This document provides an overview of the musculoskeletal system, including bones, muscles, joints, and common disorders. It begins by describing bone tissue and classifying bone shapes. It then discusses skeletal muscle structure and function. Various joint types and structures are outlined. Common musculoskeletal disorders like fractures, dislocations, muscle tears, and bone diseases such as osteoporosis are then summarized. Diagnostic tests and treatment approaches for musculoskeletal conditions are also briefly reviewed.
The document provides information on minimally invasive spine surgery techniques. It describes conditions such as degenerative disc disease, spondylolisthesis, and spinal stenosis. Traditional open fusion techniques are outlined along with newer minimally invasive techniques such as AxiaLIF fusion, which involves inserting an implant through a small incision without dissecting muscles or cutting ligaments. Benefits of AxiaLIF include less tissue disruption, less post-operative pain, shorter hospital stays and faster recovery times compared to traditional open fusion.
At the end of this session the students will be able to:
define fracture
classify fracture
list out the causes of fracture
explain the clinical features of fracture
specify the diagnostic studies for identification of fracture
elaborate the process of fracture healing
explain the management of fracture
describe various approaches of treatment of fracture
discuss the nursing management for fracture
enlist the complications
1) There are 33 vertebrae in the spine, but due to fusion only 26 are functional. The vertebrae are divided into 7 cervical, 12 thoracic, and 5 lumbar vertebrae.
2) Degenerative disc disease is the most common cause of lower back pain. It involves the gradual drying out and loss of the intervertebral disc's ability to function as a shock absorber. This transfer of stress can lead to further degeneration of surrounding structures like facet joints.
3) Stages of disc degeneration include disc bulge, annular tears, and disc herniation which can be protruded, extruded, or sequestrated as it progresses. Identification of the specific
Freiberg's disease is characterized by aseptic necrosis of the metatarsal head, usually in the second metatarsal, during adolescence. Repeated trauma from weight bearing causes microfractures in the epiphysis, depriving it of blood supply. Over time, the metatarsal head collapses and becomes irregular and enlarged, causing pain in the metatarsophalangeal joint. Conservative treatment involves rest, NSAIDs, and protected weight bearing. Surgery is usually not recommended initially but may be needed later for pain, deformity or disability relief using procedures like bone grafting or joint replacement.
Locking compression plates (LCP) provide several benefits for fracture fixation:
1) They form a fixed angle construct that increases screw pullout strength, prevents sequential failure, and resists bending and torsional forces.
2) As a biological fixation, LCP acts as an internal splint that allows micromovement at the fracture site to promote secondary fracture healing.
3) LCP are indicated for use in osteoporotic bone, periprosthetic fractures, and periarticular fractures where they provide good control of the bone segment and help maintain reduction.
4) Potential abuses of LCP include using too many screws which can strip the bone, being too aggressive during insertion, and using
Comminuted, Simple, and Compound Fracturesbmarkward
There are three main types of fractures: comminuted, simple, and compound. A comminuted fracture occurs when the bone is shattered into more than two pieces due to crushing force, often affecting elderly people or those with weak bones. Simple fractures break the bone into two pieces without breaking the skin. Compound fractures break both the bone and skin, requiring immediate surgery to reduce infection risks and immobilization of the bone. All fractures cause pain, swelling, and warmth at the injury site and are diagnosed via x-ray. Treatment focuses on immobilizing the bone through casting, pinning, or plating.
The document discusses the anatomy, physiology, causes, symptoms, diagnosis and management of intervertebral disc herniation. Key points include:
1) Intervertebral discs act as shock absorbers between vertebrae and allow limited spinal movement. Herniation occurs when a tear in the disc allows the nucleus pulposus to bulge beyond the annulus fibrosus.
2) Common causes are repetitive strain, trauma, obesity and poor posture. Symptoms vary depending on location but often include back pain radiating into the legs.
3) Diagnosis involves physical examination including the straight leg raise test and sometimes imaging tests. Management focuses on reducing pressure on neural elements through treatments like
The document provides information on minimally invasive spine surgery techniques. It describes conditions such as degenerative disc disease, spondylolisthesis, and spinal stenosis. Traditional open fusion techniques are outlined along with newer minimally invasive techniques such as AxiaLIF fusion, which involves inserting an implant through a small incision without dissecting muscles or cutting ligaments. Benefits of AxiaLIF include less tissue disruption, less post-operative pain, shorter hospital stays and faster recovery times compared to traditional open fusion.
At the end of this session the students will be able to:
define fracture
classify fracture
list out the causes of fracture
explain the clinical features of fracture
specify the diagnostic studies for identification of fracture
elaborate the process of fracture healing
explain the management of fracture
describe various approaches of treatment of fracture
discuss the nursing management for fracture
enlist the complications
1) There are 33 vertebrae in the spine, but due to fusion only 26 are functional. The vertebrae are divided into 7 cervical, 12 thoracic, and 5 lumbar vertebrae.
2) Degenerative disc disease is the most common cause of lower back pain. It involves the gradual drying out and loss of the intervertebral disc's ability to function as a shock absorber. This transfer of stress can lead to further degeneration of surrounding structures like facet joints.
3) Stages of disc degeneration include disc bulge, annular tears, and disc herniation which can be protruded, extruded, or sequestrated as it progresses. Identification of the specific
Freiberg's disease is characterized by aseptic necrosis of the metatarsal head, usually in the second metatarsal, during adolescence. Repeated trauma from weight bearing causes microfractures in the epiphysis, depriving it of blood supply. Over time, the metatarsal head collapses and becomes irregular and enlarged, causing pain in the metatarsophalangeal joint. Conservative treatment involves rest, NSAIDs, and protected weight bearing. Surgery is usually not recommended initially but may be needed later for pain, deformity or disability relief using procedures like bone grafting or joint replacement.
Locking compression plates (LCP) provide several benefits for fracture fixation:
1) They form a fixed angle construct that increases screw pullout strength, prevents sequential failure, and resists bending and torsional forces.
2) As a biological fixation, LCP acts as an internal splint that allows micromovement at the fracture site to promote secondary fracture healing.
3) LCP are indicated for use in osteoporotic bone, periprosthetic fractures, and periarticular fractures where they provide good control of the bone segment and help maintain reduction.
