The document discusses electrocardiography (ECG), which is a method for recording the electrical activity of the heart. It provides definitions of ECG and electrocardiogram. It then covers the historical development of ECG from early experiments in the 1800s to the invention of the electrocardiograph by Willem Einthoven in the early 1900s. The document goes on to discuss membrane potentials, action potentials, and how the propagation of electrical signals through the heart is recorded via ECG leads to analyze the heart's function.
The property of automaticity of the sinus node is responsible foe the impulse initiation and travels along the cardiac tissue as depolarizations which result in its contraction. So, when activated, the heart is a concentrated locus of time varying potentials in the body. These voltage fluctuations can be measured by the placement of electrodes on the surface of the body. This forms the basis of electrocardiography. In this presentation we will see the basics, the lead systems and the principles behind recording of ECG.
The property of automaticity of the sinus node is responsible foe the impulse initiation and travels along the cardiac tissue as depolarizations which result in its contraction. So, when activated, the heart is a concentrated locus of time varying potentials in the body. These voltage fluctuations can be measured by the placement of electrodes on the surface of the body. This forms the basis of electrocardiography. In this presentation we will see the basics, the lead systems and the principles behind recording of ECG.
The electrocardiogram, a basic tool in cardiology has been developed two centuries ago. It was recorded by a giant machine at that time, which is now being recorded on a mobile. Such is the advancement in ECG, which is still the gold standard in diagnosis of VT .
This presentation is very useful for undergraduate medical students, premedical students to know about the basics of ECG in a very less time.This presentation teaches us how to proceed systematically to interprate an electrocardiographic tracing.
Salient features of the book are -
- The book provides a shortcut to understand and remember certain specific formulae and points you require to interpret the 12-lead ECG.
- Treatment protocols (in green boxes) for most of the important conditions are also included.
- View sample ECGs as you read along the topics.
- The content is explained in a very simple language to provide good conceptions, written from a student’s point of view.
- People can gain their belief in the book after going through sample ECGs which would be available at www.themedicalpost.net/ecg
- The book competes with the other books available in the market in simplicity, summaries, treatment protocols, live diagrams and regularly updated sample ECGs on the website.
The electrocardiogram, a basic tool in cardiology has been developed two centuries ago. It was recorded by a giant machine at that time, which is now being recorded on a mobile. Such is the advancement in ECG, which is still the gold standard in diagnosis of VT .
This presentation is very useful for undergraduate medical students, premedical students to know about the basics of ECG in a very less time.This presentation teaches us how to proceed systematically to interprate an electrocardiographic tracing.
Salient features of the book are -
- The book provides a shortcut to understand and remember certain specific formulae and points you require to interpret the 12-lead ECG.
- Treatment protocols (in green boxes) for most of the important conditions are also included.
- View sample ECGs as you read along the topics.
- The content is explained in a very simple language to provide good conceptions, written from a student’s point of view.
- People can gain their belief in the book after going through sample ECGs which would be available at www.themedicalpost.net/ecg
- The book competes with the other books available in the market in simplicity, summaries, treatment protocols, live diagrams and regularly updated sample ECGs on the website.
Lecture on the basics of Electrocardiography designed for Applied Physics 195 (Biomedical Instrumentation and Measurement) students of the University of the Philippines, Manila.
The Action and resting potential of the body are discussed. The working of body cell, tissue and how the electrical activity of body cell done? are discussed.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ocular injury ppt Upendra pal optometrist upums saifai etawah
Electrocardiography (ECG or EKG)
1. interactive physiology 1
Prof. dr. Milan TaradiProf. dr. Milan Taradi
Department of Physiology and ImmunologyDepartment of Physiology and Immunology
is a method of recording electrical activity of the heart.is a method of recording electrical activity of the heart.
