Eales' disease is an idiopathic inflammatory retinal vasculitis that primarily affects young males in India. It involves peripheral retinal perivasculitis and ischemia leading to neovascularization and recurrent vitreous hemorrhage. While its exact etiology is unknown, it has been associated with tuberculosis and hypersensitivity to tubercular proteins. Treatment involves corticosteroids to reduce inflammation, laser photocoagulation to ablate new vessels and reduce hemorrhage risk, and vitrectomy for non-resolving hemorrhage or retinal detachment.

1. Eales’ Disease Dr Gyanendra Lamichhane, Dr I. Kansakar Lumbini Eye Institute Bhairahawa,Nepal

17. Active periphlebitis with tortuosity of veins as well as multiple superficial retinal hemorrhage

18. Montage fundus photograph showing an active perivasculitis involving predominantly the peripheral retina of an Eales disease patient.

21. Sea fan–like neovascularisation of the retina.

27. Healed perivasculitis as sheathing of the veins Macular changes uncommon Peripheral retinal neovascularisation reported in 36-84% of cases Recurrent vitreous hemorrhages, the hall mark of the disease Some vitreous hemorrhages resolve, some do not ( organize with multiple VR adhesions & RRD/TRD) Some patient specially with multiple sclerosis are asymptomatic.

28. Proliferative stage

29. Vitreous hemorrhage

31. Healed perivasculitis with anastomotic arteriovenous shunt

32. Fibrovascular proliferation causing tractional retinal detachment

33. Healed perivasculitis with sclerosed vein and multiple chorioretinal atrophic patches

38. FFA following laser photocoagulation of neovascular frond

39. Multiple veno venous shunts in late AV phase

45. Sarcoidosis Wegener Granulomatosis III. Radiological tests:

48. Sarcoidosis Sarcoid nodules Bilateral hilar lymphadenopathy

49. Candle wax dipping

50. Vitritis and snowball Peripheral neovascularisation

51. leukemia

52. Sickle cell retinopathy Seafan neovascularisation

54. Behcet disease Aphthous ulceration Erythema nodusum like lesions

55. Dermatographism Hypopyon

56. Occlusive vasculitis Retinal exudation and vascular occlusion

65. FFA following laser photocoagulation of neovascular frond

68. Tractional radial retinal fold after vitrectomy

71. Thankyou Thankyou