This document provides information on emulsions and suspensions. It defines emulsions as dispersions with one liquid dispersed in another immiscible liquid, stabilized by an emulsifying agent. Emulsions are classified based on the dispersed and continuous phases. Suspensions are heterogeneous mixtures where particles settle out over time. Key factors that affect sedimentation rates in suspensions are described by Stokes' equation. Common emulsifying agents and suspending agents used in pharmaceutical formulations are also outlined.
The document defines an emulsion as a mixture of two or more liquids that are normally immiscible. It then discusses the internal and external phases of emulsions, types of emulsions based on dispersed phase and size, advantages and disadvantages, identification tests, emulsifying agents, theories of emulsification, and factors that contribute to emulsion stability like interfacial tension. In summary, the key topics covered are the definition of emulsions, classification based on phase and size, tests to identify emulsion types, role of emulsifying agents, and theories to explain emulsion stabilization mechanisms.
Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions.
The document discusses pharmaceutical suspensions. A suspension is a coarse dispersion where an insoluble internal phase is dispersed uniformly throughout an external phase. Reasons for formulating suspensions include insolubility of the drug, masking bitter taste, increasing stability, and achieving controlled drug release. Common types of suspensions include antacids, antibiotics, analgesics, anthelmintics, and antifungals. Suspending agents are used to prevent sedimentation and ensure uniform dosing. Preparation involves grinding the insoluble drug into a paste and incorporating suspending agents before making up the final volume. Advantages include improved stability and bioavailability for some drugs, while disadvantages include issues with physical stability and accurate dosing.
1) An emulsion is an unstable mixture of two immiscible liquids, where one liquid is dispersed as globules in the other liquid. Emulsions can be O/W (oil in water) or W/O (water in oil) types.
2) Pharmaceutical emulsions are used to deliver unpleasant tasting drugs, provide slow release of water-soluble drugs, and enhance absorption of oil-soluble drugs.
3) The key steps in formulating an emulsion are selecting an emulsifying agent based on its HLB value, adding preservatives and antioxidants, and using methods like trituration or the bottle method to prepare the emulsion.
This document discusses emulsions and suspensions. It defines emulsions as biphasic liquid preparations containing two immiscible liquids, one dispersed as globules in the other. Suspensions are biphasic preparations where finely divided solids are dispersed in a liquid vehicle. The document describes the types of emulsions and suspensions, how they are formulated, stabilized, and evaluated. Key factors that determine stability include particle size, choice of emulsifying or flocculating agents, viscosity, and electrokinetic properties.
That presentation is about the stability of the drug, why it's necessary?? What is the shelf life of a drug? Purpose of stability testing and its importance.Also a review article of Sanjay Bajaj et al published in Journal of applied pharmaceutical sciences.
This document defines and describes emulsions. It states that an emulsion is a two-phase system consisting of two immiscible liquids where one liquid is dispersed as globules in the other with the help of an emulsifying agent and mechanical energy. The document discusses emulsion types including oil-in-water and water-in-oil. It also covers emulsion components, applications in pharmaceuticals, formulation, identification of emulsion type, selection of emulsifying agents, mechanisms of action, and factors affecting stability. The key points are emulsions are thermodynamically unstable systems requiring emulsifying agents and mechanical energy to form and maintain.
This document provides an overview of microemulsions and multiple emulsions. It defines microemulsions as thermodynamically stable, optically isotropic and clear dispersions of oil and water stabilized by an amphiphile. Three types of microemulsions are described: oil-in-water, water-in-oil, and bi-continuous. Preparation methods and characterization of microemulsions are also outlined. Multiple emulsions involve a second level of emulsification, forming either oil-in-water-in-oil or water-in-oil-in-water dispersions. Common preparation techniques for multiple emulsions include two-step emulsification and phase inversion methods.
The document defines an emulsion as a mixture of two or more liquids that are normally immiscible. It then discusses the internal and external phases of emulsions, types of emulsions based on dispersed phase and size, advantages and disadvantages, identification tests, emulsifying agents, theories of emulsification, and factors that contribute to emulsion stability like interfacial tension. In summary, the key topics covered are the definition of emulsions, classification based on phase and size, tests to identify emulsion types, role of emulsifying agents, and theories to explain emulsion stabilization mechanisms.
Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions.
The document discusses pharmaceutical suspensions. A suspension is a coarse dispersion where an insoluble internal phase is dispersed uniformly throughout an external phase. Reasons for formulating suspensions include insolubility of the drug, masking bitter taste, increasing stability, and achieving controlled drug release. Common types of suspensions include antacids, antibiotics, analgesics, anthelmintics, and antifungals. Suspending agents are used to prevent sedimentation and ensure uniform dosing. Preparation involves grinding the insoluble drug into a paste and incorporating suspending agents before making up the final volume. Advantages include improved stability and bioavailability for some drugs, while disadvantages include issues with physical stability and accurate dosing.
1) An emulsion is an unstable mixture of two immiscible liquids, where one liquid is dispersed as globules in the other liquid. Emulsions can be O/W (oil in water) or W/O (water in oil) types.
2) Pharmaceutical emulsions are used to deliver unpleasant tasting drugs, provide slow release of water-soluble drugs, and enhance absorption of oil-soluble drugs.
3) The key steps in formulating an emulsion are selecting an emulsifying agent based on its HLB value, adding preservatives and antioxidants, and using methods like trituration or the bottle method to prepare the emulsion.
