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7/29/2014 1
• SACHITA KHADKA
• RUPA SHRESTHA
• RASHMI GAUTAM
• RAMA PARIYAR
• RANJANA BC
• RADHA THAPA MAGAR
• RASHNA MAHARJAN
• RACHANA RAI
• RUBINA RAI
• PRATIVA KHADKA
7/29/2014 2
HOPE INTERNATIONAL
COLLEGE
PCL NURSING 3rd / 3rd BATCH
7/29/2014 3
UMBILICAL CORD
 The part of placenta
that delivers nutrients
to a fetus.
 It help fetus to survive
during intrauterine
period.
7/29/2014 4
INTRODUCTION
o Cord blood banking involves collecting blood left in
newborn’s umbilical cord and placenta and storing it
for future medical use .
o Cord blood contains potentially lifesaving cells called
STEM CELL.
7/29/2014 5
7/29/2014 6
Stem cell
 Stem cell are essentially the building blocks of the
human body .
 Stem cell is capable of dividing for long periods of time
, are unspecialized , but can develop into specialized
cells .
• The earliest stem cell inside an embryo will eventually
give rise to every cell , tissue and organ in the fetus’s
body .
When it divides , it can make any one of the different
cells in human body .
7/29/2014 7
7/29/2014 8
Stem cell
There are several types of
stem cells
 Embryonic stem cells
 Adult stem cells
 Induced pluripotent stem cells (IPSC)
 Umbilical cord blood stem cell
7/29/2014 9
7/29/2014 10
Embryonic stem cell Adult stem cell
Induced
pluripotent
stem cells
Umbilical cord
stem cell
Purposes:
o Two main purpose for cord
blood storage :
 Donate baby’s cord blood to a public cord blood
banking for anyone who needs its
 To store for baby’s cord blood bank for family’s
use .
7/29/2014 11
METHODS
There are two types and
they are ;
7/29/2014 12
Syringe method: a syringe is used to draw
blood from the umbilical cord shortly after the
umbilical cord has been cut. The process is similar to
drawing blood for a regular blood test .
7/29/2014 13
Syringe
method
7/29/2014 14
Bag method: The umbilical cord is elevated to
drain the blood into a bag. ( Anti-coagulate already
kept in the bag )
7/29/2014 15
Bag
method
7/29/2014 16
7/29/2014 17
 Most common method of cord blood is bag method
7/29/2014 18
COLLECTION
Cord blood is collected right after
birth.
The collection process is painless and
safe for both mother and baby .
In fact , it’s so quick and painless that
parents caught up in holding and
bonding with their baby are often
unaware it has even happened .
7/29/2014 19
PROCESS
 Clamping and cutting the cord :
After the delivery of the baby whether vaginally
or by C-section , the cord is clamped and then cut in
usual way .
7/29/2014 20
Contd……
 Extracting the cord blood :
The medical provider then inserts a needle into
the umbilical vein on the part of the cord that’s still
attached to the placenta . The needle doesn’t go
anywhere near the baby .
The blood drains into a collection bag .
Typically , entire umbilical blood are collected . The
entire process takes less than 5 minutes .
7/29/2014 21
Contd……
 Off to the bank :
The blood is transfer to a cord blood bank ,
where it is tested , processed , and cryopreserved
(preserved by controlled freezing) for long-term storage.
Some family cord blood banks now offer to
collect a segment of umbilical cord tissue contains stem
cells , and researchers are studying their possible .
7/29/2014 22
VALUABLE OF CORD
BLOOD
 Cord blood is a rich source of blood
stem cells .
Stem cells are the building blocks of
the blood and immune system .
They have the ability to develop into
other types of cells , so they can help
to repair tissue , organs , and blood
vessels and can be used to treat a host
of diseases .
7/29/2014 23
Contd……
 Stem cells are also found in bone
marrow, human embryos , fetal tissue
, hair follicles , baby teeth , fat ,
circulating blood , and muscle .
 Every part of the human body
contains some stem cells , but most
are not a rich enough source to have
be harvest for therapeutic
applications.
7/29/2014 24
Contd……
 In 2012 , 38 % of Haspanic (spanish people in ancient
time )patient and 44% of African American patients
undergoing stem cell transplants received cord blood .
