1. Treatment Supportive requires intensive care unit Not feasible in certain areas Not feasible in mass casualty events Limited treatment options Ribavirin is suggested treatment 30 mg/kg loading dose, followed by 15 mg/kg every 6 hours for 4 days, followed 7.5 mg/kg every 6hours for 6 days Not approved by the FDA Early recognition is key for mortality and transmission control

2. Transmission Hyalommagenus Demacentor genus Rhipicephalus genus Reservoir + Vector Mammals are amplifying hosts Animal blood and ticks are implicated in transmission. Nosocomial infections Sudan outbreak

3. Geographic Distribution of CCHF http://www.who.int/csr/disease/crimean_congoHF/Global_CCHFRisk_20080918.png

4. Vector (tick) and Disease (Lyme) Ixodesscapularis distribution Lyme disease Cases

5. Importance Most important disease causing Nairovirus Occurs in limited epidemics Fast induced disease with high CFR Widespread and ubiquitous vector Isolation for bioweapon?

6. Bibliography Aradaib IE, Erickson BR, Mustafa ME, Khristova ML, Saeed NS, Elageb RM, et al. Nosocomial outbreak of Crimean-Congo hemorrhagic fever, Sudan. Emerg Infect Dis. 2010 May Cleri DJ, Ricketti AJ, Porwancher RB, Ramos-Bonner LS, Vernaleo JR. Viral Hemorrhagic Fevers: Current Status of Endemic Disease and Strategies for Control. Infect. Dis. Dlin. N. Am. 20 (2006) 359-393 WHO. Crimean-Congo Hemorrhagic Fever. Accessed April 30, 2010. http://www.who.int/csr/disease/crimean_congoHF/Global_CCHFRisk_20080918.png