Hypothyroidism is a common endocrinopathy in dogs resulting from a deficiency of thyroid hormones. It can be primary, secondary, or tertiary in origin. Primary hypothyroidism accounts for over 95% of cases and is usually caused by lymphocytic thyroiditis or idiopathic thyroid atrophy. Clinical signs vary but commonly include dermatological abnormalities such as hair loss and skin infections, obesity, lethargy, neurologic issues like peripheral neuropathy, and cardiovascular effects like bradycardia. Untreated hypothyroidism can impact multiple body systems and result in long-term health problems.
Hypothyroidism and hyperthyroidism in dogs are endocrine diseases caused by impaired or excessive thyroid hormone production respectively. Hypothyroidism is more common and seen as lethargy, weight gain, hair loss, and other metabolic signs. It is diagnosed via low thyroid hormone levels and treated with levothyroxine supplementation. Hyperthyroidism is rare in dogs and caused by functional thyroid tumors, seen as weight loss and other hypermetabolic signs.
Diagnosis and Treatment of Canine Pyodermaupstatevet
Ed Jazic, DVM, DACVD
The prevalence of Canine Pyoderma is increasing very quickly and the clinical condition can present in a variety of ways. It is a common secondary manifestation of a variety of clinical conditions like allergic skin diseases, endocrinopathies, autoimmune skin diseases, and keratinization disorders. An efficient and correct diagnosis is essential as is proper therapy in the face of ever-increasing development of Canine Methicillin-Resistant Staphylococcal Pyoderma.
Babesiosis is the diseased state caused by the protozoal (single celled) parasites of the genus Babesia. Infection in a dog may occur by tick transmission, direct transmission via blood transfer from dog bites, blood transfusions, or transplacental transmission.
Azoturia, also known as Monday morning disease or tying-up syndrome, is a metabolic muscular disorder in horses characterized by stiffness, lameness, and muscle swelling. It occurs after a period of at least 2 days rest when horses return to exercise on a full ration. The major cause is carbohydrate overloading from excessive glycogen buildup in muscles during rest, leading to lactic acid accumulation during subsequent exercise and muscle damage. Clinical signs range from poor performance to an inability to rise. Diagnosis involves detecting myoglobin in the urine and elevated muscle enzyme levels in blood. Treatment focuses on rest, pain relief, intravenous fluids, and thiamine supplementation.
ICAWC 2013 - Sarcoptic and Demodectic Mange - David GrantDogs Trust
Demodectic and sarcoptic mange are parasitic skin diseases caused by mites. Canine demodicosis is caused by Demodex canis mites and generally presents in young dogs, though some cases occur in older dogs. It is not contagious between dogs. Canine scabies is caused by Sarcoptes scabiei mites and is highly contagious between dogs. It causes severe itching that escalates over time. Both diseases can be diagnosed via skin scrapings and treated with licensed products. Canine demodicosis can be difficult to cure and require multiple treatments, while canine scabies usually responds well to treatment with high cure rates.
www.petsgroomingtips.com is one of the front-runners in providing complete digital information to the pet owners, which would guide theme through various process of grooming their beloved kids. A shabby puppy or kitten not only appears dirty but soon infested with disease if not treated properly. Our various tutorials and free PDF guides cover every aspect of the grooming process.
This document discusses diabetes mellitus, including:
- It is a disease where the body does not properly produce or use insulin, leading to high blood glucose levels.
- There are two main types - type 1 caused by lack of insulin production and type 2 caused by insulin resistance.
- Clinical signs include increased urination, thirst, weight loss, and cataracts in dogs. Diagnosis involves testing blood glucose and fructosamine levels. Treatment focuses on achieving normal blood sugar through insulin, diet, exercise and medication. Medical nutrition therapy and exercise are important parts of long-term diabetes management.
Hypothyroidism and hyperthyroidism in dogs are endocrine diseases caused by impaired or excessive thyroid hormone production respectively. Hypothyroidism is more common and seen as lethargy, weight gain, hair loss, and other metabolic signs. It is diagnosed via low thyroid hormone levels and treated with levothyroxine supplementation. Hyperthyroidism is rare in dogs and caused by functional thyroid tumors, seen as weight loss and other hypermetabolic signs.
Diagnosis and Treatment of Canine Pyodermaupstatevet
Ed Jazic, DVM, DACVD
The prevalence of Canine Pyoderma is increasing very quickly and the clinical condition can present in a variety of ways. It is a common secondary manifestation of a variety of clinical conditions like allergic skin diseases, endocrinopathies, autoimmune skin diseases, and keratinization disorders. An efficient and correct diagnosis is essential as is proper therapy in the face of ever-increasing development of Canine Methicillin-Resistant Staphylococcal Pyoderma.
Babesiosis is the diseased state caused by the protozoal (single celled) parasites of the genus Babesia. Infection in a dog may occur by tick transmission, direct transmission via blood transfer from dog bites, blood transfusions, or transplacental transmission.
Azoturia, also known as Monday morning disease or tying-up syndrome, is a metabolic muscular disorder in horses characterized by stiffness, lameness, and muscle swelling. It occurs after a period of at least 2 days rest when horses return to exercise on a full ration. The major cause is carbohydrate overloading from excessive glycogen buildup in muscles during rest, leading to lactic acid accumulation during subsequent exercise and muscle damage. Clinical signs range from poor performance to an inability to rise. Diagnosis involves detecting myoglobin in the urine and elevated muscle enzyme levels in blood. Treatment focuses on rest, pain relief, intravenous fluids, and thiamine supplementation.
ICAWC 2013 - Sarcoptic and Demodectic Mange - David GrantDogs Trust
Demodectic and sarcoptic mange are parasitic skin diseases caused by mites. Canine demodicosis is caused by Demodex canis mites and generally presents in young dogs, though some cases occur in older dogs. It is not contagious between dogs. Canine scabies is caused by Sarcoptes scabiei mites and is highly contagious between dogs. It causes severe itching that escalates over time. Both diseases can be diagnosed via skin scrapings and treated with licensed products. Canine demodicosis can be difficult to cure and require multiple treatments, while canine scabies usually responds well to treatment with high cure rates.
www.petsgroomingtips.com is one of the front-runners in providing complete digital information to the pet owners, which would guide theme through various process of grooming their beloved kids. A shabby puppy or kitten not only appears dirty but soon infested with disease if not treated properly. Our various tutorials and free PDF guides cover every aspect of the grooming process.
This document discusses diabetes mellitus, including:
- It is a disease where the body does not properly produce or use insulin, leading to high blood glucose levels.
- There are two main types - type 1 caused by lack of insulin production and type 2 caused by insulin resistance.
- Clinical signs include increased urination, thirst, weight loss, and cataracts in dogs. Diagnosis involves testing blood glucose and fructosamine levels. Treatment focuses on achieving normal blood sugar through insulin, diet, exercise and medication. Medical nutrition therapy and exercise are important parts of long-term diabetes management.
A Downer's cow is a cow that lies down for more than 24 hours and cannot get up due to hypocalcemia, or low calcium levels. Hypocalcemia is commonly caused by metabolic, traumatic, or toxic factors and results in prolonged recumbency and muscle damage. Treatment involves calcium, phosphorus, magnesium, potassium, and glucose supplementation to correct electrolyte imbalances and metabolic acidosis. Prevention focuses on proper nutrition, calving facilities, and herd management to reduce the risk of hypocalcemia in dairy cattle.
Mange is among the common illnesses that many dog owners are concerned about. People usually get tensed and do not know how to handle such situations. I present you this Presentation that speaks about Mange, a skin disease caused by tiny parasite mites on dogs. You can refer to this to know what Mange is all about, the types of Mange, the causes, the symptoms and a few easy ways to deal with it. Mange, if left untreated can be fatal. Therefore, timely knowledge and treatment about this disease is important. You can also add your views in the comments below.
For more information about Mange, you can refer to the following links:
http://www.vet-organics.com/types-of-mange-in-dogs/
http://pets.webmd.com/dogs/mange-dogs-canine-scabies
CANINE DIABETES MELLITUS AND ITS MANAGEMENTSourabh Kant
This document discusses canine diabetes mellitus and its management. It begins by listing dog breeds with higher or moderate risk of developing diabetes. It then covers the pathogenesis of the disease, symptoms, disease complications like ketoacidosis and dehydration, diagnosis including blood glucose guidelines, and treatment including insulin therapy, managing hypoglycemia, and monitoring blood glucose levels. The document concludes with a case study showing the treatment and monitoring of an 8-year old male dog over several visits for diabetes, with improvements seen in symptoms and bloodwork.