ELECTROCARDIOGRAPHYELECTROCARDIOGRAPHY
(ECG or EKG)(ECG or EKG)
2. interactive physiologyECG Taradi 2
ELECTROCARDIOGRAPHYELECTROCARDIOGRAPHY
DefinitionsDefinitions
Historical overviewHistorical overview
Transmembrane resting potential and actionTransmembrane resting potential and action
potentialpotential
Propagation of the depolarization andPropagation of the depolarization and
repolarisation over the membranerepolarisation over the membrane
Propagation of the waves on the surface of aPropagation of the waves on the surface of a
cardiac muscle mass in volume conductorcardiac muscle mass in volume conductor
Propagations of waves through atria andPropagations of waves through atria and
ventriculesventricules
Spreading the impulse through the heartSpreading the impulse through the heart
Flow of current around the heartFlow of current around the heart
Recording the standard electrocardiographicRecording the standard electrocardiographic
leadsleads
Normal ECG recorded in one leadNormal ECG recorded in one lead
Projection of current in frontal planeProjection of current in frontal plane
Reconstruction of current in spaceReconstruction of current in space
3. interactive physiologyECG Taradi 3
ECG is a method of recording electrical activity of the heartECG is a method of recording electrical activity of the heart
ElectrocardiographyElectrocardiography is ais a
science of recording andscience of recording and
interpreting the electricalinterpreting the electrical
activity that precedes and is aactivity that precedes and is a
measure of the action of heartmeasure of the action of heart
muscles.muscles.
ElectrocardiogphElectrocardiogph is ais a
instrument for recording theinstrument for recording the
changes of electrical potentialchanges of electrical potential
occurring during the heartoccurring during the heart beatbeat
used especially in diagnosingused especially in diagnosing
abnormalities of heart action.abnormalities of heart action.
ElectrocardiogramElectrocardiogram (EKG or(EKG or
ECG) is a graphical record (onECG) is a graphical record (on
paper or screen) of thepaper or screen) of the
electrical waves of the heart, aselectrical waves of the heart, as
registred on theregistred on the
electrocardiograph.electrocardiograph.
4. interactive physiologyECG Taradi 4
A brief history of electrocardiographyA brief history of electrocardiography
1843. Carlo Matteucci, professor of Physics at the University of Pisa, shows1843. Carlo Matteucci, professor of Physics at the University of Pisa, shows
that an electric current accompanies each heart beat. He used a preparationthat an electric current accompanies each heart beat. He used a preparation
known as a 'rheoscopic frog' in which the cut nerve of a frog's leg was used asknown as a 'rheoscopic frog' in which the cut nerve of a frog's leg was used as
the electrical sensor.the electrical sensor.
1856. Rudolph von K1856. Rudolph von Kölliker and Heinrich Muller confirm that an electricallliker and Heinrich Muller confirm that an electrical
current accompanies each heart beat by applying a galvanometer to the basecurrent accompanies each heart beat by applying a galvanometer to the base
and apex of an exposed ventricle.and apex of an exposed ventricle.
1887. British physiologist Augustus D. Waller of St Mary's Medical School,1887. British physiologist Augustus D. Waller of St Mary's Medical School,
London publishes the first human electrocardiogram. It is recorded with aLondon publishes the first human electrocardiogram. It is recorded with a
capillary electrometer from Thomas Goswell, a technician in the laboratory.capillary electrometer from Thomas Goswell, a technician in the laboratory.
1893 Dutch physiologist Willem Einthoven introduces the term1893 Dutch physiologist Willem Einthoven introduces the term
'electrocardiogram''electrocardiogram'
1903. Einthoven invents a new galvanometer for producing1903. Einthoven invents a new galvanometer for producing
electrocardiograms. In this device a fine quartz string is suspended verticallyelectrocardiograms. In this device a fine quartz string is suspended vertically
between the poles of a magnet.between the poles of a magnet.
1924 Einthoven wins the Nobel prize for inventing the electrocardiograph.1924 Einthoven wins the Nobel prize for inventing the electrocardiograph.
1932. Wilson defines the unipolar limb leads VR, VL and VF where 'V' stands1932. Wilson defines the unipolar limb leads VR, VL and VF where 'V' stands
for voltage.for voltage.
1947. Emanuel Goldberger increases the voltage of Wilson's unipolar leads by1947. Emanuel Goldberger increases the voltage of Wilson's unipolar leads by
50% and creates the augmented limb leads aVR, aVL and aVF.50% and creates the augmented limb leads aVR, aVL and aVF.
5. interactive physiologyECG Taradi 5
Inductive or deductive?Inductive or deductive?