4) Potential abuses of LCP include using too many screws which can strip the bone, being too aggressive during insertion, and using
Comminuted, Simple, and Compound Fracturesbmarkward
There are three main types of fractures: comminuted, simple, and compound. A comminuted fracture occurs when the bone is shattered into more than two pieces due to crushing force, often affecting elderly people or those with weak bones. Simple fractures break the bone into two pieces without breaking the skin. Compound fractures break both the bone and skin, requiring immediate surgery to reduce infection risks and immobilization of the bone. All fractures cause pain, swelling, and warmth at the injury site and are diagnosed via x-ray. Treatment focuses on immobilizing the bone through casting, pinning, or plating.
The document discusses the anatomy, physiology, causes, symptoms, diagnosis and management of intervertebral disc herniation. Key points include:
1) Intervertebral discs act as shock absorbers between vertebrae and allow limited spinal movement. Herniation occurs when a tear in the disc allows the nucleus pulposus to bulge beyond the annulus fibrosus.
2) Common causes are repetitive strain, trauma, obesity and poor posture. Symptoms vary depending on location but often include back pain radiating into the legs.
3) Diagnosis involves physical examination including the straight leg raise test and sometimes imaging tests. Management focuses on reducing pressure on neural elements through treatments like
1. The document discusses principles of fractures, including definitions, causes, types, open fractures, fracture healing, and management. It defines a fracture as a break in bone structure.
2. Common causes of fractures include direct traumatic force, indirect force, pathological fractures from weakened bone, and stress fractures from repetitive stress. Types include transverse, oblique, spiral, impacted and comminuted.
3. Open fractures involve a break in the skin and soft tissues, and are classified using the Gustilo system from Type I to III based on wound size, soft tissue damage, and bone comminution.
This document discusses fractures, including their definition, classification, causes, signs and symptoms, diagnosis, management, and healing process. It defines a fracture as a disruption in bone continuity and classifies fractures as closed or open, complete or incomplete. The causes of fractures include direct blows, twisting motions, muscle contractions, and pathological bone conditions. Diagnosis involves history, physical exam, and x-rays. Management principles are to immobilize the area, prevent further displacement, alleviate pain, and allow movement of unaffected areas. Surgical management may include open reduction internal fixation or external fixation.
1. The document discusses the anatomy, physiology, and clinical presentation of herniated intervertebral discs. It describes the composition and functions of the nucleus pulposus and annulus fibrosus.
2. Signs and symptoms of herniated discs vary depending on location but commonly include back pain radiating into the buttock and leg. Physical examination involves testing for limited range of motion and tenderness as well as straight leg raise.
3. Diagnosis involves assessing patient history, symptoms on physical exam, and sometimes imaging tests. Herniated discs most often occur in the lumbar spine and can impinge on lumbar or sacral nerve roots.
Biomechanics of fracture and fracture healingsara kowsar
A bone fracture is a broken bone that
occurs when a force impels against a
bone that is stronger than it can structurally withstand.Bone healing refers to complex and sequential events that occur to restore injured bone to pre-injury state.
Classification of Fractures & Compound Fracture ManagmentKevin Ambadan
This document discusses the classification and management of fractures, including compound fractures. It describes several classification systems for fractures based on their relationship to the environment, degree of displacement, fracture pattern, and etiology. It also discusses the Gustilo classification system for open fractures. For treatment of compound fractures, the document emphasizes the importance of antibiotic prophylaxis, debridement of the wound and fracture, stabilization of the fracture, and early wound coverage. It describes various methods of fracture stabilization, including external and internal fixation.
1) A fracture is a break in the continuity of bone caused by stress greater than the bone can withstand. This can damage surrounding soft tissues and organs.
2) Fractures are caused by direct blows, crushing forces, twisting motions, or muscle contractions. Types include simple, compound, impacted, and stress fractures.
3) Treatment involves reducing the fracture by aligning bone fragments, immobilizing the area, and rehabilitation to regain function and strength. Complications can include infection, delayed healing, or nonunion if not properly treated.
The document discusses the history and anatomy of lumbar disc disease. Key points include:
1) Aurelianus in the 5th century described symptoms of sciatica and Andreas Vesalius in 1543 first described the intervertebral disc.
2) Mixter and Barr in 1934 described disc herniation as the cause of sciatica.
3) The lumbar spine has intervertebral discs that can prolapse and press on nerve roots, commonly occurring posterolaterally at L4-L5 and L5-S1 levels.
This document provides information on various imaging modalities and findings related to bone trauma. It discusses plain radiographs, bone scans, ultrasound, CT scans, and MRI for evaluating bone injuries and fractures. It then describes different fracture types including closed versus open fractures, single versus multiple fracture lines, complete versus incomplete fractures, and plastic, torus, and greenstick fractures. Finally, it outlines various complications that can arise from bone fractures such as malunion, dislocation, avulsion injuries, stress fractures, and post-traumatic conditions.
1) The document discusses lumbar and cervical disc prolapses, with a focus on the anatomy, clinical presentation, examination, investigations, and treatment options.
2) It notes that 90% of lumbar disc prolapses occur at the L4/L5 and L5/S1 levels, while cervical disc prolapses usually occur in a posterolateral direction due to the strong posterior longitudinal ligament.
3) Conservative treatment is effective for many cases, while indications for surgery include incapacitating pain, neurological deficits, or motor/sphincter issues. Surgical options include discectomy with minimal bone removal or laminectomy.
A fracture is a broken bone that will heal whether or not a physician resets the bone. There are different types of fractures named according to their severity and location. The healing process of a fracture involves formation of a fracture hematoma, development of a fibrocartilaginous callus, formation of a bony callus, and remodeling of the bone. Stress fractures are microscopic cracks in the bone that result from repeated strenuous activity and can be detected using a bone scan.
This document discusses prolapsed intervertebral discs, beginning with the typical features of lumbar vertebrae that distinguish them from other vertebrae. It then covers the epidemiology, types, risk factors, stages, pathophysiology, clinical manifestations, diagnostic findings, and medical and surgical management of lumbar disc herniations. Common surgical procedures discussed include discectomy, laminectomy, nucleoplasty, fusion, and arthroplasty. Nursing care focuses on pain management, mobility, bowel and bladder function, education, and prevention of recurrence through exercise.