Strangles is a highly contagious bacterial infection caused by Streptococcus equi subspecies equi that commonly affects young horses. It primarily causes fever and swelling of the lymph nodes in the head and neck. While most horses recover without complications, the disease can spread easily through nasal discharge from infected or carrier horses. Proper outbreak management includes isolation of sick horses, thorough disinfection, and vaccination to help control spread.
Lactation tetany, also known as hypomagnesaemic tetany or grass tetany, is a metabolic disease of lactating ruminants characterized by low magnesium levels and clinical signs of hyperaesthesia, tetany, and convulsions. It occurs in cattle grazing on pastures high in potassium 2-4 months after calving, which decreases magnesium absorption. Affected cattle experience sudden onset of muscle twitching and spasms, leading to staggering, falling, and potentially fatal convulsions. Diagnosis is based on clinical signs and low serum magnesium levels below 2.5 mg%, and treatment involves intravenous calcium followed by magnesium supplementation.
Urolithiasis, or bladder stones, is a common nutritional disorder in ruminants caused by an imbalance in minerals like calcium, phosphorus, and magnesium in the diet. When cattle, sheep, and goats consume grain-heavy rations instead of their normal forage, it can cause stones to form in the bladder or urethra. Clinical signs include difficulty urinating, abdominal pain, and swelling. Left untreated, the blockage can cause the bladder or urethra to rupture, resulting in uremia and death. Veterinarians may use medications to relax the bladder or flush out stones, or surgery to remove blockages or create bypasses. Proper mineral balance in the diet and
Ketosis is a metabolic disease that occurs in cattle and sheep during periods of negative energy balance, such as early lactation in cattle and late pregnancy in ewes. It is characterized by hypoglycemia and the accumulation of ketone bodies in the blood, urine, and milk. There are several forms of ketosis, including a wasting form with decreased appetite and weight loss, and a nervous form with neurological symptoms like aimless wandering. Treatment involves replacing lost glucose through oral administration of propylene glycol or intravenous dextrose, as well as supporting liver function. Preventive measures focus on proper nutrition and avoiding negative energy balance around calving or lambing.
This document discusses canine demodicosis, a parasitic skin disease in dogs caused by an overpopulation of Demodex mites in the hair follicles. It covers the etiology (Demodex canis mites), pathogenesis (mites enter follicles and multiply), clinical signs (alopecia, scaling, crusting of the skin), diagnosis (identifying mites in skin scrapings under a microscope), prognosis (guarded for generalized cases), and treatment (miticidal dips and oral medications). The life cycle and types of Demodex mites are also described.
The document summarizes traumatic reticular perforation (TRP) in cattle. TRP occurs when a sharp foreign body penetrates the wall of the reticulum, causing acute local peritonitis. Clinical signs include abdominal pain, anorexia, and fever. Diagnosis involves abdominal ultrasound or laparoscopy to detect foreign bodies. Treatment involves surgical removal of foreign bodies via rumenotomy. Complications can include peritonitis, abscesses, and traumatic pericarditis if the foreign body penetrates the diaphragm. Prognosis is poor if complications like pericarditis develop.
The document describes various types of skin lesions and diseases in veterinary medicine. It defines different types of lesions such as macules, papules, plaques, nodules, vesicles, bullae, pustules, scale, crusts, erosions, and ulcers. It also describes lesion characteristics like color, shape, texture, location, and configuration. Finally, it lists common causes of skin diseases in animals such as bacteria, parasites, fungi, viruses, coagulopathies, endocrine diseases, physical irritation, chemicals, neoplasms, and nutritional deficiencies.
Nitrate toxicity can occur in ruminants when they consume feeds containing high levels of nitrates, which are broken down into toxic nitrites in the rumen. Symptoms include weakness, brown mucous membranes, rapid breathing, and death from asphyxiation. Nitrate levels above 0.5% in feed are unsafe, with young animals being most at risk. Methylene blue treatment can convert nitrites back to hemoglobin. Proper forage testing and dilution of high-nitrate feeds can help prevent toxicity.
Ear new affection of ear and its treatmentBikas Puri
Otitis, or ear infections, can affect the outer, middle, or inner ear in dogs and cats and are commonly caused by parasites, bacteria, yeast, or skin issues. Symptoms include ear scratching, redness, discharge, and in severe cases neurological signs. Treatment involves cleaning and flushing the ears under anesthesia followed by topical and oral antibiotics, antifungals, or other medications based on diagnostic tests and addressing any underlying issues.
This document discusses urinary calculi (stones) in animals. It defines urinary calculi as mineral or salt crystals that form in the urinary tract. Common types include struvite, calcium oxalate, urate and cystine crystals. Risk factors include diet, genetics, pH, and infections. Clinical signs depend on location but can include pain, hematuria, dysuria, and obstruction. Diagnosis involves urinalysis, radiography, ultrasound and possibly cystoscopy. Treatment focuses on relieving obstruction, altering urine pH, managing infections, and dissolving or removing stones through various surgical techniques.
Angels presenting chronic patellar luxation in cattle.by pavulPavulraj Selvaraj
Patellar luxation is a non-inflammatory disorder of the femoropatellar articulation in cattle and dogs where the patella is displaced from its normal position. In cattle, it causes jerky limb movements and an extended limb stance. Surgical treatment involves cutting the medial patellar ligament to allow the patella to move freely. In dogs, it causes intermittent lameness and abnormal gaits. Surgical options aim to deepen the trochlear groove or reinforce the lateral soft tissues to stabilize the patella.
This document provides an overview of colic in horses. It begins by defining colic as acute abdominal pain in horses. Colic can be classified as spasmodic, tympanitic, obstructive, or impactive. Spasmodic colic involves hypermotility of the intestines. Tympanitic colic is caused by gas accumulation in the intestines. Obstructive colic blocks intestinal passages, while impactive colic specifically involves food or other material blocking the stomach or intestines. The document discusses causes, signs, diagnosis, and treatment for each type of colic. Common signs of colic include pawing, looking at the flank, lip curling, rolling, and abdominal distension
Dourine is caused by the protozoan Trypanosoma equiperdum, which is transmitted directly during mating between horses. It is characterized by genital edema and lesions. Diagnosis involves clinical signs, serology, and parasitological identification. Treatment has been attempted but drug resistance occurs. Control relies on quarantine of new animals, serological testing, and ceasing breeding or culling infected animals as there is no vaccine. Proper treatment and prevention of sexual contact are recommended to control the economically impactful disease.
This document discusses cystitis, or inflammation of the urinary bladder. It notes that cystitis can be caused by trauma, ascending or descending infections, iatrogenic factors, nutritional issues, urinary stasis, hyperadrenocorticism, diabetes mellitus, and rare neoplasms. Common symptoms in dogs and cats include frequent and painful urination, cloudy urine, abdominal pain, and dullness. Diagnosis involves urinalysis, culture and sensitivity testing, ultrasound or cystoscopy. Treatment focuses on removing the cause, managing pain and inflammation, flushing out organisms, correcting urine pH, and controlling infections with antibiotics based on sensitivity testing.
Enterotoxemia, also known as overeating disease or pulpy kidney disease, is caused by toxins produced by Clostridium perfringens bacteria in the intestines of small ruminants. The bacteria normally live harmlessly in the gut but can multiply rapidly under certain conditions, releasing toxins that cause inflammation of the intestines and blood vessels. Affected animals may show sudden nervous system signs and death, or gastrointestinal signs like diarrhea before death. Post-mortem examination reveals kidney and lung damage. Treatment focuses on supportive care but vaccination and careful feeding strategies are most effective for prevention.
Phosphorus deficiency hemoglobinuria, also known as red water disease, is a hemolytic disease affecting dairy cattle around calving. It is characterized by intravascular hemolysis and severe anemia, which can lead to death. Clinical signs include hemoglobinuria, weakness, inappetence, and reduced milk yield. Diagnosis is based on dark red-brown urine despite the absence of red blood cells, along with anemia and hypophosphatemia. Treatment involves intravenous and oral phosphorus supplementation along with fluid therapy. Prevention focuses on ensuring adequate phosphorus intake in early lactation and correcting copper deficiencies.
