Cellular adaptations allow cells to survive stress by changing their environment through physiologic or pathologic means. Cells can adapt by decreasing or increasing in size (atrophy and hypertrophy), increasing in number (hyperplasia), or changing phenotype (metaplasia and dysplasia). Common cellular adaptations include atrophy, hypertrophy, hyperplasia, metaplasia, and dysplasia, which allow cells to respond to various stresses or stimuli.
Cellular Adaptation
as cells encounter stresses they undergo functional or structural adaptations to maintain viability / homeostasis.
Injury - altered homeostasis
if limits of the adaptive response are exceeded or if adaptation not possible, a sequence of events called cell injury occurs.
Reversible Cell Injury
removal of stress results in complete restoration of structural & functional integrity.
b) Irreversible Cell Injury / Cell Death
if stimulus persists or is severe enough from the start, the cell suffers irreversible cell injury and death.
2 main morphologic patterns: necrosis & apoptosis.
Adaptations are reversible changes in the size, number, phenotype, metabolic activity, or functions of cells in response to changes in their environment.
Physiologic adaptations are responses of cells to normal stimulation by hormones or endogenous chemical mediators
Pathologic adaptations are responses to stress that allow cells to modulate their structure and function and thus escape injury.
Hypertrophy refers to an increase in the size of cells, that results in an increase in the size of the affected organ
The hypertrophied organ has no new cells, just larger cells.
Types:
a) physiologic b) pathologic
Causes:
a) increased functional demand b) hormonal stimulation
Adaptive disorders are the adjustments which the cells make in response to stresses which may be for physiologic needs (physiologic adaptation) or a response to non-lethal pathologic injury (pathologic adaptation).
Such physiologic and pathologic adaptations occur by following processes.
Decreasing or increasing their size i.e. atrophy and
hypertrophy respectively, or by increasing their number i.e. Hyperplasia (postfi x word -trophy means nourishment; -plasia means growth of new cells).
Changing the pathway of phenotypic diff eren tia tion of cells i.e. metaplasia and dysplasia (prefi x word meta- means transformation; dys- means bad development).
2. ATROPHY
Reduction of the number and size of parenchymal cells of an organ or its parts which was once normal is called atrophy
CAUSES Atrophy may occur from physiologic or pathologic causes:
A. Physiologic atrophy
) Atrophy of lymphoid tissue with age.
ii) Atrophy of thymus in adult life.
iii) Atrophy of gonads after menopause.
iv) Atrophy of brain with ageing.
v) Osteoporosis with reduction in size of bony trabeculae due to ageing.
2. ATROPHY
B. Pathologic atrophy
1. Starvation atrophy
2. Ischaemic atrophy
3. Disuse atrophy
4. Neuropathic atrophy
5. Endocrine atrophy
6. Pressure atrophy
7. Idiopathic atrophy
3.HYPERTROPHY
Hypertrophy is an increase in the size of parenchymal cells resulting in enlargement of the organ or tissue, without any change in the number of cells.
A. Physiologic hypertrophy
Enlarged size of the uterus in Pregnancy is an example of physiologic hypertrophy as well as
hyperplasia.
B. Pathologic hypertrophy
1. Hypertrophy of cardiac muscle may occur in a number of cardiovasculardiseases. A few conditions producing left ventricular hypertrophy are as under:
i) Systemic hypertension
ii) Aortic valve disease (stenosis and insuffi ciency)
iii) Mitral insuffi ciency
2.Hypertrophy of skeletal muscle e.g. hypertrophied mus cles in athletes and manual labourers.
3.Hypertrophy of smooth muscle e.g.
i) Cardiac achalasia (in oesophagus)
ii) Pyloric stenosis (in stomach)
iii) Intestinal strictures
iv) Muscular arteries in hypertension.
4. Compensatory hypertrophy may occur in an organ when the contralateral organ is removed e.g.
i) Following nephrectomy on one side in a young patient, there is compensatory hypertrophy as well as hyperplasia of the nephrons of the other kidney.
ii) Adrenal hyperplasia following removal of one adrenal gland
4.HYPERPLASIA
Hyperplasia is an increase in the number of paren chymal cells resulting in enlargement of the organ or tissue.
Physiologic hyperplasia
The two most common types are hormonal and compensatory:
1. Hormonal hyperplasia i.e. hyperplasia occurring under the influence of hormonal stimulation e.g.
i) Hyperplasia of female breast at puberty, during preg nancy and lactation.
ii) Hyperplasia of pregnant uterus.
iii) Proliferative activity of normal endometrium after a normal menstrual cycle.
iv) Prostatic hyperplasia in old
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2. CELLULAR ADAPTATIONS
For the sake of survival on exposure to stress, the cells make
adjustments with the changes in their environment to the
physiologic adaptation and to pathologic adaptation.