This document discusses emulsions and suspensions. It defines emulsions as biphasic liquid preparations containing two immiscible liquids, one dispersed as globules in the other. Suspensions are biphasic preparations where finely divided solids are dispersed in a liquid vehicle. The document describes the types of emulsions and suspensions, how they are formulated, stabilized, and evaluated. Key factors that determine stability include particle size, choice of emulsifying or flocculating agents, viscosity, and electrokinetic properties.
That presentation is about the stability of the drug, why it's necessary?? What is the shelf life of a drug? Purpose of stability testing and its importance.Also a review article of Sanjay Bajaj et al published in Journal of applied pharmaceutical sciences.
This document defines and describes emulsions. It states that an emulsion is a two-phase system consisting of two immiscible liquids where one liquid is dispersed as globules in the other with the help of an emulsifying agent and mechanical energy. The document discusses emulsion types including oil-in-water and water-in-oil. It also covers emulsion components, applications in pharmaceuticals, formulation, identification of emulsion type, selection of emulsifying agents, mechanisms of action, and factors affecting stability. The key points are emulsions are thermodynamically unstable systems requiring emulsifying agents and mechanical energy to form and maintain.
This document provides an overview of microemulsions and multiple emulsions. It defines microemulsions as thermodynamically stable, optically isotropic and clear dispersions of oil and water stabilized by an amphiphile. Three types of microemulsions are described: oil-in-water, water-in-oil, and bi-continuous. Preparation methods and characterization of microemulsions are also outlined. Multiple emulsions involve a second level of emulsification, forming either oil-in-water-in-oil or water-in-oil-in-water dispersions. Common preparation techniques for multiple emulsions include two-step emulsification and phase inversion methods.
This document provides an overview of disperse systems, including emulsions and suspensions. It discusses key concepts such as interfacial phenomena, wetting, adsorption, surfactants, and micelle formation. Theories of emulsification including electric double layer, phase volume, oriented wedge, and surface tension are presented. Methods for determining emulsion type including dilution, dye, conductivity, and fluorescence tests are described. Emulsifying agents and factors influencing emulsion stability are also summarized. Suspensions are defined as biphasic systems with solid particles between 0.5-5 microns dispersed in a liquid. Particle size and sedimentation theories are briefly covered.
This document provides an overview of pharmaceutical gels. It defines gels as semisolid systems where liquid movement is restricted by a 3D network. Gels are classified as single-phase or two-phase systems. Key properties include swelling, syneresis, aging, and thixotropy. Gels are used to deliver drugs orally, topically, and via injection. They are formulated by choosing appropriate vehicles, gelling agents, and additives. Gels are prepared via thermal, flocculation, or chemical methods. Evaluation parameters include homogeneity, pH, drug content, viscosity, spreadability, extrudability, skin irritation, and in vitro diffusion studies.
Pharmaceutical Emulsions are thermodynamically unstable mixtures of two immiscible liquids stabilized by an emulsifying agent. They can be oil-in-water (O/W) or water-in-oil (W/O) emulsions depending on the dispersed and continuous phases. Emulsifying agents like surfactants, hydrocolloids, and solid particles form protective films around droplets and increase viscosity to prevent coalescence. Stability issues include creaming, cracking, and phase inversion. Methods to enhance stability are reducing droplet size, increasing viscosity, using emulsifying agents, and controlling storage temperature.
The document discusses various methods to improve drug solubility including physical modifications like particle size reduction through micronization or formation of nanosuspensions, modification of crystal habit through polymorphism, and drug dispersion in carriers through techniques like solid dispersions. It also discusses chemical modifications such as changing pH, use of buffers, and derivatization. Other methods covered are complexation, solubilization by surfactants to form microemulsions, co-crystallization, cosolvency, hydrotrophy, and solvent deposition. The biopharmaceutical classification system relating solubility and permeability to drug absorption is also summarized.
Pharmaceutical Suspensions Brief Presentation on Definition, Classification of suspension, Sedimentation, Brownian movement, Electro kinetic Properties of suspension, Stability of suspensions, Formulation of Suspensions, Preparation of Suspensions, Quality control of Suspensions, Recent Advancement in Suspensions
Emulsions are mixtures of two or more liquids where one liquid is dispersed as droplets in the other liquid. There is a dispersed phase and a continuous phase. Emulsions can be classified as oil-in-water (O/W), water-in-oil (W/O), or multiple emulsions. Emulsions are stabilized using emulsifying agents which lower the interfacial tension between the phases. Common emulsifying agents include carbohydrates, proteins, and alcohols. Emulsions are used to deliver poorly water-soluble drugs and provide benefits like masking unpleasant tastes, sustained release, and dermal delivery in cosmetics and topicals. However, emulsions are
This document provides an overview of semi-solid dosage forms. It defines semi-solids as products that tend to alleviate or treat pathological conditions when applied to the skin or mucous membranes. Ideal properties include a smooth texture, elegant appearance, and non-irritating qualities. Common types are ointments, creams, pastes, gels, and suppositories. Formulation involves selecting appropriate bases, preservatives, and other excipients. Methods of preparation include size reduction, levigation, mixing, homogenization, and filling. Evaluation tests physical properties, drug release, and stability.
Suspension are biphasic liquids dosage form in which insoluble solid particulate are uniformly distributed in liquid phase which may be stabilized by inclusion of suspending agents.
