Dengue fever is transmitted by the Aedes Aegypti mosquito and is caused by any of the five dengue virus serotypes. It causes diseases ranging from dengue fever to the more severe dengue hemorrhagic fever and dengue shock syndrome. There are 50 million infections annually resulting in 500,000 cases of dengue hemorrhagic fever and 22,000 deaths. There is currently no vaccine for dengue and treatment involves managing symptoms, with blood transfusions used for dengue hemorrhagic fever. The dengue virus is replicated inside host cells with proteins such as NS1, NS3, NS4B and NS5 playing important roles in viability and replication.

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Amjad Khan Afridi Date: 12th
May, 2017
DENGUE FEVER
THE DENGUE FEVER
 Dengue virus (DENV) belong to the Flavivirus genus of the Flaviviridae family.
 Transmitted by Aedes Aegypti.
 The disease:
 Dengue fever.
 Dengue hemorrhagic fever ( DHF).
 Dengue shock syndrome.
 Threats:
 50 million infections per year.
 500000 develop DHF.
 22000 deaths per year.
 Current treatment :
 No vaccine.
 Limited efficiency of antiviral drugs.
 Treatment for DHF is blood transfusion.
Dengue serotypes
 There are 5-dengue virus serotypes Den1- Den5.
 All dengue i.e flaviviruses have common group epitopes on the envelope proteins.
 Results in extensive cross- section of Ag and Ab complex.
TRANSMISSION:
 Global warming
 Virus unable to transmitted at <26c
 Peak season is 15 April---15 Oct
 Source is infected person
 Incubation period: 4---7 days

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Amjad Khan Afridi Date: 12th
May, 2017

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Amjad Khan Afridi Date: 12th
May, 2017
 NS1: it is imp for viability of den V. And is present in high conc, in blood of patient.
 NS3: it is a serine protease and RNA helicase and its co factor is NS2B.
 NS5: it codes for RNA dept RNA polymerase.
 NS4B: it is hydrophobic protein located in a association with ER. It blocks phosphorylation of
STAT1 (Signal transducer and activator of transcription) after induction by IF a, beta.
 NS2A, NS4A are cofactors.
Replication

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Amjad Khan Afridi Date: 12th
May, 2017
Symptoms of Dengue fever
Diagnosis and treatment:
 Dx: CBC,LFTs
 Dengue serology,PCR(Ns1)
 Treatment: panadol only, no antibiotics NSAIDs etc
 Fresh juices of fruits and papaya leaves are better to give.
Prepared by
Amjad Khan Afridi Date: 12th
May, 2017