This document summarizes 14 chest radiology cases presented at a case conference. Case 1 involved a 30-year-old male with severe diffuse alveolitis and inflammatory nodules consistent with pulmonary inhalational injury. Case 2 involved a 33-year-old female with diffuse ground-glass opacities concerning for interstitial edema, pneumonia, or acute injury. Unfortunately, the first patient in Case 2 succumbed to her illness. Case 3 involved a 39-year-old female with centrally distributed ground-glass opacity concerning for pulmonary edema or infection. Case 4 involved a 39-year-old female with reduced ejection fraction consistent with cardiogenic pulmonary edema.
Bronchiectasis is a long-term condition where the airways of the lungs become abnormally widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection.
In bronchiectasis , one or more of bronchi are abnormally widened . Damage caused to the lungs by bronchiectasis is permanent.
Bronchiectasis – first described- rené Laennec (inventor – stethoscope).
Dynamic Central Airway Obstruction: Tracheomalacia, Tracheobronchomalacia, An...Bassel Ericsoussi, MD
Dynamic Central Airway Obstruction: Tracheomalacia, Tracheobronchomalacia, And Excessive Dynamic Airway Collapse: Classification, Diagnosis, and Treatment
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
Do Not Forget To Visit Our Pages On Facebook on the following Links:
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Bronchiectasis is a long-term condition where the airways of the lungs become abnormally widened, leading to a build-up of excess mucus that can make the lungs more vulnerable to infection.
In bronchiectasis , one or more of bronchi are abnormally widened . Damage caused to the lungs by bronchiectasis is permanent.
Bronchiectasis – first described- rené Laennec (inventor – stethoscope).
Dynamic Central Airway Obstruction: Tracheomalacia, Tracheobronchomalacia, An...Bassel Ericsoussi, MD
Dynamic Central Airway Obstruction: Tracheomalacia, Tracheobronchomalacia, And Excessive Dynamic Airway Collapse: Classification, Diagnosis, and Treatment
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
Do Not Forget To Visit Our Pages On Facebook on the following Links:
https://www.facebook.com/groups/569435236444761/
AND
https://www.facebook.com/groups/690331650977113/
Slides of 60 Seconds To Diagnosis Finals. An intercollegiate quiz on Medicine. Very informative and Self inspiring Quiz. Self learning for PG aspirants and Medicine enthusiasts.
PNEUMONIA,
DEFINITION
Pneumonia is an infection of the pulmonary parenchyma.
To the pathologist, pneumonia is an infection of the alveoli ,distal airways, and interstitium of the lung that is manifested by increased weight of the lungs, replacement of normal lung’s sponginess by consolidation ,and alveoli filled with white blood cells ,red blood cells and fibrin .To the clinician, pneumonia is a constellation of symptoms and signs in combination with at least one opacity on CXR.
Epidemiology
Between 5 and 10 million cases of infectious pneumonia occur annually in the United States and result in more than 1 million hospitalizations.
Pneumonia is a leading cause of death worldwide, the sixth leading cause of death in the United States, and the most common lethal infectious disease.
Bronchiectasis and Role of Surgical Management.pptxRohanReddy66
The pathophysiology and management aspects of Brtonchiectasis are outlined; emphasis on indications of surgery, types of surgery and their implications.
Oncologic18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) / computed tomography (CT)
essential for initial cancer staging and treatment monitoring
Focal FDG activity is a sensitive tool to localize malignant process
Focal FDG activity can be physiologic or non-malignant process (infection, inflammation)
Cardiac FDG uptake
Often not evaluated for oncologic PET-CT due to variable uptake pattern
Physiologic findings can include diffusely increased, focally increased, or regionally increased uptake
Differentiating malignant and non-malignant causes of focal cardiac FDG activity is important, as it can prevent unnecessary diagnostic steps and treatment
WHITEOUT LEFT HEMITHORAX: WHAT DO YOU THINK IS GOING ON HERE?Jayanth Hiremagalur
Hepatic hydrothorax (HH) is a rare cause of unilateral pleural effusion generally seen in patients withcirrhosis who do not have other reasons to explain their effusion.1 Most commonly HH presents in patients with ascites andtypically results in right sided pleural effusion; however, we detail a unique case below of left sided HH seen in the absence of ascites.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
5. IMPRESSION:
• 1. Severe diffuse alveolitis and inflammatory nodules
consistent with pulmonary parenchymal inhalational
injury. No pneumothorax.
•
2. Trachea and central bronchi are patent.
6. FINDINGS
• Ground glass centri lobular nodules.
• Apical predominance
• So likely route of exposure via airway
11. IMPRESSION:
•
1. Diffuse bilateral groundglass opacities with
peribronchial thickening concerning for interstitial edema
which may be cardiogenic (correlate with BNP) versus
atypical pneumonia versus acute noxious injury .
2. Trace pericardial effusion.
3. No CT evidence for pulmonary embolism or aortic
dissection.
12. Better
• 1. Is there Cardiogenic pulmonary edema.
• 2. Is there PH?
• 3. Is there centrilobular nodules?
• 4. Is there pleural effusion, etc or other signs of
pulmonary edema?
16. IMPRESSION:
1. Bilateral segmental and subsegmental pulmonary embolism
with left lobar pulmonary embolism. There is straightening of the
intraventricular septum, consistent with right heart strain. Mild
cardiomegaly.
2. Diffuse bilateral airspace opacities with bilateral crazy paving
and subpleural sparing. Findings are highly concerning for
bilateral multifocal pneumonia.