This document discusses factors that can cause instability in emulsions over time during storage. The three main changes that can occur are cracking, creaming, and phase inversion. Cracking is the separation of phases and can result from changes in emulsifying agents, solvents, microbes, temperature, or creaming. Creaming is the upward movement of dispersed globules, which depends on globule size, density differences, viscosity, and storage temperature. Phase inversion is a change from one emulsion type to the other, such as oil-in-water to water-in-oil, brought on by electrolytes, phase volume ratios, temperature, or emulsifying agents. Proper packaging, labeling, and storage conditions can help promote emulsion
This document provides an overview of suspensions, including their classification, properties, formulation, and stability. Key points include:
- Suspensions are heterogeneous systems with an insoluble dispersed phase distributed throughout a continuous phase. They can be classified based on their intended use, concentration of solids, particle size, and electrokinetic properties.
- Interfacial properties like surface tension affect particle flocculation and sedimentation. Surfactants can reduce surface tension to promote deflocculation.
- Particle size, concentration, and Brownian motion influence sedimentation rates. Flocculated particles settle faster but are easier to redisperse than deflocculated particles.
- Stable suspensions are formulated using vehicles to
This document discusses emulsions. It defines an emulsion as a dispersion of small globules of one liquid distributed throughout another immiscible liquid. Emulsions are classified based on the dispersed phase as oil-in-water or water-in-oil, and based on droplet size as macroemulsions or microemulsions. Emulsifying agents are substances that stabilize emulsions by forming films at the liquid interfaces. Various natural, semi-synthetic, and synthetic agents are described. Methods for preparing emulsions include dry gum, wet gum, and bottle methods. Factors that cause emulsion instability like cracking and creaming are also outlined.
This document discusses pharmaceutical suspensions. It begins by defining suspensions as heterogeneous systems with one substance dispersed in small units throughout another substance. Suspensions are classified based on route of administration and electrokinetic nature. Benefits include masking unpleasant tastes and controlling drug release. Challenges include physical instability and accurate dosing. Key factors in developing suspensions are preventing sedimentation, achieving uniformity, and pleasing attributes. Formulation considers vehicle structure, controlled flocculation, suspending agents, viscosity, surface tension, wetting agents, and solvents.
Surfactants and their applications in pharmaceutical dosage formMuhammad Jamal
This presentation is very much helpful for the medical students,pharmacists, researchers and other health care providers. i hope it will provide important information regarding surfactants and their applications in pharmaceutical dosage forms.
1. Dissolution and drug release tests measure the rate and extent of drug release from a product under specified conditions. They are important quality control tests linked to in vivo performance.
2. Many factors can affect drug dissolution, including drug properties, formulation excipients, test medium conditions, temperature, and apparatus type and settings.
3. Common apparatuses include baskets, paddles, cylinders and flow cells suited for different drug products like tablets, capsules, suspensions or films. Test conditions are selected based on the product type to simulate gastrointestinal conditions.
PHYSICAL PHARMACEUTICS II COARSE DISPERSION VijayaKumarR28
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli.
As per PCI syllabus for B Pharm / 2nd Year ,III Semester.
UNIT-III / Coarse dispersion
This document summarizes several theories of emulsions:
- The monomolecular adsorption theory explains how emulsifying agents reduce interfacial tension by adsorbing at the oil-water interface to form monolayer films. Combinations of hydrophilic and hydrophobic emulsifiers are often used to form complex films.
- The oriented-wedge theory describes how emulsifying agents curve around emulsion droplets, with their structure "fitting" the curvature.
- The plastic or interfacial film theory views emulsifying agents forming a thin layer surrounding droplets, with water-soluble agents favoring oil-in-water emulsions and vice versa.
- Other theories addressed include the surface tension theory, inter
This document discusses in-vitro dissolution testing and drug release. It defines dissolution as the process where a solid substance is solubilized in a liquid solvent. Dissolution is the rate determining step for drug absorption if the drug is highly soluble. The document then covers various theories of dissolution, types of in-vitro dissolution testing models and apparatuses, and factors that can affect drug dissolution and release such as drug properties, formulation components, and test conditions.
Solubility enhancement by using various techniques Prajakta Chavan
This document discusses various techniques for enhancing the solubility of drugs, including particle size reduction, hydrotropy, cosolvency, solubilization by surfactants, solid dispersions, pH adjustment, high pressure homogenization, supercritical fluid recrystallization, sonocrystallization, complexation, spray drying, inclusion complex formation, liquisolid technique, microemulsions, and self-emulsifying drug delivery systems. Particle size reduction techniques like micronization and nanosuspensions increase surface area to enhance dissolution rate and solubility. Other techniques utilize excipients like surfactants, cosolvents, and polymers to solubilize drugs.
Multiple emulsions are complex systems that contain both water-in-oil (W/O) and oil-in-water (O/W) emulsions. They are thermodynamically unstable and require a combination of hydrophilic and hydrophobic surfactants to stabilize them. Common types include W/O/W and O/W/O emulsions. Multiple emulsions can prolong the release of active ingredients and have applications in controlled drug delivery, targeted delivery, and more. They are prepared using techniques like solvent evaporation or double emulsification and provide a novel carrier system for drugs, cosmetics, and other agents.
Pharmaceutical emulsions are dispersions of one liquid in another immiscible liquid. An emulsion consists of at least two liquid phases, one dispersed as globules in the other, and stabilized by an emulsifying agent. Emulsions can be oil-in-water or water-in-oil depending on which phase is dispersed. Emulsions are thermodynamically unstable and rely on emulsifying agents to kinetically stabilize the system by reducing interfacial tension or forming protective films around globules. Physical instabilities like flocculation, creaming, and phase inversion can still occur over time due to density differences, globule interactions, or changes in environmental conditions. Proper formulation with emulsifiers, viscosity
This document presents theories of dispersion and mechanisms of emulsion formation. It discusses four traditional theories of dispersion: viscosity theory, film theory, wedge theory, and interfacial tension theory. It also describes limitations of these theories. The document then introduces a modern approach involving droplet formation and stabilization by emulsifying agents. Three mechanisms of emulsion stabilization are described: monomolecular adsorption, multimolecular adsorption, and solid particle adsorption.