Forward problemForward problem
Inverse problemInverse problem
6. interactive physiologyECG Taradi 6
Membrane Potentials Caused by DiffusionMembrane Potentials Caused by Diffusion
The membrane isThe membrane is
permeable to thepermeable to the
potassium ions but notpotassium ions but not
for anions.for anions.
Because of the largeBecause of the large
potassiumpotassium
concentration gradientconcentration gradient
from the inside towardfrom the inside toward
outside, there is aoutside, there is a
strong tendency forstrong tendency for
extra numbers ofextra numbers of
potassium ions topotassium ions to
diffuse outward.diffuse outward.
7. interactive physiologyECG Taradi 7
The Resting Membrane PotentialThe Resting Membrane Potential
The potentialThe potential
inside the cell isinside the cell is
more negativemore negative
than thethan the
potential in thepotential in the
extracelularextracelular
fluid on thefluid on the
outside of theoutside of the
cell.cell.
8. interactive physiologyECG Taradi 8
Membrane Potentials Caused by DiffusionMembrane Potentials Caused by Diffusion
The membrane is semipermeable for the ions.The membrane is semipermeable for the ions.
Concentration gradients exist.Concentration gradients exist.
The stady state of gradients is maintained by the pump.The stady state of gradients is maintained by the pump.
There is a lot of nondiffusible anions inside the cell.There is a lot of nondiffusible anions inside the cell.
diffusion of Na+
diffusion of K+
3 Na3 Na++
2 K+
ATP
Mg++
ADP + Pi
ICT
9. interactive physiologyECG Taradi 9
Contributions of the NaContributions of the Na++
-K-K++
PumpPump
NaNa++
-K-K++
pump ispump is
electrogenic.electrogenic.
There isThere is
continuouscontinuous
pumping of 3 Napumping of 3 Na++
to outside forto outside for
each 2 Keach 2 K++
pumpedpumped
to the inside ofto the inside of
the membrane.the membrane.
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Taradi
10
Recording Membrane Potentials and ActionRecording Membrane Potentials and Action
PotentialsPotentials
0
-
The micropipetteThe micropipette
(active electrode)(active electrode)
is inserted intois inserted into
the interior of thethe interior of the
cell.cell.
The otherThe other
electrode is onelectrode is on
infinite distance,infinite distance,
on potential 0 V.on potential 0 V.
MonophasicMonophasic
potential ispotential is
recorded on therecorded on the
one spot of theone spot of the
membrane.membrane.
11. interactive physiologyECG
Taradi
11
Recording Biphasic PotentialRecording Biphasic Potential
TwoTwo
electrodes areelectrodes are
placed outsideplaced outside
the cell.the cell.
BiphasicBiphasic
potential ispotential is
recorded.recorded.
BothBoth
electrodes areelectrodes are
active.active.
0
15. interactive physiologyECG
Taradi
16
Propagations of action potentialsPropagations of action potentials
The action potentialThe action potential
elicited at any pointelicited at any point
excites adjacentexcites adjacent
portions of theportions of the
membrane in allmembrane in all
directions.directions.
Depolarization waveDepolarization wave
Repolarization waveRepolarization wave
No potential is recordedNo potential is recorded
when the cell is eitherwhen the cell is either
completely polarized orcompletely polarized or
depolarized.depolarized.
- +
- +
- +
- +
- +
+++++++++++++++++++++
----------------------
---------+++++++++++++
++++++++--------------
---------------------- ++++++++++
+++++++++++
+++++++++-------------
----------++++++++++++
++++++++++++++++++++
----------------------
16. interactive physiologyECG
Taradi
17
Principles of Vectorial AnalysisPrinciples of Vectorial Analysis
Resultant vector depends on the length of the vector andResultant vector depends on the length of the vector and
the angle between the lead axis and the vector (projectedthe angle between the lead axis and the vector (projected
vector = length x cos of an angle)vector = length x cos of an angle)
Also, resultant vector is diminish with the square of axisAlso, resultant vector is diminish with the square of axis
distance.distance.
18. interactive physiologyECG
Taradi
19
Cardiac muscle is a functional syncycium.Cardiac muscle is a functional syncycium.
The cardiac muscle cells are joined end toThe cardiac muscle cells are joined end to
end by specialized cell junction calledend by specialized cell junction called
intercalated discs.intercalated discs.
