The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Engineering bone tissue using human Embryonic Stem CellsBalaganesh Kuruba
Bone defects lead by traumatic injuries, congenital malformations and other surgical rescissions rises the immediate need for a more evolved and safer approaches in tissue repair at alarming rates for the downgrading issues with existing strategies which needs to be addressed. Currently practiced treatment methods addressing the issue with bone defects are invasive, traumatic and are not cost effective. Yet, issues of immune rejection either immediately or in the later stages have been reported claiming its ineffectiveness in some selective case studies.
Previous work by researchers carried out the "Biomimetic" approach to provide the cells with the microenvironment and in situ conditions for the cells seeded into the 3D Osteogenic scaffolds enriched with growth supplments. Here, we address the issue of non-availability of therapeutic cells - a major problem with current translational medicine by proposing the use of Human Embryonic Stem Cells in generating strong and structurally rigid bone tissue. Inducing the production of Mesenchymal Progenitor cells from Human Embryonic Stem cells in Serum supplemented expansion medium and elimination of bone Fibroblast growth factor produced high quality MPCs which were induced in osteogenic medium to result in bone differentiating cells. Culturing these MPCs produced from three different protocols into 3D Scaffold and 3D-Endoret Osteogenic Scaffold produced tissue constructs which are analysed both biochemically and Histologically to check for the Bone tissue differentiation parameters such as Bone sialoprotein deposition, Osteopontin accumulation and Collagen deposition. Matrix mineralization in these constructs were studied by uCT imaging and safety studies were conducted by studying Orthotopic implantation models in SCID mouse. And the results are expected to be optimistically affirmative which shall lay a new foundation and pioneer a whole new approach in the field of Tissue Engineering.
Bone tissue engineering challenges in oral and maxillofacial surgerySeyed Mohammad Zargar
In this presentation, I talked about maxillofacial deformities, Different Reconstruction methods and at tissue engineering approach.
S.Mohammad Zargar
Biomedical Engineering Student at University of Isfahan, Iran
Autologous Mesenchymal Stem Cells in OrthopaedicsVladimir Bobic
Nuffield Health, The Grosvenor Hospital Chester, UK
27 June 2013. GP and Physiotherapy Seminar: Autologous Stem Cell Therapies in Orthopaedics. Moderator and Presenter: Vladimir Bobic, Chester Knee Clinic
Advancement in Scaffolds for Bone Tissue Engineering: A Reviewiosrjce
In last decade, Tissue Engineering has moved a way ahead and has proposed solutions by replacing
the permanently or severely damaged tissues of our body. The field has expanded to tissue regeneration of
cartilage, bone, blood vessels, skin, etc. The domain of tissue engineering is very wide and is the combination of
bioengineering, biology & biochemistry. This review is focus on recent research advancement in bone tissue
engineering. Bone grafting techniques are used to replace the severely damaged due to any accident, trauma or
any disease. These are either allograft, autologous or synthetic bone properties similar to bone. Bone Tissue
Engineering is part of a synthetic technique and overcome the limitations faced in other two mentioned
techniques. Bone Tissue engineering is rapidly developing field and has become important due to its remarkable
therapeutic properties. Mesenchymal stem cells are used as starting cells in tissue regeneration. These cells get
differentiated into bone cells and start multiplying to form bone. One inevitable requirement of these growing
human cells is a strong support which helps in the proper growth. This support is known as scaffold, in tissue
engineering. For proper regeneration of cells scaffold materials plays vital importance in the field of bone tissue engineering. This review attempts is illustrate the biology of natural bone, various desirable properties of scaffold, biomaterials used for fabrication of scaffold and various fabrication techniques with examples of bone regenerate.
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Bone and Cartilage regeneration with cells and tissue engineering products - ...Enric Caceres
Bone and Cartilage regeneration with cells and tissue engineering products - Dr. Enric Cáceres - B-Debate 17/02/2015 http://www.bdebate.org/en/forum/advanced-therapies-and-regenerative-medicine-promise-21st-century
Engineering bone tissue using human Embryonic Stem CellsBalaganesh Kuruba
Bone defects lead by traumatic injuries, congenital malformations and other surgical rescissions rises the immediate need for a more evolved and safer approaches in tissue repair at alarming rates for the downgrading issues with existing strategies which needs to be addressed. Currently practiced treatment methods addressing the issue with bone defects are invasive, traumatic and are not cost effective. Yet, issues of immune rejection either immediately or in the later stages have been reported claiming its ineffectiveness in some selective case studies.
