This document summarizes key aspects of sleep and sleep disorders. It describes the sleep-wake cycle including non-REM (NREM) sleep which makes up 75-80% of sleep and is characterized by slow wave sleep, and REM sleep which makes up 20-25% and features rapid eye movements. It discusses EEG wave patterns in different sleep stages and underlying brain regions and chemicals involved in sleep regulation. Common sleep disorders like sleep apnea, insomnia and parasomnias are outlined. Physiological changes in breathing, heart rate and brain activity during sleep are also summarized.
This document provides an overview of physiology of sleep and sleep disorders. It discusses brain waves during different sleep stages, the cycles of non-REM and REM sleep, theories of what causes sleep, the effects of sleep on physiological functions, comparative aspects of sleep across species, and consequences of sleep deprivation. Key topics covered include the different sleep stages, roles of neurotransmitters like serotonin in regulating sleep, and restoration of brain and body during sleep.
Physiology of Sleep and its correlation with EEG wavesABHILASHA MISHRA
Content includes Physiology of sleep and and its correlation with EEG waves along with specific characteristics of different phases of sleep as well as an account of sleep disorders.
This document discusses the stages and physiology of sleep. It defines sleep as a state of unconsciousness that one can be aroused from, and coma as a state of unconsciousness that one cannot be aroused from. It describes the four stages of non-rapid eye movement (NREM) sleep - stages 1, 2, 3, and 4 - as well as rapid eye movement (REM) sleep. It provides details on the EEG patterns, duration, and characteristics of each sleep stage. Overall, it provides a comprehensive overview of the stages and cycles of sleep.
Classification of sleep disorders and parasomniasEnoch R G
Sleep is made up of two physiological states: non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. There are several brain regions and neurotransmitters that regulate the sleep-wake cycle, including serotonin, norepinephrine, acetylcholine, melatonin, and dopamine. Sleep disorders are classified in the DSM-5 and ICSD-2 and include insomnia, sleep-related breathing disorders, hypersomnias, circadian rhythm sleep-wake disorders, parasomnias, and other sleep-related movement disorders.
This document summarizes key aspects of sleep and circadian rhythms. It discusses that healthy sleep is on average 7.5 hours per day but decreases with age. Circadian cycles regulate body temperature, growth hormone, and cortisol levels throughout the day and night. The suprachiasmatic nucleus contains a molecular clock that generates circadian rhythms and receives light input from retinal ganglion cells. Molecular mechanisms involve activation of clock and BMAL1 genes by light and subsequent negative feedback involving PER and CCG proteins to maintain a 24.5 hour cycle. Melatonin and brain waves also vary across sleep stages and between wakefulness and sleep states.
This document discusses the physiology of sleep and EEG waves. It begins by defining sleep and coma, then outlines the objectives and functions of sleep. The mechanisms of sleep are explored, including theories about what causes sleep onset. The four main EEG wave types - alpha, beta, theta, and delta - are defined. The two types of sleep, NREM and REM, are described along with the sleep cycle and stages. Common sleep disorders and basic sleep hygiene recommendations are also summarized.
This document summarizes key aspects of sleep and sleep disorders. It describes the sleep-wake cycle including non-REM (NREM) sleep which makes up 75-80% of sleep and is characterized by slow wave sleep, and REM sleep which makes up 20-25% and features rapid eye movements. It discusses EEG wave patterns in different sleep stages and underlying brain regions and chemicals involved in sleep regulation. Common sleep disorders like sleep apnea, insomnia and parasomnias are outlined. Physiological changes in breathing, heart rate and brain activity during sleep are also summarized.
This document provides an overview of physiology of sleep and sleep disorders. It discusses brain waves during different sleep stages, the cycles of non-REM and REM sleep, theories of what causes sleep, the effects of sleep on physiological functions, comparative aspects of sleep across species, and consequences of sleep deprivation. Key topics covered include the different sleep stages, roles of neurotransmitters like serotonin in regulating sleep, and restoration of brain and body during sleep.
Physiology of Sleep and its correlation with EEG wavesABHILASHA MISHRA
Content includes Physiology of sleep and and its correlation with EEG waves along with specific characteristics of different phases of sleep as well as an account of sleep disorders.
This document discusses the stages and physiology of sleep. It defines sleep as a state of unconsciousness that one can be aroused from, and coma as a state of unconsciousness that one cannot be aroused from. It describes the four stages of non-rapid eye movement (NREM) sleep - stages 1, 2, 3, and 4 - as well as rapid eye movement (REM) sleep. It provides details on the EEG patterns, duration, and characteristics of each sleep stage. Overall, it provides a comprehensive overview of the stages and cycles of sleep.
Classification of sleep disorders and parasomniasEnoch R G
Sleep is made up of two physiological states: non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. There are several brain regions and neurotransmitters that regulate the sleep-wake cycle, including serotonin, norepinephrine, acetylcholine, melatonin, and dopamine. Sleep disorders are classified in the DSM-5 and ICSD-2 and include insomnia, sleep-related breathing disorders, hypersomnias, circadian rhythm sleep-wake disorders, parasomnias, and other sleep-related movement disorders.