This document discusses cervical disc prolapse. It begins by describing the anatomy of the spine and intervertebral discs. It then discusses the causes, symptoms, and treatments of cervical disc prolapse. Conservative treatments include rest, medications, and traction. Surgical treatments include posterior or anterior approaches to remove the herniated disc material. Anterior cervical discectomy with fusion or disc arthroplasty are described as surgical options.
A disc prolapse occurs when the outer layer of an intervertebral disc ruptures, causing part of the soft inner material to bulge out and press on nerves. It often results from wear and tear on the spine from physical labor, injuries, obesity, or aging. Common symptoms include low back pain that radiates into the legs, accompanied by numbness, tingling, and muscle weakness. Diagnosis is made through x-rays, CT scans, MRIs, or electromyography. Treatment options range from pain medications and rest to surgical procedures to remove the protruding disc material or fuse the vertebrae.
This document discusses bone and fracture healing. It covers the key stages and processes of both endochondral and intramembranous ossification. Endochondral healing involves the formation of a cartilage callus that is later replaced with bone, while intramembranous healing forms bone directly without a cartilage intermediate. Both involve cells, scaffolding, blood supply, and signaling molecules. Complications like malunion, delayed union, and nonunion can occur if healing is disrupted by factors like instability, open fractures, or patient health issues.
This document discusses new advances in spine surgery. It describes minimally invasive techniques that are becoming more common, such as balloon kyphoplasty to treat vertebral fractures, cervical disc replacement instead of fusion, and minimal access lumbar surgery. These new approaches aim to reduce trauma to muscles and soft tissues compared to conventional open surgeries. The document also discusses the importance of selecting the right surgical treatment and technique based on a patient's individual clinical findings and investigational results.
A spinal disc herniation occurs when a tear in the outer ring of an intervertebral disc allows the soft central portion to bulge out. Most herniations occur in the lumbar region and cause pain that may radiate into the legs. Diagnosis is made based on symptoms and physical exam, and may include imaging tests. While minor herniations may heal on their own, severe or persistent cases sometimes require surgery.
The document discusses four common types of bone fractures:
1. Comminuted fractures involve multiple bone fragments and can be challenging to treat.
2. Spiral fractures result from twisting forces and may require surgery or months in a cast.
3. Greenstick fractures are most common in children and cause partial bone breaks like bending a green twig.
4. Proper diagnosis and immobilization are needed for fractures to heal completely.
This document discusses imaging of the lumbar spine. It begins with an introduction and overview of spine nomenclature and the evidence for imaging. Key points include prevalence data for common disc findings in asymptomatic individuals. The document also reviews rationales for imaging, such as ruling out red flag conditions or confirming treatable abnormalities like stenosis or herniated discs. Consensus nomenclature is presented for describing lumbar disc findings.
The document discusses different types of fractures, including:
1. Simple and compound fractures. Simple fractures involve just bone, while compound fractures break the skin.
2. Classification by type (incomplete, complete, transverse, oblique, etc.) and location (diaphyseal, metaphyseal, epiphyseal).
3. Etiology can be intrinsic factors like muscle contraction or extrinsic like direct/indirect violence. Diagnosis involves identifying dysfunction like lameness. Treatment and potential complications are also mentioned.
The document summarizes the structure and function of the nervous system in three main divisions:
1) The central nervous system (CNS) consists of the brain and spinal cord. The peripheral nervous system (PNS) consists of the nerve network outside the CNS.
2) Neuroglia are supportive cells in the nervous system that form myelin sheaths and blood-brain barriers. The most numerous neuroglial cell is the astrocyte.
3) Neurons handle communication in the nervous system and are classified as sensory, motor, or interneurons. Impulse conduction in neurons involves changes in membrane potential and the firing of action potentials.
The document discusses endocrine system disorders and diabetes mellitus. It covers the location and functions of endocrine glands, classification of hormones, control of the endocrine system through feedback loops, sources and effects of major hormones, and disorders that can result from excess or deficits of hormones. Specific attention is given to diabetes mellitus, including the different types, manifestations, diagnostic tests, treatment principles, and acute and chronic complications if blood glucose levels are not well-controlled.
1. The document discusses principles of fractures, including definitions, causes, types, open fractures, fracture healing, and management. It defines a fracture as a break in bone structure.
2. Common causes of fractures include direct traumatic force, indirect force, pathological fractures from weakened bone, and stress fractures from repetitive stress. Types include transverse, oblique, spiral, impacted and comminuted.
3. Open fractures involve a break in the skin and soft tissues, and are classified using the Gustilo system from Type I to III based on wound size, soft tissue damage, and bone comminution.
This document discusses fractures, including their definition, classification, causes, signs and symptoms, diagnosis, management, and healing process. It defines a fracture as a disruption in bone continuity and classifies fractures as closed or open, complete or incomplete. The causes of fractures include direct blows, twisting motions, muscle contractions, and pathological bone conditions. Diagnosis involves history, physical exam, and x-rays. Management principles are to immobilize the area, prevent further displacement, alleviate pain, and allow movement of unaffected areas. Surgical management may include open reduction internal fixation or external fixation.
1. The document discusses the anatomy, physiology, and clinical presentation of herniated intervertebral discs. It describes the composition and functions of the nucleus pulposus and annulus fibrosus.
2. Signs and symptoms of herniated discs vary depending on location but commonly include back pain radiating into the buttock and leg. Physical examination involves testing for limited range of motion and tenderness as well as straight leg raise.
3. Diagnosis involves assessing patient history, symptoms on physical exam, and sometimes imaging tests. Herniated discs most often occur in the lumbar spine and can impinge on lumbar or sacral nerve roots.
Biomechanics of fracture and fracture healingsara kowsar
A bone fracture is a broken bone that
occurs when a force impels against a
bone that is stronger than it can structurally withstand.Bone healing refers to complex and sequential events that occur to restore injured bone to pre-injury state.
