Cancer develops due to genetic mutations that cause cells to multiply uncontrollably. There are several known causes of genetic mutations, including carcinogens such as tobacco, radiation, and viruses. Cancer treatment options include surgery, chemotherapy, radiation therapy, hormone therapy, biological therapy, and lifestyle changes to prevent cancer. The goal of treatment is to kill cancer cells or stop their growth and division while limiting side effects to healthy cells.
Cancer is disease where cells grows out of control and invade, erode and destroy normal tissues
Normal body cells grow, divide and die in orderly fashion
Cancer cell does not obey this path
Cancer cells don't die (Immortality). They just continue to grow and divide in disorderly fashion
This makes it hard for the body to work the way it should
Oncology - For nursing students - tumors classification, cancer, differences between benign and malignant neoplasm,spread of cancer, pathophysiology with cancer cells, carcinogenesis, etiology, cancer screening, cancer prevention, management of cancer, radiation therapy, chemotherapy, bone marrow transplantation, oncologic emergencies
Presentation for the cytology (cell biology) course on cancer/tumour. A document with more information can be found for better presenting and understanding of the material.
Cancer is disease where cells grows out of control and invade, erode and destroy normal tissues
Normal body cells grow, divide and die in orderly fashion
Cancer cell does not obey this path
Cancer cells don't die (Immortality). They just continue to grow and divide in disorderly fashion
This makes it hard for the body to work the way it should
Oncology - For nursing students - tumors classification, cancer, differences between benign and malignant neoplasm,spread of cancer, pathophysiology with cancer cells, carcinogenesis, etiology, cancer screening, cancer prevention, management of cancer, radiation therapy, chemotherapy, bone marrow transplantation, oncologic emergencies
Presentation for the cytology (cell biology) course on cancer/tumour. A document with more information can be found for better presenting and understanding of the material.
Cancer is the general name for a group of more than 100 diseases. Although there are many kinds of cancer, all cancers start because of abnormal cells grow out of control.
This file is about cancer knowledge of initial level along with its cycle that shows how a cell change into cancerous one.
It's given cell cycle also help one in getting idea about what and how is it going on.
Cancer is the uncontrolled growth of abnormal cells anywhere in a body
Causative agents – chemical, toxic compound exposures, ionizing radiation, some pathogens
Most cancer form tumors, but not all tumors are cancerous.
For more Info visit www.healthlibrary.com "Understanding Facts and Myths About Cancer And Its Cure" by Dr. Sunita Polampalli held on 6th May 2016.
Cancer is considered as most dreadful disease. Incidence of cancer has been rising in recent times. Number of reasons like harmful environment, irregular lifestyle & bad inherited genes contribute to it. It causes lot of emotional stress & anxiety, not only to patients but also to family & friends. In order to fight cancer, it is essential to understand why cancer occurs & how it can be cured with a more holistic approach.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Index
-Introduction.
-The characteristics of cancer.
-Cancer is genetic disease.
-Types of cancer genes.
-What causes cancer?
-Carcinogens.
-Benign and malignant.
-Cancer treatment and prevention.
3. Introduction of cancer
The division of normal cells is precisely
controlled. New cells are only formed for
growth or to replace dead ones.
Cancerous cells divide repeatedly out of
control even though they are not needed,
they crowd out other normal cells and
function abnormally. They can also
destroy the correct functioning of major
organs.
4. The Characteristics of Cance
As genes switch on and off, they
determine when and how fast the cell will
grow and divide, when it will stop
dividing, and even when it will die.
Cancer can result when controls over cell
division are lost…
5. Cancer is a Genetic Diseas
Cancer is a genetic disease that develops
in a predictable sequence of steps..
Carcinogenesis
• Transformation of a normal cell
into a cancerous cell.
• Step-by-step transformation.
7. A Common Type of Colorectal
Cancer May Develop by These
Steps
8.
9. Types of cancer genes
Type of gene Normal function Mutated function Types of proteins
Promotes
Oncogene Promotes division - Growth factors
division abnormal time
or cell type
Tumor
Suppresses Fails to Checkpoint
suppressor
cell division suppress molecules
gene
division
DNA repair Enzymes for
Repair DNA Fail to repair
gene mismatch or
mutations DNA mutations
mutation excision repair
10. What causes cancer?
Cancer arises from the mutation of a
normal gene.
Mutated genes that cause cancer are
called oncogenes.
