The document discusses various challenges that can arise during endodontic treatment and ways to address them. It notes that the pulp chamber and canals have complex anatomy, so problems should be expected. It emphasizes the importance of experience, skill, care, observation, patience and proper patient/tooth selection and treatment procedures to avoid issues. Specific potential problems discussed include ledges, zips, transportations, perforations in curved canals, under/over instrumentation, and tissue emphysema from excess irrigation. The document provides guidance on addressing any perforations or other procedural accidents that occur.