these stages. Key recommendations include 300 extra calories per day during pregnancy, 10-12 kg total weight gain, and extra 20-30g protein during lactation. Deficiencies of iron, iodine, calcium and vitamin D can lead to complications. A balanced diet with milk, fruits and vegetables can meet nutritional demands.
Benefit-risk Assessment for Including Dairy Foods in the DietNicoleGeurin
Uploaded with permission from Melissa Nickle
Consumption of milk and milk products is an important component of a healthy diet. It is recommended by the Dietary Guidelines for Americans to consume 3 cups per day of fat-free or low-fat milk or equivalent milk products. The benefits of milk and milk products outweigh the perceived risks. If milk is avoided in a diet, careful planning and monitoring is needed to assure adequate essential nutrients such as calcium, vitamin D, potassium, and magnesium. Calcium and vitamin D adequacy is critical to bone health, especially the prevention of osteoporosis.
The document discusses nutritional assessment and requirements for lactating women. It recommends that lactating women consume at least 500 extra calories per day to support milk production. Nutritional assessment should include analysis of diet, lifestyle, cultural practices, food intake, and appetite. Key indicators like hemoglobin, serum ferritin, and skinfold thickness are used to assess nutritional status. The needs for important nutrients like protein, calcium, iron, and vitamins increase during lactation. Risk factors for delayed lactation onset include long second stage of labor, high pre-pregnancy BMI, breastfeeding problems, and flat or inverted nipples.
The document discusses nutritional requirements during stressful conditions such as pregnancy, lactation, and for newborns. It notes that during pregnancy nutritional needs change and the health of the baby and mother's comfort can be affected by diet. It provides details on increased energy, protein, folate, iron, calcium, and iodine needs during pregnancy. Complications of malnutrition in pregnancy include emotional stress, complicated deliveries, and increased risk of miscarriages and infant mortality. Nutritional needs are also increased during lactation to support milk production and the infant. Breastfeeding is advocated as the best option for newborns for its health benefits though modified formula is also suitable for the first 4-6 months.
Nutrition during Pregnancy and Lactation.pptxmehwishbibi560
This document discusses nutrition needs during pregnancy and lactation. It notes that the developing baby relies entirely on nutrients from the mother's diet. During pregnancy and lactation, a mother needs more energy, proteins, vitamins, and minerals to support her increased needs and the growth of the fetus/baby. Specifically, it recommends that protein intake for pregnant women be increased to 71g/day compared to 46g/day for non-pregnant women. Adequate calcium, iron, folate, and vitamin D are especially important for both mother and baby's development. Meeting increased nutritional needs through diet supports a healthy pregnancy and lactation.
Micronutrients like iron, folic acid, zinc, iodine, calcium, and vitamins are important during pregnancy for the health of the mother and fetus. Deficiencies can lead to complications such as anemia, birth defects, preterm delivery, and low birth weight. While more research is still needed, studies suggest that supplements of iron, folic acid, and calcium may help reduce health risks for both mother and baby. Ensuring adequate micronutrient intake through diet and supplements is important for supporting fetal growth and development.
Nutrition before and during pregnancy is critical for both mother and baby's health. Pre-pregnancy weight, weight gain during pregnancy, and intake of key nutrients like folic acid, iron, calcium, and iodine can significantly impact outcomes. Being underweight, overweight, or gaining too much or too little weight during pregnancy increases health risks for both. Inadequate intake of critical nutrients can lead to issues like birth defects, preterm birth, low birthweight, and developmental problems. The document outlines recommended intakes and sources for important nutrients to support a healthy pregnancy.
The document discusses nutrition requirements during pregnancy and lactation. During pregnancy, a woman's metabolic rate and nutrient absorption increases to nourish the growing fetus. Her blood volume also expands. Inadequate nutrition can harm both mother and baby. Extra calories, protein, iron, calcium and other nutrients are needed. During lactation, a woman needs additional nutrients to produce breast milk that nourishes the infant. Her energy, protein, calcium, iron and vitamin needs all increase. She must consume a varied, nutrient-rich diet and stay hydrated to support milk production.
1. The document discusses maternal nutrition during pregnancy, outlining nutrient requirements and dietary guidelines. It covers topics like pre-pregnancy nutrition, ideal weight gain, increased needs for calories, protein, iron and other nutrients during pregnancy.
2. Nutritional concerns during pregnancy like nausea, constipation and heartburn are addressed, along with interventions like eating small frequent meals and staying hydrated.
