The document summarizes the pathophysiology of dengue fever. It involves the bite of the Aedes Aegypti mosquito, which transmits the dengue virus and allows it to penetrate the skin. The virus then infects and replicates inside Langerhans cells in the skin. Infected Langerhans cells travel to lymph nodes and alert the immune system. This leads to viremia as the virus spreads through the bloodstream. The immune response is activated, causing the release of pyrogens that trigger fever through the hypothalamus. It also causes an increase in blood pressure in vessels, resulting in the characteristic rash of dengue fever.

1. XI. Pathophysiology
Modifiable
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Non- Modifiable
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Environment uncovered
Gender
stock water
Bite of Aedes Aegypti
Virus penetration to skin
Virus infects and replicate inside the Langerhans cell (immunity of the skin)
Langerhans cell release interferon (to limit the spread of infection)
Infected Langerhans cells go to the lymphatic (alert the immune system)
Then goes to the circulation
Results in viremia (high level of virus in bloodstream)
Activation of immune response
Lymphocytes
Neutrophils and White blood cells
Release of pyrogen
Reset of hypothalamus
FEVER
Increase blood pressure in vessel
RASH
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