Introduction
Features
Fissures and Lobes
Root of the Lung
Differences b/w Right and Left Lungs
Arterial Supply of Lungs
Venous Drainage of Lungs
Lymphatic Drainage of Lungs
Nerve Supply
Bronchial Tree
Bronchopulmonary Segments
The lungs are a pair of spongy, air-filled organs located on either side of the chest (thorax). The trachea (windpipe) conducts inhaled air into the lungs through its tubular branches, called bronchi. The bronchi then divide into smaller and smaller branches (bronchioles), finally becoming microscopic.
The bronchioles eventually end in clusters of microscopic air sacs called alveoli. In the alveoli, oxygen from the air is absorbed into the blood. Carbon dioxide, a waste product of metabolism, travels from the blood to the alveoli, where it can be exhaled. Between the alveoli is a thin layer of cells called the interstitium, which contains blood vessels and cells that help support the alveoli.
Introduction
Features
Fissures and Lobes
Root of the Lung
Differences b/w Right and Left Lungs
Arterial Supply of Lungs
Venous Drainage of Lungs
Lymphatic Drainage of Lungs
Nerve Supply
Bronchial Tree
Bronchopulmonary Segments
The lungs are a pair of spongy, air-filled organs located on either side of the chest (thorax). The trachea (windpipe) conducts inhaled air into the lungs through its tubular branches, called bronchi. The bronchi then divide into smaller and smaller branches (bronchioles), finally becoming microscopic.
The bronchioles eventually end in clusters of microscopic air sacs called alveoli. In the alveoli, oxygen from the air is absorbed into the blood. Carbon dioxide, a waste product of metabolism, travels from the blood to the alveoli, where it can be exhaled. Between the alveoli is a thin layer of cells called the interstitium, which contains blood vessels and cells that help support the alveoli.
INTRODUCTION: Lungs are a pair of respiratory organs
2. lungs function and landmarks
3. related diseases
4. arterial and venous supply
5. Fissures and lobes
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. OBJECTIVE
• Explain the anatomy and neurovascular supply
to the trachea, bronchus and lung
• Know the anatomy of the trachea and the
central bronchial airways, as well as the
relations between its adjacent structures
4. INTRODUCTION
• from endodermal layer
• laryngotracheal diverticulum the
ventral foregut,
• begins on 4th week and
• complete maturation
approximately 8 years of age.
• Fetal breathing movements
observed at 20–21 weeks.
• surfactant
5.
6. TRACHEA
DEFINITION
• The trachea or a wind pipe is membranocartilaginous
tube which extends downwards as a continuation of
the larynx.
• It begins at the lower border of cricoid cartilage
opposite C6 , passes downward through the neck and
the superior mediastinem of the thorax, and ends by
dividing into right and left bronchi, opposite the sternal
angle.
7. • The bifurcation of trachea corresponds with
lower border of T4 In cadaver and in supine
position, but it extends to T6 in the living and
in standing position
8.
9. • In an adult person, the length is
between 10 and 13 cm,
• 18–22 cartilage rings
• the coronal diameter 2–2.5 cm,
• the sagittal diameter 1.4 to 1.8 cm
• Internal measurement 12mm in
adult.
• In newborn, 3mm which persists
upto 3yrs off life .
• There after the lumen increases by
1mm each year upto 12th year after
which it remains fairly constant.
13. • The total volume of tracheobronchial secretions
varies normally from 10 mL/d to 100 mL/d, under
the infuence of local irritants.
• Irritative substances to the mucosa, e.g. tobacco
smoke, may produce squamous metaplasia and
damage to the cilia.
14. Relation of the trachea
In the neck
A. anteriorly
1. Jugula venous arch crossing in the supra sternal space
2. sternohyoid and sternothyroid muscles
3. Isthmus of thyroid gland
4. Below the isthmus covered by pretracheal fascia inferior
thyroid vein, occasionally arteria thyrioidia ima
15. B. Posteriorly
1. Oesophagus
2. Recurrent laryngeal nerve
C. On each side
1. Lateral lobe of the thyroid gland
2. Common carotid and inferior thyroid arteries
16. IN THE THORAX
• Thoracic - in the superior mediastinum, 5-6 cm
– Anteriorly - brachiocephalic artery & left common carotid artery
– Posteriorly – esophagus and recurrent laryngeal nerves
– Left – arch of aorta, left common carotid and left subclavian arteries, left
recurrent and pleura
– Right - vagus, azgos vein and pleura
17. Arterial supply
• inferior thyroid artery
• which pass either anteriorly or posteriorly to
the recurrent laryngeal nerves
• bronchial arteries which arise from the
descending aorta
18.
