Wegener's granulomatosis, lung
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A 48-year-old woman had a lung nodule detected on a PET CT scan. Her lung nodule showed multiple areas of necrosis, as did a biopsy of her kidney. Tests determined she had a positive P-ANCA serum level of 1:160, leading to a diagnosis of Wegener's granulomatosis, a form of necrotizing vasculitis involving small blood vessels that can affect the lungs and kidneys.
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This document summarizes Wegener's granulomatosis, a multisystem disease characterized by necrotizing vasculitis affecting the respiratory tract and glomerulonephritis. It involves the upper respiratory tract in 100% of cases, lower respiratory tract in 90% of cases, and kidneys in 80% of cases. Common presentations include rhinitis, sinusitis, cough, hemoptysis, and hematuria. Radiological manifestations include nodules, alveolar opacities, ground glass opacities, and consolidation. Subglottic tracheal stenosis and bronchial stenosis are also seen.
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This document discusses Wegener's granulomatosis (now called granulomatosis with polyangiitis or GPA), a rare multisystem autoimmune disease characterized by necrotizing vasculitis and granulomatous inflammation that commonly involves the respiratory tract and kidneys. Key points include:
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Wegener's granulomatosis, lung
- 1. A 48-year-old woman with a lung nodule
- 2. PET CT
- 3. WEGENER’S GRANULOMAOSIS A solid nodule with multiple punctate or geographic necrosis
- 4. WEGENER’S GRANULOMAOSIS A solid nodule with multiple punctate or geographic necrosis
- 5. WEGENER’S GRANULOMAOSIS Necrosis and granuloma
- 6. WEGENER’S GRANULOMAOSIS Necrotizing vasculitis involving small vessels
- 7. WEGENER’S GRANULOMAOSIS Necrotizing vasculitis involving small vessels