19. interactive physiologyECG
Taradi
20
Depolarization wave in the muscle massDepolarization wave in the muscle mass
The potentials developed on the surface of cardiacThe potentials developed on the surface of cardiac
muscle mass.muscle mass.
20. interactive physiologyECG
Taradi
21
The genesis of theThe genesis of the
electrocardiogramelectrocardiogram
Propagation of thePropagation of the
action potential inaction potential in
the group ofthe group of
myocytesmyocytes
21. interactive physiologyECG
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22
Activation frontActivation front
The signal producedThe signal produced
by the propagatingby the propagating
activation frontactivation front
between a pair ofbetween a pair of
extracellularextracellular
electrodes.electrodes.
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Taradi
23
Propagation of action potentials in cardiac musclePropagation of action potentials in cardiac muscle
vectorsvectors
resultant vectorresultant vector
depolarizationdepolarization
wavewave
23. interactive physiologyECG
Taradi
24
The Hart is in Volume ConductorThe Hart is in Volume Conductor
Flow of electrical currents in the chest aroundFlow of electrical currents in the chest around
the heart.the heart.
24. interactive physiologyECG
Taradi
25
The record depends on the locations of electrodesThe record depends on the locations of electrodes
It is crucialIt is crucial
where towhere to
placeplace
electrode.electrode.
28. interactive physiologyECG
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29
The P wave – Depolarization of the AtriaThe P wave – Depolarization of the Atria
Depolarization of the atria andDepolarization of the atria and
generation of the P wavegeneration of the P wave
6
1
2
3
4
5
1
2 3
4
5
6
1 6
29. interactive physiologyECG
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30
The cathode ray tubeThe cathode ray tube
produces theproduces the
vectorcardiogramvectorcardiogram
in the frontalin the frontal
plane from theplane from the
Einthoven limbEinthoven limb
leads.leads.
33. interactive physiologyECG
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34
The QRS complex – Depolarization of the VentriclesThe QRS complex – Depolarization of the Ventricles
The QRS complex is often composed of three separateThe QRS complex is often composed of three separate
waves.waves.
Lead I.
35. interactive physiologyECG
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The J Point – The Zero Reference PotentialThe J Point – The Zero Reference Potential
The damaged part of the heart muscle is partially or totally depolarized all the time.The damaged part of the heart muscle is partially or totally depolarized all the time.
Lead I.
0
36. interactive physiologyECG
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The T Wave – Repolarization of the VentriclesThe T Wave – Repolarization of the Ventricles
The septum and the other endocardial areas have a longer period ofThe septum and the other endocardial areas have a longer period of
contraction and therefore are slower to repolarize then the most of the externalcontraction and therefore are slower to repolarize then the most of the external
surfaces of the heart.surfaces of the heart.
The reason is the high blood pressure inside the ventricules during sistole.The reason is the high blood pressure inside the ventricules during sistole.
Lead I.
41. interactive physiologyECG
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43
The J PointThe J Point
The zero referenceThe zero reference
potential for analyzingpotential for analyzing
current of injurycurrent of injury
The damaged part ofThe damaged part of
the heart muscle isthe heart muscle is
partially or totallypartially or totally
depolarized all thedepolarized all the
time.time.
64. interactive physiologyECG
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All Leads and AxisAll Leads and Axis
Lead I.Lead I. STANDARDSTANDARD
Lead II. (3)Lead II. (3)
Lead III.Lead III.