19.
20. Venous and lymphatic drainage
• Mostly drain into inferior thyroid vein .
• Drain into pre-tracheal and para-tracheal
lympnodes
21. Nerve supply
• Parasympathetic nerves are derived from both
vagus and recurrent laryngeal nerves; are
– motor to trachealis ms ,
– secretomotor to glands and
– sensory to mucous membrane.
• Sympathetic (T1-T4) – smooth muscles (dilator)
and blood vessels (vasoconstrictors
22. BRONCHI AND LUNG
• the two principal bronchi
begin at the bifurcation of
trachea and enter the hilum
of the corresponding lung
• each bronchus connsists of
extra pulmonary and intra
pulmonary parts.
23. RIGHT BRONCHUS
• right bronchus is wider , shorter and more
vertical than the left bronchus
• length of extra pulmonary part is about 2cm
• it passes below the azygos vein, enters the
root of the right lung `and reaches the hilum
at the level of 5th thoracic vertebra
24.
25. • With in the lung , the principal bronchus divides
into secondary or lobar bronchi , one for each
lobe.
• Each secondary bronchus subdivides into
segmental or tertiary bronchi
26.
27. • The area of the lung aerated by a teritary
bronchus is known as bronchopulmonary
segment, which is an independent respiratory
district.
• A bronchopulmonary segment is the smallest
functionally independent region of a lung
28.
29. • Beyond the tertiary/segmental bronchi , there
are 20 to 25 generations of branching
conducting bronchioles that eventually end as
terminal bronchioles
30. • Each terminal bronchiole gives rise to
several generations of respiratory bronchioles,
characterized by scattered, thin-walled
outpocketings (alveoli) that extend from
their lumens.
31. • The pulmonary alveolus is the basic structural
unit of gas exchange in the lung. Due to the
presence of the alveoli, the respiratory
bronchioles are involved both in air
transportation and gas exchange.
32. • Each respiratory bronchiole gives rise to 2–11
alveolar ducts, each of which gives rise to 5–6
alveolar sacs. Alveolar ducts are elongated airways
densely lined with alveoli, leading to common spaces,
the alveolar sacs, into which clusters of alveoli open.
• New alveoli continue to develop until about age 8
years, by which time there are approximately 300
million alveoli.
33. Distribution of the right principal
bronchus
• Upper lobe bronchus (eparterial) aspect
• about 2cm distal to the bifurcation of trachea
• divides usually into three tertiary bronchi
apical , posterior and anterior
34.
35. • About 2cm below the origin of the upper lobe
bronchus , gives off from the front a lobar
bronchus to the middle lobe of the lung,
• where it divides into lateral and medial
tertiary bronchi.
36. • The middle lobe bronchus is long and
surrounded by a group of hilar lymph nodes
which drain lymphatics from middle and lower
lobes of right lung.
37. • Remaining part of supplies the lower lobe of
the right lung by five tertiary branches
1. Apical
2. Anterior basal
3. Middle basal
4. Posterior basal
5. Lateral basal
38. LEFT BRONCHUS
• left principal bronchus is longer, narrower, and
more horizontal than the right bronchus.
• length of extra pulmonary part is about 5cm.
• it enters the lung root and reaches the hilum
at the level of 6th thoracic vertebra.
39. INTRA PULMONARY PART
• The left principal bronchus divides into upper
and lower lobar bronchi to supply the
respective lobe of the left lung.
• upper lobar bronchus arises about 5cm distal
to bifurcation of trachea
• divides into ascending and descending
branches.
40. • ascending branches subdivides into three
tertiary bronchi, apical, posterior and anterior
• descending branch subdivides into upper and
lower lingular bronchi to supply the lingula
41. • lower lobe bronchus passes downwards, and
divides usually into four teritary bronchi
– apical,
– anterior basal,
– lateral basal and
– posterior basal.
42. Right bronchus Left bronchus
wider narrower
shorter longer
steeper More horizontal
2cm 5cm
43. Lung
• The two lungs are organs of respiration and lie
on either side of the mediastinum surrounded
by the right and left pleural cavities. Air enters
and leaves the lungs via main bronchi, which
are branches of the trachea.
44. Characteristic features
• Lung is porous, highly elastic and spongy in
texture
• It crepitates to touch and floats on water
• In still born lungs sink in water
• In newborn it is rosy pink
• In adult it is dark grey
45. • An apex, the blunt superior end of the lung
ascending above the level of the 1st rib into the
root of the neck that is covered by cervical
pleura.
