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COX inhibitors
Nonsteroidal anti-
inflammatory drugs
Nonopioid analgesics
Nirmal Raj Marasine
CMC
E-mail- Nirmalrajmarasine@gmai.com
• A therapeutic agent which relieves pain and
fever by inhibiting the inflammatory response.
• These drugs are available over the counter
and by prescription.
• Some common examples include aspirin,
ibuprofen, indomethacin, and less commonly
acetaminophen (Tylenol).
MOA
GENERAL CONTRAINDICATION
• Don’t use in the: kidney problems, liver problems,
stomach problems (e.g., ulcers), heart disease
(e.g., arrhythmias, heart failure), high blood
pressure (hypertension), diabetes, blood
problems (e.g., anemia, bleeding disorders,
porphyria),asthma, nasal polyps, eye problems,
severe or long-lasting headaches, any allergies -
especially aspirin/NSAID allergy (e.g., ibuprofen,
celecoxib). This drug may make you dizzy or
drowsy. Use caution engaging in activities
requiring alertness such as driving or using
machinery. Limit alcoholic beverages
• This medication may make you more sensitive to the
sun. Avoid prolonged sun exposure, use a sunscreen,
and wear protective clothing when outdoors. This
medicine may cause stomach bleeding. Daily use of
alcohol and this medicine may increase your risk for
stomach bleeding. Caution is advised when using this
drug in the elderly because they may be more sensitive
to the effects of the drug. This medication should be
used only when clearly needed during pregnancy.
Discuss the risks and benefits with your doctor. Using
this drug during the last 6 months of pregnancy is not
recommended. This drug may pass into breast milk.
Consult your doctor before breast-feeding
• if you had an asthma attack, hives, or other
allergic reaction with aspirin or any other
NSAID medicine
• for pain right before or after heart bypass
surgery
Aspirin
• contraindications
 peptic ulcer
 bleeding disorder
 hypersensitivity to nsaids
 under <12 children
 liver disease
 pregnancy and lactation
 chickenpox or influenza infection
Paracetamol(acetoaminophen)
contraindication
 liver disease (eg,jaundice)
indomethacin
• Contraindication
• machinery operators
• Drivers
• Psychiatric patients
• Epileptics
• Kidney disease
• Pregnant women
• children
ibuprofen
• Contraindications
• peptic ulcer
• Lactting mother
• Pregnancy
• Hypersensitivity
• Unknown bleeding
• Children under seven
Diclofenac sodium
• Contraindication
• Peptic ulcer
• Children under seven years
• Kidney and liver disease

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Pr3

  • 1. COX inhibitors Nonsteroidal anti- inflammatory drugs Nonopioid analgesics Nirmal Raj Marasine CMC E-mail- Nirmalrajmarasine@gmai.com
  • 2. • A therapeutic agent which relieves pain and fever by inhibiting the inflammatory response. • These drugs are available over the counter and by prescription. • Some common examples include aspirin, ibuprofen, indomethacin, and less commonly acetaminophen (Tylenol).
  • 3. MOA
  • 4. GENERAL CONTRAINDICATION • Don’t use in the: kidney problems, liver problems, stomach problems (e.g., ulcers), heart disease (e.g., arrhythmias, heart failure), high blood pressure (hypertension), diabetes, blood problems (e.g., anemia, bleeding disorders, porphyria),asthma, nasal polyps, eye problems, severe or long-lasting headaches, any allergies - especially aspirin/NSAID allergy (e.g., ibuprofen, celecoxib). This drug may make you dizzy or drowsy. Use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages
  • 5. • This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, use a sunscreen, and wear protective clothing when outdoors. This medicine may cause stomach bleeding. Daily use of alcohol and this medicine may increase your risk for stomach bleeding. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Using this drug during the last 6 months of pregnancy is not recommended. This drug may pass into breast milk. Consult your doctor before breast-feeding
  • 6. • if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine • for pain right before or after heart bypass surgery
  • 7. Aspirin • contraindications  peptic ulcer  bleeding disorder  hypersensitivity to nsaids  under <12 children  liver disease  pregnancy and lactation  chickenpox or influenza infection
  • 9. indomethacin • Contraindication • machinery operators • Drivers • Psychiatric patients • Epileptics • Kidney disease • Pregnant women • children
  • 10. ibuprofen • Contraindications • peptic ulcer • Lactting mother • Pregnancy • Hypersensitivity • Unknown bleeding • Children under seven
  • 11. Diclofenac sodium • Contraindication • Peptic ulcer • Children under seven years • Kidney and liver disease