Wegener's granulomatosis is a rare disease characterized by inflammation of blood vessels. It was first described in 1936 based on three patients who had lung and respiratory tract involvement. The disease causes inflammation in various parts of the body including the lungs, kidneys, and skin. A biopsy showing vasculitis, granulomas and tissue damage along with positive ANCA antibodies is used for diagnosis. Treatment typically involves high doses of steroids and cyclophosphamide to induce remission, though relapses are common.