Classification of Fractures & Compound Fracture ManagmentKevin Ambadan
This document discusses the classification and management of fractures, including compound fractures. It describes several classification systems for fractures based on their relationship to the environment, degree of displacement, fracture pattern, and etiology. It also discusses the Gustilo classification system for open fractures. For treatment of compound fractures, the document emphasizes the importance of antibiotic prophylaxis, debridement of the wound and fracture, stabilization of the fracture, and early wound coverage. It describes various methods of fracture stabilization, including external and internal fixation.
1) A fracture is a break in the continuity of bone caused by stress greater than the bone can withstand. This can damage surrounding soft tissues and organs.
2) Fractures are caused by direct blows, crushing forces, twisting motions, or muscle contractions. Types include simple, compound, impacted, and stress fractures.
3) Treatment involves reducing the fracture by aligning bone fragments, immobilizing the area, and rehabilitation to regain function and strength. Complications can include infection, delayed healing, or nonunion if not properly treated.
The document discusses the history and anatomy of lumbar disc disease. Key points include:
1) Aurelianus in the 5th century described symptoms of sciatica and Andreas Vesalius in 1543 first described the intervertebral disc.
2) Mixter and Barr in 1934 described disc herniation as the cause of sciatica.
3) The lumbar spine has intervertebral discs that can prolapse and press on nerve roots, commonly occurring posterolaterally at L4-L5 and L5-S1 levels.
This document provides information on various imaging modalities and findings related to bone trauma. It discusses plain radiographs, bone scans, ultrasound, CT scans, and MRI for evaluating bone injuries and fractures. It then describes different fracture types including closed versus open fractures, single versus multiple fracture lines, complete versus incomplete fractures, and plastic, torus, and greenstick fractures. Finally, it outlines various complications that can arise from bone fractures such as malunion, dislocation, avulsion injuries, stress fractures, and post-traumatic conditions.
1) The document discusses lumbar and cervical disc prolapses, with a focus on the anatomy, clinical presentation, examination, investigations, and treatment options.
2) It notes that 90% of lumbar disc prolapses occur at the L4/L5 and L5/S1 levels, while cervical disc prolapses usually occur in a posterolateral direction due to the strong posterior longitudinal ligament.
3) Conservative treatment is effective for many cases, while indications for surgery include incapacitating pain, neurological deficits, or motor/sphincter issues. Surgical options include discectomy with minimal bone removal or laminectomy.
A fracture is a broken bone that will heal whether or not a physician resets the bone. There are different types of fractures named according to their severity and location. The healing process of a fracture involves formation of a fracture hematoma, development of a fibrocartilaginous callus, formation of a bony callus, and remodeling of the bone. Stress fractures are microscopic cracks in the bone that result from repeated strenuous activity and can be detected using a bone scan.
This document discusses prolapsed intervertebral discs, beginning with the typical features of lumbar vertebrae that distinguish them from other vertebrae. It then covers the epidemiology, types, risk factors, stages, pathophysiology, clinical manifestations, diagnostic findings, and medical and surgical management of lumbar disc herniations. Common surgical procedures discussed include discectomy, laminectomy, nucleoplasty, fusion, and arthroplasty. Nursing care focuses on pain management, mobility, bowel and bladder function, education, and prevention of recurrence through exercise.
This document discusses cervical disc prolapse. It begins by describing the anatomy of the spine and intervertebral discs. It then discusses the causes, symptoms, and treatments of cervical disc prolapse. Conservative treatments include rest, medications, and traction. Surgical treatments include posterior or anterior approaches to remove the herniated disc material. Anterior cervical discectomy with fusion or disc arthroplasty are described as surgical options.
A disc prolapse occurs when the outer layer of an intervertebral disc ruptures, causing part of the soft inner material to bulge out and press on nerves. It often results from wear and tear on the spine from physical labor, injuries, obesity, or aging. Common symptoms include low back pain that radiates into the legs, accompanied by numbness, tingling, and muscle weakness. Diagnosis is made through x-rays, CT scans, MRIs, or electromyography. Treatment options range from pain medications and rest to surgical procedures to remove the protruding disc material or fuse the vertebrae.
This document discusses bone and fracture healing. It covers the key stages and processes of both endochondral and intramembranous ossification. Endochondral healing involves the formation of a cartilage callus that is later replaced with bone, while intramembranous healing forms bone directly without a cartilage intermediate. Both involve cells, scaffolding, blood supply, and signaling molecules. Complications like malunion, delayed union, and nonunion can occur if healing is disrupted by factors like instability, open fractures, or patient health issues.
This document discusses new advances in spine surgery. It describes minimally invasive techniques that are becoming more common, such as balloon kyphoplasty to treat vertebral fractures, cervical disc replacement instead of fusion, and minimal access lumbar surgery. These new approaches aim to reduce trauma to muscles and soft tissues compared to conventional open surgeries. The document also discusses the importance of selecting the right surgical treatment and technique based on a patient's individual clinical findings and investigational results.
A spinal disc herniation occurs when a tear in the outer ring of an intervertebral disc allows the soft central portion to bulge out. Most herniations occur in the lumbar region and cause pain that may radiate into the legs. Diagnosis is made based on symptoms and physical exam, and may include imaging tests. While minor herniations may heal on their own, severe or persistent cases sometimes require surgery.
The document discusses four common types of bone fractures:
1. Comminuted fractures involve multiple bone fragments and can be challenging to treat.
2. Spiral fractures result from twisting forces and may require surgery or months in a cast.
3. Greenstick fractures are most common in children and cause partial bone breaks like bending a green twig.
4. Proper diagnosis and immobilization are needed for fractures to heal completely.
This document discusses imaging of the lumbar spine. It begins with an introduction and overview of spine nomenclature and the evidence for imaging. Key points include prevalence data for common disc findings in asymptomatic individuals. The document also reviews rationales for imaging, such as ruling out red flag conditions or confirming treatable abnormalities like stenosis or herniated discs. Consensus nomenclature is presented for describing lumbar disc findings.
The document discusses different types of fractures, including:
1. Simple and compound fractures. Simple fractures involve just bone, while compound fractures break the skin.
2. Classification by type (incomplete, complete, transverse, oblique, etc.) and location (diaphyseal, metaphyseal, epiphyseal).
