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Drugs for treating shock
- 1. DRUGS FOR TREATING SHOCK DR.SAROJ SUWAL
- 2. SHOCK • Syndrome characterizeby collapse of Circulatory System Vitals tissue doesn’t receive enough blood to function properly Cell cannot carry on normal metabolism Shock is a systemic state of low tissue perfusion, which is inadequate for normal cellular respiration.
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- 5. TYPES OF SHOCK •Hypovolemic: • Due to loss of blood volume • Two types • hemorrhagic, • non-hemorrhagic (GI or renal losses, burns, etc.) •
- 7. • Septic Shock •Multiple organ Dysfunction due to organism in blood • Cardiogenic: • Failure to pump blood to issue • Acute myocardial infraction resulting in massive damage to myocardium, CHF ,Pulmonary embolism
- 8. ANAPHYLATIC SHOCK • dueto acute allergic reactions • Due to severe reaction to allergens • Drugs: penicillin , radio contrast, lignocaine , anesthetic drugs, iron injectable . . etc. • Blood transfusion • Stings and snake bite • New clothes • Dusting smokes • Suddenly climate change
- 11. DRUGS USED FORSHOCK •3 categories •Vasoconstrictors •Cardio Tonic Drugs •Fluid Replacement agents
- 12. VASOCONSTRICTORS • EPINEPHRINE • NOR-EPINEPHRINE SHOCKBP drop Initially inscrease sympathetic Nervous System Vasoconstriction Inscrease BP
- 13. EPINEPHRINE/ ADRENALINE • Nonselective adrenergic agent • stimulates both the alpha- and beta- adrenergic systems • causes • systemic VASOCONSTRICTION • gastrointestinal relaxation, • stimulates the HEART, and • dilates BRONCHI and cerebral vessels.
- 16. Increase BP •due to alpha 1 receptor in smooth muscle of blood vessels Cardia output increase • due to stimulation of beta 1 receptor in hear Airway open • due to stimulation of beta 2
- 19. NON EPINEPHRINE • Norepinephrineis similar to adrenaline. • chemical released from the sympathetic nervous system • Stress Hormone • It works by constricting (narrowing) the blood vessels and increasing blood pressure and blood glucose (sugar) levels. • Norepinephrine is used to treat life-threatening low blood pressure (hypotension) • Has both alpha and beta one activity
- 22. CARDIO TONIC DRUGS •Ionotropic agents – inscrease force of contraction of heart muscles • Digoxin • Dobutamine • Dopamine
- 23. • Dermotropic affect tissue of heart
- 24. DIGIOXIN • cardiotonic glycosideobtained mainly from Digitalis lanata • has positive inotropic and negative chronotropic activity • used for • congestive heart failure and • supraventricular arrhythmias • control ventricular rate
- 25. DOBUTAMINE • Used intreatment of cardiogenic shock and severe heart failure. • Beta 1 adrenergic agent Dobutamine Chonotropic Effect Increase heart beat forcibly Inscrease in CO maintaining blood flow to vital organs
- 26. DOPAMINE • Released frombrain • dopamine as neurotransmitter—a chemical released by neurons (nerve cells) to send signals to other nerve cells.
- 27. DOPAMINE • Acts differentlyin different dose ( LOW, MEDIUM and HIGH Dose ) • Acts on dopamine, alpha and beta receptors • Low dose : • Used for treating hypovolemic and cardiogenic shock stimulate beta 1 receptor in kidney Cause vasodilation Inscrease blood flow to kidney
- 28. • Modrate dose •Stimulates beta 1 receptor cause increase rate with force inscrease CO • High Dose • Stimulates alpha recetor vasoconstriction increase BP
- 30. FLUID REPLACEMENT • Usedto replace blood or other fluids during hypovolemic shock • Generally replacement done are • Blood, • colloids, • crystalloids
- 31. BLOOD • Whole Blood •Blood from standard donation • indicated for acute and massive blood loss • Will replace plasma volume • Supply RBC’s
- 33. COLLOIDS • Used when1/3 blood volume is lost • Are proteins that stay suspended in blood for long period • Draw water from body’s cells and tissues into blood vessels • Colloids are • Serum albumin, plasma protein fractions, dextrans
- 35. CRYSTALLOIDS • IV solutionsthat contain electrolyes that is same as contained in plasma • Like colloids leave blood and enter into cell • Used for • replacing fluid lost • Inscrese urine output • Include • NS, RL, Hypertonic Saline • 5% dextrose
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