Dog Diseases
Like all pets, dogs are also susceptible to diseases. It is important to exercise good pet care by having a sound knowledge of various diseases that dogs suffer from, its symptoms, familiarity of breed along with routine check-ups, proper immunizations and vaccinations and regular visits to the vet .
Hypothyroidism is a common endocrine disease in dogs that results from a deficiency of thyroid hormones. It is primarily caused by lymphocytic thyroiditis or idiopathic thyroid atrophy in 95% of cases. Clinical signs vary but commonly include dermatological abnormalities like hair loss and skin infections, obesity, lethargy, mental dullness, and cold intolerance. Untreated hypothyroidism can also impact the nervous, cardiovascular, ocular, and reproductive systems. Diagnosis is based on abnormal thyroid hormone levels and is typically treated with lifelong thyroid hormone supplementation.
The document discusses the thyroid gland and hypothyroidism. It notes that the thyroid gland produces two important hormones, T4 and T3, and is located in the neck. Hypothyroidism is a common condition where the thyroid gland does not produce enough hormones. It has various causes including autoimmune disease and can cause symptoms like tiredness, dry skin, constipation, and weight gain. Long-term treatment involves daily levothyroxine replacement therapy.
A Downer's cow is a cow that lies down for more than 24 hours and cannot get up due to hypocalcemia, or low calcium levels. Hypocalcemia is commonly caused by metabolic, traumatic, or toxic factors and results in prolonged recumbency and muscle damage. Treatment involves calcium, phosphorus, magnesium, potassium, and glucose supplementation to correct electrolyte imbalances and metabolic acidosis. Prevention focuses on proper nutrition, calving facilities, and herd management to reduce the risk of hypocalcemia in dairy cattle.
Mange is among the common illnesses that many dog owners are concerned about. People usually get tensed and do not know how to handle such situations. I present you this Presentation that speaks about Mange, a skin disease caused by tiny parasite mites on dogs. You can refer to this to know what Mange is all about, the types of Mange, the causes, the symptoms and a few easy ways to deal with it. Mange, if left untreated can be fatal. Therefore, timely knowledge and treatment about this disease is important. You can also add your views in the comments below.
For more information about Mange, you can refer to the following links:
http://www.vet-organics.com/types-of-mange-in-dogs/
http://pets.webmd.com/dogs/mange-dogs-canine-scabies
CANINE DIABETES MELLITUS AND ITS MANAGEMENTSourabh Kant
This document discusses canine diabetes mellitus and its management. It begins by listing dog breeds with higher or moderate risk of developing diabetes. It then covers the pathogenesis of the disease, symptoms, disease complications like ketoacidosis and dehydration, diagnosis including blood glucose guidelines, and treatment including insulin therapy, managing hypoglycemia, and monitoring blood glucose levels. The document concludes with a case study showing the treatment and monitoring of an 8-year old male dog over several visits for diabetes, with improvements seen in symptoms and bloodwork.
Strangles is a highly contagious bacterial infection caused by Streptococcus equi subspecies equi that commonly affects young horses. It primarily causes fever and swelling of the lymph nodes in the head and neck. While most horses recover without complications, the disease can spread easily through nasal discharge from infected or carrier horses. Proper outbreak management includes isolation of sick horses, thorough disinfection, and vaccination to help control spread.
Lactation tetany, also known as hypomagnesaemic tetany or grass tetany, is a metabolic disease of lactating ruminants characterized by low magnesium levels and clinical signs of hyperaesthesia, tetany, and convulsions. It occurs in cattle grazing on pastures high in potassium 2-4 months after calving, which decreases magnesium absorption. Affected cattle experience sudden onset of muscle twitching and spasms, leading to staggering, falling, and potentially fatal convulsions. Diagnosis is based on clinical signs and low serum magnesium levels below 2.5 mg%, and treatment involves intravenous calcium followed by magnesium supplementation.
Urolithiasis, or bladder stones, is a common nutritional disorder in ruminants caused by an imbalance in minerals like calcium, phosphorus, and magnesium in the diet. When cattle, sheep, and goats consume grain-heavy rations instead of their normal forage, it can cause stones to form in the bladder or urethra. Clinical signs include difficulty urinating, abdominal pain, and swelling. Left untreated, the blockage can cause the bladder or urethra to rupture, resulting in uremia and death. Veterinarians may use medications to relax the bladder or flush out stones, or surgery to remove blockages or create bypasses. Proper mineral balance in the diet and
Ketosis is a metabolic disease that occurs in cattle and sheep during periods of negative energy balance, such as early lactation in cattle and late pregnancy in ewes. It is characterized by hypoglycemia and the accumulation of ketone bodies in the blood, urine, and milk. There are several forms of ketosis, including a wasting form with decreased appetite and weight loss, and a nervous form with neurological symptoms like aimless wandering. Treatment involves replacing lost glucose through oral administration of propylene glycol or intravenous dextrose, as well as supporting liver function. Preventive measures focus on proper nutrition and avoiding negative energy balance around calving or lambing.
This document discusses canine demodicosis, a parasitic skin disease in dogs caused by an overpopulation of Demodex mites in the hair follicles. It covers the etiology (Demodex canis mites), pathogenesis (mites enter follicles and multiply), clinical signs (alopecia, scaling, crusting of the skin), diagnosis (identifying mites in skin scrapings under a microscope), prognosis (guarded for generalized cases), and treatment (miticidal dips and oral medications). The life cycle and types of Demodex mites are also described.
The document summarizes traumatic reticular perforation (TRP) in cattle. TRP occurs when a sharp foreign body penetrates the wall of the reticulum, causing acute local peritonitis. Clinical signs include abdominal pain, anorexia, and fever. Diagnosis involves abdominal ultrasound or laparoscopy to detect foreign bodies. Treatment involves surgical removal of foreign bodies via rumenotomy. Complications can include peritonitis, abscesses, and traumatic pericarditis if the foreign body penetrates the diaphragm. Prognosis is poor if complications like pericarditis develop.
The document describes various types of skin lesions and diseases in veterinary medicine. It defines different types of lesions such as macules, papules, plaques, nodules, vesicles, bullae, pustules, scale, crusts, erosions, and ulcers. It also describes lesion characteristics like color, shape, texture, location, and configuration. Finally, it lists common causes of skin diseases in animals such as bacteria, parasites, fungi, viruses, coagulopathies, endocrine diseases, physical irritation, chemicals, neoplasms, and nutritional deficiencies.
Nitrate toxicity can occur in ruminants when they consume feeds containing high levels of nitrates, which are broken down into toxic nitrites in the rumen. Symptoms include weakness, brown mucous membranes, rapid breathing, and death from asphyxiation. Nitrate levels above 0.5% in feed are unsafe, with young animals being most at risk. Methylene blue treatment can convert nitrites back to hemoglobin. Proper forage testing and dilution of high-nitrate feeds can help prevent toxicity.
Ear new affection of ear and its treatmentBikas Puri
Otitis, or ear infections, can affect the outer, middle, or inner ear in dogs and cats and are commonly caused by parasites, bacteria, yeast, or skin issues. Symptoms include ear scratching, redness, discharge, and in severe cases neurological signs. Treatment involves cleaning and flushing the ears under anesthesia followed by topical and oral antibiotics, antifungals, or other medications based on diagnostic tests and addressing any underlying issues.
This document discusses urinary calculi (stones) in animals. It defines urinary calculi as mineral or salt crystals that form in the urinary tract. Common types include struvite, calcium oxalate, urate and cystine crystals. Risk factors include diet, genetics, pH, and infections. Clinical signs depend on location but can include pain, hematuria, dysuria, and obstruction. Diagnosis involves urinalysis, radiography, ultrasound and possibly cystoscopy. Treatment focuses on relieving obstruction, altering urine pH, managing infections, and dissolving or removing stones through various surgical techniques.