3. Etiology can be intrinsic factors like muscle contraction or extrinsic like direct/indirect violence. Diagnosis involves identifying dysfunction like lameness. Treatment and potential complications are also mentioned.
The document summarizes the structure and function of the nervous system in three main divisions:
1) The central nervous system (CNS) consists of the brain and spinal cord. The peripheral nervous system (PNS) consists of the nerve network outside the CNS.
2) Neuroglia are supportive cells in the nervous system that form myelin sheaths and blood-brain barriers. The most numerous neuroglial cell is the astrocyte.
3) Neurons handle communication in the nervous system and are classified as sensory, motor, or interneurons. Impulse conduction in neurons involves changes in membrane potential and the firing of action potentials.
The document discusses endocrine system disorders and diabetes mellitus. It covers the location and functions of endocrine glands, classification of hormones, control of the endocrine system through feedback loops, sources and effects of major hormones, and disorders that can result from excess or deficits of hormones. Specific attention is given to diabetes mellitus, including the different types, manifestations, diagnostic tests, treatment principles, and acute and chronic complications if blood glucose levels are not well-controlled.
This document provides an overview of the nervous system, including its main components and functions. It describes the central nervous system including the brain and spinal cord, as well as the peripheral nervous system. It then discusses the various parts of the brain in detail, including protective structures like the meninges and cerebrospinal fluid. It also outlines the cranial nerves, spinal cord, spinal nerves, reflexes, and basic neuron structure and function.
The document discusses the respiratory system, including its purpose of transporting oxygen and removing carbon dioxide. It describes the anatomy of the upper and lower respiratory tract. Key points include that the upper tract has resident flora while the lower tract is sterile. It also discusses ventilation, gas exchange, control of breathing, diagnostic tests for respiratory disorders, and general manifestations of respiratory disease such as coughing, sputum, and breathing patterns.
The document provides an overview of the digestive system and common digestive disorders. It describes the anatomy and functions of the digestive tract organs, the processes of digestion and absorption, and neural and hormonal controls. Common manifestations of digestive disorders discussed include anorexia, nausea, vomiting, diarrhea, blood in stool, gas, and constipation. Dehydration and electrolyte imbalances are noted as potential complications.
This document discusses nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used over-the-counter and prescription pain relievers that work by inhibiting inflammation. Some common examples are aspirin, ibuprofen, and acetaminophen. The document outlines several general contraindications for NSAID use, such as kidney, liver, heart, or stomach problems. It then provides more specific contraindications for some common NSAIDs like aspirin, paracetamol, indomethacin, ibuprofen, and diclofenac sodium.
The document discusses urology and the urinary system. It covers the anatomy and physiology of the urinary system, including the structures of the kidneys, ureters, bladder, and urethra. It describes the process of urine production in the nephrons of the kidneys and the transportation of urine through the urinary system to be excreted from the body. It also lists learning objectives about the urinary system, diseases, diagnostic tests, and medical terminology.
The document is a chapter from a medical terminology textbook about male reproductive medicine. It includes learning objectives about the male genitourinary system, as well as sections on anatomy and physiology, spermatogenesis, sexual maturity, and ejaculation. Figures and diagrams are provided to illustrate the structures of the male reproductive system.
The document summarizes key aspects of the immune system. It describes the components of the immune system including lymphoid structures, immune cells, and tissues responsible for immune cell development. It also discusses the nonspecific and specific immune responses, antibodies, immunity types, hypersensitivity reactions, and immunodeficiencies.
The document discusses various skin disorders and lesions. It begins by reviewing the normal anatomy and layers of the skin, including the epidermis, dermis, and hypodermis. It then describes common inflammatory disorders like contact dermatitis, urticaria, atopic dermatitis, and psoriasis. The document also covers various skin infections caused by bacteria, viruses, and other microbes like impetigo, cellulitis, herpes simplex, and leprosy. Diagnostic tests and general treatment measures for skin conditions are also mentioned.
The document summarizes the anatomy and physiology of the eye and visual system. It describes the main parts of the eye including the cornea, iris, lens, retina, and optic nerve. It explains how light enters the eye and is focused on the retina to initiate visual signals through the optic nerve. The document also discusses common eye disorders like myopia, hyperopia, glaucoma, and conjunctivitis as well as infections, injuries, and defects that can affect vision.
This document discusses neoplasms and cancer. It begins by defining key terms like differentiation, mitosis, mutation, and apoptosis. It then describes the characteristics of benign and malignant tumors, noting that malignant tumors lack control of cell growth and can spread to other sites. The document outlines various diagnostic tests for cancer and explains how cancer spreads through invasion and metastasis. It discusses factors that can increase cancer risk and lists some treatment options like surgery, chemotherapy, and radiation therapy.
The document summarizes key aspects of the respiratory system, including:
- External respiration involves gas exchange between the lungs and blood, transporting oxygen to tissues and carbon dioxide away. Internal respiration occurs via cellular respiration in mitochondria.
- The respiratory tract involves the nose, pharynx, larynx, trachea, bronchi and bronchioles leading to alveoli where gas exchange occurs by diffusion across pulmonary capillaries.
- Breathing is driven by changes in thoracic pressure and lung volumes via contraction of respiratory muscles and elastic recoil of the lungs and chest wall. Inspiration occurs as lungs fill a expanded chest cavity, expiration when it relaxes.
This document provides an overview of blood and circulatory system disorders. It begins with a review of the circulatory system and its components. It then discusses blood vessels including arteries, veins, and capillaries. Next, it covers the components and functions of blood, including plasma, red blood cells, white blood cells, and platelets. The document proceeds to describe various blood disorders such as anemias, hemolytic anemia, sickle cell anemia, and aplastic anemia. It provides details on diagnostic tests and blood therapies for treating various blood-related conditions.