This document summarizes key aspects of sleep and circadian rhythms. It discusses that healthy sleep is on average 7.5 hours per day but decreases with age. Circadian cycles regulate body temperature, growth hormone, and cortisol levels throughout the day and night. The suprachiasmatic nucleus contains a molecular clock that generates circadian rhythms and receives light input from retinal ganglion cells. Molecular mechanisms involve activation of clock and BMAL1 genes by light and subsequent negative feedback involving PER and CCG proteins to maintain a 24.5 hour cycle. Melatonin and brain waves also vary across sleep stages and between wakefulness and sleep states.
This document discusses the physiology of sleep and EEG waves. It begins by defining sleep and coma, then outlines the objectives and functions of sleep. The mechanisms of sleep are explored, including theories about what causes sleep onset. The four main EEG wave types - alpha, beta, theta, and delta - are defined. The two types of sleep, NREM and REM, are described along with the sleep cycle and stages. Common sleep disorders and basic sleep hygiene recommendations are also summarized.
Basic science of sleep by dr. rujul modiRujul Modi
The document provides an overview of the basic science of sleep. It discusses the stages of sleep including REM and NREM sleep. It describes the neurobiology and physiology of sleep, including the structures and neurotransmitters involved in regulating sleep and wakefulness. The document also discusses how sleep is organized in cycles and how it changes with age. It provides definitions of sleep and covers topics like the functions of sleep and its assessment.
Circadian rhythms refer to biological cycles that occur over approximately 24 hours. The suprachiasmatic nucleus (SCN) in the hypothalamus acts as the master pacemaker regulating circadian rhythms. Lesions to the SCN abolish circadian rhythms, while transplanted SCN tissue can impart rhythms to recipient animals. The SCN receives light input from retinal ganglion cells that contain melanopsin photoreceptors sensitive to blue light wavelengths.
Physiology of sleep - medical information martinshaji
This document summarizes the physiology of sleep. It discusses how sleep is regulated by both homeostatic and circadian mechanisms in the brain. Sleep involves the suppression of arousal systems in the brain by sleep-promoting areas like the VLPO. NREM and REM sleep are controlled by different brain regions and neurotransmitters in a cyclical manner. Physiological changes in hormones like growth hormone, prolactin, cortisol and TSH occur across the sleep-wake cycle. Overall, sleep is an actively regulated, metabolically distinct state that impacts whole-body physiology and metabolism.
Understanding the sleep cycle is often the first step to better sleep quality. When you know, what affects your sleep cycle, you can take measures to cut out distractions and get ample restful sleep every night.
Also, to help you understand the various sleep stages and sleep cycles easily, we have also created an infographic for this.
Read more details on the source site: https://sleepsherpa.com/stages-of-sleep-and-sleep-cycles-explained/
The outcome of this course is for the learner to describe the normal stages of sleep, common sleep measurement tools sleep characteristic, common sleep disorders, the changes that affect the quality and quantity of sleep as an individual ages, and methods the healthcare provider can use to assess and assist clients with sleep disorders.
Nearly one third of human life is spent sleeping, which occurs regularly each day in a state of unresponsiveness and calm. Sleep is defined by stages based on EEG, EOG, and EMG patterns, with two main states: rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep. NREM sleep is further divided into four stages characterized by different brain wave frequencies and muscle movements. REM sleep involves eye movements similar to waking and a lack of muscle movement in the body. Sleep cycles through NREM and REM stages throughout the night, with REM sleep making up 20-25% of total sleep.
This document discusses sleep and the brain waves associated with it. It defines sleep and describes the two types: slow wave sleep and REM sleep. It explains that sleep is an active process involving different neuronal centers and neurohormonal substances that cause different stages of sleep. The brain waves associated with different stages are also described, including alpha, beta, theta, and delta waves. Various sleep disorders are also mentioned.
The document summarizes the five stages of sleep in order: stage 1 (light sleep), stage 2 (45-55% of sleep), stage 3 (first stage of deep sleep), stage 4 (second stage of deep sleep), and REM sleep. It then discusses important functions of REM sleep such as its role in learning, memory consolidation, and problem solving. Finally, it briefly outlines common sleep disorders according to the DSM-5 classification and common causes of sleep disorders.
EEG and sleep are described. EEG records electrical activity of the cerebrum and shows different wave patterns (alpha, beta, theta, delta) associated with different brain states. Sleep involves physiological changes and is classified into NREM and REM sleep based on EEG patterns and muscle tone. The sleep cycle consists of alternating NREM and REM sleep stages over 4-5 cycles per night that are controlled by the brainstem and hypothalamus.
There are two types of glands - exocrine glands which secrete chemicals through ducts and endocrine glands which secrete hormones directly into the bloodstream. Hormones have different types and properties depending on their chemical structure, with steroid hormones being hydrophobic and able to influence gene expression. The hypothalamus and pituitary gland work together to regulate hormone release, with the hypothalamus secreting tropic hormones and the pituitary gland secreting tropic and other hormones in response. Sexual development is determined by sex hormones like testosterone and their influence on internal and external genital development.
The document discusses sleep disorders and the measurement and stages of sleep. It provides details on:
1) How sleep is measured using EEG, EOG, and EMG electrodes to record brain waves, eye movements, and muscle activity.
2) The stages of sleep including NREM stages 1-4 and REM sleep, characterized by different brain wave patterns.
3) Common sleep disorders like insomnia, hypersomnia, sleep apnea, circadian rhythm disorders and parasomnias. Treatment options are also outlined.