aVRaVR AUGMENTEDAUGMENTED
aVL (3)aVL (3)
aVFaVF
VV11 PRECORDIALPRECORDIAL
VV22 (6)(6)
VV33
VV44
VV55
VV66
total (12)total (12)
72. interactive physiologyECG
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74
Wandering pacemakerWandering pacemaker
Impuses originate from varying points in atriaImpuses originate from varying points in atria
Variation in P-wave contour, P-R and P-P intervalVariation in P-wave contour, P-R and P-P interval
and therefore in R-R intervalsand therefore in R-R intervals
1.1. RHYTHM DIAGNOSISRHYTHM DIAGNOSIS
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Atrial flutterAtrial flutter
Impulses travel in circular course in atriaImpulses travel in circular course in atria
Rapid flutter waves, ventricular responseRapid flutter waves, ventricular response
irregularirregular
1.1. RHYTHM DIAGNOSISRHYTHM DIAGNOSIS
76. interactive physiologyECG
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Atrial fibrillationAtrial fibrillation
Impuses have chaotic, random pathways in atriaImpuses have chaotic, random pathways in atria
Baseline irregular, ventricular response irregularBaseline irregular, ventricular response irregular
1.1. RHYTHM DIAGNOSISRHYTHM DIAGNOSIS
77. interactive physiologyECG
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Junctional rhythmJunctional rhythm
Impuses originate at AV node with retrograde andImpuses originate at AV node with retrograde and
antegrade directionantegrade direction
P-wave is often inverted, may be under or afterP-wave is often inverted, may be under or after
QRS complex, Heart rate is slowQRS complex, Heart rate is slow
1.1. RHYTHM DIAGNOSISRHYTHM DIAGNOSIS
78. interactive physiologyECG
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ArrhythmiaArrhythmia
Premature ventricular contractionPremature ventricular contraction
A single impulse originates at right ventricleA single impulse originates at right ventricle
Time interval between normal R peaks is aTime interval between normal R peaks is a
multiple of R-R intervalsmultiple of R-R intervals
1.1. RHYTHM DIAGNOSISRHYTHM DIAGNOSIS
86. interactive physiologyECG
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88
Right bundle-branch blockRight bundle-branch block
2.2. ACTIVATION SEQUENCEACTIVATION SEQUENCE
QRSQRS
durationduration
greater thangreater than
0.12 s0.12 s
Wide SWide S
wave inwave in
leads I, V5leads I, V5
and V6and V6
87. interactive physiologyECG
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89
Left bundle-branch blockLeft bundle-branch block
QRS durationQRS duration
greater thangreater than
0.12 s0.12 s
Wide S waveWide S wave
in leads V1in leads V1
and V2, wideand V2, wide
R wave in V5R wave in V5
and V6and V6
2.2. ACTIVATION SEQUENCEACTIVATION SEQUENCE
89. interactive physiologyECG
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Right ventricular hypertrophyRight ventricular hypertrophy
3.3. HYPERTROPHYHYPERTROPHY
Large R wave in leads V1 and V3Large R wave in leads V1 and V3
Large S wave in leads V5 and V6Large S wave in leads V5 and V6
90. interactive physiologyECG
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Left ventricular hypertrophyLeft ventricular hypertrophy
Large S wave inLarge S wave in
leads V1 and V2leads V1 and V2
Large R wave inLarge R wave in
leads V5 and V6leads V5 and V6
3.3. HYPERTROPHYHYPERTROPHY
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Myocardial InfarctionMyocardial Infarction
A. Normal ECG prior to MIA. Normal ECG prior to MI
B. Hyperacute T wave changes -B. Hyperacute T wave changes -
increased T wave amplitude andincreased T wave amplitude and
width; may also see ST elevationwidth; may also see ST elevation
C. Marked ST elevation withC. Marked ST elevation with
hyperacute T wave changeshyperacute T wave changes
(transmural injury)(transmural injury)
D. Pathologic Q waves, less STD. Pathologic Q waves, less ST
elevation, terminal T waveelevation, terminal T wave
inversion (necrosis) (Pathologic Qinversion (necrosis) (Pathologic Q
waves are usually defined aswaves are usually defined as
duration >0.04 s or >25% of R-waveduration >0.04 s or >25% of R-wave
amplitude)amplitude)
E. Pathologic Q waves, T waveE. Pathologic Q waves, T wave
inversion (necrosis and fibrosis)inversion (necrosis and fibrosis)
F. Pathologic Q waves, upright TF. Pathologic Q waves, upright T
waves (fibrosis)waves (fibrosis)
Editor's Notes
- T he electrocardiogram (ECG i si đi or EKG i kej đi ) is a recording of the electric potential, generated by the electric activity of the heart, on the surface of the thorax. - The ECG thus represents the extracellular electric behavior of the cardiac muscle tissue. - In this lecture we explain the genesis of the ECG signal .
- As you know. ECG is the most valuble diagnostic prosidges in klinical diagnoses of the heart disease. - We start first with definition.