3. Reactive hilar lymphadenopathy.
18. Marijuana induced acute necrotizing
bronchiolitis- unfortunately first patient
succumbed to her illness.
19. Ivan A. Morales, Caralee J. Forseen, Paul W. Biddinger, Jayanth H. Keshavamurthy, Norman B. Thomson, Thomas Fortson
Medical College of Georgia at Augusta University
Augusta, GA
• Use of marijuana for recreational and medicinal
purposes has been prevalent for thousands of
years in many cultures
• Advent prior to 2700 BCE in China
• Recent data shows trends of increased use
worldwide
• Lifetime use in the U.S. reached a prevalence of
42.8%
• Marijuana's safety is brought into question
• Here we describe a case necrotizing
bronchiolitis after marijuana use
• With other etiologies ruled out, this case was an
example of necrotizing bronchiolitis secondary
to inhalation of noxious stimuli likely from the
marijuana from a new dealer
• Marijuana has been shown to have a wide
variety of beneficial uses, but the question
remains, is it safe?
• Inhalation of the smoke produced by igniting
marijuana is the most common route for use
• Combustion of marijuana emits hundreds of
compounds, including the primary psychoactive
ingredient THC and over 100 other cannabinoids
• Marijuana smoke also deposits tar and an array
of noxious chemicals including NH3, HCN, NOx,
aromatic amines, and polycyclic aromatic
hydrocarbons at equal or higher concentrations
than tobacco smoke
• Respiratory symptoms including chronic cough,
bronchitis, and wheezing were reported at
similar percentages for marijuana and tobacco
smokers
• Analysis of respiratory mucosa biopsies in
marijuana smokers show extensive airway
inflammation comparable to tobacco smokers,
which is likely responsible for the increased
respiratory symptoms
1. United Nations Office on Drugs and Crime. World Drug Report 2014. United Nations publication,
Sales No. E.14.XI.7.
2. Joshi M, et al. Marijuana and Lung Diseases. Curr Opin Pulm Med. 2014; 20(2): 173-9.
3. Moir D, et al. A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke
produced under two machine smoking conditions. Chem Res Toxicol. 2008; 21(2):494-502.
4. Moore, BA et al. Respiratory Effects of Marijuana and Tobacco Use in a U.S. Sample. J Gen Intern
Med. 2005; 20(1): 33–37.
5. Tetrault, JT, et al. Effects of Marijuana Smoking on PulmonaryFunction and Respiratory
Complications: A Systematic Review . Arch Intern Med. 2007; 167(3): 221–228.
Marijuana: Is It Safe?
A Case of Fatal Necrotizing Bronchiolitis
• 31-year-old female presented to the emergency department (ED) with shortness of breath, cough, and chest
pain for 2 weeks
• Diagnosed with an upper respiratory infection at an urgent care clinic 4 days prior and prescribed a steroid
taper and azithromycin with no improvement
• History of cigarette smoking 1 pack/day and smoking marijuana
• In the ED she has a pulse of 110 bpm, a respiratory rate of 24 breaths/min, and a SaO2 of 77% on room air.
• Lungs clear to auscultation
• Laboratory findings showed ↑ WBC count, ↑ BNP of 223, and ↑ troponin of 0.24.
• Portable CXR demonstrated nodular changes bilaterally (below)
• Echocardiogram revealed no abnormalities
• CTA revealed no evidence of pulmonary embolism but showed severe diffuse bilateral groundglass
opacification with diffuse centrilobular nodules (below)
• Treatment for pneumonia was initiated
• Lung biopsies revealed necrotizing bronchiolitis associated with diffuse interstitial and intralveolar pneumonia
• The samples were negative for fungi, acid-fast bacilli, bacteria, HSV 1/2, and CMV
• Inhalation of a toxic substance was suspected
• Patient admitted to smoking marijuana from a new dealer 2 weeks ago when the symptoms began
• Unfortunately, she succumbed to her illness due to diminished gas exchange from severe acute necrotizing
bronchiolitis.
Conclusion
Discussion
References
Introduction Clinical Presentation
AP Portable Chest X-Ray:
Demonstrated nodular changes bilaterally with no
consolidation
CT Angiogram:
Revealed no evidence of pulmonary embolism
Showed severe diffuse bilateral groundglass
opacification with diffuse centrilobular nodules,
bronchiolar thickening, and interspersed
parenchymal blebs.
A. Diffuse effacement of lung architecture and
bronchiole containing necrotic cell debri,
macrophages, and lymphocytes
B. Bronchiole showing squamous metaplasia,
necrotic cell debris; intralveolar inflammatory
exudate
A. B.
24. IMPRESSION
1. Centrally distributed groundglass opacity involving all lobes
possibly representing pulmonary edema, but multilobar infection is
a concern given leukocytosis. Specifically, there are no cavitary
lesions to suggest septic emboli.
2. Mild centrilobular emphysema with 6 mm right lower lobe
pulmonary nodule.
3. Likely reactive prominent mediastinal and hilar lymph nodes.
4. Multivessel coronary artery calcifications advanced for the
patient's age.
30. Echo
• Compared to prior echo done
The left ventricle is mildly dilated with normal wall thickness.
There are multiple wall motion abnormalities; the
anteroapical area appears
more hypokinetic than on previous echo 11/2014.
• Left ventricular systolic function is moderately to severely
reduced;ejection fraction is 31% by the biplane method of
disks.
The left ventricular filling pattern is pseudonormal.