Angels presenting chronic patellar luxation in cattle.by pavulPavulraj Selvaraj
Patellar luxation is a non-inflammatory disorder of the femoropatellar articulation in cattle and dogs where the patella is displaced from its normal position. In cattle, it causes jerky limb movements and an extended limb stance. Surgical treatment involves cutting the medial patellar ligament to allow the patella to move freely. In dogs, it causes intermittent lameness and abnormal gaits. Surgical options aim to deepen the trochlear groove or reinforce the lateral soft tissues to stabilize the patella.
This document provides an overview of colic in horses. It begins by defining colic as acute abdominal pain in horses. Colic can be classified as spasmodic, tympanitic, obstructive, or impactive. Spasmodic colic involves hypermotility of the intestines. Tympanitic colic is caused by gas accumulation in the intestines. Obstructive colic blocks intestinal passages, while impactive colic specifically involves food or other material blocking the stomach or intestines. The document discusses causes, signs, diagnosis, and treatment for each type of colic. Common signs of colic include pawing, looking at the flank, lip curling, rolling, and abdominal distension
Dourine is caused by the protozoan Trypanosoma equiperdum, which is transmitted directly during mating between horses. It is characterized by genital edema and lesions. Diagnosis involves clinical signs, serology, and parasitological identification. Treatment has been attempted but drug resistance occurs. Control relies on quarantine of new animals, serological testing, and ceasing breeding or culling infected animals as there is no vaccine. Proper treatment and prevention of sexual contact are recommended to control the economically impactful disease.
This document discusses cystitis, or inflammation of the urinary bladder. It notes that cystitis can be caused by trauma, ascending or descending infections, iatrogenic factors, nutritional issues, urinary stasis, hyperadrenocorticism, diabetes mellitus, and rare neoplasms. Common symptoms in dogs and cats include frequent and painful urination, cloudy urine, abdominal pain, and dullness. Diagnosis involves urinalysis, culture and sensitivity testing, ultrasound or cystoscopy. Treatment focuses on removing the cause, managing pain and inflammation, flushing out organisms, correcting urine pH, and controlling infections with antibiotics based on sensitivity testing.
Enterotoxemia, also known as overeating disease or pulpy kidney disease, is caused by toxins produced by Clostridium perfringens bacteria in the intestines of small ruminants. The bacteria normally live harmlessly in the gut but can multiply rapidly under certain conditions, releasing toxins that cause inflammation of the intestines and blood vessels. Affected animals may show sudden nervous system signs and death, or gastrointestinal signs like diarrhea before death. Post-mortem examination reveals kidney and lung damage. Treatment focuses on supportive care but vaccination and careful feeding strategies are most effective for prevention.
Phosphorus deficiency hemoglobinuria, also known as red water disease, is a hemolytic disease affecting dairy cattle around calving. It is characterized by intravascular hemolysis and severe anemia, which can lead to death. Clinical signs include hemoglobinuria, weakness, inappetence, and reduced milk yield. Diagnosis is based on dark red-brown urine despite the absence of red blood cells, along with anemia and hypophosphatemia. Treatment involves intravenous and oral phosphorus supplementation along with fluid therapy. Prevention focuses on ensuring adequate phosphorus intake in early lactation and correcting copper deficiencies.
Dog Diseases
Like all pets, dogs are also susceptible to diseases. It is important to exercise good pet care by having a sound knowledge of various diseases that dogs suffer from, its symptoms, familiarity of breed along with routine check-ups, proper immunizations and vaccinations and regular visits to the vet .
Hypothyroidism is a common endocrine disease in dogs that results from a deficiency of thyroid hormones. It is primarily caused by lymphocytic thyroiditis or idiopathic thyroid atrophy in 95% of cases. Clinical signs vary but commonly include dermatological abnormalities like hair loss and skin infections, obesity, lethargy, mental dullness, and cold intolerance. Untreated hypothyroidism can also impact the nervous, cardiovascular, ocular, and reproductive systems. Diagnosis is based on abnormal thyroid hormone levels and is typically treated with lifelong thyroid hormone supplementation.
The document discusses the thyroid gland and hypothyroidism. It notes that the thyroid gland produces two important hormones, T4 and T3, and is located in the neck. Hypothyroidism is a common condition where the thyroid gland does not produce enough hormones. It has various causes including autoimmune disease and can cause symptoms like tiredness, dry skin, constipation, and weight gain. Long-term treatment involves daily levothyroxine replacement therapy.
The document provides an overview of the thyroid gland including its embryology, histology, physiology, hormone synthesis, functions, and common disorders. It discusses that the thyroid originates from the pharynx and contains follicles composed of epithelial cells and colloid. The thyroid's primary function is to produce the hormones T3, T4, and calcitonin. Common disorders mentioned include hyperthyroidism, hypothyroidism, thyroiditis (such as Hashimoto's), goiter, and tumors. Graves' disease is highlighted as a cause of diffuse toxic goiter characterized by the triad of hyperthyroidism, diffuse thyroid enlargement, and ophthalmopathy.
This document summarizes research on the genetic basis of autoimmune thyroid disease (AITD). It discusses that AITD is more prevalent in females than males, with peak prevalence between ages 40-49. This female predominance may be due to skewed X-chromosome inactivation. The FOXP3 gene, located on the X chromosome, is important for regulatory T cell development and function. Mutations in this gene have been linked to AITD and other autoimmune disorders by reducing regulatory T cell numbers. Polymorphisms in the FOXP3 gene may contribute to genetic susceptibility to AITD in some populations.
The document provides an overview of thyroid pathophysiology, covering topics such as:
1. Thyroid anatomy, hormone synthesis, regulation of thyroid function, and thyroid hormone actions in the body.
2. Causes of thyroid dysfunction including hyperthyroidism, hypothyroidism, and thyroid nodules/cancer.
3. Evaluation of thyroid disease through history, physical exam, laboratory tests, and imaging. The goal is to understand thyroid function and disease states.
This document discusses thyroid disorders in children. It covers objectives related to hypothyroidism and hyperthyroidism. For hypothyroidism, it discusses the anatomy and physiology of the thyroid gland, hypothalamic-pituitary regulation, causes of primary, secondary and tertiary hypothyroidism including congenital and acquired forms. For hyperthyroidism, it discusses causes including neonatal forms and the clinical presentation and investigations of thyrotoxicosis. It also provides details on the thyroid gland, hormone synthesis and effects. Causes, clinical features and management of hypothyroidism and hyperthyroidism in children are outlined.
The document discusses various endocrine glands and hormones, including the thyroid gland which produces hormones that regulate metabolism, and the adrenal glands which produce cortisol to help the body cope with stress and aldosterone to regulate sodium levels. It also covers conditions that can arise from too much or too little of these hormones, such as hypothyroidism, hyperthyroidism, Cushing's syndrome, and adrenal insufficiency.
This document discusses thyrotoxicosis, which results from excess thyroid hormone production regardless of cause. It is one of the more common endocrine disorders seen by family physicians. The causes of thyrotoxicosis include Graves' disease, toxic multinodular goiter, solitary toxic nodule, and thyroiditis. Graves' disease is an autoimmune condition characterized by a diffuse goiter, ophthalmopathy, and dermopathy. Toxic multinodular goiter develops from autonomy in a pre-existing nodular goiter. A solitary toxic nodule refers to autonomy developing in an otherwise normal thyroid. Thyroiditis can cause a transient thyrotoxic phase followed by hypothyroidism. Treatment depends on
lecture class for 4th year MBBS students. this lecture is based on the book 'Robbins' Pathologic basis of disease'. This is delivered by Dr. Umme Kulsum Munmun, Assistant professor (pathology) to the 4th year MBBS students of Chandpur Meducal College, Bangladesh
The document discusses the thyroid gland and various thyroid conditions. It begins by describing the location of the thyroid gland and possible enlargements or nodules. It then discusses the main functions of the thyroid gland and the hormones it secretes. Various thyroid conditions are summarized such as hyperthyroidism, hypothyroidism, thyroiditis, thyroid cancer, and dental management considerations for patients with thyroid disease.
Hashimoto's thyroiditis is an autoimmune disease where the body's immune system attacks the thyroid gland. It is the most common cause of hypothyroidism in the United States. A 48-year-old female presented with a painless, diffuse swelling of the neck along with symptoms of fatigue, depression, constipation, weight gain, cold intolerance, and dry skin and hair. Laboratory tests showed high thyroid stimulating hormone and antibodies against thyroid peroxidase, consistent with a diagnosis of Hashimoto's thyroiditis. Treatment involves thyroid hormone replacement medication like levothyroxine to manage hypothyroidism.