3. Inadequate or excessive weight gain is also covered, noting the risks and recommended rates of gain depending on pre-pregnancy BMI. Maintaining a balanced diet according to daily food group guidelines is emphasized.
This document discusses iron deficiency anemia, which affects over 700 million people worldwide. It is most prevalent in young children, pregnant women, and non-pregnant women. Causes include iron deficiency, malaria, hookworm disease, and genetic conditions. Consequences include impaired development, decreased activity, and increased morbidity. Treatment involves oral or injectable iron supplements. Prevention strategies include nutrition education, food fortification, breastfeeding promotion, and public health measures.
This document discusses Lexidex-M, a medication containing loratadine and montelukast used to treat allergic reactions. It describes allergic reactions as an overreaction of the immune system to substances like pollen or dust. Allergens cause inflammation by producing histamine and leukotrienes which bind to receptors in the respiratory system. Lexidex-M works by having loratadine bind to H1 receptors to inhibit histamine secretion while montelukast blocks leukotriene receptors to prevent inflammation in the airways. The medication is indicated for seasonal allergic rhinitis, asthma prophylaxis, and nasal polyps, and has a dosage of 4mg once daily
Mechanism Of Action:
Loratadine: Loratadine is a antihistamine, which binds with H1-receptors present in periphery and inhibit secretion of histamine.
Montelukast: It is a leukotriene receptor antagonist, stop release of LTD-4 in air way. These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.
Esdom is a combination of esomeprazole and domperidone. esomeprazole inhibits the H + /K + - AT Pase enzyme(proton pump inhibitor), which is responsible for gastric acid secretion in the parietal cells of the stomach and irreversibly block the final step of acid secretion. It increases motility of GI tract by inhibiting the action of dopamine and fastens gastric emptying. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptor.
Esomeprazole 40mg, Domperidone -SR 30mg.
Esomeprazole and Domperidone, it is most commonly used to treat or prevent conditions, such as: heartburn, ulcers, Gastritis and GERD. Side effects may include: nausea, dizziness, stomach pain and flatulence.
Analgesics continue to be the mainstay of therapy in osteoarthritis. Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role, particularly where there is a significant inflammatory component to the osteoarthritis. Piroxicam-beta-cyclodextrin (PBC) is a new formulation in which piroxicam has been complexed with beta-cyclodextrin, a cyclic oligosaccharide. This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action. PBC, like piroxicam, is administered once daily. PBC has been used in the treatment of osteoarthritis. In comparison with piroxicam, PBC showed a more rapid analgesic-anti-inflammatory action after the first administration in patients with active osteoarthritis. Subsequent evaluations at the second, fifth and last day of treatment demonstrated a comparable efficacy of the two drugs. The efficacy and tolerability of PBC was compared with other NSAIDs given intramuscularly, such as diclofenac and ketoprofen. The three compounds provided marked pain relief within thirty minutes and this increased progressively until the third to fourth hour. The efficacy of oral PBC was comparable to that of intramuscular diclofenac or ketoprofen. In comparison with metamisole PBC achieved a more rapid and sustained reduction in pain intensity during the first twelve hours of treatment. This rapid and marked reduction in pain intensity with PBC was also observed in patients with low-back pain when compared with etodolac. In view of its efficacy, tolerability and rapid onset of action, piroxicam-beta-cyclodextrin appears to be an useful analgesic and a prominent progress in the treatment of acute rheumatic pain.
ref: https://www.ncbi.nlm.nih.gov/pubmed/7805703
levofloxacin plus metronidazole combination.
A once-daily regimen of levofloxacin plus metronidazole looks promising for the treatment of intra-abdominal infections.
Vitamin D is a hormone precursor that is important for calcium absorption and bone health. It exists in two forms, D2 and D3, and requires two hydroxylation steps to become the active form. Vitamin D deficiency can lead to bone diseases like rickets and osteomalacia as well as increased risk of cancer, cardiovascular disease, autoimmune disorders, and infections. Risk factors for deficiency include inadequate sun exposure, older age, darker skin, obesity, and certain medical conditions or medications. Maintaining sufficient vitamin D levels through supplementation and diet may help reduce disease risk.
Vitamin D is a hormone precursor that is important for calcium absorption and bone health. It exists in two forms, D2 and D3, and requires two hydroxylation steps to become the active form. Vitamin D deficiency can lead to bone diseases like rickets and osteomalacia as well as increased risk of cancer, cardiovascular disease, autoimmune disorders, and infections. Risk factors for deficiency include inadequate sun exposure, older age, darker skin, obesity, and certain medical conditions or medications. Maintaining sufficient vitamin D levels through supplementation and diet may help reduce disease risk.