This document provides an overview of disperse systems, including emulsions and suspensions. It discusses key concepts such as interfacial phenomena, wetting, adsorption, surfactants, and micelle formation. Theories of emulsification including electric double layer, phase volume, oriented wedge, and surface tension are presented. Methods for determining emulsion type including dilution, dye, conductivity, and fluorescence tests are described. Emulsifying agents and factors influencing emulsion stability are also summarized. Suspensions are defined as biphasic systems with solid particles between 0.5-5 microns dispersed in a liquid. Particle size and sedimentation theories are briefly covered.
This document provides an overview of pharmaceutical gels. It defines gels as semisolid systems where liquid movement is restricted by a 3D network. Gels are classified as single-phase or two-phase systems. Key properties include swelling, syneresis, aging, and thixotropy. Gels are used to deliver drugs orally, topically, and via injection. They are formulated by choosing appropriate vehicles, gelling agents, and additives. Gels are prepared via thermal, flocculation, or chemical methods. Evaluation parameters include homogeneity, pH, drug content, viscosity, spreadability, extrudability, skin irritation, and in vitro diffusion studies.
Pharmaceutical Emulsions are thermodynamically unstable mixtures of two immiscible liquids stabilized by an emulsifying agent. They can be oil-in-water (O/W) or water-in-oil (W/O) emulsions depending on the dispersed and continuous phases. Emulsifying agents like surfactants, hydrocolloids, and solid particles form protective films around droplets and increase viscosity to prevent coalescence. Stability issues include creaming, cracking, and phase inversion. Methods to enhance stability are reducing droplet size, increasing viscosity, using emulsifying agents, and controlling storage temperature.
The document discusses various methods to improve drug solubility including physical modifications like particle size reduction through micronization or formation of nanosuspensions, modification of crystal habit through polymorphism, and drug dispersion in carriers through techniques like solid dispersions. It also discusses chemical modifications such as changing pH, use of buffers, and derivatization. Other methods covered are complexation, solubilization by surfactants to form microemulsions, co-crystallization, cosolvency, hydrotrophy, and solvent deposition. The biopharmaceutical classification system relating solubility and permeability to drug absorption is also summarized.
Pharmaceutical Suspensions Brief Presentation on Definition, Classification of suspension, Sedimentation, Brownian movement, Electro kinetic Properties of suspension, Stability of suspensions, Formulation of Suspensions, Preparation of Suspensions, Quality control of Suspensions, Recent Advancement in Suspensions
Emulsions are mixtures of two or more liquids where one liquid is dispersed as droplets in the other liquid. There is a dispersed phase and a continuous phase. Emulsions can be classified as oil-in-water (O/W), water-in-oil (W/O), or multiple emulsions. Emulsions are stabilized using emulsifying agents which lower the interfacial tension between the phases. Common emulsifying agents include carbohydrates, proteins, and alcohols. Emulsions are used to deliver poorly water-soluble drugs and provide benefits like masking unpleasant tastes, sustained release, and dermal delivery in cosmetics and topicals. However, emulsions are
This document provides an overview of semi-solid dosage forms. It defines semi-solids as products that tend to alleviate or treat pathological conditions when applied to the skin or mucous membranes. Ideal properties include a smooth texture, elegant appearance, and non-irritating qualities. Common types are ointments, creams, pastes, gels, and suppositories. Formulation involves selecting appropriate bases, preservatives, and other excipients. Methods of preparation include size reduction, levigation, mixing, homogenization, and filling. Evaluation tests physical properties, drug release, and stability.
Suspension are biphasic liquids dosage form in which insoluble solid particulate are uniformly distributed in liquid phase which may be stabilized by inclusion of suspending agents.
This document discusses factors that can cause instability in emulsions over time during storage. The three main changes that can occur are cracking, creaming, and phase inversion. Cracking is the separation of phases and can result from changes in emulsifying agents, solvents, microbes, temperature, or creaming. Creaming is the upward movement of dispersed globules, which depends on globule size, density differences, viscosity, and storage temperature. Phase inversion is a change from one emulsion type to the other, such as oil-in-water to water-in-oil, brought on by electrolytes, phase volume ratios, temperature, or emulsifying agents. Proper packaging, labeling, and storage conditions can help promote emulsion
This document provides an overview of suspensions, including their classification, properties, formulation, and stability. Key points include:
- Suspensions are heterogeneous systems with an insoluble dispersed phase distributed throughout a continuous phase. They can be classified based on their intended use, concentration of solids, particle size, and electrokinetic properties.
- Interfacial properties like surface tension affect particle flocculation and sedimentation. Surfactants can reduce surface tension to promote deflocculation.
- Particle size, concentration, and Brownian motion influence sedimentation rates. Flocculated particles settle faster but are easier to redisperse than deflocculated particles.
- Stable suspensions are formulated using vehicles to
This document discusses emulsions. It defines an emulsion as a dispersion of small globules of one liquid distributed throughout another immiscible liquid. Emulsions are classified based on the dispersed phase as oil-in-water or water-in-oil, and based on droplet size as macroemulsions or microemulsions. Emulsifying agents are substances that stabilize emulsions by forming films at the liquid interfaces. Various natural, semi-synthetic, and synthetic agents are described. Methods for preparing emulsions include dry gum, wet gum, and bottle methods. Factors that cause emulsion instability like cracking and creaming are also outlined.