The homeostatic process (S) and circadian process (C) interact to regulate the sleep-wake cycle. Process S represents the buildup of sleep pressure and increasing need for sleep with time spent awake. Process C is controlled by the suprachiasmatic nucleus and follows a 24 hour circadian rhythm promoting wakefulness during the day and sleep at night. When the distance between processes S and C is largest, sleep propensity is highest. Together these two processes maintain optimal times for sleep, wakefulness, and transitions between states.
Sleep disorders are characterized by disturbances in sleep amount, quality, or timing. There are over 70 different sleep disorders divided into two main categories - dyssomnias involving problems falling or staying asleep, and parasomnias involving abnormal behaviors during sleep. The document provides detailed descriptions of common sleep disorders like insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, nightmares, and sleep terrors. Diagnostic criteria are also outlined for each disorder.
- Animals generate circadian and circannual rhythms that regulate sleep/wake cycles, eating/drinking patterns, temperature, hormone secretion and other functions on 24-hour and yearly cycles respectively.
- Humans have a circadian rhythm slightly longer than 24 hours that is reset by light/dark cues. Disruption of circadian rhythms can cause jet lag. The suprachiasmatic nucleus regulates circadian rhythms.
- Sleep stages include NREM (stages 1-4) and REM sleep. REM is characterized by dreaming and paralysis while NREM deepens across stages 1-4. Sleep aids restoration, energy conservation, memory consolidation and more.
This document provides an overview of sleep, its functions, stages and disorders. It defines sleep as a state of unconsciousness where the brain is more responsive to internal stimuli. Sleep has restorative and homeostatic functions. There are two main stages - NREM and REM sleep. Dyssomnias are disorders of sleep quantity/timing and include insomnia, hypersomnia, narcolepsy and sleep apnea. Parasomnias involve abnormal behaviors during sleep transitions and include nightmares, sleepwalking and REM sleep behavior disorder. Many common sleep disorders are described along with their symptoms, causes and treatment options.
Sleep involves distinct stages including non-REM and REM sleep in cycles. The sleep-wake cycle is regulated by two processes - a homeostatic drive (Process S) for sleep that increases with wakefulness and a circadian rhythm (Process C) that promotes wakefulness during the day. Key structures like the suprachiasmatic nucleus and ventrolateral preoptic area help generate and regulate sleep and wake states.
This document provides information about various sleep disorders. It begins with definitions and descriptions of normal sleep stages. It then discusses specific sleep disorders like insomnia, hypersomnia, sleep apnea, narcolepsy, restless leg syndrome and circadian rhythm disorders. Diagnosis involves questionnaires, sleep diaries and polysomnography. Treatment depends on the disorder but may include lifestyle changes, medications, therapies and surgery. Sleep disorders can negatively impact quality of life so proper diagnosis and management is important.
The document discusses neurobiology of memory, including:
1. It describes the anatomical and functional organization of memory, focusing on the hippocampus formation, its afferents and efferents, and its role in learning and memory.
2. It discusses the different types of memory including explicit and implicit memory, and the cellular and molecular processes underlying short-term and long-term memory formation.
3. It explains mechanisms of memory formation and consolidation at the synaptic level, including the roles of proteins like CaMKII and CREB.
Evoked potentials, clinical importance & physiological basis of consciousness...Rajesh Goit
This document summarizes key aspects of electroencephalography (EEG), including its uses and physiological basis. EEG is used to diagnose epilepsy and study sleep disorders. It records electrical activity in the brain through scalp electrodes. Specific EEG rhythms like alpha, beta, theta, and delta waves are associated with different brain states. Evoked potentials are EEG responses to sensory stimuli and are clinically used to assess hearing, vision, and somatosensory pathways. Epilepsy is classified as focal or generalized seizures. EEG patterns in epilepsy include sharp waves in focal seizures and high-voltage discharges in generalized seizures. Non-rapid eye movement (REM) and REM sleep have distinct EEG signatures and functions in brain and body restoration.
The document summarizes key topics in biological psychology, including the physiological, evolutionary, and developmental mechanisms of behavior. It discusses the mind-body problem, genetics of behavior, evolution of behavior, sociobiology/evolutionary psychology, animal research, and careers in biological psychology. The main areas covered are the biological explanations of behavior, genetics and heritability, evolution as it relates to behavior, and ethical issues around animal research.
Basic science of sleep by dr. rujul modiRujul Modi
The document provides an overview of the basic science of sleep. It discusses the stages of sleep including REM and NREM sleep. It describes the neurobiology and physiology of sleep, including the structures and neurotransmitters involved in regulating sleep and wakefulness. The document also discusses how sleep is organized in cycles and how it changes with age. It provides definitions of sleep and covers topics like the functions of sleep and its assessment.
Circadian rhythms refer to biological cycles that occur over approximately 24 hours. The suprachiasmatic nucleus (SCN) in the hypothalamus acts as the master pacemaker regulating circadian rhythms. Lesions to the SCN abolish circadian rhythms, while transplanted SCN tissue can impart rhythms to recipient animals. The SCN receives light input from retinal ganglion cells that contain melanopsin photoreceptors sensitive to blue light wavelengths.
Physiology of sleep - medical information martinshaji
This document summarizes the physiology of sleep. It discusses how sleep is regulated by both homeostatic and circadian mechanisms in the brain. Sleep involves the suppression of arousal systems in the brain by sleep-promoting areas like the VLPO. NREM and REM sleep are controlled by different brain regions and neurotransmitters in a cyclical manner. Physiological changes in hormones like growth hormone, prolactin, cortisol and TSH occur across the sleep-wake cycle. Overall, sleep is an actively regulated, metabolically distinct state that impacts whole-body physiology and metabolism.
