This document summarizes research on Ranaviral disease pathology and physiology across different classes of animals. Key points include: 1) Lesions from Ranavirus infections often include hemorrhage, swelling and tissue necrosis across amphibians, reptiles and fish. 2) Host susceptibility and disease severity varies between virus isolates and host species. 3) Concurrent infections with other pathogens can influence Ranavirus disease progression. 4) Current research is characterizing Ranavirus pathogenesis in different hosts and exploring the effects of concurrent infections.