This document provides information on the nervous system and common neurological diseases and disorders. It begins with an overview of the key structures of the nervous system, including neurons, dendrites, axons, and myelin sheath. It then describes the central nervous system, including the brain and spinal cord, and peripheral nervous system. Several common neurological conditions are then discussed in more detail, including stroke, transient ischemic attack, encephalitis, meningitis, brain abscess, poliomyelitis, Guillain-Barré syndrome, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, dementia, Huntington's disease, cerebral concussion/contusion, and spinal cord injury. For each condition, the
The document provides an overview of the human respiratory system, including its key functions, organs, and mechanics. The respiratory system functions to exchange gases, purify air, and produce sound. Its organs include the nose, pharynx, larynx, trachea, bronchi, and lungs. Within the lungs, gas exchange takes place in tiny air sacs called alveoli. Breathing is driven by the contraction and relaxation of the diaphragm and intercostal muscles, pulling air into and pushing air out of the lungs.
This document contains 22 multiple choice microbiology questions. The questions cover topics such as Group A streptococci virulence factors, Group B streptococci characteristics, pneumococcal vaccines, Enterobacteriaceae identification and characteristics, E. coli virulence factors, Proteus mirabilis identification, Enterotoxigenic E. coli pathogenesis, plasmid transfer mechanisms, PCR applications, Koch's postulates, septicemia risk factors and presentations, Pseudomonas aeruginosa as a cause of infection in immunocompromised patients, staphylococcal osteomyelitis treatment challenges, tularemia presentation and identification, Neisseria meningitidis as a cause of a sore throat with findings of petechiae
Mandibular fractures have been documented since ancient Greece. Hippocrates described reducing displaced but incomplete mandibular fractures by pressing on the lingual surface with fingers while applying counterpressure externally. The Edwin Smith Treatise also described examining for mandibular fractures by feeling for crepitus under the fingers. Mandibular fractures typically involve the body, angle, condyle, symphysis, or ramus. Physical exam may reveal changes in occlusion, inability to open or close the mouth, anesthesia of the lower lip, or trismus. Diagnosis is made by identifying these physical exam findings along with the patient's mechanism of injury.
1. The document provides a set of 50 multiple choice questions related to various topics in dentistry. The questions cover subjects like dental anatomy, operative dentistry, endodontics, oral pathology, oral surgery and more.
2. The questions are based on people's memories of past exams and cannot be relied on 100% but provide an idea of topics that may be covered.
3. Answers are not provided for the questions.
This course covers the anatomy, physiology, pathology, and physical therapy treatment of the musculoskeletal system. Key topics include the structure and function of bones, joints, tendons, ligaments and muscles. Common diagnostic tests, procedures, and pathologies of the musculoskeletal system are discussed. The course also covers medical terminology, combining forms, pharmacology, and physical therapy interventions for musculoskeletal conditions.
ORTHOPEADIC NURSING (1).pptx BY KELVIN KEANKelvinkebu
This document outlines the objectives and content of an orthopedic nursing course. The course aims to provide knowledge and skills for nursing care of patients with musculoskeletal conditions. Key topics covered include anatomy and physiology of the musculoskeletal system, bone healing, fractures and soft tissue injuries, orthopedic inflammatory conditions, diagnostic tests, and nursing management of orthopedic disorders. The course objectives are to understand the structure and function of tissues in the musculoskeletal system, describe components of nursing assessment for orthopedic patients, and explain the nurse's role in managing fractures and preventing complications.
Osteoarthritis is a degenerative joint disease that involves the breakdown of articular cartilage and underlying bone. It most commonly affects weight-bearing joints like the knees and hips. Risk factors include age over 45, female sex, joint injuries, obesity, and hereditary factors. Symptoms include pain, stiffness, swelling, and loss of function. Diagnosis is made based on symptoms and confirmed with x-rays showing cartilage loss, bone spurs, and bone changes. Treatment focuses on pain management, physical therapy, braces, and surgery like joint replacement for severe cases.
1) There are four main types of bones - long, short, flat, and irregular. Long bones such as the femur and humerus are named based on their length and shape.
2) The structure of long bones includes a shaft (diaphysis), bulbous ends (epiphyses), articular cartilage covering joint surfaces, and bone marrow cavity (medullary cavity) containing blood vessels.
3) Bone tissue consists of cells, fibers, and a mineralized organic matrix. The matrix includes collagen fibers and hydroxyapatite calcium crystals which harden the bones and provide strength.
76. General Anatomy of Bone.pptx........RanaTalha67
This document provides an overview of bone anatomy, including:
- Classifying bones based on their architecture, regional distribution, size/shape, and embryological development. Long bones have diaphysis, epiphysis, and metaphyses while flat bones have thin inner/outer layers.
- Describing the structure of long bones which consist of diaphysis, epiphysis, metaphysis, marrow cavity, and periosteum/endosteum membranes.
- Explaining blood and nerve supply to bones from nutrient arteries, medullary arteries, and periosteal arteries. Nerves accompany nutrient vessels and have receptors in osteoblasts.
The document provides information about a Level 2 Anatomy and Physiology for Exercise course through YMCA Awards, including unit aims covering basic anatomy and physiology relating to exercise programming for healthy adults. The skeleton unit covers identifying major bones, the structure and functions of the skeleton, and types of joints. Special populations like young people, pregnant women, older adults and those with disabilities may require modified exercise approaches due to anatomical and physiological changes.
1) Bones provide structure, protect organs, store minerals, and enable blood cell production. They form through two processes and consist of cortical, trabecular, woven, and lamellar bone.
2) Fractures occur when a bone breaks, and can be open (skin broken) or closed (skin intact). They result from trauma, disease, or stress and are described by location, completeness, configuration, and relationship of fragments.
3) Fracture treatment aims to unite the bone in proper alignment to maximize function. Methods include casting, surgery, and managing complications like infection, nonunion, and stiffness. Proper diagnosis and treatment type selection seek to help the body heal naturally over time.
The document discusses distraction osteogenesis, which is a technique for regenerating bone and soft tissue by gradually separating bone segments that have been surgically cut. It describes the history, biological process, phases involving surgery, latency period and distraction period, factors to consider like rate and rhythm of distraction, applications for maxillofacial deficiencies and reconstruction, and techniques involved. Distraction osteogenesis is an alternative to orthognathic surgery that allows for gradual adjustment of bony and soft tissues.
Bones provide support, protection, movement, mineral storage, and blood cell formation. With aging, bones become thinner and more porous due to increased bone absorption. This bone loss leads to loss of height and increased curvature of the spine and joints, contributing to osteoporosis.