Understanding the sleep cycle is often the first step to better sleep quality. When you know, what affects your sleep cycle, you can take measures to cut out distractions and get ample restful sleep every night.
Also, to help you understand the various sleep stages and sleep cycles easily, we have also created an infographic for this.
Read more details on the source site: https://sleepsherpa.com/stages-of-sleep-and-sleep-cycles-explained/
The outcome of this course is for the learner to describe the normal stages of sleep, common sleep measurement tools sleep characteristic, common sleep disorders, the changes that affect the quality and quantity of sleep as an individual ages, and methods the healthcare provider can use to assess and assist clients with sleep disorders.
Nearly one third of human life is spent sleeping, which occurs regularly each day in a state of unresponsiveness and calm. Sleep is defined by stages based on EEG, EOG, and EMG patterns, with two main states: rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep. NREM sleep is further divided into four stages characterized by different brain wave frequencies and muscle movements. REM sleep involves eye movements similar to waking and a lack of muscle movement in the body. Sleep cycles through NREM and REM stages throughout the night, with REM sleep making up 20-25% of total sleep.
This document discusses sleep and the brain waves associated with it. It defines sleep and describes the two types: slow wave sleep and REM sleep. It explains that sleep is an active process involving different neuronal centers and neurohormonal substances that cause different stages of sleep. The brain waves associated with different stages are also described, including alpha, beta, theta, and delta waves. Various sleep disorders are also mentioned.
The document summarizes the five stages of sleep in order: stage 1 (light sleep), stage 2 (45-55% of sleep), stage 3 (first stage of deep sleep), stage 4 (second stage of deep sleep), and REM sleep. It then discusses important functions of REM sleep such as its role in learning, memory consolidation, and problem solving. Finally, it briefly outlines common sleep disorders according to the DSM-5 classification and common causes of sleep disorders.
EEG and sleep are described. EEG records electrical activity of the cerebrum and shows different wave patterns (alpha, beta, theta, delta) associated with different brain states. Sleep involves physiological changes and is classified into NREM and REM sleep based on EEG patterns and muscle tone. The sleep cycle consists of alternating NREM and REM sleep stages over 4-5 cycles per night that are controlled by the brainstem and hypothalamus.
There are two types of glands - exocrine glands which secrete chemicals through ducts and endocrine glands which secrete hormones directly into the bloodstream. Hormones have different types and properties depending on their chemical structure, with steroid hormones being hydrophobic and able to influence gene expression. The hypothalamus and pituitary gland work together to regulate hormone release, with the hypothalamus secreting tropic hormones and the pituitary gland secreting tropic and other hormones in response. Sexual development is determined by sex hormones like testosterone and their influence on internal and external genital development.
The document discusses sleep disorders and the measurement and stages of sleep. It provides details on:
1) How sleep is measured using EEG, EOG, and EMG electrodes to record brain waves, eye movements, and muscle activity.
2) The stages of sleep including NREM stages 1-4 and REM sleep, characterized by different brain wave patterns.
3) Common sleep disorders like insomnia, hypersomnia, sleep apnea, circadian rhythm disorders and parasomnias. Treatment options are also outlined.
The homeostatic process (S) and circadian process (C) interact to regulate the sleep-wake cycle. Process S represents the buildup of sleep pressure and increasing need for sleep with time spent awake. Process C is controlled by the suprachiasmatic nucleus and follows a 24 hour circadian rhythm promoting wakefulness during the day and sleep at night. When the distance between processes S and C is largest, sleep propensity is highest. Together these two processes maintain optimal times for sleep, wakefulness, and transitions between states.
Sleep disorders are characterized by disturbances in sleep amount, quality, or timing. There are over 70 different sleep disorders divided into two main categories - dyssomnias involving problems falling or staying asleep, and parasomnias involving abnormal behaviors during sleep. The document provides detailed descriptions of common sleep disorders like insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, nightmares, and sleep terrors. Diagnostic criteria are also outlined for each disorder.
- Animals generate circadian and circannual rhythms that regulate sleep/wake cycles, eating/drinking patterns, temperature, hormone secretion and other functions on 24-hour and yearly cycles respectively.
- Humans have a circadian rhythm slightly longer than 24 hours that is reset by light/dark cues. Disruption of circadian rhythms can cause jet lag. The suprachiasmatic nucleus regulates circadian rhythms.
- Sleep stages include NREM (stages 1-4) and REM sleep. REM is characterized by dreaming and paralysis while NREM deepens across stages 1-4. Sleep aids restoration, energy conservation, memory consolidation and more.
This document provides an overview of sleep, its functions, stages and disorders. It defines sleep as a state of unconsciousness where the brain is more responsive to internal stimuli. Sleep has restorative and homeostatic functions. There are two main stages - NREM and REM sleep. Dyssomnias are disorders of sleep quantity/timing and include insomnia, hypersomnia, narcolepsy and sleep apnea. Parasomnias involve abnormal behaviors during sleep transitions and include nightmares, sleepwalking and REM sleep behavior disorder. Many common sleep disorders are described along with their symptoms, causes and treatment options.