- Carlo Matteucci, - So twitching of the muscle was used as the visual sign of electrical activity. Rudolph von Koelliker and Heinrich Muller- They also applied a nerve-muscle preparation, similar to Matteucci's, to the ventricle and observed that a twitch of the muscle occured just prior to ventricular systole and also a much smaller twitch after systole. - These twitches would later be recognised as caused by the electrical currents of the QRS and T waves.
- The electrocardiogram which is recorded from body surface electrodes is the result of a vast number of systematically propagated electrical event taking place in the individual muscle cell fibers of the herat. - Two simplified approachs to undenstanding the complex phenomenon involved will be now presented. - The problem in which the source and the conducting medium are known but the field is unknown and must be determinated, is called the forward problem . The forward problem has a unique solution. It is always possible to calculate the field with an accuracy. However, this problem does not arise in clinical (diagnostic) situations, since in this case only the field can be measured (noninvasively) at the body surface. - The problem in which the field and the conductor are known but the source is unknown, is called the inverse problem . In medical applications of bioelectric phenomena, it is the inverse problem that has clinical importance. For instance, in everyday clinical diagnosis the cardiologist and the neurologist seek to determine the source of the measured bioelectric signals. The possible pathology affecting the source provides the basis for their diagnostic decisions - that is, the clinical status of the corresponding organ. - T he heart has on the order of 10 exponent 10 cells . - source - final field (ECG record) We desidet to take inductive way. - From single point of cellular membrane to hole cell, then a muscular streep, atrial syncycium, ventricular syncycium, the whole heart, the heart in the chest, the recording on the skin!
- How we can record this electical fenomenon on membrane. Whot kinde of problem doo we have? - Thy take place in space that means in three dimension. - But we do not have instrument for spacial recording. - Voltmeter has onli tvo electrodec and it record difference between tvo point. - This is the projection of actual currentod the axs of theelectic lead.
- The pair of electrocardiogram electrodes defines a lead. - In a lead one electrode is treated as a positive side of voltmeter, and one as a negaive side. - The lead records the fluctuation in voltage difference between positive and negative electrodes.
- The action potential recorded in ventricular muscle swown on this slide, averages about 110 milivolts. - This means that the mombrane potential rises from its very negative value about -90 mV between beats to a slightly positive value about +20 mV during each beat.
- The Na+ current is responsible for the rapid depolarizing phase of the action potential in atrial, ventricular and in Purkinje fibers. - The K+ current is responsible for the repolarizing phase in all cardiomyocytes. - Duration of the action potential and the contraction is the equal, but not synchron.
- The SA nodal cells are self-excitatory, pacemaker cells . - Because the intrinsic rate of the sinus node is the greatest, it sets the activation frequency of the whole heart. - The Ca++ current is responsible for the rapid depolarizing phase of the action potential in SA and AV node. It also trigger contraction in all cardiomyocytes.
- Spread of the impulse through the myocyte - Although it is known that repolarization does not actually propagate, a boundary between repolarized and still active regions can be defined as a function of time. It is "propagation" in this sense that is described here.
- In volume conductor the current flow in all direction, but predominantly in one particular direction at a given instant during cardiac cycle. - A vector is an arrow that points in the current flow direction with arrowhead in the positive direction. - The lenght of the vector is drown proportional to the voltage of potential. - At any given instant current flow is represented by resultant, summated vector. - Because the movement of charge (dipol) has both a three-dimensional direction and a magnitude. - The signal measured on an ECG is a vector.
- We come to the single cell - cardiomyocyte. - The nexst step is the small streep of cardiac muscle.
- The fluctuation in extracellular voltage recorded by each lead vary from fractions of millivolt to several millivolts. - These fluctuation are called waves.
- The depolaruzation zone is narow, but repolarization is wide. - Direction of wavefront movement is the same! - Polarity of the duble layer is oposit, and the local current across the membrane is oposit.
- Before we discuss the generation of the ECG signal in detail, we consider a simple example explaining what kind of signal a propagating activation front produces in a volume conductor. - Slide presents a volume conductor and a pair of electrodes on its opposite surfaces. The figure is divided into four cases, where both the depolarization and repolarization fronts propagate toward both positive and negative electrodes. In various cases the detected signals have the following polarities: - Case A: When the depolarization front propagates toward a positive electrode, it produces a positive signal. First we note that the transmembrane voltage ahead of the wave is negative since this region is still at rest. Behind the wave front, the transmembrane voltage is in the plateau stage; hence it is positive . - Case B : When the propagation of activation is away from the positive electrode, the signal has the corresponding negative polarity. - Case C : It is easy to understand that when the repolarization front propagates toward a positive electrode, the signal is negative. - Case D : When the direction of propagation of a repolarization front is away from the positive electrode, a positive signal is produced.
