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Development of Respiratory System
• It begins at the end of third week by formation of
endodermal laryngo-tracheal groove at floor of
pharynx caudal to hypobranchial eminence.
• Laryngotracheal tube is separated from foregut by
formation of tracheo-esophageal septum. This tube
elongates till the thorax.
• Upper part of the tube forms the mucus membrane
of larynx while lower part form mucus membrane
of trachea and bronchi.
• The lower end of the tube will divides to form 2
lung buds.
• Surrounding mesoderm will form muscles and
cartilages of larynx and trachea. Dr. Sherif
Formation of Lungs
• Each lung bud divides into 3 branches, but on left
side one of the branches disappears. Right lung has
3 lobes, left lung has 2 lobes.
• Each branch of the lung bud divides repeatedly to
form bronchioles and lastly alveoli.
• Blood vessels are formed from surrounding
mesoderm.
• Lung invades pleura from medial aspect, so pleura
surrounds lung by 2 layers.
• Expansion of lung occurs after birth when the baby
takes his first inspiration
Dr. Sherif Fahmy
2 lingual swellings
Tuberculum
impar
Foramen ceacum
Copul
a
Hypobranchial
eminence
Laryngeo-trachial
Pharynx
Respiratory
diverticulum
Dr. Sherif Fahmy
Laryngeo-
tracheal duct
esophagus
Dr. Sherif Fahmy
Laryngo-
tracheal
duct
Foregut
Tracheo-esophageal
ridges
Lung
buds
Dr. Sherif Fahmy
Dr. Sherif Fahmy
Congenital Anomalies
• 1- Tracheo-oesphageal fistula: Due to
incomplete formation of tracheo-
oesophageal septum.
• 2- variations in branching of lung bud:
Leads to extra or missed lobe and may be
missed lung.
• 3- Congenital cyst.
• 4- Esophageal atresia.
• 5- Respiratory distress syndrom.
Dr. Sherif Fahmy
Dr. Sherif Fahmy

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Development of Respiratory System (Special Embryology)

  • 1. Development of Respiratory System • It begins at the end of third week by formation of endodermal laryngo-tracheal groove at floor of pharynx caudal to hypobranchial eminence. • Laryngotracheal tube is separated from foregut by formation of tracheo-esophageal septum. This tube elongates till the thorax. • Upper part of the tube forms the mucus membrane of larynx while lower part form mucus membrane of trachea and bronchi. • The lower end of the tube will divides to form 2 lung buds. • Surrounding mesoderm will form muscles and cartilages of larynx and trachea. Dr. Sherif
  • 2. Formation of Lungs • Each lung bud divides into 3 branches, but on left side one of the branches disappears. Right lung has 3 lobes, left lung has 2 lobes. • Each branch of the lung bud divides repeatedly to form bronchioles and lastly alveoli. • Blood vessels are formed from surrounding mesoderm. • Lung invades pleura from medial aspect, so pleura surrounds lung by 2 layers. • Expansion of lung occurs after birth when the baby takes his first inspiration
  • 3. Dr. Sherif Fahmy 2 lingual swellings Tuberculum impar Foramen ceacum Copul a Hypobranchial eminence Laryngeo-trachial
  • 8. Congenital Anomalies • 1- Tracheo-oesphageal fistula: Due to incomplete formation of tracheo- oesophageal septum. • 2- variations in branching of lung bud: Leads to extra or missed lobe and may be missed lung. • 3- Congenital cyst. • 4- Esophageal atresia. • 5- Respiratory distress syndrom.