Nutrition for pregnant and lactating ladiesNadia Qayyum
Nutrients:
A nutrient is a chemical substance in food that helps maintain the body. Some provide energy. All help build cells and tissues, regulate bodily processes such as breathing. No single food supplies all the nutrients the body needs to function.
Ferrous Bisglycinate is chelated iron form, in which iron is chelated with two amino acids.
Small, stable molecule with no ionic charge
Does not react with other nutrients
Bioavailable (easily absorbed)
Safe
Less gastric upset
Folic acid and vitamin B9, is one of the B vitamins.The recommended daily intake level of folate is 400 micrograms from foods or dietary supplements.Folic acid is used to treat anemia caused by folic acid deficiency.It is also used as a supplement by women during pregnancy to prevent neural tube defects (NTDs) in the baby.
How to make call in the Doctor chamberNadia Qayyum
This document provides tips for medical representatives to improve their professional personality and sales skills. It emphasizes the importance of proper grooming, dress, communication skills, and product knowledge. Specific advice includes dressing professionally, speaking clearly, using visual aids during presentations, emphasizing the brand, and closing calls by seeking prescriptions while maintaining a positive relationship with doctors. The overall message is that medical representatives need to represent themselves and their products professionally in order to succeed in sales.
Escitalopram is a selective serotonin reuptake inhibitor (SSRI) used to treat mood disorders like depression and anxiety disorders like generalized anxiety disorder. It works by inhibiting the reuptake of the neurotransmitter serotonin in the brain. Unlike other SSRIs, escitalopram binds to both the primary and allosteric sites of the serotonin transporter, resulting in a stronger and longer-lasting inhibition of serotonin reuptake. The usual starting dose for depression is 10 mg per day, while for panic disorder it is 5 mg for the first week then increasing to 10 mg. Maximum effectiveness may take 2-4 weeks for depression or up to 3 months for panic disorder.
Zara is a Spanish clothing retailer known for fast fashion. It was created in 1975 and now has over 2,100 stores globally. Zara's mission is to offer low-priced, on-trend clothing that mimics higher-end designs. It achieves this through vertical integration, just-in-time production, and a supply chain that can deliver new designs to stores within 15 days. Zara's success also comes from optimizing inventory, centralized logistics, and a large portfolio of young designers that help keep up with the latest trends.
The story of Dr. Ranjit Jagtap's daughters is more than a tale of inherited responsibility; it's a narrative of passion, innovation, and unwavering commitment to a cause greater than oneself. In Poulami and Aditi Jagtap, we see the beautiful continuum of a father's dream and the limitless potential of compassion-driven healthcare.
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Research, Monitoring and Evaluation, in Public Healthaghedogodday
This is a presentation on the overview of the role of monitoring and evaluation in public health. It describes the various components and how a robust M&E system can possitively impact the results or effectiveness of a public health intervention.
Sectional dentures for microstomia patients.pptxSatvikaPrasad
Microstomia, characterized by an abnormally small oral aperture, presents significant challenges in prosthodontic treatment, including limited access for examination, difficulties in impression making, and challenges with prosthesis insertion and removal. To manage these issues, customized impression techniques using sectional trays and elastomeric materials are employed. Prostheses may be designed in segments or with flexible materials to facilitate handling. Minimally invasive procedures and the use of digital technologies can enhance patient comfort. Education and training for patients on prosthesis care and maintenance are crucial for compliance. Regular follow-up and a multidisciplinary approach, involving collaboration with other specialists, ensure comprehensive care and improved quality of life for microstomia patients.
Cancer treatment has advanced significantly over the years, offering patients various options tailored to their specific type of cancer and stage of disease. Understanding the different types of cancer treatments can help patients make informed decisions about their care. In this ppt, we have listed most common forms of cancer treatment available today.
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The Ultimate Guide in Setting Up Market Research System in Health-TechGokul Rangarajan
How to effectively start market research in the health tech industry by defining objectives, crafting problem statements, selecting methods, identifying data collection sources, and setting clear timelines. This guide covers all the preliminary steps needed to lay a strong foundation for your research.
"Market Research it too text-booky, I am in the market for a decade, I am living research book" this is what the founder I met on the event claimed, few of my colleagues rolled their eyes. Its true that one cannot over look the real life experience, but one cannot out beat structured gold mine of market research.