Bones are rigid organs that form the endoskeleton and have several important functions, including movement, support, protection and storage of minerals. There are two types of ossification that form bones - intramembranous and endochondral ossification. Intramembranous ossification forms some flat bones directly in fibrous membranes, while endochondral ossification first forms cartilage templates that are later replaced by bone. Long bones develop primarily through endochondral ossification, beginning as cartilage that is later invaded by blood vessels and replaced with spongy bone. Growth plates allow bones to lengthen, and remodeling allows bones to increase in thickness. Calcium homeostasis and bone health rely on adequate vitamin D, which facilitates intestinal
Orthopedic surgery 2nd general principles in fracturesRamiAboali
The document discusses bone formation and fracture classification. There are three types of bone formation: enchondral, where bone replaces cartilage; intramembranous, where bone develops directly from mesenchymal cells; and appositional, where new bone forms on top of existing bone. Fractures can be classified in several ways, including by shape (transverse, oblique, comminuted), location (proximal, distal), stability (stable, unstable), and degree of displacement. Fracture healing occurs either through direct union if the fracture is absolutely stable, or through callus formation involving inflammation, soft callus development, hard callus formation, and remodeling if there is movement at the fracture site.
Distraction osteogenesis of craniofacial regionKunaal Agrawal
The document provides an overview of distraction osteogenesis (DO). It discusses the historical origins and development of DO, from Hippocrates applying traction on broken bones to Ilizarov's modern principles of bone regeneration through gradual traction. The biological basis and phases of DO are explained, including fracture/osteotomy, latency period, distraction period, and consolidation period. Each phase is accompanied by the histological and cellular processes involved in regenerating new bone through gradual traction rather than acute advancement. The document serves as an introduction to DO and its application in craniofacial reconstruction.
Bone healing and Replacement surgeries.pptxvenbarani
Bone healing and replacement surgeries address broken bones and damaged joints. The document discusses the stages of fracture healing, including tissue destruction and callus formation. It also covers total joint replacement, which involves replacing arthritic or damaged parts of a joint with prosthetic implants. Common replacement surgeries described are total hip replacement, total knee replacement, and finger joint arthroplasty. Nursing priorities for these surgeries include managing pain and preventing complications like infection.
Bone healing and Replacement surgeries.pptxvenbarani
The document discusses bone healing and replacement surgeries. It describes the stages of fracture healing including tissue destruction, inflammation, callus formation, consolidation, and remodeling. It also discusses total joint replacement surgeries, noting they are commonly performed to treat arthritis and involve replacing damaged bone and cartilage with prosthetic implants made of metal, plastic or ceramic. Complications can include malunion, delayed union, nonunion, dislocation, infection, and implant failure.
This document discusses bone grafting in orthopedics. It defines bone grafting as surgically harvesting bone from one site and placing it into another site, either within the same person or between individuals. Bone grafting has several indications including filling bone defects, bridging joints, and promoting bone union. The document discusses the biological concepts of bone grafts, ideal characteristics, advantages, disadvantages, common sites, and classifications of bone grafts. It also provides examples of vascularized fibular and iliac crest grafts and synthetic graft variants made from ceramics. Complications of bone grafting include infection, bleeding, nerve injury, and graft rejection. Autograft is considered the gold standard but stem cell research offers promising
This document contains an exam review covering topics related to the skeletal and muscular systems. It includes questions about bone types, the functions of different bone structures, types of joints and their characteristics, muscle contractions, and terminology used to describe muscle and joint actions. The review covers key anatomical structures and their functions to prepare students for an exam on musculoskeletal anatomy and kinesiology.
This document provides an introduction to osteology, the study of bones. It discusses the classification, macro and microstructure, properties, and functions of bones. Bones are composed of both organic and inorganic materials and come in four types - long, short, flat, and irregular. Cortical bone forms the hard outer layer of bones and has concentric osteons, while cancellous bone is spongy and found at the ends of long bones. Bones provide structure, movement, protection and store minerals in the body.
Osteology is the study of bones. Bones provide structure, protection, movement, mineral storage, blood cell formation, and energy storage. Bone tissue consists of cells within an organic collagen-rich extracellular matrix as well as an inorganic mineral component. Cortical bone forms the dense outer layer of long bones and has concentric osteons. Cancellous or spongy bone is found at the ends of long bones and in flat and irregular bones. Bones experience both compression and tension forces and have adapted structures like osteons and layered lamellae to withstand these stresses.
This document provides an overview of chapter 10 from the third edition of the textbook Medical Language by Susan M. Turley. The chapter covers neurology and includes learning objectives, multimedia resources, and detailed descriptions of the anatomy and physiology of the central nervous system including the brain, cerebrum, lobes, ventricles, brainstem, cerebellum, and spinal cord.
The document discusses the muscular system and orthopedics. It covers the anatomy and physiology of muscles, including the three types of muscles (skeletal, cardiac, smooth), origins and insertions, and related structures like tendons. It describes the specialty of orthopedics and different types of muscle movement like flexion, extension, abduction, and rotation. It includes diagrams of muscle anatomy and movements. It also provides learning objectives and multimedia resources for further study.
This document provides an overview of the chapter on dermatology from the third edition of the textbook Medical Language. It begins with learning objectives for the chapter, which cover topics like the anatomy of the integumentary system, allergic reactions, common dermatological diseases and procedures, and medical terminology related to the skin. The bulk of the document then describes in detail the anatomy and physiology of the integumentary system, including the layers of the skin, hair follicles, sebaceous and sweat glands, and nails. It also discusses the process of allergic reactions and lists some general dermatological diseases. Diagrams and links to multimedia are provided throughout for additional reference.
This document summarizes key concepts about ratios, proportions, and percents from Chapter 3 of a textbook on math and dosage calculations for healthcare professionals. It defines important terms like ratio, proportion, and percent. It provides rules and examples for converting between ratios, proportions, percents, fractions and decimals. It also explains how to use proportions to solve for unknown quantities, including setting up equations and checking solutions. The overall purpose is to explain essential skills for understanding relationships between quantities and solving dosage calculation problems.