• A base, the concave inferior surface of the lung,
opposite the apex, resting on and
accommodating the ipsilateral dome of the
diaphragm.
46. Lobes and fissures
• The right lung has three lobes (upper, middle
and lower) and
• two fissures (oblique and horizontal).
• In more than 50% of cases, the horizontal
fissure is incomplete and the middle lobe is
fused to the anterior part of the upper lobe.
47. • The left lung has two lobes (upper and lower)
separated by the oblique fissure
• The orientations of the oblique and horizontal
fissures determine where clinicians should
listen for lung sounds from each lobe
50. • When planning resection, surgeons look
carefully for the fissures on CT scans;
• they are usually visible and will indicate which
lobe contains a lesion and whether more than
one lobe is involved.
51. • Each lung has a half-cone shape, with a base,
apex, two surfaces, and three borders
52. • The two surfaces—the costal surface lies
immediately adjacent to the ribs and
intercostal spaces of the thoracic wall.
• The mediastinal surface lies against the
mediastinum anteriorly and the vertebral
column posteriorly
53. • The three borders—the inferior border of the
lung is sharp and separates the base from the
costal surface.
• The anterior and posterior borders separate the
costal surface from the medial surface.
54. Root and hilum
• The root of each lung is a short tubular collection
of structures that together attach the lung to
structures in the mediastinum. It is covered by a
sleeve of mediastinal pleura that reflects onto the
surface of the lung as visceral pleura.
• The region outlined by this pleural reflection on
the medial surface of the lung is the hilum, where
structures enter and leave.
55. • A thin blade-like fold of pleura projects
inferiorly from the root of the lung and
extends from the hilum to the mediastinum.
This structure is the pulmonary ligament.
56.
57.
58. Arterial supply
• Bronchial arteries
– right bronchial artery
• third posterior intercostal artery
• occasionally, it originates from the upper left bronchial artery
• Two left bronchial arteries
– anterior surface of the thoracic aorta
• Superior and inferior left bronchial artery
• The most distal branches of the bronchial arteries
anastomose with branches of the pulmonary arteries in
the walls of the bronchioles and in the visceral pleura.
59.
60. Venous drainage
• bronchial veins
– Superficial
• into the azygos vein on the right
• into the superior intercostal vein
or hemiazygos vein on the left.
– Deep
• Receive blood from
intrapulmonary bronchi and
bronchioles
• Terminate into one of the
pulmonary veins or directly into
the left atrium
61. Lymphatic drainage
– Superficial set
• Ramifies beneath the pulmonary pleura and around the
extra pulmonary bronchi, drains in to broncho pulmoonary
lymph nodes at the hilum
– Deep set is arranged around the intrapulmonary
bronchi and bronchiole,
• These lymphatics converge centripetally towards the hilum
and drain into bronchopulmunary lymph nodrs
• The lymph vessels in the interlobular septa communicate
with pleural lymphatics
62.
63. Innervation
• anterior pulmonary plexus and posterior
pulmonary plexu
• These interconnected plexuses lie anteriorly
and posteriorly to the tracheal bifurcation and
main bronchi.
• The anterior plexus is much smaller than the
posterior plexus.
64. • Parasympathetic preganglionic fibers
– Motor to airway smooth muscle (constriction), glands
(secretomotor), inhibitory to vascular smooth muscle
(vasodilation)
• Sympathetic fibers
– These are inhibitory to the smooth muscle and mucus
glands of bronchial tree.
These segments are separeted from one another by intersegmental areolar septa which prevent the spread of infection from one segment to the other
A segmental bronchus may branch 6 to 18 times to produce 50 to70 respiratorybronchioles, which merge with the alveolar sacs and terminate into alveoli constituting the lung parenchyma.
Each terminal bronchiole gives rise to several generations of respiratory bronchioles, characterized by scattered, thin-walled outpocketings (alveoli) that extend from their lumens.
Bronchioles lack cartilage in their walls. Conducting bronchioles transport air but lack glands or alveoli.
Essential organ of respiration
Each lung is invested by pulmonary pleura
The oblique fissure separates the lower lobe from the middle and upper lobes; it begins posteriorly at the level of the fifth rib and runs forward along the course of the sixth rib to the diaphragm.
The horizontal fissure separates the middle from the upper lobe; it begins in the oblique fissure in the mid-axillary line at the level of the sixth rib and runs anteriorly to the costochondral junction of the fourth rib.