Many 0 to 1 startup founders often overlook market research, but this critical step can make or break a venture, especially in health tech.
But Why do they skip it?
Limited resources—time, money, and manpower—are common culprits.
"In fact, a survey by CB Insights found that 42% of startups fail due to no market need, which is like building a spaceship to Mars only to realise you forgot the fuel."
Sudharsan Srinivasan
Operational Partner Pitchworks VC Studio
Overconfidence in their product’s success leads founders to assume it will naturally find its market, especially in health tech where patient needs, entire system issues and regulatory requirements are as complex as trying to perform brain surgery with a butter knife. Additionally, the pressure to launch quickly and the belief in their own intuition further contribute to this oversight. Yet, thorough market research in health tech could be the key to transforming a startup's vision into a life-saving reality, instead of a medical mishap waiting to happen.
Example of Market Research working
Innovaccer, founded by Abhinav Shashank in 2014, focuses on improving healthcare delivery through data-driven insights and interoperability solutions. Before launching their platform, Innovaccer conducted extensive market research to understand the challenges faced by healthcare organizations and the potential for innovation in healthcare IT.
Identifying Pain Points: Innovaccer surveyed healthcare providers to understand their difficulties with data integration, care coordination, and patient engagement. They found widespread frustration with siloed systems and inefficient workflows.
Competitive Analysis: Analyzed competitors offering similar solutions in healthcare analytics and interoperability. Identified gaps in comprehensive data aggregation, real-time analytics, and actionable insights.
Regulatory Compliance: Ensured their platform complied with HIPAA and other healthcare data privacy regulations. This compliance was crucial to gaining trust from healthcare providers wary of data security issues.
Customer Validation: Conducted pilot programs with several healthcare organizations to validate the platform's effectiveness in improving care outcomes and operational efficiency. Gathered feedback to refine features and user interface.
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7. Role of Calcium In Pregnancy
• Calcium decrease risk of:
1. Pre-eclampsia.
2. Low birth weight.
• Increase chances of normal delivery.
• Further:
1. Maintaining bone/teeth strength
2. Proper muscle contraction
3. In secretion of hormones as insulin
4. In cell division
5. In nerve impulse transmission
6. Cell membrane function
7. Calcium also helps your baby grow a healthy heart, nerves, and muscles as well as develop a
normal heart rhythm and blood-clotting abilities.
8. Calcium Halves Risk in Pregnancy
• Met analysis of studies from developing countries
• Pooled analysis showed that calcium supplementation
during pregnancy reduce risk of
• Gestational hypertension 45%
• Preeclampsia 59%
Ref: BMC Public health 2011
• Cochrane Review
• Calcium supplementation (greater then or equal to
1000mg/day) is associated with reduction in pre-eclampsia,
particularly for women with low calcium diet.
Ref: Cochrane database syst Rev 2014 June
9. Importance of Calcium in Pregnancy
• 1st trimester:
• 0-13 weeks gestation.
• Calcium (500-800 mg) – Vitamin D (5 mg)
Needed for regulate heart rhythm, for blood clotting, for regulating nerve and muscle activity and
for absorbing iron.
2nd trimester:
• 14-26 weeks gestation
• 1,200 milligrams of calcium per day.
• Calcium is very important during pregnancy, because it helps make your baby's teeth and bones.
Calcium may also prevent leg and muscle cramps in pregnant women. If you don't get enough
calcium, your body takes this mineral from your bones to get the baby what it needs. This may
contribute to osteoporosis as you age.
• Calcium deficiency in pregnant women cause increased blood pressure, myocyte contraction and
arteriolar constriction.
• Baby I.Q level disturb
3rd trimester:
Chance of rickets increase because of calcium and vitamin D deficiency.
10. Importance of Calcium in Pregnancy
• During gestation the average foetus requires
about 30 g of calcium to mineralize its skeleton
and maintain normal physiological process.
• The suckling neonates requires more than this
amount in breast milk during six month of
exclusive lactation.
• About 80 % of the accretion occurs rapidly during
third trimester.
• Daily accretion rate of about 250-300mg calcium
by the foetal skeleton during the third trimester.
11. Calcium-supplementation in pregnancy--is
it a must?.
Beinder E.
• Ther Umsch. 2007 May;64(5):243-7.