Sleep involves distinct stages including non-REM and REM sleep in cycles. The sleep-wake cycle is regulated by two processes - a homeostatic drive (Process S) for sleep that increases with wakefulness and a circadian rhythm (Process C) that promotes wakefulness during the day. Key structures like the suprachiasmatic nucleus and ventrolateral preoptic area help generate and regulate sleep and wake states.
This document provides information about various sleep disorders. It begins with definitions and descriptions of normal sleep stages. It then discusses specific sleep disorders like insomnia, hypersomnia, sleep apnea, narcolepsy, restless leg syndrome and circadian rhythm disorders. Diagnosis involves questionnaires, sleep diaries and polysomnography. Treatment depends on the disorder but may include lifestyle changes, medications, therapies and surgery. Sleep disorders can negatively impact quality of life so proper diagnosis and management is important.
The document discusses neurobiology of memory, including:
1. It describes the anatomical and functional organization of memory, focusing on the hippocampus formation, its afferents and efferents, and its role in learning and memory.
2. It discusses the different types of memory including explicit and implicit memory, and the cellular and molecular processes underlying short-term and long-term memory formation.
3. It explains mechanisms of memory formation and consolidation at the synaptic level, including the roles of proteins like CaMKII and CREB.
Evoked potentials, clinical importance & physiological basis of consciousness...Rajesh Goit
This document summarizes key aspects of electroencephalography (EEG), including its uses and physiological basis. EEG is used to diagnose epilepsy and study sleep disorders. It records electrical activity in the brain through scalp electrodes. Specific EEG rhythms like alpha, beta, theta, and delta waves are associated with different brain states. Evoked potentials are EEG responses to sensory stimuli and are clinically used to assess hearing, vision, and somatosensory pathways. Epilepsy is classified as focal or generalized seizures. EEG patterns in epilepsy include sharp waves in focal seizures and high-voltage discharges in generalized seizures. Non-rapid eye movement (REM) and REM sleep have distinct EEG signatures and functions in brain and body restoration.
The document summarizes key topics in biological psychology, including the physiological, evolutionary, and developmental mechanisms of behavior. It discusses the mind-body problem, genetics of behavior, evolution of behavior, sociobiology/evolutionary psychology, animal research, and careers in biological psychology. The main areas covered are the biological explanations of behavior, genetics and heritability, evolution as it relates to behavior, and ethical issues around animal research.
Circadian rhythms are biological processes that display an endogenous cycle of approximately 24 hours. They are influenced by external cues like light and regulated by the brain's circadian pacemaker. Common circadian rhythms include the sleep-wake cycle and fluctuations in body temperature and hormone levels. Disruptions to circadian rhythms can result in circadian rhythm disorders like delayed sleep phase syndrome or jet lag. Nurses play a role in assessing patients' circadian rhythms, providing sleep hygiene advice, and referring patients to specialists when needed.
The document summarizes key concepts about temperature regulation and hunger/thirst regulation in the human body. It discusses how the hypothalamus regulates body temperature through mechanisms like sweating, shivering, and blood flow. It also explains how the hypothalamus and hormones regulate hunger, thirst, and satiety in response to glucose levels, stomach distention, leptin, and other factors. Genetic and environmental factors can influence conditions like obesity.
Faraz Tak's sleep pattern and circadian rhythm were disrupted by his 24-hour work shifts as a medical student. During shifts, his melatonin release was not sufficient at night due to artificial light exposure, preventing him from falling asleep. To remedy this, he created a dark environment when sleeping during the day to trick his brain into thinking it was nighttime and releasing melatonin, allowing him to get a more restful sleep.
Almost all species exhibit daily changes in their biological activity with respect to a 24 hour light-dark cycle known as the circadian rhythm. The synchrony of an organism with both its external and internal environments is critical for the organism’s well-being and survival.
The presentation focuses on the fundamentals of circadian rhythm, components, development, molecular mechanism, functional and clinical implications of this astonishing system.
PSYA3 - Biological Rhythms powerpoint.
100 slides because there's a lot to know! Condensed it as much as possible.
Includes:
Biological rhythms - Circadian, Infradian, Ultradian, endogenous pacemakers, exogenous zeitgebers & consequences of disruption of said rhythms
Sleep states -
lifespan changes, restorative theory, evolutionary evaluations
Disorders of sleep - Insomnia & other sleep disorders.
There's minimal evaluation for Infradian - so do it yourself :D
The document discusses how alcohol affects circadian rhythms. It begins by introducing circadian rhythms as the body's natural sleep-wake cycle regulated on a 24-hour schedule. The author then reviews research showing that alcohol lowers body temperature, destroys brain cells, and impacts motor functions controlled by the cerebellum. By disrupting temperature regulation and balance, alcohol intake makes it difficult for the body to transition to sleep. Therefore, the conclusion is that alcohol does influence circadian rhythms by acting as an inhibitor.
Sleep progresses through distinct stages in a cycle. Non-REM sleep begins with light sleep in stages 1 and 2, characterized by theta waves and sleep spindles. Stages 3 and 4 involve deep sleep with synchronized brain activity appearing as delta waves. REM sleep involves dreaming and similar brain activity to wakefulness. The circadian rhythm and homeostatic processes regulate sleep cycles, with the circadian rhythm promoting wakefulness opposed by the increasing homeostatic drive for sleep with time spent awake.
