Benign ovarian masses include functional cysts and tumors; most are asymptomatic.Most functional cysts and benign tumors are asymptomatic. Sometimes they cause menstrual abnormalities. Hemorrhagic corpus luteum cysts may cause pain or signs of peritonitis, particularly when they rupture. Occasionally, severe abdominal pain results from adnexal torsion of a cyst or mass, usually > 4 cm. Treatment varies depending on the patient's reproductive status.
Benign ovarian masses include functional cysts and tumors; most are asymptomatic.Most functional cysts and benign tumors are asymptomatic. Sometimes they cause menstrual abnormalities. Hemorrhagic corpus luteum cysts may cause pain or signs of peritonitis, particularly when they rupture. Occasionally, severe abdominal pain results from adnexal torsion of a cyst or mass, usually > 4 cm. Treatment varies depending on the patient's reproductive status.
Role of hrct in interstitial lung diseases pk uploadDr pradeep Kumar
Role of hrct in interstitial lung diseases pk , This is best powerpoint slides presentation including Latest American thoracic society and fleishners society guidelines . this includes radiographic images a well HRCT chest findings of various ILD. This will help alot for md pg radiology resident and radiologist. Thanks
types of lymphomas, imaging modalities, imaging features of lymphomas, treatment follow up and pulmonary lymphoproliferative disorders and their imaging findings.
Oncologic18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) / computed tomography (CT)
essential for initial cancer staging and treatment monitoring
Focal FDG activity is a sensitive tool to localize malignant process
Focal FDG activity can be physiologic or non-malignant process (infection, inflammation)
Cardiac FDG uptake
Often not evaluated for oncologic PET-CT due to variable uptake pattern
Physiologic findings can include diffusely increased, focally increased, or regionally increased uptake
Differentiating malignant and non-malignant causes of focal cardiac FDG activity is important, as it can prevent unnecessary diagnostic steps and treatment
WHITEOUT LEFT HEMITHORAX: WHAT DO YOU THINK IS GOING ON HERE?Jayanth Hiremagalur
Hepatic hydrothorax (HH) is a rare cause of unilateral pleural effusion generally seen in patients withcirrhosis who do not have other reasons to explain their effusion.1 Most commonly HH presents in patients with ascites andtypically results in right sided pleural effusion; however, we detail a unique case below of left sided HH seen in the absence of ascites.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Bronchus-associated lymphoid
tissue lymphoma
• Primary pulmonary lymphoma is distinguished from the
more common secondary pulmonary lymphoma by lack
of extrapulmonary involvement.
• BALT lymphoma is the most common type of primary
pulmonary lymphoma.
• In a case of chronic multifocal consolidation or multiple
pulmonary nodules, BALT lymphoma should be
included in the differential diagnosis.
3. • Bronchus-associated lymphoid tissue (BALT) lymphoma is a rare
subtype of primary non-Hodgkin lymphoma that may occur within the
lung.
• BALT lymphoma has variable imaging findings and can mimic other
malignancies such as lung adenocarcinoma on CT.
• The most common findings include parenchymal abnormalities such as
nodules, masses, consolidation, and ground-glass opacity.
• Intrathoracic (hilar or mediastinal) lymphadenopathy is usually absent.
4. • Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of
non-Hodgkin B-cell lymphoma that can occur anywhere in the body,
although it most frequently affects the gastrointestinal system.
• When it presents in the lung, it is called BALT lymphoma.
• BALT lymphoma accounts for at least two-thirds of primary pulmonary
non-Hodgkin lymphoma but is overall very uncommon.
• The pathogenesis involves long-term antigenic stimulation from
autoimmune, inflammatory, or infectious etiologies.
• Associations between BALT lymphoma and smoking, Sjögren disease,
multiple sclerosis, rheumatoid arthritis, diffuse panbronchiolitis, chronic
hypersensitivity pneumonitis, and Hashimoto thyroiditis have been
proposed.
• Most cases occur in patients over 50 years of age. Patients usually have
no symptoms at presentation, although chest discomfort, cough,
breathing difficulty, or hemoptysis may be present.
5. • On cross-sectional imaging with CT, BALT lymphoma typically
demonstrates nonspecific imaging findings, which include nodules,
masses, consolidation, and ground-glass opacity.