- T he conducting medium extends continuously; it is three-dimensional and referred to as a volume conductor . - The human body may be considered as a resistive, piecewise homogeneous and linear volume conductor. Most of the tissue is isotropic. The muscle is, however, strongly anisotropic, and the brain tissue is anisotropic as well.
- Depolarisation of the atria begins in SA node. - The direction of depalarisation is in direction noted by the red vector on the slide.
- The cathode ray tube (oscilloscope) of W. Hollman and H. F. Hollman has three pairs of deflection plates oriented in the directions of the edges of the Einthoven triangle. - The elliptical figure generated by the positive ends of the vector is called vectorcardiogram.
- The mammalian electrocardiogram contains three major components during each cardiac cycle. - According to the nomenclature devised by Einthoven, the component producen by atrial activation is called the P wave, the one produced by ventricular activation is the QRS complex, and the component produced by ventricular recovery is the T wave.
- I (positive connection to left arm, negative connection to right arm) The lead defines an axis in the frontal plane at 0 degrees. - II (positive connection to left leg, negative connection to right arm) The lead defines an axis in the frontal plane at 60 degrees. - III (positive connection to left leg, negative connection to left art) The lead defines an axis in the frontal plane at 120 degrees.
- The positive and negative ends of these six leads define axes every 30 degrees in the frontal plane.
- The precordial leds lie in the transverse plane, perpendicular to the plane of the frontal leads. - The positive connection is one of six different locations on the chest wall, and the negative connection is electronically defined in the middle of the heart by averaging the three limb electrodes.
- Recording from all 12 leads is extremely usefulbecause a signal of interest may be easier to see in one lead than another.
- Normal sinus rhythm - The sinus rhythm is normal if its frequency is between 60 and 100/min . - A sinus rhythm of less than 60/min is called sinus bradycardia. This may be a consequence of increased vagal or parasympathetic tone. - A sinus rhythm of higher than 100/min is called sinus tachycardia. It occurs most often as a physiological response to physical exercise or psychical stress, but may also result from congestive heart failure.
- If the sinus rhythm is irregular such that the longest PP- or RR-interval exceeds the shortest interval by 0.16 s, the situation is called sinus arrhythmia. This situation is very common in all age groups.
- When the heart rate is sufficiently elevated so that the isoelectric interval between the end of T and beginning of P disappears, the arrhythmia is called atrial flutter. The origin is also believed to involve a reentrant atrial pathway. - The AV-node and, thereafter, the ventricles are generally activated by every second or every third atrial impulse (2:1 or 3:1 heart block).
- The activation in the atria may also be fully irregular and chaotic, producing irregular fluctuations in the baseline. A consequence is that the ventricular rate is rapid and irregular . - Atrial fibrillation occurs as a consequence of rheumatic disease, atherosclerotic disease, hyperthyroidism, and pericarditis. (It may also occur in healthy subjects as a result of strong sympathetic activation.)
- If the heart rate is slow (40-55/min), the QRS-complex is normal, the P-waves are possibly not seen, then the origin of the cardiac rhythm is in the AV node. - Because the origin is in the juction between atria and ventricles, this is called junctional rhythm .
- A premature ventricular contraction is one that occurs abnormally early. If its origin is in the atrium or in the AV node, it has a supraventricular origin. The complex produced by this supraventricular arrhythmia lasts less than 0.1 s. If the origin is in the ventricular muscle, the QRS-complex has a very abnormal form and lasts longer than 0.1 s. Usually the P-wave is not associated with it.
A rhythm of ventricular origin may also be a consequence of a slower conduction in ischemic ventricular muscle that leads to circular activation (re-entry). The result is activation of the ventricular muscle at a high rate (over 120/min), causing rapid, bizarre, and wide QRS-complexes; the arrythmia is called ventricular tachycardia. As noted, ventricular tachycardia is often a consequence of ischemia and myocardial infarction.