This document discusses circadian rhythms, which are biological processes that repeat approximately every 24 hours. Examples include the sleep-wake cycle, body temperature fluctuations, and hormone levels such as cortisol. Studies on animals and humans in controlled environments show that circadian rhythms are endogenously generated but can be adjusted by external cues like light levels. Disruptions to circadian rhythms, as in jet lag or shift work, can impair performance and health. The stages of sleep are also described, from light sleep to deep sleep and REM sleep. Age affects sleep cycles and quality. Insomnia and narcolepsy are discussed as disorders of sleep amount and timing.
Orem's Self-Care Deficit Nursing Theory has three related theories: self-care, self-care deficit, and nursing systems. The self-care theory focuses on an individual's ability to care for themselves, while the self-care deficit theory examines when people require nursing assistance. The nursing systems theory describes the relationships needed to provide nursing care. Orem identified universal, developmental, and health deviation self-care requisites and defined a self-care deficit as the inability to meet one's therapeutic self-care demand.
This chapter discusses how culture influences communication contexts. It covers several key topics:
- Culture helps determine appropriate communication behaviors and rules within various social and physical contexts. Miscommunication can occur when people from different cultures interact.
- Context is important, as it helps specify appropriate communication rules. However, communication rules vary across cultures.
- Business communication must be sensitive to cultural differences in areas like formality, power dynamics, gift-giving, and conversation topics. Understanding different cultural norms is important for success.
- Education also reflects a culture's values. While subjects like literacy are universal, each culture emphasizes its own history. Teachers must navigate student body diversity and different learning preferences across cultures.
Circadian rhythms also known as "The Body Clock" is the physical, mental and behavioral changes that follow roughly 24 hrs. cycle responding to light and darkness in the organism.
The document discusses biological rhythms and sleep stages, explaining that circadian rhythms operate on a 24-hour cycle and influence sleep and wakefulness, and describing the five distinct sleep stages that occur in a repeating cycle approximately every 90 minutes. It also reviews theories about why we sleep and dream, such as for physiological functions like neural development and information processing, and examines some common sleep disorders like insomnia, narcolepsy, and sleep apnea.
This document summarizes key chapters from the 4th edition of the textbook "Psychology" by Saundra K. Ciccarelli and J. Noland White. It covers topics related to sexuality and gender, including physical and biological differences between males and females, gender roles and stereotypes, sexual response and behavior, sexual orientation, and sexual dysfunction. The document provides learning objectives, definitions, theories, figures, and summaries for each topic.
The document discusses the biological clock and circadian rhythms in humans. It begins by posing questions about increased risks of heart attacks in the morning and car crashes in the afternoon, which are related to our biological clocks. It then discusses evidence from experiments that show our bodies operate on regular daily routines, regulated by biological clocks in every cell. These clocks are influenced by light exposure and can differ slightly between individuals, but generally follow a 24 hour cycle. The document goes on to describe how our biological clocks impact functions from waking and sleeping to performance at different times of day. It also discusses sleep stages and dreams.
EEG measures the electrical activity of the brain through electrodes placed on the scalp. It can detect different wave patterns associated with different brain states. Evoked potentials involve stimulating a sensory pathway and measuring the electrical response along the pathway. This allows localization of lesions. Somatosensory evoked potentials involve stimulating a peripheral nerve like the median nerve and measuring the response along the pathway to detect spinal cord or brain injuries. Auditory evoked potentials involve measuring the brainstem response to a click stimulus to detect acoustic neuromas or other posterior fossa lesions. Both evoked potentials and EMG monitoring are used during surgery to detect injuries.
This document provides an overview of sleep and sleep disorders. It defines sleep and describes the physiology and stages of normal sleep. It discusses factors that influence sleep such as circadian rhythms, neurotransmitters, and the sleep-wake cycle. Common sleep disorders are explained like insomnia, narcolepsy, sleep apnea, restless leg syndrome and parasomnias. Assessment methods and treatment options for sleep disorders are also summarized.
All behavior patterns are co-ordinated sequences of neuromuscular activity. A rhythm is a periodically recurring event.
chronobiology is the study of science of life in relation with time.
The majority of organisms show daily and annual cycles of activity and development.
1. The document discusses the physiology of respiration and speech. It describes the anatomy and functions of structures involved in breathing and vocalization, including the trachea, bronchi, lungs, diaphragm and other muscles.
2. Key parts of the respiratory system are described in detail, such as the trachea, bronchi, bronchioles, alveoli and lungs. The roles of various muscles in inhalation and exhalation are also explained.
3. Detailed information is provided about the anatomy and divisions of the lungs, as well as surrounding structures like the ribs, sternum, and thoracic cavity. The processes of respiration, vocalization, and their underlying physiology are thoroughly
People need between 7 to 9 hours of sleep per night. Sleep serves important restorative functions such as rebuilding proteins, replenishing energy supplies, and facilitating learning and memory consolidation. Damage to the suprachiasmatic nucleus disrupts circadian rhythms. The suprachiasmatic nucleus regulates the pineal gland which secretes melatonin, increasing sleepiness. There are various stages of sleep including REM and non-REM sleep. Brain mechanisms such as the reticular formation, locus coeruleus, and basal forebrain regulate arousal and sleep cycles.
This chapter discusses consciousness and various states of consciousness. It covers circadian rhythms and the body's biological clock. There are different stages of sleep characterized by different brain wave patterns, as well as sleep disorders. Dreams occur during REM sleep and there are different theories about their meaning and purpose. Other topics covered include hypnosis, meditation, psychoactive drugs and their effects, and drug abuse.