• Regions of consolidation may demonstrate indistinct borders and air
bronchograms. The lung may be involved in a focal or more diffuse
manner. Pleural effusions are uncommon. I
• ntrathoracic (hilar or mediastinal) lymphadenopathy is not a typical
feature of BALT. Differential considerations include such entities as
lung adenocarcinoma, organizing pneumonia,alveolar sarcoid,
multifocal pneumonia and pulmonary metastasis.
• Treatment usually consists of a combination of surgical resection,
chemotherapy, radiation therapy, and/or immunotherapy.
• Survival rates are relatively high because the disease is typically
diagnosed prior to extrapulmonary extension, and disease
progression is slow.
6.
7.
8.
9.
10.
11.
12. • Lymphangitic carcinomatosis, or lymphangitis
carcinomatosa, is the term given to tumour spread
through the lymphatics of the lung, and is most
commonly seen secondary to adenocarcinoma.
13. Pathology
• Lymphangitis carcinomatosa is most commonly seen
secondary to adenocarcinomas such as:
• breast cancer - most common
• lung cancer (bronchogenic adenocarcinoma)
• colon cancer
• stomach cancer
• prostate cancer
• cervical cancer
• thyroid cancer
• It can also be seen in numerous other primary cancers,
e.g. laryngeal cancer,pancreatic cancer, etc.
14. Radiographic features
• Radiographic appearances can most easily be divided
into those due to involvement of the peripheral
(interlobular septae) and central lymphatic system.
Involvement may be diffusely of both, or predominantly
of one or other compartment .
• Distribution of changes is variable, but most are
asymmetric and patchy .
• It is usually bilateral but may be unilateral especially in
cases of lung and breast cancer.
15. • CT, especially HRCT, is excellent at demonstrating both
peripheral and central changes.
• Typically the appearance is that of interlobular septal
thickening most often nodular and irregular, although
smooth thickening may also sometimes be seen . This
results in prominent definition of the secondary pulmonary
nodules, manifesting as tessellating polygons.
• Thickening of the bronchovascular interstitium is usually
irregular and nodular, with changes seen extending
towards the hilum .
• The combination may give a characteristic "dot in box"
appearance.
16. • subpleural nodules, and thickening on the interlobar
fissures
• pleural effusion(s): pleural carcinomatosis
• hilar and mediastinal nodal enlargement (40-50%)
• relatively little destruction of overall lung architecture
17. Differential diagnosis
• Considerations include a differential for that
of thickened interlobular septae, with common entities
comprising of :
• sarcoidosis
• viral pneumonia
• pulmonary oedema - changes are commonly bilateral
and often have a gravitational distribution
• radiation pneumonitis
• lymphocytic interstitial pneumonitis (LIP)
18.
19.
20.
21.
22. • KS should be considered in the differential in patients
with AIDS who have localized bone pain or a febrile
illness of unknown origin.
• Tissue sampling is required to confirm the diagnosis.
• Even though the majority of the lesions are lytic they
are usually not seen on plain films. CT or MRI is the
preferred imaging modality.
23. KS is caused by Human Herpesvirus 8. It is a low-grade mesenchymal neoplasm of blood and lymphatic origin primarily
affecting the skin. To date, four different types have been described: AIDS-related, African, classic, and transplantation/
immunosuppression. KS usually involves the lungs, gastrointestinal (GI) tract, liver, spleen, and skin. It rarely involves the
bone marrow, but there have been multiple biopsy-proven case reports. Bone marrow involvement has been associated
with a poor prognosis.
24. • On chest plain films, KS usually presents as middle to
lower lung zone reticular opacities and parenchymal
nodules. On CT, the pulmonary findings are bilateral,
symmetric, and poorly marginated nodules arising from
the hila. They are characteristically referred to as
“flame-shaped” nodules. These nodules tend to
coalesce and can grow to measure more than 1 cm
and show surrounding ground-glass opacities—this is
known as the “halo” sign. Diffuse lymphadenopathy
and bilateral pleural effusions are common findings.
27. • Pancoast syndrome results from involvement of brachial
plexus and sympathetic chain by a Pancoast tumour, or
less commonly from other tumours involving the superior
pulmonary sulcus.