Abstract
• The pregnant woman's body provides daily doses between 50 and 330 mg to support the developing fetal
skeleton. This high fetal demand for calcium in pregnancy is facilitated by profound physiological
interactions between mother and fetus. The D-A-CH organization (which represents the German, Austrian
and Swiss Nutrition Offices) and the Institute of Medicine (IOM) of the US recommend a daily
consumption of 1000 mg calcium for pregnant and lactating women at an age over 19 years. The average
consumption of calcium in western countries is about 800 mg in young women. Therefore calcium
consumption in pregnancy should be encouraged, especially during the second and third trimester of
pregnancy and during lactation. Proper calcium consumption can be attained by diet with healthy
nourishment including 3-4 snacks of milk or milk-derived products such as yogurt and cheese and calcium-
rich mineral waters. In these women calcium-supplementation in pregnancy is not necessary. In women
with chronic autoimmunologic disorders, low-molecular-weight-heparin therapy during pregnancy, lactose
intolerance or in women who prefer to skip milk and milk products due to personal preference the
supplementation of 500 to 1000 mg calcium in addition to dietary measures is recommended. Calcium
supplementation in pregnancy has been associated with a reduced risk of pregnancy-induced
hypertension, but this effect is only seen in persons with a low basal calcium intake. There are reports in
literature that calcium supplementation in pregnancy protects against low-birthweight in newborns,
which is defined as a birthweight of < 2500 g or that calcium supplementation lowers offspring blood
pressure thus helping to prevent hypertension in the next generation. Calcium supplementation is only
recommended in order to achieve a daily uptake of at least 1000 mg/day in pregnant women.
13. Maternal calcium excretion
Physiological hypercalciuria occurs during pregnancy as
a result of increased maternal calcium absorption.
Interestingly, urinary calcium is within normal limits
during fasting but increases postprandially, indicating
that elevated excretion is related to the increase in
calcium absorption.
Urinary calcium excretion has been shown to increase
by as much as 43% between prepregnancy and the
third trimester, reflecting the 50% increase in the
glomerular filtration rate (GFR) that also occurs during
pregnancy.
14. Transfer of Calcium in breast milk
• Calcium transfer between the mother and infant
averages about 200 mg/day during full breast-
feeding. There is wide variability in the amount of
calcium secreted daily into breast milk, even
among women who are exclusively breast-
feeding, and can be as high as 400 mg/day in
some individuals. For mothers who breast-feed
for more than 3–6 months, the total calcium
transfer via breast milk in one lactation period is
greater than that transferred across the placenta
during the whole of pregnancy
15. Preeclampsia and pregnancy-induced
hypertension
• There is an inverse relationship between calcium intake and pregnancy-induced hypertension (PIH), it has been
estimated to complicate 5% of all pregnancies and 11% of first pregnancies.
• Low calcium intakes during pregnancy may
1) stimulate PTH secretion, increasing intracellular calcium and smooth musclecontractibility
2) release renin from the kidney, leading to vasoconstriction and retention of sodium and fluid. These
physiological changes can lead to the development of PIH and preeclampsia.
A meta-analysis of the role of calcium supplementation during pregnancy in the prevention of gestational
hypertensive disorders found a 45% reduction in the development of PIH in women receiving calcium versus
placebo.
Ref:Imdad A, Jabeen A, Bhutta ZA. Role of calcium supplementation during pregnancy in reducing risk of developing
gesSuppl 3):S18tational hypertensive disorders: a meta-analysis of studies from developing countries. BMC Public
Health. 2011; 11
16. Maternal Bone-Mineral Status
• Studies have demonstrated that lactation is accompanied by significant
reductions in maternal bone mineral content during the first
3–6 months .The reductions are most marked in the axial skeleton, where
average decreases of 3%–5% have been observed at the spine and hip.
• These rates of change are remarkable, given the fact that rates of
postmenopausal bone loss at these sites are typically 1%–3% per annum.
17. LONG-TERM EFFECTS ON THE MOTHER
• The possibility that the calcium requirements
of human reproduction may be met by
mobilization of calcium from the maternal
skeleton has led to concerns that a woman’s
risk of osteoporosis in later life may be
increased as a result of pregnancy and
lactation, especially if her dietary calcium
supply is poor.