The document discusses inflammation and healing. It describes the three lines of defense in the body against pathogens: mechanical barriers, inflammation, and specific immune responses. Inflammation is defined as a protective response to infection or injury and involves redness, swelling, heat, pain, and loss of function. The stages of acute inflammation and factors that influence the inflammatory response like chemical mediators are examined. Treatment options for inflammation including medications are also reviewed.
This document describes the cardiovascular system and its anatomy. It discusses the structures of the heart including the chambers, valves, layers and muscles. It describes the major blood vessels including arteries, capillaries and veins. It explains the dual circulation of blood through the systemic and pulmonary circuits. Learning objectives cover identifying cardiovascular structures, describing diseases and procedures, and building medical terminology related to cardiology.
This document provides an overview of pharmacology and common medical therapies. It defines pharmacology and describes how drugs can be used to treat diseases, relieve symptoms, and replace deficient hormones or enzymes. Various drug administration routes, mechanisms of action, and factors influencing drug effects are examined. Common medical therapies including physiotherapy, occupational therapy, nutrition, and complementary/alternative approaches like herbalism and aromatherapy are also summarized.
The document describes the anatomy and physiology of the gastrointestinal (GI) system. It details the structures of the GI tract from the mouth through the esophagus, stomach, small intestine, large intestine and rectum. It explains the functions of these structures in digesting food, absorbing nutrients and removing waste from the body. Key parts include the oral cavity, pharynx, esophagus, stomach, small intestine, large intestine and associated structures like the salivary glands, liver and pancreas.
Chapter 2 PowerPoint Dosages and Calculationskevinyocum4
This document summarizes key concepts from Chapter 2 of a textbook on decimals. It discusses writing, comparing, rounding, and converting decimals and fractions. Arithmetic operations like addition, subtraction, multiplication and division of decimals are also covered. Examples and practice problems are provided to illustrate the rules and steps for working with decimals. The goal is to help healthcare professionals feel comfortable using decimals for dosage calculations.
Chapter 1 PowerPoint Dosages and Calculationskevinyocum4
This document provides an overview of fractions and their uses in dosage calculations for healthcare professionals. It defines key terms related to fractions and covers how to produce, identify, simplify, compare, add, subtract, multiply and divide fractions. The document includes examples and practice problems for each concept. The overall goal is to build students' confidence in basic math skills needed for accurate medication dosage calculations.
This document provides an overview of pathophysiology concepts. It defines health and disease, noting that health involves well-being while disease is a deviation from homeostasis. It describes factors that can impact "normal" health indicators and outlines seven steps to health. It then discusses key pathophysiology topics like the functional changes caused by disease, disease prevention strategies, and the language used to describe pathophysiological concepts.
The document discusses the structure of medical language. It covers the origins of medical terminology from Latin and Greek, how medical words are formed using combining forms, suffixes, and prefixes, and provides examples of common word parts. The objectives are to learn the basics of medical terminology including word structures, meanings, spellings, and pronunciations.
- Video recording of this lecture in English language: https://youtu.be/RvdYsTzgQq8
- Video recording of this lecture in Arabic language: https://youtu.be/ECILGWtgZko
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Applications of NMR in Protein Structure Prediction.pptxAnagha R Anil
This presentation explores the pivotal role of Nuclear Magnetic Resonance (NMR) spectroscopy in predicting protein structures. It delves into the methodologies, advancements, and applications of NMR in determining the three-dimensional configurations of proteins, which is crucial for understanding their function and interactions.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)MuskanShingari
Skin is the largest organ of the human body, serving crucial functions that include protection, sensation, regulation, and synthesis. Structurally, it consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous layer).
1. **Epidermis**: The outermost layer primarily composed of epithelial cells called keratinocytes. It provides a protective barrier against environmental factors, pathogens, and UV radiation.
2. **Dermis**: Located beneath the epidermis, the dermis contains connective tissue, blood vessels, hair follicles, and sweat glands. It plays a vital role in supporting and nourishing the epidermis, regulating body temperature, and housing sensory receptors for touch, pressure, temperature, and pain.
3. **Hypodermis**: Also known as the subcutaneous layer, it consists of fat and connective tissue that anchors the skin to underlying structures like muscles and bones. It provides insulation, cushioning, and energy storage.
Skin performs essential functions such as regulating body temperature through sweat production and blood flow control, synthesizing vitamin D when exposed to sunlight, and serving as a sensory interface with the external environment.
Maintaining skin health is crucial for overall well-being, involving proper hygiene, hydration, protection from sun exposure, and avoiding harmful substances. Skin conditions and diseases range from minor irritations to chronic disorders, emphasizing the importance of regular care and medical attention when needed.
Allopurinol, a uric acid synthesis inhibitor acts by inhibiting Xanthine oxidase competitively as well as non- competitively, Whereas Oxypurinol is a non-competitive inhibitor of xanthine oxidase.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Receptor Discordance in Breast Carcinoma During the Course of Life
Definition:
Receptor discordance refers to changes in the status of hormone receptors (estrogen receptor ERα, progesterone receptor PgR, and HER2) in breast cancer tumors over time or between primary and metastatic sites.
Causes:
Tumor Evolution:
Genetic and epigenetic changes during tumor progression can lead to alterations in receptor status.
Treatment Effects:
Therapies, especially endocrine and targeted therapies, can selectively pressure tumor cells, causing shifts in receptor expression.
Heterogeneity:
Inherent heterogeneity within the tumor can result in subpopulations of cells with different receptor statuses.
Impact on Treatment:
Therapeutic Resistance:
Loss of ERα or PgR can lead to resistance to endocrine therapies.
HER2 discordance affects the efficacy of HER2-targeted treatments.
Treatment Adjustment:
Regular reassessment of receptor status may be necessary to adjust treatment strategies appropriately.
Clinical Implications:
Prognosis:
Receptor discordance is often associated with a poorer prognosis.
Biopsies:
Obtaining biopsies from metastatic sites is crucial for accurate receptor status assessment and effective treatment planning.
Monitoring:
Continuous monitoring of receptor status throughout the disease course can guide personalized therapy adjustments.
Understanding and managing receptor discordance is essential for optimizing treatment outcomes and improving the prognosis for breast cancer patients.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.