This document discusses the history and applications of calcium sulfate (CS). It summarizes that CS has been used for over 9,000 years in ancient Mesopotamia and Egypt. CS has a variety of construction, art, agriculture, food, cosmetic, and medical applications. In medicine, CS is used as a bioresorbable bone graft material that is osteoconductive and osteoinductive. CS promotes bone healing through its resorption properties and ability to release calcium ions and growth factors that promote bone growth.