This document discusses pharmaceutical suspensions. It begins by defining suspensions as heterogeneous systems with one substance dispersed in small units throughout another substance. Suspensions are classified based on route of administration and electrokinetic nature. Benefits include masking unpleasant tastes and controlling drug release. Challenges include physical instability and accurate dosing. Key factors in developing suspensions are preventing sedimentation, achieving uniformity, and pleasing attributes. Formulation considers vehicle structure, controlled flocculation, suspending agents, viscosity, surface tension, wetting agents, and solvents.
Surfactants and their applications in pharmaceutical dosage formMuhammad Jamal
This presentation is very much helpful for the medical students,pharmacists, researchers and other health care providers. i hope it will provide important information regarding surfactants and their applications in pharmaceutical dosage forms.
1. Dissolution and drug release tests measure the rate and extent of drug release from a product under specified conditions. They are important quality control tests linked to in vivo performance.
2. Many factors can affect drug dissolution, including drug properties, formulation excipients, test medium conditions, temperature, and apparatus type and settings.
3. Common apparatuses include baskets, paddles, cylinders and flow cells suited for different drug products like tablets, capsules, suspensions or films. Test conditions are selected based on the product type to simulate gastrointestinal conditions.
PHYSICAL PHARMACEUTICS II COARSE DISPERSION VijayaKumarR28
R. VIJAYAKUMAR., M Pharm,
Research Scholar
department of Pharmaceutical Technology.
Anna university- BIT
Tiruchirappalli.
As per PCI syllabus for B Pharm / 2nd Year ,III Semester.
UNIT-III / Coarse dispersion
This document summarizes several theories of emulsions:
- The monomolecular adsorption theory explains how emulsifying agents reduce interfacial tension by adsorbing at the oil-water interface to form monolayer films. Combinations of hydrophilic and hydrophobic emulsifiers are often used to form complex films.
- The oriented-wedge theory describes how emulsifying agents curve around emulsion droplets, with their structure "fitting" the curvature.
- The plastic or interfacial film theory views emulsifying agents forming a thin layer surrounding droplets, with water-soluble agents favoring oil-in-water emulsions and vice versa.
- Other theories addressed include the surface tension theory, inter
This document discusses in-vitro dissolution testing and drug release. It defines dissolution as the process where a solid substance is solubilized in a liquid solvent. Dissolution is the rate determining step for drug absorption if the drug is highly soluble. The document then covers various theories of dissolution, types of in-vitro dissolution testing models and apparatuses, and factors that can affect drug dissolution and release such as drug properties, formulation components, and test conditions.
Solubility enhancement by using various techniques Prajakta Chavan
This document discusses various techniques for enhancing the solubility of drugs, including particle size reduction, hydrotropy, cosolvency, solubilization by surfactants, solid dispersions, pH adjustment, high pressure homogenization, supercritical fluid recrystallization, sonocrystallization, complexation, spray drying, inclusion complex formation, liquisolid technique, microemulsions, and self-emulsifying drug delivery systems. Particle size reduction techniques like micronization and nanosuspensions increase surface area to enhance dissolution rate and solubility. Other techniques utilize excipients like surfactants, cosolvents, and polymers to solubilize drugs.
Multiple emulsions are complex systems that contain both water-in-oil (W/O) and oil-in-water (O/W) emulsions. They are thermodynamically unstable and require a combination of hydrophilic and hydrophobic surfactants to stabilize them. Common types include W/O/W and O/W/O emulsions. Multiple emulsions can prolong the release of active ingredients and have applications in controlled drug delivery, targeted delivery, and more. They are prepared using techniques like solvent evaporation or double emulsification and provide a novel carrier system for drugs, cosmetics, and other agents.
Pharmaceutical emulsions are dispersions of one liquid in another immiscible liquid. An emulsion consists of at least two liquid phases, one dispersed as globules in the other, and stabilized by an emulsifying agent. Emulsions can be oil-in-water or water-in-oil depending on which phase is dispersed. Emulsions are thermodynamically unstable and rely on emulsifying agents to kinetically stabilize the system by reducing interfacial tension or forming protective films around globules. Physical instabilities like flocculation, creaming, and phase inversion can still occur over time due to density differences, globule interactions, or changes in environmental conditions. Proper formulation with emulsifiers, viscosity
This document presents theories of dispersion and mechanisms of emulsion formation. It discusses four traditional theories of dispersion: viscosity theory, film theory, wedge theory, and interfacial tension theory. It also describes limitations of these theories. The document then introduces a modern approach involving droplet formation and stabilization by emulsifying agents. Three mechanisms of emulsion stabilization are described: monomolecular adsorption, multimolecular adsorption, and solid particle adsorption.
Emulsions , Topic by University College of Pharmacyumerbutt4244
The document discusses different types of dispersions including molecular, colloidal, and coarse dispersions. It defines an emulsion as a system comprising two immiscible liquid phases, one dispersed in the other. Emulsions can be oil-in-water or water-in-oil. Tests to differentiate emulsion types include dilution, conductivity, dye solubility, and cobalt chloride tests. Emulsification involves mixing immiscible liquids using emulsifying agents to stabilize the system by lowering interfacial tension. Theories of emulsification include interfacial tension, viscosity, oriented wedge, and interfacial film theories.