Congenital hypothyroidism MEDICAL STUDENTS level,Mohamed Alfaki
Congenital hypothyroidism is the most common neonatal metabolic disorder and can cause severe physical and neurological impairment if left untreated. It occurs in approximately 1 in 3,000-4,000 births. The thyroid gland normally develops between weeks 3-7 of gestation and begins secreting hormones around week 12. After birth, there is a surge in TSH levels in response to cooling which returns to normal after 3 days. Congenital hypothyroidism can be primary, from defects in the thyroid gland itself, or secondary, from deficiency in TSH. The most common cause is developmental defects of the gland such as hypoplasia or aplasia. Treatment involves lifelong levothyroxine replacement therapy.
This document discusses various thyroid disorders including goiter, cretinism, myxedema, Hashimoto's disease, Graves' disease, and thyroid nodules. It provides information on the causes, symptoms, diagnosis, and treatment of each condition. Goiter is commonly caused by iodine deficiency and can lead to hyperthyroidism or hypothyroidism. Cretinism causes physical and mental stunting and is treated with thyroid supplements. Myxedema is caused by diminished thyroid hormone production and causes edema of the skin. Hashimoto's disease is an autoimmune condition where the thyroid is gradually destroyed, while Graves' disease leads to thyroid overactivity from abnormal antibodies. Thyroid nodules can
This document discusses hyperthyroidism and thyrotoxicosis. It begins by defining the terms and describing the thyroid gland's normal function. It then discusses the various causes of hyperthyroidism including Graves' disease, toxic multinodular goiter, subacute thyroiditis, and toxic adenoma. The document outlines the anatomy and physiology of the thyroid gland. It describes the clinical manifestations, diagnostic tests including thyroid function tests, ultrasound, and thyroid scintigraphy. It provides algorithms for diagnosis and outlines treatment options for hyperthyroidism including anti-thyroid medications, radioactive iodine treatment, and thyroidectomy.
This document discusses hyperthyroidism and thyrotoxicosis. It defines the terms and describes the thyroid gland's normal function of producing thyroid hormones. The main causes of hyperthyroidism are Graves' disease, toxic multinodular goiter, subacute thyroiditis, and toxic adenoma. The clinical manifestations and signs of hyperthyroidism are then outlined, along with specific symptoms of Graves' disease. Diagnostic tests like thyroid function tests, ultrasound, and thyroid scintigraphy are also summarized. The document concludes with treatments options for hyperthyroidism including anti-thyroid medications, radioactive iodine, and surgery.
The thyroid gland is the body's largest single organ specialized for endocrine hormone production. Its function is to secrete an appropriate amount of the thyroid hormones, primarily (thyroxine, T4) , and a lesser quantity of triiodothyronine (T3) , which arises mainly from the subsequent extrathyroidal deiodination ofT4.
Benign thyroid diseases discusses thyroid abnormalities including hypothyroidism and hyperthyroidism. Graves' disease is described as the most common cause of hyperthyroidism, resulting from autoimmune stimulation of the thyroid by antibodies. Symptoms and signs of hyperthyroidism include rapid heartbeat, sweating, anxiety and eye changes. Treatment involves antithyroid drugs, radioactive iodine therapy which destroys thyroid tissue, or surgery. Radioactive iodine is often used as it avoids surgery risks and provides definitive treatment, though can cause hypothyroidism in some cases.
The document discusses disorders of the thyroid gland, including hypothyroidism and hyperthyroidism. It begins by reviewing the anatomy and physiology of the thyroid gland and hypothalamic-pituitary-thyroid feedback system. Hypothyroidism can be congenital or acquired, and if during childhood causes cretinism. Acquired hypothyroidism in adults is called myxedema. Hyperthyroidism results from increased thyroid hormone secretion and can be caused by Graves' disease. Thyroid storm is a life-threatening exacerbation of hyperthyroidism.
This document discusses various aspects of hyperthyroidism and thyrotoxicosis. It defines hypothyroidism and hyperthyroidism, listing their typical metabolic, skin, ocular, gastrointestinal, musculoskeletal, reproductive, neuropsychiatric, and cardiovascular findings. It then discusses Graves' disease, its autoimmune pathogenesis, clinical features including diffuse goiter, exophthalmos and pretibial myxedema. Diffuse toxic goiter and its etiology, physical exam findings, and pathophysiology are outlined. Multinodular goiter and its causes are also summarized. Thyrotoxicosis is defined and its origins from thyroid, extrathyroidal, or exogenous sources are listed.
Haemorrhagic_Septicemia in Ruminant ,Gal ghotusKavitaJaidiya
Pasteruella multocida and Mannheimia haemolytica are bacteria that can cause pasteurellosis in cattle and other animals. P. multocida causes haemorrhagic septicemia in cattle, fowl cholera in fowl, and atropic rhinitis in pigs. M. haemolytica causes shipping fever in cattle. Haemorrhagic septicemia is an acute disease in cattle characterized by fever, respiratory distress, and diarrhea. The bacteria enter through ingestion or inhalation and spread systemically, causing hemorrhages on membranes. Johne's disease is a chronic wasting disease of ruminants caused by Mycobacterium paratuberculosis.
Canine hypoadrenocorticism, also known as Addison's disease, is a disorder caused by a lack of hormones produced by the adrenal glands. It results in electrolyte and blood pressure issues and can be fatal if not treated. Diagnosis involves ruling out other causes through tests of electrolyte and cortisol levels before and after administration of ACTH. Treatment focuses on rapid fluid therapy and steroid hormone replacement to correct electrolyte imbalances and restore blood volume and pressure. Long term management relies on mineralocorticoid and glucocorticoid supplementation through oral or injectable medications.
This document discusses the Trade-Related Aspects of Intellectual Property Rights (TRIPS) agreement. It notes that TRIPS sets minimum standards for intellectual property protection as part of the World Trade Organization agreements. It was signed by 153 parties and subjects intellectual property rights to enforcement mechanisms, national treatment principles, and the WTO dispute settlement process. The document outlines some of the key provisions of TRIPS regarding availability and scope of intellectual property rights, enforcement, procedures, transitional agreements, and dispute resolution.
East Coast Fever is caused by the parasite Theileria parva, which is transmitted between cattle via ticks. It causes high mortality in cattle and poses a major economic burden for farmers in sub-Saharan Africa. The study examined treating cattle naturally infected with ECF early through diagnosis and chemotherapy. It found a high recovery rate with this approach and that it can help cattle develop immunity against future infections, providing an alternative to vaccination.
The document provides information on hepatic (liver) diseases in canines and felines. It discusses the structure and functions of the liver. It describes infectious causes of hepatitis including viral, parasitic, and bacterial sources. Non-infectious causes such as drugs/toxins, autoimmunity, and endocrine disorders are also outlined. Clinical signs, diagnosis including liver enzymes and imaging, and treatment approaches including medications, fluid therapy, and nutrition are summarized.
The document summarizes autophagy and electron microscopy. It defines autophagy as the degradation of cells through lysosomes and discusses its importance in survival, cancer, and disease. Three forms of autophagy are identified: macroautophagy, microautophagy, and chaperone-mediated autophagy. Electron microscopes use electron beams for high magnification imaging of cells and materials. Transmission electron microscopes image thin samples while scanning electron microscopes image surface structure of bulk samples. Sample preparation for electron microscopy involves cleaning, coating, and thin film deposition depending on the analysis needs.
This document provides an overview of microbiology and principles of laboratory diagnosis of infectious diseases. It discusses the history of microbiology from the discovery era to the modern era. Key figures who contributed to early discoveries include Van Leeuwenhoek, Pasteur, Koch, Fleming and others. The document also summarizes different sample types used for diagnosis, specimen collection and transport, staining techniques including Gram staining and acid-fast staining, and isolation of bacteria through culture. The overall principles of laboratory diagnosis involve direct examination, culture, antigen detection and antibody detection.
Malassezia dermatitis is a common skin infection in dogs caused by the yeast Malassezia pachydermatis. It develops due to disorders that alter the skin environment or immune system. Clinically, it presents as erythematous, alopecic, and scaly skin with pruritus. Diagnosis is based on cytology and culture. Treatment involves systemic antifungals like ketoconazole for 3-4 weeks along with topical shampoos. Prognosis is good with prolonged therapy and follow up to prevent recurrence.
ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
and the revised UWWTD (Urban Waste Water Treatment Directive)”
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Leonel Morgado
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
The debris of the ‘last major merger’ is dynamically youngSérgio Sacani
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
Authoring a personal GPT for your research and practice: How we created the Q...Leonel Morgado
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Immersive Learning That Works: Research Grounding and Paths ForwardLeonel Morgado
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
1. Department of Veterinary Medicine
College of Veterinary & Animal science, Bikaner
Rajasthan University of Veterinary & Animal Science , Bikaner
Submtited By
Kavita Jaidiya
PHD Scholar
2. Introduction
Hypothyroidism (HpoT) is a multisystemic disease that results from
deficiency of thyroid hormones (TH), thyroxine (T4) and
triiodothyronine (T3)( Cooper and Ladenson 2013) .
Hypothyroidism is of primary origin in about 95% of cases,
affecting mainly middle-aged dogs ( Feldman and Nelson 2015) .
Most frequently diagnosed endocrinopathy in dogs (Pöppl2016)
infact, one of the most over diagnosed.
It is a single endocrinological disease suspected most commonly in
canine suffering from alopecia (Doering and Jensen, 1973).
3. Anatomy of Thyroid Gland
Located lateral to the trachea, in the region of the proximal
tracheal rings (evans et al , 2013).
Functional unit is the thyroid follicle, which comprises the
follicular cells (thyrocytes) and colloid, each gland containing
both large (resting) follicles and small (active) follicles.
1: Resting follicles (larger and with numerous
vacuoles)
2: Active follicles (smaller in size).
4. hyroid Hormone
It is a Iodine-containing amino acids.
100 % of T4, but only 20% of T3 is derived from the thyroid gland. Rest of
T3 is derived from extrathyroidal enzymatic deiodination of T4 (Catharine,
2010).
In the dog T4 is bound to: TBG (thyroid hormone-binding globulin) 60 %,
TBPA (transthyretin)17%, Albumin 12% and HDL2 (apolipoprotiens)11%
(Victor, 2011).
Only 0.1% is free T4 fraction (FT4), which is the bioavailable hormone
(Wang et al., 2000) and determines the thyroid condition of the individual.
In contrast to the protein-bound T4 fraction, FT4 concentration remains
constant regardless of fluctuations in plasma transporter proteins (Morreale
et al.,2002).
5. Function of thyroid
hormone
Thyroid hormones increase the metabolic rate and oxygen
consumption of most tissues, (with the exception of the adult brain,
testes, uterus, lymph nodes, spleen, and anterior pituitary).
Thyroid hormones have positive inotropic and chronotropic effects
on the heart. They increase the number and affinity of beta-
adrenergic receptors and enhance the response to catecholamines.
Thyroid hormones have catabolic effects on muscle and adipose
tissue, stimulate erythropoiesis, and regulate both cholesterol
synthesis and degradation.
Thyroid hormones are also essential for the normal growth and
development of the neurologic and skeletal systems.
6. Classification based on etiology
Primary hypothyroidism accounts for more than 95 percent of the
cases and is usually caused by lymphocytic thyroiditis or idiopathic
thyroid atrophy (Carmel, 2003).
Secondary Hypothyroidism (thyroid stimulating hormone, TSH)
deficiency due to congenital malformation, pituitary destruction
(tumors, trauma, autoimmune hypophysitis) or even its
suppression, normally caused by hormones or drugs such as
glucocorticoids ( Feldman and Nelson 2015)
Tertiary hypothyroidism, caused by a thyrotropin releasing
hormone (TRH) deficiency due to pituitary adenoma with
effacement of the overlying hypothalamus was reported (Robert et
al., 2007)
7. Primary hypothyroidism
A- Lymphocytic thyroiditis
Lymphocytic thyroiditis is a common canine condition that can lead to
functional hypothyroidism. It is associated with more than 50% of cases of
canine hypothyroidism.(Peter A. Graham et al., 2001)
heritable in beagles and borzois(Patty, 2012).
Presence of antithyroglobulin,/antimicrosomal/T3 and T4 autoantibodies
Characterized by infiltration of the thyroid gland by lymphocytes, plasma
cells, and macrophages.
Lastly fibrous connective tissue replaces parenchyma.
Clinical hypothyroidism develops only when greater than 75% of the
functioning thyroid tissue has been destroyed by the infiltrative process.
8. B. Idiopathic atrophy
45 -50 % of cases
Degenerative disorder ,no inflammatory infiltrate
although initially the disease is characterized by goiter (slight to
significant increase in gland volume) (Feldman and Nelson, 1996), in last
parenchyma replaced by adipose tissue.
Fibrosis and inflammation are minimal.
Idiopathic thyroid atrophy may be the result of thyroiditis.
Role of antithyroid AB’s ?
As with thyroiditis, hypothyroidism develops slowly over time .
C- Thyroid neoplasia
Does not develop until at least 75% of the thyroid has been destroyed
(Patty, 2012).
Most are euthyroid , 7 % hyperthyroid , 40 % hypothyroid
D- Other congenital or acquired forms of primary hypothyroidism (thyroid gland
dysgenesis, dyshormonogenesis, iodine deficiency) are rare.
9. Central Hypothyroidism (secondary and tertiary)
Naturally-occurring secondary hypothyroidism is rare and is
usually congenital but if acquired is most likely the result of a
pituitary tumour.
Central hypothyroidism is most commonly associated with
congenital disorders affecting the pituitary gland (Kooistra et
al., 2000) in association with neoplasia (Mooney and
Anderson , 1993).
10. Congenital hypothyroidism
Congenital hypothyroidism (CH) is one of the most common neonatal endocrine
disorders, presenting with abnormal growth and intellectual impairment.(shiguo
liu et al,2018)
Congenital hypothyroidism is caused by thyroid dysgenesis, dyshormonogenesi,
defects in the transport of thyroid hormones, TSH receptor-blocking antibodies,
maternal medications, or a deficiency (endemic goitre) or excess of iodine
(LaFranchi 2007).
During the growth phase the puppy can develop hypothyroidism in the same
way as the adult animal (Snyder, 2000).
Congenital hypothyroidism causes impaired development of the central nervous
system (CNS) and skeleton (Beaver and Haug , 2003 ).
Congenital hypothyroidism is an inherited autosomal recessive trait in rat
terriers, toy fox terriers, and giant schnauzers (Patty,2012).
11. Signs of congenital
hypothyroidism
Congenital hypothyroidism results in mental retardation and
stunted disproportionate growth due to epiphyseal dysgenesis and
delayed skeletal maturation (Cathrine, 2010). Vertebral physeal
fracture causing tetraparesis was reported in a dog with congenital
hypothyroidism.
Affected dogs are mentally dull and have large, broad heads, short
thick necks, short limbs, macroglossia, hypothermia, delayed
dental eruption, ataxia, and abdominal distention.
Dermatologic findings are similar to those seen in the adult
hypothyroid dog.
Other clinical signs may include gait abnormalities, stenotic ear
canals, sealed eyelids, and constipation.
Affected puppies are often the largest in the litter at birth but start
to lag behind their littermates within three to eight weeks of age.
12. Subclinical hypothyroidism is the first phase of the disease, representing
approximately 25% of all cases (Snyder,2000).
Subclinical hypothyroidism is defined as an elevated serum TSH level associated
with normal total or free T4 and T3 values(Michael et al .,2001)
Subclinical hypothyroidism is associated with an increased risk of CHD events and
CHD mortality in those with higher TSH levels, particularly in those with a TSH
concentration of 10 mIU/L or greater.(rodondi et al.,2010)
The system responds with increased thyrotropic cell sensitivity to TRH
stimulation (Castillo et al., 2001).
The first changes are seen in lipid metabolism (increase in the LDL-cholesterol
fraction), the reproductive and immune systems, and the skin (with recurrent
infections) (Victor, 2011) .
13. At this stage the daily secretion of T4 is severely affected.
Clinical signs vary greatly because thyroid hormone impacts
myriad of systems .
Clinical are not always the typical obesity, lethargy and poor hair
cover as described in many textbooks (Victor, 2011) .