Previous work by researchers carried out the "Biomimetic" approach to provide the cells with the microenvironment and in situ conditions for the cells seeded into the 3D Osteogenic scaffolds enriched with growth supplments. Here, we address the issue of non-availability of therapeutic cells - a major problem with current translational medicine by proposing the use of Human Embryonic Stem Cells in generating strong and structurally rigid bone tissue. Inducing the production of Mesenchymal Progenitor cells from Human Embryonic Stem cells in Serum supplemented expansion medium and elimination of bone Fibroblast growth factor produced high quality MPCs which were induced in osteogenic medium to result in bone differentiating cells. Culturing these MPCs produced from three different protocols into 3D Scaffold and 3D-Endoret Osteogenic Scaffold produced tissue constructs which are analysed both biochemically and Histologically to check for the Bone tissue differentiation parameters such as Bone sialoprotein deposition, Osteopontin accumulation and Collagen deposition. Matrix mineralization in these constructs were studied by uCT imaging and safety studies were conducted by studying Orthotopic implantation models in SCID mouse. And the results are expected to be optimistically affirmative which shall lay a new foundation and pioneer a whole new approach in the field of Tissue Engineering.
Bone tissue engineering challenges in oral and maxillofacial surgerySeyed Mohammad Zargar
In this presentation, I talked about maxillofacial deformities, Different Reconstruction methods and at tissue engineering approach.
S.Mohammad Zargar
Biomedical Engineering Student at University of Isfahan, Iran
Autologous Mesenchymal Stem Cells in OrthopaedicsVladimir Bobic
Nuffield Health, The Grosvenor Hospital Chester, UK
27 June 2013. GP and Physiotherapy Seminar: Autologous Stem Cell Therapies in Orthopaedics. Moderator and Presenter: Vladimir Bobic, Chester Knee Clinic
Advancement in Scaffolds for Bone Tissue Engineering: A Reviewiosrjce
In last decade, Tissue Engineering has moved a way ahead and has proposed solutions by replacing
the permanently or severely damaged tissues of our body. The field has expanded to tissue regeneration of
cartilage, bone, blood vessels, skin, etc. The domain of tissue engineering is very wide and is the combination of
bioengineering, biology & biochemistry. This review is focus on recent research advancement in bone tissue
engineering. Bone grafting techniques are used to replace the severely damaged due to any accident, trauma or
any disease. These are either allograft, autologous or synthetic bone properties similar to bone. Bone Tissue
Engineering is part of a synthetic technique and overcome the limitations faced in other two mentioned
techniques. Bone Tissue engineering is rapidly developing field and has become important due to its remarkable
therapeutic properties. Mesenchymal stem cells are used as starting cells in tissue regeneration. These cells get
differentiated into bone cells and start multiplying to form bone. One inevitable requirement of these growing
human cells is a strong support which helps in the proper growth. This support is known as scaffold, in tissue
engineering. For proper regeneration of cells scaffold materials plays vital importance in the field of bone tissue engineering. This review attempts is illustrate the biology of natural bone, various desirable properties of scaffold, biomaterials used for fabrication of scaffold and various fabrication techniques with examples of bone regenerate.
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Introduction
Anatomy and Physiology of bone
Bone Tissue Engineering
Recent studies related to bone tissue engineering
Commercialized products and ongoing clinical trials
Biomedical start-ups
Concluding remarks
Bone and Cartilage regeneration with cells and tissue engineering products - ...Enric Caceres
Bone and Cartilage regeneration with cells and tissue engineering products - Dr. Enric Cáceres - B-Debate 17/02/2015 http://www.bdebate.org/en/forum/advanced-therapies-and-regenerative-medicine-promise-21st-century
A stem cell is a "blank" cell that can give rise to multiple tissue types such as a skin, muscle, or nerve cell.
Under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
Regenerative endodontic procedures are designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex
"Exploring Regenerative Endodontics: A Paradigm Shift in Root Canal Therapy" aims to delve into the groundbreaking approach of regenerative endodontics, which has revolutionized traditional root canal treatments. This presentation serves as a comprehensive guide for dental professionals, researchers, and students who are keen on understanding the shift towards biologically-based procedures designed to replace damaged tooth structures, including dentin and root structures, as well as cells of the pulp-dentin complex.
Key Points Covered:
Introduction to Traditional Endodontics: A brief overview of conventional root canal treatments, setting the stage for the limitations that regenerative endodontics aims to address.
Fundamentals of Regenerative Endodontics: Understand what regenerative endodontics is, its aims, and the principles guiding this new approach.
Materials and Techniques: Discover the novel materials and technologies used in regenerative endodontics including scaffolds, growth factors, and stem cells.
Clinical Applications and Benefits: Discuss various case studies and clinical trials that demonstrate the effectiveness and benefits of regenerative procedures.
Challenges and Future Prospects: A balanced view on the hurdles facing regenerative endodontics and what the future holds.
This presentation is essential viewing for anyone interested in the future of dental science and how regenerative approaches can offer effective and more natural alternatives to traditional endodontic treatments."