Decreasing or increasing their size i.e. atrophy and
hypertrophy respectively, or by increasing their number i.e.
hyperplasia.
Changing the pathway of phenotypic differentiation of cells
i.e. metaplasia and dysplasia.
Various mechanisms which may be involved in adaptive
cellular responses include the following:
Altered cell surface receptor binding.
Alterations in signal for protein synthesis.
Synthesis of new proteins by the target cell such as heatshock
proteins (HSPs).
3. Common forms of cellular adaptive responses along
with examples of physiologic and pathologic
adaptations are briefly discussed below
1. ATROPHY
2. HYPERTROPY
3. HYPERPLASIA
4. METAPLASIA
5. DYSPLASIA
4.
5. ATROPHY
Reduction of the number and size of parenchymal cells of an organ or its
parts which was once normal is called atrophy.
CAUSES. Atrophy may occur from physiologic or pathologic
A. Physiologic atrophy. Atrophy is a normal process of aging in some
tissues, which could be due to loss of endocrine stimulation or
arteriosclerosis. For example:
i) Atrophy of lymphoid tissue in lymph nodes, appendix and thymus.
ii) Atrophy of gonads after menopause.
iii) Atrophy of brain with aging.
B. Pathologic atrophy. The causes are as under:
1. Starvation atrophy:- In starvation, there is first depletion of
carbohydrate and fat stores followed by protein catabolism. There is
general weakness, emaciation and anaemia referred to as cachexia
seen in cancer and severely ill patients.
2. Ischaemic atrophy:- Gradual diminution of blood supply due to
atherosclerosis may result in shrinkage of the affected organ e.g.
i) Small atrophic kidney in atherosclerosis of renal artery.
ii) Atrophy of brain in cerebral atherosclerosis.
6. 3. Disuse atrophy:- Prolonged diminished functional activity is associated with
disuse atrophy of the organ e.g.
i) Wasting of muscles of limb immobilised in cast.
ii) Atrophy of .the pancreas in obstruction of pancreatic duct.
4. Neuropathic atrophy:- Interruption in nerve supply leads to wasting of muscles
e.g.
i) Poliomyelitis
ii) Motor neuron disease
iii) Nerve section.
5. Endocrine atrophy:- Loss of endocrine regulatory mechanism results in reduced
metabolic activity of tissues and hence atrophy e.g.
i) Hypopituitarism may lead to atrophy of thyroid, adrenal and gonads.
ii) Hypothyroidism may cause atrophy of the skin and its adnexal structures.
6. Pressure atrophy:- Prolonged pressure from benign tumours or cyst or aneurysm
may cause compression and atrophy of the tissues e.g.
i) Erosion of spine by tumour in nerve root.
ii) Erosion of skull by meningioma arising from piaarachnoid.
iii) Erosion of sternum by aneurysm of arch of aorta.
7. Idiopathic atrophy:- There are some examples of atrophy where no obvious cause
is present e.g.
i) Myopathies.
ii) Testicular atrophy.
7. HYPERTROPHY
Hypertrophy is an increase in the size of parenchymal cells resulting in
enlargement of the organ or tissue, without any change in the number of cells.
CAUSES. Hypertrophy may be physiologic or pathologic.
Physiologic hypertrophy.:-
Enlarged size of the uterus in pregnancy is an excellent example of
physiologic hypertrophy as well as hyperplasia.
Pathologic hypertrophy:-
1. Hypertrophy of cardiac muscle may occur in a number of cardiovascular
diseases
i) Systemic hypertension
ii) Aortic valve disease
iii) Mitral insufficiency
2. Hypertrophy of smooth muscle e.g. Cardiac achalasia, Pyloric stenosis, Intestinal
strictures, Muscular arteries in hypertension.
3. Hypertrophy of skeletal muscle e.g. hypertrophied muscles in athletes and
manual labourers.
4. Compensatory hypertrophy may occur in an organ when the contralateral organ
is removed e.g. Adrenal hyperplasia.
8. HYPERPLASIA
It is an increase in the number of parenchymal cells resulting in enlargement of the
organ or tissue.
It occurs due to increased recruitment of cells from resting phase of the cell cycle to
undergo mitosis, when stimulated. All body cells do not possess hyperplastic
growth Potential.
Labile and stable cells can undergo hyperplasia, while permanent cells have little
or no capacity for regenerative hyperplastic growth.