When ventricular depolarization occurs chaotically, the situation is called ventricular fibrillation. This is reflected in the ECG, which demonstrates coarse irregular undulations without QRS-complexes. The cause of fibrillation is the establishment of multiple re-entry loops usually involving diseased heart muscle. In this arrhythmia the contraction of the ventricular muscle is also irregular and is ineffective at pumping blood. The lack of blood circulation leads to almost immediate loss of consciousness and death within minutes. The ventricular fibrillation may be stopped with an external defibrillator pulse and appropriate medication.
A ventricular rhythm originating from a cardiac pacemaker is associated with wide QRS-complexes because the pacing electrode is (usually) located in the right ventricle and activation does not involve the conduction system. In pacer rhythm the ventricular contraction is usually preceded by a clearly visible pacer impulse spike. The pacer rhythm is usually set to 72/min..
- When the P-wave always precedes the QRS-complex but the PR-interval is prolonged over 0.2 s, first-degree atrioventricular block is diagnosed. - If the PQ-interval is longer than normal and the QRS-complex sometimes does not follow the P-wave, the atrioventricular block is of second-degree. If the PR-interval progressively lengthens, leading finally to the dropout of a QRS-complex, the second degree block is called a Wenkebach phenomenon . - Complete lack of synchronism between the P-wave and the QRS-complex is diagnosed as third-degree (or total) atrioventricular block. The conduction system defect in third degree AV-block may arise at different locations such as: Over the AV-node In the bundle of His Bilaterally in the upper part of both bundle branches Trifascicularly, located still lower, so that it exists in the right bundle-branch and in the two fascicles of the left bundle-branch.
- If the right bundle-branch is defective so that the electrical impulse cannot travel through it to the right ventricle, activation reaches the right ventricle by proceeding from the left ventricle. It then travels through the septal and right ventricular muscle mass. This progress is, of course, slower than that through the conduction system and leads to a QRS-complex wider than 0.1 s. Usually the duration criterion for the QRS-complex in right bundle-branch block (RBBB) as well as for the left brundle- branch block (LBBB) is >0.12 s. Activation of the left ventricle takes place normally
- The situation in left bundle-branch block (LBBB) is similar, but activation proceeds in a direction opposite to RBBB. Again the duration criterion for complete block is 0.12 s or more for the QRS-complex. Because the activation wavefront travels in more or less the normal direction in LBBB, the signals' polarities are generally normal. However, because of the abnormal sites of initiation of the left ventricular activation front and the presence of normal right ventricular activation the outcome is complex and the electric heart vector makes a slower and larger loop to the left and is seen as a broad and tall R-wave, usually in leads I, aVL, V5, or V6.
- Right atrial hypertrophy is a consequence of right atrial overload. This may be a result of tricuspid valve disease (stenosis or insufficiency), pulmonary valve disease, or pulmonary hypertension (increased pulmonary blood pressure). The latter is most commonly a consequence of chronic obstructive pulmonary disease or pulmonary emboli. In right atrial hypertrophy the electrical force due to the enlargened right atrium is larger. This electrical force is oriented mainly in the direction of lead II but also in leads aV F and III. In all of these leads an unusually large (i.e., 0.25 mV) P-wave is seen.
- Right ventricular hypertrophy is a consequence of right ventricular overload. - This is caused by pulmonary valve stenosis, tricuspid insufficiency, or pulmonary hypertension (see above). Also many congenital cardiac abnormalities, such as a ventricular septal defect, may cause right ventricular overload. Right ventricular hypertrophy increases the ventricular electrical forces directed to the right ventricle - that is, to the right and front. This is seen in lead V1 as a tall R-wave of 0.7 mV.
- Left ventricular hypertrophy is a consequence of left ventricular overload. - It arises from mitral valve disease, aortic valve disease, or systemic hypertension. Left ventricular hypertrophy may also be a consequence of obstructive hypertrophic cardiomyopathy, which is a sickness of the cardiac muscle cells. Left ventricular hypertrophy increases the ventricular electric forces directed to the left ventricle - that is, to the left and posteriorly. Evidence of this is seen in lead I as a tall R-wave and in lead III as a tall S-wave ( 2.5 mV). Also a tall S-wave is seen in precordial leads V1 and V2 and a tall R-wave in leads V5 and V6, ( 3.5 mV).