This document provides an overview of pharmaceutical emulsions. It defines emulsions as dispersions of one liquid in another immiscible liquid, stabilized by an emulsifying agent. The key topics covered include the classification of emulsions as oil-in-water or water-in-oil, theories of emulsification, common emulsifying agents like surfactants and hydrocolloids, and factors affecting the stability of emulsions such as flocculation and creaming. Pharmaceutical applications of emulsions include lotions, creams, and ointments.
Suspensions are finely divided drugs dispersed in a liquid vehicle. They can be stabilized through electrostatic, steric, or hydration repulsive forces between particles. Emulsions are dispersions of one liquid in another, stabilized by surfactants. Key parameters that impact stability include choice of emulsifier, phase ratio, manufacturing method, and temperature during processing and storage. Different types of suspensions and emulsions exist for various dosage forms. Understanding colloid science principles is important for developing stable formulations.
An emulsion is a dispersion of one liquid in another in which globules of one liquid are dispersed throughout the other liquid. The document discusses various topics related to emulsions including definitions, types, theories, additives, methods of preparation, testing, stability, and applications. Large scale methods for manufacturing emulsions include stirrers, homogenizers, and colloid mills which reduce droplet size through various mechanical means like high pressure homogenization. Small scale methods include mixing oil and water directly by hand shaking or using handheld homogenizers. Factors like emulsifier type and concentration, energy input, and temperature control affect emulsion properties and stability over time.
The document discusses different types of colloidal systems including emulsions, sols, gels, and foams. It provides examples of each type in foods such as salad dressing as an emulsion, gravy as a sol, baked custard as a gel, and egg white foam as a foam. It also describes key properties of colloids like small particle size visible only under microscope and Brownian motion. Common colloidal systems in foods, properties of each type, and methods of formation and stabilization are summarized.
In present presentation information related emulsion like definition of emulsion it's types , theories and other information is covered.also it include the information about SMEDDS.
physical pharmacy Theroies of emulsion.pptxchetanvgh
This document discusses various theories of emulsions, including:
- The monomolecular adsorption theory which states that emulsifying agents reduce interfacial tension by forming monolayers at oil-water interfaces.
- The oriented-wedge theory which proposes that emulsifying agents orient themselves in a curved configuration around emulsion droplets.
- The plastic or interfacial film theory which views emulsifying agents forming thin films surrounding emulsion droplets.
- Additional theories discussed are the surface tension theory, interfacial tension theory, Fischer's theory of hydrates and solvates, and the viscosity theory. The document provides examples and explanations of each theory.
An emulsion is a two-phase system consisting of two immiscible liquids, where one liquid is dispersed as globules in the other. Emulsions can be oil-in-water or water-in-oil depending on the dispersed and continuous phases. Emulsions are used pharmaceutically for oral, rectal, topical, and injectable drug delivery to mask tastes/odors and enhance absorption. Emulsion stability depends on the emulsifying agent and preventing effects like creaming, flocculation, coalescence, cracking, and phase inversion.
This document discusses pharmaceutical calculations including molarity, molality, and percentage concentration. It then covers topics related to emulsions including HLB value, emulsion types (O/W and W/O), emulsion stability testing, and factors that can cause emulsion instability such as creaming, flocculation, coalescence, and phase inversion. Specific examples are provided to illustrate pharmaceutical calculations for molarity and molality. Testing methods are also described for determining emulsion type using staining, fluorescence, and wetting of filter paper.
1. An emulsion is a mixture of two immiscible liquids, where one liquid is dispersed as globules in the other liquid.
2. Emulsions are thermodynamically unstable and require an emulsifying agent to stabilize the globules and prevent separation.
3. The key types of emulsions are oil-in-water and water-in-oil emulsions, as well as multiple emulsions containing both oil and water phases. Microemulsions are transparent, thermodynamically stable mixtures of oil, water and surfactants.
Coarse dispersions are heterogeneous systems where the dispersed particles are larger than 1000 nm. They are characterized by relatively fast sedimentation. The dispersed phase may be easily separated from the continuous phase by filtration. A pharmaceutical suspension is a coarse dispersion where the internal phase is uniformly dispersed throughout the external phase. The internal phase typically has particle sizes between 0.5-5 microns. Suspensions demonstrate properties like pseudoplasticity and thixotropy which influence stability during manufacture and storage.
This document discusses pharmaceutical emulsions. It begins by defining emulsions as dispersions of one liquid in another immiscible liquid, stabilized by an emulsifying agent. The key types of emulsions are defined as oil-in-water and water-in-oil emulsions. Pharmaceutical applications of emulsions are described, such as masking unpleasant tastes or odors and enhancing drug absorption. Theories of emulsification and factors influencing emulsion stability are summarized. Common methods for manufacturing emulsions on small and large scales are also outlined.
An emulsion is a mixture of two or more liquids that are normally immiscible. Emulsions are part of a more general class of two-phase systems of matter called colloids.
This document discusses emulsions and factors that influence their physical stability. Emulsions are biphasic systems containing both oil and water phases. Emulsifying agents stabilize emulsions by preventing globule coalescence. Stability depends on globule size, viscosity, density differences between phases, and properties of the interface film formed by emulsifying agents. Physical instability can occur via flocculation, creaming, coalescence, and breaking. Phase inversion is also discussed. Methods for evaluating and improving stability include assessing phase separation, globule size, and centrifugation testing. The document outlines preparation of emulsions on small and large scales.