Neoplasia differs from hyperplasia in having hyperplastic growth with loss of
growth-regulatory mechanism due to change in genetic composition of the cell.
CAUSES:- As with other non-neoplastic adaptive disorders of growth, hyperplasia has
also been divided into physiologic and pathologic.
A. Physiologic hyperplasia:- The two most common types are as follows:
1. Hormonal hyperplasia i.e. hyperplasia occurring under the influence of hormonal
stimulation e.g.
i) Hyperplasia of female breast at puberty, during pregnancy and lactation.
ii) Hyperplasia of pregnant uterus.
iii) Proliferative activity of normal endometrium after a normal menstrual cycle.
iv) Prostatic hyperplasia in old age.
9. 2. Compensatory hyperplasia i.e. hyperplasia occurring following
removal of part of an organ or a contralateral organ in paired organ
e.g.
i) Regeneration of the liver following partial hepatectomy
ii) Regeneration of epidermis after skin abrasion
iii) Following nephrectomy on one side, there is hyperplasia of
nephrons of the other kidney.
B. Pathologic hyperplasia:- Most examples of pathologic
hyperplasia are due to excessive stimulation of hormones or growth
factors e.g.
i) Endometrial hyperplasia following oestrogen excess.
ii) In wound healing, there is formation of granulation tissue due to
proliferation of fibroblasts and endothelial cells.
iii) Formation of skin warts from hyperplasia of epidermis due to
human papilloma virus.
iv) Pseudocarcinomatous hyperplasia of the skin.
v) Intraductal epithelial hyperplasia in the breast in fibrocystic breast
disease.
10. METAPLASIA
It is defined as a reversible change of one type of adult
cells to another type of cells.
If the stimulus persists for a long time, epithelial
metaplasia may transform into cancer.
Metaplasia is broadly divided into 2 types:
1. Epithelial Metaplasia
I. Squamous metaplasia
II. Columnar metaplasia
2. Mesenchymal Metaplasia
I. Osseous metaplasia
II. Cartilaginous metaplasia.
11. A. EPITHELIAL METAPLASIA. The metaplastic change may be
patchy or diffuse and usually results in replacement by stronger
but less well specialised epithelium.
Depending upon the type epithelium transformed, two types of
epithelial metaplasia are seen squamous and columnar:
1. Squamous metaplasia. This is more common. Various types of
specialised epithelium are capable of undergoing squamous
metaplastic change due to chronic irritation that may be
mechanical, chemical or infective in origin. Some common
examples
i) In bronchus in chronic smokers.
ii) In uterine endocervix in prolapse of the uterus and in old age
iii) In gallbladder in chronic cholecystitis with cholelithiasis.
iv) In prostate in chronic prostatitis and oestrogen therapy.
v) In renal pelvis and urinary bladder in chronic infection and
stones.
vi) In vitamin A deficiency, apart from xerophthalmia
12. 2. Columnar metaplasia. There are some conditions in which there is
transformation to columnar epithelium. For example:
i) Intestinal metaplasia in healed chronic gastric ulcer.
ii) Columnar metaplasia in Barrett’s oesophagus.
iii) Conversion of pseudostratified ciliated columnar epithelium in
chronic bronchitis and bronchiectasis to columnar type.
iv) In cervical erosion there is variable area of endocervical glandular
mucosa everted into the vagina
B. MESENCHYMAL METAPLASIA:- Less often, there is transformation
of one adult type of mesenchymal tissue to another. The examples are
as under:
1. Osseous metaplasia:- It is formation of bone in fibrous tissue,
cartilage and myxoid tissue. Examples
i) In arterial wall in old age
ii) In soft tissues in myositis ossificans
iii) In cartilage of larynx and bronchi in elderly people
iv) In scar of chronic inflammation of prolonged duration
v) In the fibrous stroma of tumour
2. Cartilaginous metaplasia:- In healing of fractures, cartilaginous
metaplasia may occur where there is undue mobility.
13.
14. DYSPLASIA It means ‘disordered cellular development’, often accompanied
with metaplasia and hyperplasia; it is therefore also referred to as
atypical hyperplasia.
Dysplasia occurs most often in epithelial cells. Epithelial dysplasia
is characterised by cellular proliferation and cytologic changes.
These changes include:
1. Increased number of layers of epithelial cells
2. Disorderly arrangement of cells from basal layer to the surface
layer
3. Loss of basal polarity i.e. nuclei lying away from basement
membrane
4. Cellular and nuclear pleomorphism
5. Increased nucleocytoplasmic ratio
6. Nuclear hyperchromatism
7. Increased mitotic activity.
The two most common examples of dysplastic changes are the
uterine cervix and respiratory tract.