18. Causes of Ca2+ deficiency
• Low Ca2+ intake
• Vitamin D deficiency
• Vitamin K2 deficiency
• Vegetarian diet
• Obesity
• Black skin
• Insufficiency or failure of parathyroid gland
• Chronic kidney failure
• Low blood magnesium level (in cases with severe
alcoholism)
• Diet high in phytate
19. Adequate daily intake (AI)
Life Stage Age Males (mg/day) Females (mg/day)
Infants 0-6 months 210 210
Infants 7-12 months 270 270
Children 1-3 years 500 500
Children 4-8 years 800 800
Children 9-13 years 1,300 1,300
Adolescents 14-18 years 1,300 1,300
Adults 19-50 years 1,000 1,000
Adults 51 years and older 1,200 1,200
Pregnancy 18 years and younger - 1,300
Pregnancy 19 years and older - 1,000
Breastfeeding 18 years and younger - 1,300
Breastfeeding 19 years and older - 1,000
20. Role of Vitamin D
• Function of vitamin D:
1. Absorption of calcium in blood
2. Deposition of calcium on bones.
3. During pregnancy, increased intestinal absorption of
calcium from the gut mainly due to higher generation
of calcitriol (1,25 dihydroxy vitamin D) helps in
maintaining maternal calcium levels.
• Compensatory responses to decreased
plasma ionized calcium concentration
mediated by PTH & vitamin D
• PTH regulates through 3 main effects:
- By stimulating bone resorption
- By stimulating activation of vitamin D → ↑
intestinal Ca reabsorption
- By directly increasing renal tubular calcium
reabsorption
21. keeps the calcium in its right place
• When you take vitamin D, your body creates
more of these vitamin K2-dependent proteins,
the proteins that will move the calcium
around.
• if you're taking vitamin D, you're creating an
increased demand for K2. And vitamin D and
K2 work together to strengthen your bones
and improve your heart health.
23. What's So Special About Vitamin K2?
Vitamin K is actually a group of fat-soluble vitamins.
Types of vitamin K are:
• Vitamin K1, or phylloquinone, is found naturally in plants, especially green vegetables; K1 goes
directly to your liver and helps you maintain healthy blood clotting
• Vitamin K2, also called menaquinone, is made by the bacteria that line your gastrointestinal tract; ,
but unfortunately is not absorbed from there and passes out in your stool. K2 goes straight to your
blood vessel walls, bones, and tissues other than your liver.It also plays a role in removing calcium
from areas where it shouldn't be, such as in your arteries and soft tissues.
• "K2 is really critical for keeping your bones strong
and your arteries clear," Rheaume-Bleue says.
Vitamin K2 can be broken into two additional categories, called:
• MK-4 (menaquinone-4), a short-chain form of vitamin K2 found in butter, egg yolks, and animal-
based foods
• MK-7 (menaquinone-7), longer-chain forms found in fermented foods. There's a variety of these
long-chain forms but the most common one is MK-7. This is the one you'll want to look for in
supplements, because in a supplement form, the MK-7 products are actually synthetic. They are not
derived from natural food products containing MK-4.
25. Osteocalcin: the vitamin K-dependent Ca2+-
binding protein of bone matrix.
Hauschka PV.
• Abstract
• Osteocalcin is an abundant Ca2+-binding protein indigenous to the organic matrix
of bone, dentin, and possibly other mineralized tissues. This protein contains 47-50
amino acid residues (molecular weight 5,200-5,900) depending on the species.
Osteocalcin is distinguished by its content of three gamma-carboxyglutamic (Gla)
residues. The vitamin-K-dependent biosynthesis of osteocalcin occurs in bone, and
the protein is not homologous to the Gla-containing regions of known vitamin-K-
dependent blood coagulation proteins. The two major structural features of
osteocalcin which appear to control its function include: the 'Gla helix', a compact
Ca2+-dependent alpha-helical conformation, in which the three Gla residues are
aligned to facilitate adsorption to hydroxyapatite, and the 'COOH-terminal beta-
sheet' which exhibits chemoattractant activity toward mononuclear leukocytes,
specifically monocytes, the putative precursors of osteoclasts. While the biological
function of osteocalcin is unknown, it appears to be a highly specific osteoblastic
marker produced during bone formation, and is rapidly becoming a clinically
important diagnostic parameter of bone pathology.
Nature. 2003 Oct 30;425(6961):977-80.
Editor's Notes
National Nutrition Survey 2011((Principal Survey Lead Institution: Aga Khan University, Pakistan )
(Principal Survey Lead Institution: Aga Khan University, Pakistan )
survey showed that in 2011 (Principal Survey Lead Institution: Aga Khan University, Pakistan )
Dr. Kate Rhéaume-Bleue's Vitamin K2 and the Calcium Paradox August 27, 2013