 More and more adults are receiving cord blood
transplants , too , sometimes involving two cord blood
donations if a single one doesnot contains enough
cells.
 As the end of 2012 , more than 33,900 cord blood units
had been transfer for transplants worldwise .
7/29/2014 25
TREATED DISEASES
Cord blood stem have been used
successfully to treat more than 75
different diseases , inculding:
 Some cancers
 Blood disorders
 Immune deficiencies
7/29/2014 26
Contd……
Among theses are ;
 Leukemia
Aplastic anemia
Thalassemia
 Hodgkin’s diseases
 Non-Hodgkin’s Lymphoma
7/29/2014 27
7/29/2014 28
Contd……
 Cord transplants are also
used to treat rare metabolic
disorder that would otherwise
be fatal for infants .
7/29/2014 29
POSSIBLE FUTURE USES
Studies are under way around the world
to explore new ways of using cord blood ;
Cerebral palsy and autism
Hydrocephalus
Treatment for adults
 Animal studies
7/29/2014 30
PARENTS NEED TO
KNOW
The fields of medical research with stem cells is
exploding .
The most important thing for parents to understand
about the stem cells in cord blood , by Frances Verter
(founder and executive director of the nonprofit parent’s
guide to Cord Blood Foundation );
1. Donate the baby’s cord blood to help patients seeking
transplants now or
7/29/2014 31
Contd……
2. Save the baby’s cord blood for the family in case the
need it later , most likely for a therapy that’s still being
studied .
7/29/2014 32
STORAGE
 After the collection (entire placenta and cord’s
blood collection should be done) , lab process start
through cryopreserved.
 There are many ways to process a cord blood until
, and there are differing opinions on what is the
best ways .
 Some processing methods separate out the red
blood cells and remove them , while others keeps
the red blood cells .
7/29/2014 33
Cont.……
 However the unit is processed , a cryopreservant is
added to the cord blood to allow the cells to
survive the cryogenic process.
 After the unit is slowly cooled to -90oC , it can
then be added to a liquid nitrogen tank which will
keep the cord blood unit frozen at -196oC .
 The slow freezing process is important to keep the
cells alive during the freezing process.
7/29/2014 34
Contd……
 More than 1 million units of cord blood are stored
in family banks in the United States .
 And the national Be the match Registry provides
nearly 1,85,000 donated cord blood units in the
United States , with additional access to more than
4,25,000 cord blood units through partnerships
with international registries .
7/29/2014 35
Contd……
 Verter estimates that about 5% of parents now
bank their bank’s cord blood . 90% of that cord
blood goes to family and 10% goes to public banks .
7/29/2014 36
ADVANTAGES
 Cord blood stem cells are currently used
o several life-threatening diseases
o blood and immune system related genetic diseases ,
cancer and blood disorder .
 Cord blood stem cells can also be used for siblings and
other members of the family who have a matching
tissue type .
 Siblings (75% )chance of compatibility , and the cord
blood may even be a match for parents (50%) and
grandfather .
7/29/2014 37
• PUBLIC BANKS
A primary concern with public banking is
how to ensure the safety of the cord blood .
Because of privacy concerns , it is agreed by
most ethical reviews boards that blood
donated to a public bank cannot be
permanently linked to the donor.
7/29/2014 38
PRIVATE BANKS
Private banking is costly to insures and
private parties , averaging .
 The ability to use the cord blood may also
depend on long-term commerical viability
of the enterprise .
7/29/2014 39
Contd……
 It is important to ensure the credentials of
any potential private bank .
 In the United States , the Food and Drugs
Administration regulates cord blood under
the category of “Human Cells , Tissues ,
and Cellular and Tissue Based –Products .
7/29/2014 40
Contd……
The odds that two siblings will have the
6/6 match required for a bone marrow
transplant are 25% .
The odds that two siblings will have the
4/6 match required for a cord blood
transplant are 39 % .
7/29/2014 41
• SAFETY AND EFFECTIVENESS
oUsing one’s own cord blood cells might
not wise or effective , especially in cases
of childhood cancers and leukemia .
o Children who develop an
immunological disorder often are
unable to use their own cord blood for
transplant because the blood also
contains the same genetic defect .
