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XI. Pathophysiology
Modifiable
•

Non- Modifiable
•

Environment uncovered

Gender

stock water

Bite of Aedes Aegypti
Virus penetration to skin
Virus infects and replicate inside the Langerhans cell (immunity of the skin)
Langerhans cell release interferon (to limit the spread of infection)
Infected Langerhans cells go to the lymphatic (alert the immune system)
Then goes to the circulation
Results in viremia (high level of virus in bloodstream)
Activation of immune response

Lymphocytes

Neutrophils and White blood cells
Release of pyrogen

Reset of hypothalamus
FEVER

Increase blood pressure in vessel
RASH

11

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Pathophy -Dengue Fever

  • 1. XI. Pathophysiology Modifiable • Non- Modifiable • Environment uncovered Gender stock water Bite of Aedes Aegypti Virus penetration to skin Virus infects and replicate inside the Langerhans cell (immunity of the skin) Langerhans cell release interferon (to limit the spread of infection) Infected Langerhans cells go to the lymphatic (alert the immune system) Then goes to the circulation Results in viremia (high level of virus in bloodstream) Activation of immune response Lymphocytes Neutrophils and White blood cells Release of pyrogen Reset of hypothalamus FEVER Increase blood pressure in vessel RASH 11