The document provides information on sleep patterns and disturbances. It defines sleep and describes the physiology of sleep including the reticulating activating system and sleep stages. It discusses non-REM and REM sleep in detail. It also covers sleep requirements and patterns across the lifespan as well as common sleep disorders like insomnia, hypersomnia, narcolepsy, sleep apnea, restless leg syndrome, and sleep deprivation. Finally, it briefly mentions parasomnias.
Drugs used in the management of anxiety disorders.pdfEugenMweemba
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Sleep and rest, BSC NURSING FIRST YEAR NURSING FOUNDATION , UNIT X , MEETING NEEDS OF PATIENT , PHYSIOLOGY OF SLEEP, SLEEP DISORDERS, FACTORS AFFECTING SLEEP, PROMOTING SLEEP AND STAGES OF SLEEP.
Continuum of Consciousness
- Controlled and Automatic Processes
- Altered States of Consciousness
- Psychoactive Drugs
- Sleep and Dreams
- Different Stages of Sleep (REM and N-REM)
- 4 Major Questions About Sleep
- Sleep Disorders
- The Unconscious Mind
- Unconsciousness
This document discusses sleep and the brain waves associated with it. It defines sleep and describes the two types: slow wave sleep and REM sleep. It explains the neuronal centers and neurotransmitters involved in inducing each type of sleep. The sleep cycle is described as the result of three systems - the arousal system, slow wave sleep center, and REM sleep center - interacting cyclically. The document also outlines the different brain waves seen in EEGs - alpha, beta, theta, and delta waves - and their characteristics and associations with different brain states.
The document discusses various topics related to consciousness and its variations, including circadian rhythms controlled by the suprachiasmatic nucleus, sleep stages characterized by different brain wave patterns, functions of sleep, individual differences in sleep needs, and sleep disorders. It also covers dreams and their occurrence during REM sleep, theories about the purpose of dreams, hypnosis, meditation, psychoactive drugs including their effects and risks of abuse.
Sleep has two types - rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep. REM sleep is associated with dreaming and eye movements while NREM sleep has four stages with different brain wave patterns. Sleep is regulated by circadian rhythms and homeostasis. The brainstem contains sleep centers like the raphe nucleus and locus ceruleus that induce REM and NREM sleep respectively. Common sleep disorders include insomnia, sleep apnea, nightmares, night terrors and somnambulism. Movement disorders during sleep include restless legs syndrome and leg cramps.
The document discusses various states of consciousness and related topics including circadian rhythms regulated by the suprachiasmatic nucleus, stages of sleep as measured by EEG waves, functions of sleep, individual differences in sleep needs, common sleep disorders, dreams and their relation to REM sleep, hypnosis and its effects on memory, meditation techniques, properties of psychoactive drugs including depressants, opiates, stimulants and psychedelics, and areas of the brain affected by fetal alcohol syndrome.
- Most adults need 7-9 hours of sleep per night. Sleep has important biological functions including restoring homeostasis and physiological processes that occur in sleep cycles.
- Sleep is regulated by circadian rhythms controlled by the suprachiasmatic nucleus in the hypothalamus and influenced by environmental cues like light and dark cycles. Disruptions to circadian rhythms can cause issues like jet lag.
- Sleep deprivation negatively impacts cognitive performance and mood, with effects accumulating over time without sleep. However, studies have shown some ability of the brain to adapt to long-term sleep reductions.
This document summarizes key aspects of sleep physiology. It describes the two main types of sleep - slow-wave sleep and REM sleep. Slow-wave sleep is deeper and more restorative while REM sleep is when most dreaming occurs. The brain activity and physiology differs between these sleep stages. Several theories are presented on what causes sleep, including that active inhibitory processes in the brainstem induce sleep rather than fatigue. The role of neurotransmitters like serotonin is also discussed.
This document defines sleep and outlines the physiology and stages of sleep. It discusses factors that influence sleep such as circadian rhythms, neurotransmitters, and the sleep-wake cycle. Various sleep disorders are also summarized, including insomnia, narcolepsy, sleep apnea, restless leg syndrome, and parasomnias. Assessment tools like polysomnography and the multiple sleep latency test are mentioned. Finally, medical conditions and lifestyle factors that can disrupt normal sleep patterns are briefly covered.
The document discusses the neurology of sleep. It describes the two main types of sleep - NREM and REM sleep. NREM sleep involves synchronous cortical EEG, low muscle tone, and minimal dreaming. REM sleep is characterized by rapid eye movements, muscle atonia, and vivid dreaming. The document also discusses circadian rhythms and how the suprachiasmatic nucleus regulates sleep-wake cycles. Disruptions to circadian rhythms can lead to sleep disorders like jet lag.
Sleep involves different stages including non-REM sleep and REM sleep. The stages can be measured through polysomnography which tracks brain activity, eye movements, and muscle activity. Non-REM sleep involves reduced brain and muscle activity and is when most physical restoration occurs. REM sleep involves an active brain and paralyzed muscles except for eye movements; it is when most vivid dreaming occurs. Sleep serves functions like restoration and energy conservation, and is regulated by biological processes in the brain.
Sleep is essential for health and cognitive function. It involves NREM and REM sleep stages measured using polysomnography. Common sleep disorders include insomnia, hypersomnolence, and narcolepsy. Insomnia is difficulty initiating or maintaining sleep and is treated with sleep hygiene, relaxation, and medication. Hypersomnolence involves excessive daytime sleepiness and is treated with stimulants. Narcolepsy involves REM sleep intrusion and is diagnosed by decreased REM latency on polysomnography.
