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2. Stem Cells Banking

5. What are sources/types of stem cells in the Human Body? 4.Cord Blood Stem Cells 1.Bone Marrow Stem Cells 2.Embryonic Stem cells 3.Peripheral Stem Cells 5.Cord Lining Stem Cells

8. Why not bone marrow stem cells if I ever require? Bone marrow Cord blood Old source of stem cells in use since 1950’s New source of stem cells since 1975 Harvested from pelvic / hip joint . Takes 4-6 hrs with side effects Harvested for Umbilical Cord (bio Medical waste). No harm to Mother or child Requires donation of a quart or more of bone marrow (mixed with blood) for transplant A few ounces can be used for transplantation. Large dose of stem cells. Rapid engraftment. Smaller dose of stem cells. Slower engraftment Potential donors may no longer be available or may have withdrawn consent. Donor must be found and retested to confirm the HLA typing and infectious disease results and to confirm that the donor is still willing and able to donate bone marrow. Significant donor attrition Once frozen, a cord blood unit is available until used. Otherwise, no donor attrition Generally requires a perfect match between donor and recipient for 6/6 HLA Generally requires a match between donor and recipient for 4/6 ,5/6 ,6/6 HLA After a formal search is begun, takes an average of 4 months to transplant, if a donor is available. When a match is found, can take only a few days for confirmatory and special testing and shipment to the Transplant Center (less than 24 hours in an emergency).

9. Understanding Umbilical cord blood and cord lining stem cells Cord Blood Cord lining Rich in Hematopoietic Stem Cells Rich in Mesenchymal Stem Cells Can differentiate into blood and immune cells Can differentiate into a variety of cell types Harvesting is easy and well defined As it is a new source harvesting is slow and manual, requires in house R&D for proper harvesting techniques

11. Therapy Stem cell Surgery Pharmaceutical

13. Therapy Focus

21. Future Applications

22. Indian hospitals offering stem cell therapies Hospital Area of Specialization AIMS Delhi Cardiac, Neuro Surgery, Vascular Surgery, Diabetes, Ophthalmology, cancer Christian College Vellore Cardiac, Diabetes L V Prasad eye inst Ophthalmology TATA Memorial Cancer Manipal Hospital, Bangalore Cardiac, Ophthalmology, Neurosurgery, Vascular Surgery, Diabetes, Cancers Life Line Hospital Cardiac Apollo Hospital Cardiac, Cancer