7/29/2014 42
• USABILITY OF ONE’S OWN
SAMPLE UNKNOWN
oMost cord blood samples up to 75%
may be too small to be used for
transplantation because they don’t
contain enough stem cell .
o While a private bank will store a
sample , the sample may be too small
to be usable , even by a child .
7/29/2014 43
cord blood banking cost
There are usually two fees involved in
cord blood banking;.
 The first is the initial fee which covers
enrollment, collection and storage for at
least the first year.
The second is an annual storage fee.
Some facilities vary the initial fee based
upon the length of a predetermined
period of storage.
7/29/2014 44
Contd……
 Depending on the predetermined
period of storage, the initial fee can
range from $900 to $2100.
Annual storage fees after the initial
storage fee are approximately $100 .
7/29/2014 45
Contd……
 It is common for storage facilities
to offer prepaid plans at a discount
and payment plans to help make
the initial storage a more attractive
option for baby and the family .
7/29/2014 46
AVAILABLE SERVICE IN
NEPAL
 Cord blood banking established in Nepal at
2008 A.D .
 Cord blood immediately courier at store/lab
in INDIA within 48 hours .
 Interested parents should inform the
specialist during 5-7 months of pregnancy ,
need to pay Rs.20,000 then at the time of
delivery need to pay Rs.58,000 ( TOTAL
AMOUNT IN NEPAL FOR CORD BLOOD
BANKING IS Rs.78,000 ) .
7/29/2014 47
AVAILABLE CORD BLOOD
BANKS
COUNTRIES NAME ESTABHLISHED DATE
FLORIDA 1983 A.D
GENEVA 1989 A.D
INDIA 2006 A.D
BANGKOK 2008 A.D
KENYA 2011 A.D
SINGAPORE 2013 A.D
7/29/2014 48
7/29/2014 49
7/29/2014 50
BABY
PARENTS
GRAND
PARENTS
PARENTS
SIBILING
BABY
SIBILING
MATERNAL PATERNAL
7/29/2014 51
REFERENCES
 http/www.wikipedia.com/cord blood banking
 CRYOBANKS premier cord blood bank , Cryobanks
International India Pvt.Ltd.
 Mrs . Subedi Durga , Midwifery part I , Wanmaya
Publication And Research Center , 1st 2010 March , page
no – 95 – 98
 Mr. Pankaj Chawla Professor of cord blood banking
,Gyaneshwor , phone no. : 9802031233
7/29/2014 52
7/29/2014 53

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Cord blood banking

  • 2. • SACHITA KHADKA • RUPA SHRESTHA • RASHMI GAUTAM • RAMA PARIYAR • RANJANA BC • RADHA THAPA MAGAR • RASHNA MAHARJAN • RACHANA RAI • RUBINA RAI • PRATIVA KHADKA 7/29/2014 2 HOPE INTERNATIONAL COLLEGE PCL NURSING 3rd / 3rd BATCH
  • 4. UMBILICAL CORD  The part of placenta that delivers nutrients to a fetus.  It help fetus to survive during intrauterine period. 7/29/2014 4
  • 5. INTRODUCTION o Cord blood banking involves collecting blood left in newborn’s umbilical cord and placenta and storing it for future medical use . o Cord blood contains potentially lifesaving cells called STEM CELL. 7/29/2014 5
  • 7. Stem cell  Stem cell are essentially the building blocks of the human body .  Stem cell is capable of dividing for long periods of time , are unspecialized , but can develop into specialized cells . • The earliest stem cell inside an embryo will eventually give rise to every cell , tissue and organ in the fetus’s body . When it divides , it can make any one of the different cells in human body . 7/29/2014 7
  • 9. There are several types of stem cells  Embryonic stem cells  Adult stem cells  Induced pluripotent stem cells (IPSC)  Umbilical cord blood stem cell 7/29/2014 9
  • 10. 7/29/2014 10 Embryonic stem cell Adult stem cell Induced pluripotent stem cells Umbilical cord stem cell
  • 11. Purposes: o Two main purpose for cord blood storage :  Donate baby’s cord blood to a public cord blood banking for anyone who needs its  To store for baby’s cord blood bank for family’s use . 7/29/2014 11
  • 12. METHODS There are two types and they are ; 7/29/2014 12
  • 13. Syringe method: a syringe is used to draw blood from the umbilical cord shortly after the umbilical cord has been cut. The process is similar to drawing blood for a regular blood test . 7/29/2014 13
  • 15. Bag method: The umbilical cord is elevated to drain the blood into a bag. ( Anti-coagulate already kept in the bag ) 7/29/2014 15
  • 18.  Most common method of cord blood is bag method 7/29/2014 18