This document discusses emulsions, including their definition, types, formulation considerations, and stability factors. It defines emulsions as dispersions of one liquid in another immiscible liquid, stabilized by an emulsifying agent. The key types described are oil-in-water and water-in-oil emulsions. Important formulation considerations include phase ratio, droplet size, viscosity, density differences, and use of emulsifiers. Factors affecting stability include creaming, flocculation, coalescence, phase inversion, and Ostwald ripening. Methods to enhance stability include reducing particle size and density differences and increasing viscosity.
This document defines and describes different types of emulsions. It states that an emulsion is an unstable system consisting of two immiscible liquids, one dispersed as globules in the other. The types discussed are simple (o/w and w/o), multiple (o/w/o, w/o/w), and microemulsions. Factors that influence emulsion stability like particle size, viscosity, and charge are covered. Methods to identify o/w vs w/o emulsions are provided. Theories of emulsion formation and factors that can cause instability are summarized. Ways to help preserve emulsions from microbes and oxidation are also mentioned.
Emulsion formation, stability, and rheologyAudrey Zahra
This document discusses emulsions, which are mixtures of two immiscible liquids where one liquid is dispersed as droplets in the other. There are different types of emulsions classified by the dispersed and continuous phases. Emulsions can be stabilized through the use of emulsifiers like surfactants and particles. Over time, emulsions may break down through processes like creaming, flocculation, coalescence, and Ostwald ripening. The selection of emulsifiers depends on properties like their hydrophilic-lipophilic balance number to match the oils being emulsified.
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Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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3. INTRODUCTION
An emulsion is a dispersion in which the dispersed phase is composed of small
globules of a liquid distributed throughout a vehicle in which it is immiscible.
The stability against drop coalescence is provided by the presence of a small
amount of a third component, so-called emulsifier, which is in general a
surfactent-agent or surfactant, that adsorbs at the drop interface and produces
some inter drop repulsion according to a variety of static and dynamic phenomena
4. Classification of emulsions :
Based on dispersed phase
• Oil in Water (O/W): Oil droplets dispersed in water
• Water in Oil (W/O): Water droplets dispersed in oil
Based on size of liquid droplets
• 0.2 – 50 mm Macroemulsions (Kinetically Stable)
• 0.01 – 0.2 mm Microemulsions (Thermodynamically Stable)
5. Theories of
Emulsification:
Surface Tension Theory
Oriented-Wedge Theory
Interfacial film theory
Charge repulsion theory
Steric repulsion theory
6. SURFACE TENSION THEORY
According to the surface tension theory of emulsification, the emulsifying agents
cause a reduction in the interfacial tension of the two immiscible liquids, reducing
the repellent force between the liquids and withdrawing the attraction of liquids
for their own molecules. In this way, the surfactants convert large globules into
small ones and avoid small globules from coalescing into large ones.
In this way, the surfactants convert large globules into small ones and avoid
small globules from coalescing into large ones.
7. ORIENTED-WEDGE THEORY
This theory deals with formation of monomolecular layers of emulsifying agent
curved around a droplet of the internal phase of the emulsion. Example
In a system containing two immiscible liquids, emulsifying agents would be
preferentially soluble in one of the phases and would be embeded in that phase.
A. Emulsifier molecules oriented at interface
8. INTERFACIAL FILM THEORY
When two immiscible liquids come in contact, the force causing each liquid to
resist breakage is known as interfacial tension. When a high interfacial tension
existed between two liquids emulsification is difficult, and if the tension could be
reduced emulsification facilitated.
The explanation that in oil in water dispersion, the interfacial tension is so great
that when two globules of dispersed phase approach each other it withdraws the
liquid from between them, with the result they coalesce. When the interfacial
tension is greatly reduced by the addition of emulsifier the globules remain
separate.
9. CHARGE REPULSION THEORY
This theory of emulsions says that the fine globules of dispersed phase are
separated due to the repulsive forces developed as a result of the nature of
emulsifying agent (anionic or cationic) or by adsorbing ions from the dispersion
medium.
Charge develops on the surface of oil globules (o/w) is great enough to cause
repulsion between droplets.
The electrical barrier to prevent coalescence of the oil droplets and allow the oil
phase to remain in droplet form, uniformly dispersed in continuous water phase.
10. STERIC REPULSION THEORY
This theory says that the repulsion develops between the water droplets due to the
long hydrocarbon chains of emulsifying agent which has been adsorbed on their
surface.
This repulsion is called d steric repulsion, preventing the contact or coalescence
of water droplets.
theory can explain the process of emulsification only in w/o type of emulsion.
11. EMULSIFYING
AGENT
An emulsifying agent (emulsifier) is a surface-active
ingredient which adsorbs at the newly formed oil–
water interface during emulsion preparation, and it
protects the newly formed droplets against immediate
recoalescence.
Pharmaceutically acceptable emulsifiers must also :
• be stable .
• be compatible with other ingredients .
• be non – toxic .
• possess little odor , taste , or color .
• not interfere with the stability of efficacy of the active
agent .
13. MECHANISM OF EMULSION
•The increase in the energy of an emulsion compared to the nonemulsified
components is equal to ∆W. This amount of energy can be considered as a
measure of the thermodynamic instability of an emulsion
DW = g D A
∆W is the free energy of the interface and corresponds to the reversible work
brought permanently into the system during the emulsification process . This
makes an emulsion very prone to coalescence processes which lead to a decrease
in ∆A and subsequently in ∆W. The conclusion is straightforward that ultimate
stability against coalescence processes is only achieved if s approaches zero
14. TEST FOR IDENTIFICATION
Dilution test: emulsion can be diluted only with external phase
Dye test: water or oil soluble dyes
CoCl 2/filter paper test: filter paper impregnated with CoCl 2 and dried (blue)
changes to pink when o/w emulsion is added
Fluorescence: some oils fluoresce under UV light
Conductivity: for ionic o/w emulsions (o/w emulsions conduct electric current)
15. APPLICATION OF EMULSION
In the metallurgical processes, the concentration of ore by forth floatation process
is based upon the treatment of the powdered ore with oil emulsion. The valuable
particles of the ore form foam which comes to the surface and is skimmed off.