Feel free to modify this description to better suit your specific needs and focus points.
Dedifferentiation is a term used to suggest that differentiated epithelial cells revert to a previous developmental stage before their subsequent differentiation into an alternative cell fate. Hereby we discuss about the phenomenon and their impact in medical applications.
Innovative Potential of Periodontal Ligament Cell Sheet Engineering in Functi...CrimsonpublishersITERM
Innovative Potential of Periodontal Ligament Cell Sheet Engineering in Functional Implant Therapy by Isao Ishikawa in Innovation in Tissue Engineering & Regenerative Medicine
NATIONAL INSTITUTE OF TECHNOLOGY, HAMIRPUR
CHEMICAL ENGINEERING DEPARTMENT
DISCOVERY THAT MATURE CELLS CAN BE
REPROGRAMMED TO BECOME PLURIPOTENT
SEMINAR REPORT
CH-327
NAME: MAYANK BHARDWAJ
ROLL NUMBER: 20BCH051
DISCOVERY THAT MATURE CELLS CAN BE
REPROGRAMMED TO BECOME PLURIPOTENT
ABSTRACT
The discovery of iPSCs has paved the way for numerous applications in the medical field,
including the use of patient-specific iPSCs to model diseases, the development of new drugs, and
the creation of personalized cell-based therapies. Additionally, the ability to reprogram cells
without the use of embryos has removed many ethical considerations associated with traditional
stem cell research.
Overall, the discovery of reprogramming mature cells has opened up new avenues of research
and holds immense promise for future medical treatments.
1. INTRODUCTION
Pluripotency refers to the ability of a cell to differentiate into any type of cell in the body.
Pluripotent cells are considered the building blocks of the body and have the potential to form
any tissue or organ. This unique property makes them of great importance in the field of biology
and medicine.
In biology, pluripotent cells provide a valuable tool for understanding cellular differentiation and
the development of tissues and organs. In medicine, pluripotent cells hold immense promise for
regenerative therapies and disease treatment. For example, scientists can use pluripotent cells to
generate replacement tissues and organs, thereby providing new treatments for conditions such as
heart disease, diabetes, and spinal cord injury. Additionally, the ability to generate
patient-specific pluripotent cells has allowed scientists to study the underlying causes of diseases
and develop new drugs.
Overall, pluripotency and the study of pluripotent cells are crucial for advancing our
understanding of biology and for developing new medical treatments.
The study of stem cells has a long and rich history that dates back to the early 20th century. In
the early days of stem cell research, scientists were primarily interested in the role of stem cells
in embryonic development. In the 1950s and 1960s, the discovery of stem cells in adult tissues
opened up new avenues of research and sparked interest in the potential therapeutic applications
of these cells.
In the late 20th and early 21st centuries, advances in cell culture techniques and genetic
engineering paved the way for the discovery of induced pluripotent stem cells (iPSCs). In 2006,
scientists showed that mature cells could be reprogrammed to become pluripotent, setting the
stage for a new era of stem cell research.
Since the discovery of iPSCs, the field of stem cell research has expanded rapidly, leading to
numerous scientific and medical breakthroughs. Today, stem cell research is a highly active and
interdisciplinary field that brings together scientists from diverse backgrounds, including
biology, medicine, and engineering.
Overall, the historical context of st
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Identification and nursing management of congenital malformations .pptx
Dr. Juhi Saini
1. Stem cell mantra in
periodontal regeneration
Introduction
Restoration of tissues destroyed by periodontitis
to their original form and function has been a
long standing goal of periodontal therapy. This
poster discusses the clinical utility of stem cells
in periodontal regeneration by reviewing
relevant literature that assesses the
periodontal-regenerative potential of stem cells.
Slide No. 1 Dr. JUHI SAINI Poster No.16
2. Mesenchymal stem cell collection
Tooth
•Pulp
Bone marrow •Periodontal
ligament
Magnetically activated cell sorting (MACS) or Dynal bead
selection using STRO-1 antibody
Slide No. 2 Dr. JUHI SAINI Poster No.16
6. Conclusion
Stem cells in conjunction with different physical
matrices and growth factors, have the capacity
to regenerate periodontal tissues.It is this
combined and solid knowledge base that will
underpin future treatment modalities and
ultimately make stem cell-based tissue
engineering a realistic alternative in periodontal
regeneration.
Slide No. 6 Dr. JUHI SAINI Poster No.16
7. Conclusion
Stem cells in conjunction with different physical
matrices and growth factors, have the capacity
to regenerate periodontal tissues.It is this
combined and solid knowledge base that will
underpin future treatment modalities and
ultimately make stem cell-based tissue
engineering a realistic alternative in periodontal
regeneration.
Slide No. 6 Dr. JUHI SAINI Poster No.16