  • 19. COLLECTION Cord blood is collected right after birth. The collection process is painless and safe for both mother and baby . In fact , it’s so quick and painless that parents caught up in holding and bonding with their baby are often unaware it has even happened . 7/29/2014 19
  • 20. PROCESS  Clamping and cutting the cord : After the delivery of the baby whether vaginally or by C-section , the cord is clamped and then cut in usual way . 7/29/2014 20
  • 21. Contd……  Extracting the cord blood : The medical provider then inserts a needle into the umbilical vein on the part of the cord that’s still attached to the placenta . The needle doesn’t go anywhere near the baby . The blood drains into a collection bag . Typically , entire umbilical blood are collected . The entire process takes less than 5 minutes . 7/29/2014 21
  • 22. Contd……  Off to the bank : The blood is transfer to a cord blood bank , where it is tested , processed , and cryopreserved (preserved by controlled freezing) for long-term storage. Some family cord blood banks now offer to collect a segment of umbilical cord tissue contains stem cells , and researchers are studying their possible . 7/29/2014 22
  • 23. VALUABLE OF CORD BLOOD  Cord blood is a rich source of blood stem cells . Stem cells are the building blocks of the blood and immune system . They have the ability to develop into other types of cells , so they can help to repair tissue , organs , and blood vessels and can be used to treat a host of diseases . 7/29/2014 23
  • 24. Contd……  Stem cells are also found in bone marrow, human embryos , fetal tissue , hair follicles , baby teeth , fat , circulating blood , and muscle .  Every part of the human body contains some stem cells , but most are not a rich enough source to have be harvest for therapeutic applications. 7/29/2014 24
  • 25. Contd……  In 2012 , 38 % of Haspanic (spanish people in ancient time )patient and 44% of African American patients undergoing stem cell transplants received cord blood .  More and more adults are receiving cord blood transplants , too , sometimes involving two cord blood donations if a single one doesnot contains enough cells.  As the end of 2012 , more than 33,900 cord blood units had been transfer for transplants worldwise . 7/29/2014 25
  • 26. TREATED DISEASES Cord blood stem have been used successfully to treat more than 75 different diseases , inculding:  Some cancers  Blood disorders  Immune deficiencies 7/29/2014 26
  • 27. Contd…… Among theses are ;  Leukemia Aplastic anemia Thalassemia  Hodgkin’s diseases  Non-Hodgkin’s Lymphoma 7/29/2014 27
  • 29. Contd……  Cord transplants are also used to treat rare metabolic disorder that would otherwise be fatal for infants . 7/29/2014 29
  • 30. POSSIBLE FUTURE USES Studies are under way around the world to explore new ways of using cord blood ; Cerebral palsy and autism Hydrocephalus Treatment for adults  Animal studies 7/29/2014 30
  • 31. PARENTS NEED TO KNOW The fields of medical research with stem cells is exploding . The most important thing for parents to understand about the stem cells in cord blood , by Frances Verter (founder and executive director of the nonprofit parent’s guide to Cord Blood Foundation ); 1. Donate the baby’s cord blood to help patients seeking transplants now or 7/29/2014 31
  • 32. Contd…… 2. Save the baby’s cord blood for the family in case the need it later , most likely for a therapy that’s still being studied . 7/29/2014 32
  • 33. STORAGE  After the collection (entire placenta and cord’s blood collection should be done) , lab process start through cryopreserved.  There are many ways to process a cord blood until , and there are differing opinions on what is the best ways .  Some processing methods separate out the red blood cells and remove them , while others keeps the red blood cells . 7/29/2014 33
  • 34. Cont.……  However the unit is processed , a cryopreservant is added to the cord blood to allow the cells to survive the cryogenic process.  After the unit is slowly cooled to -90oC , it can then be added to a liquid nitrogen tank which will keep the cord blood unit frozen at -196oC .  The slow freezing process is important to keep the cells alive during the freezing process. 7/29/2014 34