Asphalt emulsified in water is used for building roads without the necessity of
melting the asphalt.
Milk which is an important constituent of our diet is en emulsion of liquid fats in
water.
Several oily drugs are prepared in the form of emulsions.
The cleansing action of ordinary soap for washing clothes, crockery etc. is based
upon the formation of oil-in-water emulsion.
17. INTRODUCTION
A suspension is a heterogeneous mixture in which some of the particles settle out of the
mixture upon standing. ... The particles in a suspension are far larger than those of a solution and
thus gravity is able to pull them down out of the dispersion medium (water).
PROPERTIES:-
Heterogenous biphasic dosage form
solid is dispersed in liquid medium. Dispersed phase, dispersion medium
-Rapid settling
Easily redispersible ,pourable
if parenteral—flow through syringe needle
-if external---spread easily
-Pleasing in colour , odour, appearance.
18. CLASSIFICATION
OF SUSPENSIONS
Based On General Classes
• Oral suspension
• Externally applied suspension
• Parenteral suspension
Based On Proportion Of Solid Particle
• s Dilute suspension (2 to10%w/v solid)
• Concentrated suspension (50%w/v solid)
o Based On Electrokinetic Nature Of Solid Particles
• Flocculated suspension
• Deflocculated suspension
o Based On Size Of Solid Particles
• Colloidal suspension (< 1 micron)
• Coarse suspension (>1 micron) Nano suspension (10
ng)
19. THEORY OF SUSPENSION
Sedimentation Behaviour
Sedimentation means settling of particle or
floccules occur under gravitational force in
liquid dosage form.
Theory of Sedimentation
The factors affecting the rate of
sedimentation of a particle are described in
Stoke’s equation
20. STOKES EQUATION
Th e basic consequences of the stokes equation are that the rate of fall of a suspended particle in a
vehicle of a given density is greater for larger particles than it is for smaller particles. Also the
greater the difference in density between the particles and the vehicle, the greater will be the rate
of sedimentation. Increasing the viscosity of the dispersion medium will reduce the rate o
sedimentation. Thus decrease in the rate of sedimentation of particles in a suspension may be
achieved by reducing the size of the dispersed particles and by increasing the density and viscosity
of the dispersion/continuous phase.
21. SUSPENDING AGENTS
Suspending agents are substances that are used to keep finely divided insoluble materials suspended
in a liquid media by preventing there agglomeration (coming together) and by imparting viscosity to
the dispersion media so that the particles settle more slowly
NATURALAGENTS This class consists of those from.
a) . Animal source eg Gelatine
b) .Plant source eg. Accacia, Tragacanth, Starch, sea weed (Alginates)'
c) . mineral sources.eg Bentonite, Kaoline 2.
SEMI-SYNTHETIC AGENTS
a) These consist of substituted cellulos (minerals) eg. Hydroxyethylcellulose , Sodium
Carboxymethylcellulose , methylcellulose, Microcrystalline cellulose
22. Flocculation is a condition which occurs as a result of the lowering of electrical forces
of repulsion in a dispersed system , so that the force of attraction predominate. Systems
under this condition reduced repulsive forces the dispersed particles to approach each
other more closely and form aggregates known as flocs
In flocculated suspension, formed flocs (loose aggregates) will cause increase in
sedimentation rate due to increase in size of sedimenting particles. Hence, flocculated
suspensions sediment more rapidly.
The Sedimentation Behavior of Flocculated and
Deflocculated Suspensions:
FLOCCULATED
SUSPENSION
23. A deflocculated suspension is one in which the electrical repulsive forces between particles
exceeds the attractive forces, the particles are kept apart as individuals affected only by the
suspending vehicle. Even when brought together by random motion, they resist collision due to the
high surface tension.
In deflocculated suspension, individual particles are settling, so rate of sedimentation is slow
which prevents entrapping of liquid medium which makes it difficult to re-disperse by agitation.
This phenomenon also called ‘cracking’ or‘claying’.
In deflocculated suspension,smaller particles settle slowly and therefore remaining supernatant
liquid so supernatant appears cloudy and has a pleasing granular appearance whereby in flocculated
suspension, even the smallest particles are involved in flocs, so the supernatant does not appear
cloudy.
DEFLOCCULATED SUSPENSION
24.
25. APPLICATION OF SUSPENSION
Suspension can be formulated for parentral application in order to control rate of drug absorption,
E.g. penicillin procaine
Vaccines as a immunizing agent are often formulated as suspension.E.g. Cholera vaccine
X-ray contrast agent are also formulated as suspension. E.g. Barium sulphate for examination of
alimentary tract
If the drug is unstable when in contact with the vehicle, suspensions should be prepared
immediately prior to handing out to the patient in order to reduce the amount time that the drug
particles are in contact with the dispersion medium. Eg Amoxicilin suspension
Lotions containing insoluble solids are formulated to leave a thin coating of medicament on the
skin. As the vehicle evaporates, it gives a cooling effect and leaves the solid behind.eg calamine
lotion and sulphur lotion compound.