There are 5 dengue virus serotypes that can cause dengue fever in humans. The virus is transmitted by Aedes mosquitoes and cannot be transmitted below 26 degrees Celsius, with the peak season being April to October. Symptoms include fever, headaches, muscle and joint pains, and a rash. Diagnosis involves blood tests and dengue serology or PCR, while treatment focuses on pain relief and rest.

1. DENGUE FEVER

2. INTRODUCTION:

3. Dengue serotypes
There are 5-dengue virus serotypes
Den1- Den5.
All dengue i.e flaviviruses have
common group epitopes on the
envelope proteins.
Results in extensive cross- section of Ag
and Ab complex.

4. TRANSMISSION:
Global warming
Virus unable to transmitted at <26c
Peak season is 15 April---15 Oct
Source is infected person
Incubation period: 4---7 days

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11.  NS1: it is imp for viability of den V. And is
present in high conc, in blood of patient.
 NS3: it is a serine protease and RNA helicase and
its co factor is NS2B.
 NS5: it codes for RNA dept RNA polymerase.
 NS4B: it is hydrophobic protein located in a
association with ER. It blocks phosphorylation
of STAT1 (Signal transducer and activator of
transcription) after induction by IF a, beta.
 NS2A, NS4A are cofactors.
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12. Replication

13. DEN mosquitoe aedes

14. Symptoms of den fever

15. Symptoms:

16. Diagnosis and treatment:
Dx: CBC, LFTs
Dengue serology,PCR(Ns1)
Treatment: panadol only, no
antibiotics NSAIDs etc
Fresh juices of fruits and papaya leaves
are better to give.