• The syndrome consists of:
• shoulder pain
• C8-T2 radicular pain
• Horner syndrome
• The classical syndrome is uncommon, with the Horner
syndrome present in only 25%.
28.
29.
30.
31.
32. • Hypertrophic osteoarthropathy is characterised by
periosteal reaction without an underlying bone lesion
involving the diaphysis and metadiaphysis of the long
bones of distal extremities.
• Clubbing of the fingers is seen most commonly in
patients with lung, liver, and gastrointestinal disorders.
• When associated with a pulmonary condition it is
termed hypertrophic pulmonary osteoarthropathy
(HPOA) and when associated with cancer is
considered a paraneoplastic syndrome.
35. Ganglioneuromas
• Ganglioneuromas are benign tumors of the
sympathetic nervous system, most commonly found in
the posterior mediastinum
• They are typically homogeneously enhancing round or
oval masses which can contain punctate calcifications.
36. • Ganglioneuromas are tumors of the sympathetic nervous system that
originate from neural crest cells. Along with neuroblastomas and
ganglioneuroblastomas, ganglioneuromas are collectively known as
neurogenic tumors. These three are differentiated only by their stage of
neuroblast maturation. Ganglioneuromas are composed of mature
ganglion cells and are considered benign tumors.
Ganglioneuroblastomas and neuroblastomas are less mature and are
considered more aggressive and dangerous.
• The posterior mediastinum is the most frequent site of occurrence
(38% of cases), followed by the retroperitoneum. Tumors located in the
central nervous system are rare. Ganglioneuromas usually occur in
adolescents and young adults (60%) but patients of all ages can be
affected. The mean age of occurrence is 7 years. Patients are usually
asymptomatic and these lesions are typically discovered on routine
radiographs,
37. • On imaging, ganglioneuromas are well defined masses which
range in appearance from round to lobulated. They show
calcifications in 40% of cases and tend to grow around, rather than
displace, adjacent blood vessels.
• Tumors with intermediate to high signal intensity on T2 weighted
images have a higher degree of cellularity and more collagen,
whereas markedly high T2 signal signifies a high myxoid stroma
component and low cellularity.
• They also have characteristic curvilinear bands of low intensity on
T2 weighted sequences, giving a whorled pattern to the tumor as a
result of intertwined schwann cells and collagen fibers.
• Ganglioneuromas homogeneously enhance.
48. • IMPRESSION: Extensive sites of extramedullary soft tissue
plasmacytoma
including bilateral lung pleura, bilateral mediastinum including
intensely in the inferior wall right atrium, head of the pancreas,
large tumor extending from the posterior wall of the descending colon,
lower para-aortic retroperitoneal, 2 mesenteric nodules, large
preaortic tumor beginning at the level of the bifurcation extending
inferiorly midline/left of midline into the lower pelvis supra-vesicle
region, bilateral pelvic sidewalls and periacetabular regions, deep
subcutaneous soft tissue nodule in the right buttock.
49.
50.
51.
52.
53.
54.
55. • Primary germ cell tumors of the anterior mediastinum are unusual.
• Seminomas, embryonal carcinomas, teratocarcinomas, and
choriocarcinomas account for the majority of reported cases .
Even less common is a histologically distinctive germ cell tumor
called an endodermal sinus tumor or a yolk sac tumor. A recent
publication summarized 1 2 reported cases of this tumor primary
in the mediastinum (all single case reports).
• Radiologists should include germ cell tumors in their differential
diagnosis of anterior mediastinal tumors.
56.
57.
58. Nodular pleural thickening
• Essentially all common causes of nodular pleural thickening are malignant and
include:
• metastatic pleural disease, particularly from adenocarcinomas, e.g:
– bronchogenic adenocarcinoma
– breast cancer
– ovarian cancer
– prostate cancer
– gastrointestinal adenocarcinoma
– renal cell carcinoma
• mesothelioma
• lymphoma
• invasive thymoma
• Thoracic splenosis is a rare benign cause of pleural nodularity.
Editor's Notes
Multiple myeloma ribs
Ganglioneuroma vs plexiform neuroibroma
MM
16 months apart fibromatosis pleura in sickle cell