1- Dermatological sign
Dermatologic abnormalities are the most common presenting
complaints (Beale, 1993). But they appear in later stages of the
disease.
Dermatologic changes occur in 60-80 percent of hypothyroid
dogs (Catharine, 2010).
14. Dry scaly or greasy skin (Seborrhea sicca or oleosa), change in coloration,
strong smelling of skin along with and hyperkeratosis, hyperpigmentation.
Poor hair coat quality, fading of hair color, failure of hair re-growth.
The hair is often brittle and easily epilated, and loss of undercoat or primary
guard hairs may result in a coarse appearance or a puppy hair coat (short,
softer under coat).
Most dogs with hypothyroidism do not show generalized hair loss but “rat tail”
is common (Victor, 2011), which spares head and extremities.
Hypothyroid dogs are predisposed to recurrent bacterial infections of the skin
like Malassezia spp. infections and demodicosis.
Myxedema (cutaneous mucinosis) is a rare dermatologic manifestation of
hypothyroidism characterized by puffy but nonpitting thickening of the skin,
especially of the eyelids, cheeks, and forehead and is classically referred to as
‘tragic face’ (Doering and Jensen, 1973).
Dermatological sign---
----
15. Appearance is due to drooping of the eyelids and thickening of the lips and
of the skin over the forehead, leading to more skin folds .
It is caused by deposition of hyaluronic acid and glycosaminoglycan in the
dermis.
Satish et al. (2007) found skin abnormality – 94%, Generalized hair loss -
88%, Typical rat tail - 83%, Skin lesions, pigmentation and pruritus - 27%,
Brittle, dry and lusterless coat - 83% . Puppy – like coat - 22% , Myxedema -
16%.
Other changes include ceruminous otitis, poor wound healing and increased
bruising.
A variety of other ‘atypical’ and secondary dermatological abnormalities are
also possible. The alopecia may be patchy and asymmetric or may only affect
one area (e.g., the bridge of the nose) (Carmel, 2003).
Retarded turnover of hair (carpet coat) or hypertrichosis can occur
particularly in Irish setters and boxers (Carmel,2003).
Dermatological sign---
----
16. BMR related Signs
Common clinical signs attributable to decreased metabolic rate
include lethargy, mental dullness, weight gain, unwillingness to
exercise, and cold intolerance.
Obesity occurs in approximately 40% of hypothyroid dogs, but most
obese dogs suffer from over-nutrition rather than hypothyroidism
(Catharine, 2010). Many dogs may present with normal body
weight or even weight loss. This is due to poor digestion and
nutrient assimilation, as a result of altered motility of the small
bowel and less bile secretion (Gebhard et al., 1992).
The decrease in glucose consumption leads to lethargy and
increased sleepiness, though some dogs may become aggressive
(Beaver and Haug , 2003).
Satish et al. (2007) recorded obesity - 88%, generalized weakness,
lethargic, dull and listless, exercise intolerance, dyspnoea, gasping,
bradycardia, cyanotic tongue - 55%
25. 3- Neurologic dysfunction A-Peripheral neuropathy
About 2-4% dogs exhibit some behavioral changes and neurological
signs such as, head tilt, seizures, ataxia, circling and facial nerve
paralysis (Nesbit et al.,1980 and Baker, 1997).
Peripheral neuropathy caused by hypothyroidism affects primarily
middle-aged and older individuals (Jaggy et al., 1994), especially of
middle- to large-sized breeds.
Neurological symptoms of hypothyroidism can originate from the
central and peripheral nervous systems (Rudas et al.,2005 and
Nunez et al., 2008) as well as from the muscles.
Specific presentations and their incidence that would be included
under behavioral signs include aggression, cold intolerance (15%),
decreased libido, exercise intolerance, lethargy or mental dullness
(20% to 70%), prolonged anestrus (4% to 40%), and weight gain or
obesity (41% to 60%).(Bonnie V. Beaver et al,2013)
26. In neurological manifestations of hypothyroidism, the dog may not show
any of the classical symptoms such as lethargy and dermatological
changes (Srivastava et al., 2013 and Budsberg et al.,1993).
However, (Indrieri et al., 1987) reported dermatological changes, weight
gain and hypercholesterolaemia (Cuddon, 2002) in dogs with peripheral
neuropathies.
Symptoms from the peripheral nervous system are exercise intolerance,
general weakness, ataxia, paraparesis, tetraparesis, deficits of conscious
proprioception, and decreased spinal reflexes (Catharine, 2010) and
symptoms of the cranial nerves such as facial paralysis (McKeown, 2002)
vestibular syndrome, trigeminal nerve (Fors, 2006), reduced spinal
reflexes and muscle atrophy (Bischel et al.,1988).
Proprioceptive positioning deficits and decreased spinal reflexes are
generally more evident in the hind limbs, however(jaggy et al., 1994).
The clinical signs of generalised peripheral neuropathy reduced spinal
reflexes in all four limbs can occur caused by hypothyroidism are usually
reversible after two to three months treatment using thyroid hormone
supplements (Cizinauskas et al.,2000). Intermittent, as well as constant,
forelimb lameness is described in dogs with hypothyroidism (Budsberg et
al.,1993).
27. Cardiovascular system:
Sinus bradycardia, weak apex beat, low QRS voltages, and
inverted T waves occur in hypothyroid dogs.
Reduced left ventricular pump function but rarely myocardial
failure in dogs.
Dilated cardiomyopathy and hypothyroidism may occur
concurrently with dramatic long-term improvement in cardiac
function after treatment with l-thyroxine.
Canine hypothyroidism may occur in association with other
immune-mediated endocrine disorders such as
hypoadrenocorticism and diabetes mellitus.
Hypothyroidism causes insulin resistance and may mask the
classic electrolyte changes of hypoadrenocorticism.
Polyendocrinopathies
28. Ocular changes:
Corneal lipidosis, corneal ulceration, uveitis, lipid effusion
into the aqueous humor, secondary glaucoma, lipemia retinalis,
retinal detachment, and keratoconjunctivitis sicca may occurs
in hypothyroidism.
Hemostasis
• Decreased plasma von Willebrand factor concentration has
been reported in hypothyroid dogs but canine hypothyroidism
is rarely associated with clinical bleeding, and platelet
function.
29. Epidemiology: 1-
Incidence
Hypothyroidism is the most common hormone imbalance of
dogs with the incidence rate at about 1: 150 to 1: 500 (Chastain
and Panaciera, 1995).
Overall prevalence is 0.2 to 0.8 % (Catharine, 2010).
Central hypothyroidism reportedly accounts for less than 5% of
these cases (Feldman and Nelson, 2004).
30. Epidemiology: 2- Age
Dogs beyond 8 yrs are more susceptible (Panaciera, 1994).
Most cases are seen in dogs over one year of age middle-aged
dogs and is rarely diagnosed in dogs less than two years of age
(Carmel, 2003) although perhaps 10% may be in younger animals.
A small number (approx. 3%) of cases are congenital, while the
rest relate to pathology acquired during growth (Victor, 2011).
Hypothyroidism can affect any age or breed of dog (Dixon et al.,
1999).
Mean age is 7 years (range 0.5–15 years) (Patty, 2012).
Hypothyroidism secondary to lymphocytic thyroiditis appears to
develop at a younger age than idiopathic thyroid atrophy (Patty,
2012).
31. Epidemiology: 3- Breed & Sex
Labrador, Doberman, Golden Retriever, German shepherd,
Spaniels, Great Dane, Dachshund have great risk (Patty, 2012
and Nesbitt et al., 1980).
More common in mid to large pure-bred dogs (Carmel, 2003).
In india Spitz was showing high incidence (56%) followed by
Labrador (28%) and German shepherd (17%) (Satish et al., 2007).
This variation could probably be due to the habitation of different
breeds in different regions.
Spayed females and castrated males are at greater risk (Panaciera,
1994).
Males and females, either neutered or entire, appear to be affected
equally (Carmel, 2003).
33. Total triiodothyronine (T3)
T3 is three to five times more potent than T4 (pro-hormone).
Measurement of T3 therefore reflects metabolic status more
accurately, but it plays no role in the diagnosis of hypothyroidism
(Carmel, 2003), as circulating concentrations are often maintained
in the reference range in hypothyroid dogs (Peterson et al., 1997).