This document defines sleep and outlines the physiology and stages of sleep. It discusses factors that influence sleep such as circadian rhythms, neurotransmitters, and sleep cycles. Common sleep disorders like insomnia, narcolepsy, sleep apnea, and parasomnias are explained. Treatment options include behavioral therapies, medications, surgery, and lifestyle changes. Hospitalization can cause sleep disturbances, and medical conditions and drugs may also disrupt sleep. Nursing assessments and interventions aim to promote restful sleep.
The fund aims to provide financial support to small businesses and entrepreneurs who are just starting out or expanding their operations. It will offer loans and grants of up to $50,000 to eligible applicants looking to start a new business or grow an existing one. Priority will be given to applicants operating in rural areas, women-owned businesses, and businesses promoting environmentally sustainable practices.
Have the pseudo-religious cults promoted belief systems that create emotional...Alex Holub
Pseudo-religious cults create a specific atmosphere that attracts people. Once an individual joins their behavior changes. Are these changes psychologically and emotionally advantageous for self-development and emotional growth?
The document discusses six characteristics that goals should have:
1. Goals need to be detailed so they can be fully described using sight, sound, and feelings upon achieving the goal.
2. Goals must be assessable so progress can be measured and it's clear when the goal is reached.
3. Goals need to be producible so the steps to achieve the goal can be conceived and taken.
4. Goals should be practical and possible rather than unrealistic fantasies that cannot actually be achieved.
5. Goals should be empowering and exciting to motivate working towards them.
6. Goals must be realistic, tangible things rather than vague concepts, and mature
The document discusses whether drug addiction should be considered a disease. It notes that some see it as a disease due to genetic factors, while others argue there is limited evidence for this. The concept of addiction as a disease emerged in the late 18th/early 19th century and became popularized by treatment centers in the 1920s-1930s. However, a disease must have predictable symptoms and progression, which addiction does not. The main reason it continues to be called a disease is to justify government funding for treatment.
This is a very easy and effective way of studying. It involves an efficient technique and whole brain learning. It builds on previous learning and spaced practice. It is based on the latest research.
This chapter's focus is on Social Psychology. There is discussion of relationships, persuasion, coercion, and other types of social influence. Love and intimate relationships is also included.
This chapter discusses various psychological disorders including abnormal behavior, classifying mental disorders, psychotic disorders, mood disorders such as depression and bipolar disorder, anxiety disorders like phobias and panic disorder, dissociative disorders, personality disorders, sexual and gender identity disorders, and psychosomatic and somatoform disorders. Biological, psychological, and social factors can all contribute to the development of these conditions.
This chapter looks at how our motivations are emotionally directed and vice-versa. There is a discussion of eating disorders, sexual behavior, and the role of the amygdala.
The document discusses different aspects of human memory. It describes memory as an active system involving encoding, storage, and retrieval of information. There are different types of memory, including sensory memory, short-term memory, and long-term memory. Short-term memory can hold 7 plus or minus 2 pieces of information and uses chunking and rehearsal. Long-term memory is more permanent but can be affected by interference and forgetting over time due to factors like decay. Memory is important for learning and is stored across networks in the brain.
This document summarizes different types of learning, including classical conditioning, operant conditioning, and cognitive learning. Classical conditioning involves pairing a neutral stimulus with an unconditioned stimulus to elicit a conditioned response, as demonstrated by Pavlov's dog experiments. Operant conditioning uses reinforcement and punishment to shape behaviors, as theorized by Skinner. Cognitive learning involves higher-level thinking processes and can include imitation, modeling, and solving problems through observation rather than trial-and-error. The document also discusses how media can influence learning through observational modeling of behaviors.
Discussion in this chapter focuses on consciousness and altered states of consciousness. We look at sleep and dreaming, hypnosis, meditation, and the effects of illicit drugs.
The document summarizes key concepts about human sensory systems and perception. It discusses the main sensory systems of vision, hearing, smell, taste, touch, and balance. For each sense, it describes the basic structures and mechanisms involved in sensation and transduction. It also covers various visual illusions and perceptual phenomena like apparent motion, depth cues, and constancies that demonstrate how perception interprets and organizes sensory information.
The document summarizes key topics in human development from prenatal stages through adulthood. It discusses hereditary and environmental influences on development. Prenatal development can be impacted by factors like alcohol, tobacco, and illness. Child development involves progressing through stages of physical, cognitive, language, and social-emotional growth. Theories from Piaget, Vygotsky, Erikson, and others are summarized that explain developmental milestones and influences. Adolescence brings physical changes and identity formation. Adulthood involves additional developmental stages and factors for well-being.
This chapter discusses some of the latest research in neuroscience and human behavior. A general discussion of the different parts of the brain and their general functions is included.
1) The document discusses biological, cognitive, and environmental influences on motivation. It examines biological needs and drives like thirst, hunger, and sex that motivate behaviors.
2) Cognitive factors that influence motivation include expectations, locus of control beliefs, values, and achievement motivation. High achievement motivation is associated with persistence and goal-setting.
3) Environmental incentives can motivate behaviors, but too many incentives can undermine intrinsic motivation. The workplace can enhance intrinsic motivation through variety, autonomy, feedback, and social interaction.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.