  • 35. Contd……  More than 1 million units of cord blood are stored in family banks in the United States .  And the national Be the match Registry provides nearly 1,85,000 donated cord blood units in the United States , with additional access to more than 4,25,000 cord blood units through partnerships with international registries . 7/29/2014 35
  • 36. Contd……  Verter estimates that about 5% of parents now bank their bank’s cord blood . 90% of that cord blood goes to family and 10% goes to public banks . 7/29/2014 36
  • 37. ADVANTAGES  Cord blood stem cells are currently used o several life-threatening diseases o blood and immune system related genetic diseases , cancer and blood disorder .  Cord blood stem cells can also be used for siblings and other members of the family who have a matching tissue type .  Siblings (75% )chance of compatibility , and the cord blood may even be a match for parents (50%) and grandfather . 7/29/2014 37
  • 38. • PUBLIC BANKS A primary concern with public banking is how to ensure the safety of the cord blood . Because of privacy concerns , it is agreed by most ethical reviews boards that blood donated to a public bank cannot be permanently linked to the donor. 7/29/2014 38
  • 39. PRIVATE BANKS Private banking is costly to insures and private parties , averaging .  The ability to use the cord blood may also depend on long-term commerical viability of the enterprise . 7/29/2014 39
  • 40. Contd……  It is important to ensure the credentials of any potential private bank .  In the United States , the Food and Drugs Administration regulates cord blood under the category of “Human Cells , Tissues , and Cellular and Tissue Based –Products . 7/29/2014 40
  • 41. Contd…… The odds that two siblings will have the 6/6 match required for a bone marrow transplant are 25% . The odds that two siblings will have the 4/6 match required for a cord blood transplant are 39 % . 7/29/2014 41
  • 42. • SAFETY AND EFFECTIVENESS oUsing one’s own cord blood cells might not wise or effective , especially in cases of childhood cancers and leukemia . o Children who develop an immunological disorder often are unable to use their own cord blood for transplant because the blood also contains the same genetic defect . 7/29/2014 42
  • 43. • USABILITY OF ONE’S OWN SAMPLE UNKNOWN oMost cord blood samples up to 75% may be too small to be used for transplantation because they don’t contain enough stem cell . o While a private bank will store a sample , the sample may be too small to be usable , even by a child . 7/29/2014 43
  • 44. cord blood banking cost There are usually two fees involved in cord blood banking;.  The first is the initial fee which covers enrollment, collection and storage for at least the first year. The second is an annual storage fee. Some facilities vary the initial fee based upon the length of a predetermined period of storage. 7/29/2014 44
  • 45. Contd……  Depending on the predetermined period of storage, the initial fee can range from $900 to $2100. Annual storage fees after the initial storage fee are approximately $100 . 7/29/2014 45
  • 46. Contd……  It is common for storage facilities to offer prepaid plans at a discount and payment plans to help make the initial storage a more attractive option for baby and the family . 7/29/2014 46
  • 47. AVAILABLE SERVICE IN NEPAL  Cord blood banking established in Nepal at 2008 A.D .  Cord blood immediately courier at store/lab in INDIA within 48 hours .  Interested parents should inform the specialist during 5-7 months of pregnancy , need to pay Rs.20,000 then at the time of delivery need to pay Rs.58,000 ( TOTAL AMOUNT IN NEPAL FOR CORD BLOOD BANKING IS Rs.78,000 ) . 7/29/2014 47
  • 48. AVAILABLE CORD BLOOD BANKS COUNTRIES NAME ESTABHLISHED DATE FLORIDA 1983 A.D GENEVA 1989 A.D INDIA 2006 A.D BANGKOK 2008 A.D KENYA 2011 A.D SINGAPORE 2013 A.D 7/29/2014 48
  • 52. REFERENCES  http/www.wikipedia.com/cord blood banking  CRYOBANKS premier cord blood bank , Cryobanks International India Pvt.Ltd.  Mrs . Subedi Durga , Midwifery part I , Wanmaya Publication And Research Center , 1st 2010 March , page no – 95 – 98  Mr. Pankaj Chawla Professor of cord blood banking ,Gyaneshwor , phone no. : 9802031233 7/29/2014 52