This is presumably because of compensatory mechanisms both
within the thyroid gland (increasing secretion of T3), and possibly
in extra-thyroidal tissue (up-regulating peripheral T4 conversion).
TT3 concentrations fluctuate out of reference ranges even more
than TT4 concentrations in euthyroid dogs (Catharine,2010).
34. Circulating total T4 concentration is invariably low in hypothyroid
dogs (Peterson et al., 1997; Dixon and Mooney, 1999).
Extremely valuable screening test to rule out hypothyroidism unless
anti-T4 antibodies cause a spurious increase, which are produced in
2% of dogs with hypothyroidism (Graham et al., 2001).
Basal T4 has a 95% positive predictive value, the 5% lacking are
due to the presence of T4 antibodies (Cauzinille, 2005), but it is
poorly specific due to numerous nonthyroidal factors like non-
specific hormone fluctuation in healthy dogs, breed, any non-
thyroidal illness and numerous drug therapies including
glucocorticoids, potentiated sulphonamides and anticonvulsants
(Muller et al., 2000; Kantrowitz et al., 2001).
Thus, a low total T4 concentration alone does not confirm
hypothyroidism. Total T4 concentrations do not differ significantly
between males and females but are higher in small dogs than in
medium and large-breed dogs
36. Free thyroxin (FT4)
Free T4 is the active fraction of total T4 and is more closely reflect
metabolic status at the tissue level than total T4.
It is less affected by the myriad factors (drug therapies, non-
thyroidal illness, breed) and T4 autoantibodies etc. capable of
lowering total T4 and is thus a more specific diagnostic test for
hypothyroidism.
Overall, it is considered to be the best single diagnostic test for
hypothyroidism but it is not without problems (Peterson et al.,
1997; Dixon and Mooney, 1999), as free T4 is only accurately
measured by equilibrium dialysis or ultrafiltration techniques and
these are not widely available and are relatively expensive.
37. Certain drugs, particularly anticonvulsants and glucocorticoids,
are capable of lowering both total and free T4 concentrations
(Muller et al., 2000) and severe nonthyroidal illness has also been
associated with decreased free T4 concentration in a few cases
(Kantrowitz et al., 2001).
With regard to THs, FT4 is the fraction that best reflects the
peripheral thyroid condition and is the first to become affected
(Wang et al., 2000).
A decrease in FT4 is indicative of hypothyroidism in all dogs
diagnosed for clinical hypothyroidism, 30% presented with
protein-bound T4 levels close to the lower limit, with diminished
FT4 and increased TSH levels, together with morphological
alterations of the gland and clinical signs (Victor, 2011).
38. Endogenous thyroid-stimulating hormone
(TSH)
Decreased circulating thyroid hormone concentrations reduce the
negative feedback effect on the pituitary gland and consequently, in
primary hypothyroidism, TSH concentrations rise.
Approximately 20 to 30% (Kooistra et al., 2000), 13% to 38%
(Catharine,2010) of hypothyroid dogs have a TSH concentration
within the reference range, which might be due to suppressive
effects of concurrent non-thyroidal illnesses or from drug
therapies, non-specific fluctuation, existence of secondary
hypothyroidism or production of unrecognizable TSH isomers
39. TSH concentrations increase above the reference range in 7% to
18% of euthyroid dogs, however, limiting the specificity of
measuring TSH alone for diagnosis of hypothyroidism
(Catharine,2010).
TSH is the best estimator of the thyroid gland axis, and is the most
sensitive marker for evaluating thyroid function. TSH elevation is
diagnostic of hypothyroidism, independently of the T4 values
(Snyder, 2000).
Despite the low specificity of TSH alone for diagnosis of
hypothyroidism, in dogs with concurrent low TT4 or fT4
concentration, specificity of an increased TSH concentration for
diagnosis of hypothyroidism approaches 100%.
40. Effect of Drugs on Thyroid Hormone Concentrations
Glucocorticoids influence
peripheral metabolism of thyroid
hormones and inhibit TSH
secretion. The effect of
glucocorticoids is dependent on
the dose and specific preparation.
In most studies oral
administration of
glucocorticoids at
immunosuppressive doses (1 to 2
mg/kg q12h) resulted in rapid
decreases in TT4, fT4, and T3,
but little change in serum TSH.
41. Evaluation of the lipid
profile
30-40% of all dogs with hypothyroidism present with total
cholesterol elevation (Xenoulis and Steiner ,2010).
It is important to measure LDL-cholesterol, since an
increase in relation to HDL-cholesterol can indicate thyroid
deficiency (Xenoulis and Steiner , 2010).
43. Therapeutic response
Therapeutic response has also been suggested as a method of
confirming hypothyroidism in dogs with inconclusive total T4 and
cTSH concentrations. However, caution is advised. Thyroid
hormone supplementation suppresses TSH production and
endogenous thyroid function. Hypofunction invariably occurs once
supplementation is withdrawn and can lead to confusing clinical
signs for up to eight weeks later (Panciera et al., 1989).
Thyroid hormone supplementation is known to have several
physiological effects that can easily be misinterpreted as a
successful response to therapy in euthyroid dogs.
44. Thyroid Ultrasound
thyroid gland in many hypothyroid dogs has a smaller volume and
s-sectional area and tends to be less echogenic (Catharine, 2010).
Ultrasound is a useful imaging tool for assessment of thyroid glands
and measurement of thyroid size.(Lyshchik et al,2004)
Three-dimensional ultrasound is a useful and precise image method in
the measurement of thyroid volume as compared with 2D
ultrasonography, and this method enables to exactly detect the alteration
of the thyroid lobe volume in a relatively short time.(Alireza Vajhi et
al,2010)
45. How are hypothyroid dogs
treated?
Synthetic T4 products have greater standardization and potency
and a longer shelf life compared with crude preparations. T4 itself
is considered to be a physiological pro-hormone, serves to
normalize both circulating T4 and T3 concentrations and pituitary
cTSH production, and can effectively be administered once daily.
The recommended dose in clinical hypothyroidism is 11-22 μg/kg,
starting with the lower dose and gradually increasing the dosage
until the desired concentration has been reached. (Dixon et al.,
2002).
46. In adequately treated dogs, there is usually a dramatic improvement
in metabolic signs within days. Dermatological abnormalities can
take several months to improve and, frequently, there is worsening
of alopecia before new hair re-growth commences.
There is wide inter-individual variation in gastrointestinal
absorption and response to T4 replacement therapy. As a
consequence, it is important to monitor dogs after commencing
therapy.
47. Administration of lower doses (3-10 μg/kg) in subclinical
hypothyroidism.
Administration of lower doses in elderly animals.
Presence of heart failure or kidney disease: administration of
lower doses in order not to overburden the affected organs.
Gestation or proximity to mating: administration of higher doses
(between 25-50%) in order to secure good ovulation or
spermatogenesis and avoid embryonic and fetal
deaths/reabsorptions.
Dogs with oncological diseases or chronic infections, where
metabolic rest is indicated: administration of lower doses.
Recommendation for treatment
(Victor, 2011)
48. Dixon and Mooney (1999) advise initially administering
levothyroxine every 12h, progressing to once daily dosing).
Reassessment can then be performed every 6-12 months (Dixon
et al.,2002).
In the case of congenital hypothyroidism, treatment should start as
soon as possible in order to avoid irreparable damage to the
central nervous system. The dosage in puppies with congenital
hypothyroidism or juvenile hypothyroidism is 5-20 μg/kg.
Adequately treated animals have a normal life expectancy and
quality of life.
Regular monitoring is required and consideration needs to be
given to the development of other immune mediated
endocrinopathies (polyglandular syndromes). In such cases,
hypothyroidism most commonly occurs in association with
hypoadrenocorticism or diabetes mellitus.
49.
50.
51. Improvement in activity - first 1 to 2 weeks of treatment.
Weight loss - within 8 weeks.
Normal hair coat- several months and the coat may initially appear
worse as telogen hairs are shed.
Improvement in myocardial function - 8 weeks but may be delayed
for as long as 12 months.
Neurologic deficits - 8 to 12 weeks.
Vestibular symptoms - two to four months (Jaggy et al., 1994 and
Bischel et al., 1988 ).
Time of Clinical Improvement