It is thought that several mutations need
to occur to give rise to cancer.
Cells that are old or not functioning
properly normally self destruct and are
replaced by new cells.
However, cancerous cells do not self
destruct and continue to divide rapidly
producing millions of new cancerous cells.
11. A factor which brings about a mutation is
called a mutagen.
A mutagen is mutagenic.
Any agent that causes cancer is called a
carcinogen and is described as
carcinogenic.
So some mutagens are carcinogenic…
12. carcinogens
-Ionising radiation – X Rays, UV light.
-Chemicals – tar from cigarettes.
-Virus infection – papilloma virus can be
responsible for cervical cancer.
-Hereditary predisposition – Some
families are more susceptible to getting
certain cancers.
13. Other Factors Also May Lead to Canc
Breakdowns in immunity
Healthy immune system can target
and destroy cancer cells.
When cancer cells have altered
proteins at its surface, cells are not
destroyed.
Risk of cancer increases:
-With age.
-When an immune system has
been suppressed for a long time.
-HIV infection.
-Immunosuppressant drugs.
-Anxiety and depression.
14. Benign and malignant?
Benign tumours do not spread from their
site of origin, but can crowd out (squash)
surrounding cells eg brain tumour, warts.
Malignant tumours can spread from the
original site and cause secondary
tumours. This is called metastasis. They
interfere with neighbouring cells and can
block blood vessels, the gut, glands, lungs
etc.
Both types of tumour can tire the body
out as they both need a huge amount of
nutrients to sustain the rapid growth and
division of the cells.
17. Some Major Types of Cance
In general, a cancer is named according to the
type of tissue in which it first forms
Sarcomas: cancer of connective tissue
Carcinomas: cancer arising from
epithelium
Lymphomas: cancer of lymphoid tissue
Leukemias: cancer of stem cells
Gliomas: cancer of brain glial cells
18. Cancer Treatment and Preventio
When a person is diagnosed with cancer, a
variety of weapons are available to
combat it:
Chemotherapy drugs
Radiation therapy
Surgery
And other….
19. Chemotherapy
Drugs used to kill cancer cells; disrupt some
aspect of cell division.
Toxic to healthy cells; hair, bone marrow,
lymphocytes, and epithelial cells of intestinal
lining .
Side effects include hair loss, nausea, vomiting,
and reduced immune responses.
20. Radiation therapy
In radiotherapy, high-energy rays are used
to kill cancer cells and stop them from
growing and dividing. Like surgery,
radiotherapy is a local treatment; it can
affect cancer cells only in the treated area.
Radiotherapy is usually given on an
outpatient basis, 5 days a week, for
several weeks. Patients are not
radioactive during or after treatment.
21. The most common side effects are
tiredness, skin reactions such as rash or
redness, and loss of appetite. Radiation
therapy may also cause a temporary
lowering of the white blood cell count,
cells that help protect the body against
infection. The side effects are usually
temporary, developing gradually over the
weeks of the treatment, and improving
gradually after treatment is completed.
22. Surgery therapy
Surgery is the primary method of
treatment of most isolated solid cancers
and may play a role in palliation and
prolongation of survival. It is typically an
important part of making the definitive
diagnosis and staging the tumor as
biopsies are usually required. In localized
cancer surgery typically attempts to
remove the entire mass along with, in
certain cases, the lymph nodes in the
area. For some types of cancer this is all
that is needed for a good outcome.
23. Hormone therapy
Some types of cancer, for example, breast
cancer and prostate cancer, depend on
hormones to grow. For this reason,
doctors may recommend therapy that
prevents cancer cells from getting or using
the hormones they need. Sometimes, the
patient has surgery to remove the organs
(like the ovaries or testes) that make the
hormones. Or drugs are used to stop
hormone production or change the way
the hormones work.
24. Hormone therapy may cause nausea,
swelling of the limbs or weight gain
through water retention. In women, there
may be irregular periods and vaginal
dryness. In men, there may be impotence
or loss of sexual desire.
25. Biological Therapy
Biological therapy, also called
immunotherapy, uses the body's own
immune system to fight infection and
disease or protect the body from some of
the side effects of other forms of
treatment. Monoclonal antibodies,
interferon, interleukin-2, and colony-
stimulating factors such as GM-CSF and G-
CSF, are forms of biological therapy.
26. These treatments often cause temporary
flu-like symptoms such as fever and chills,
muscle aches and weakness, loss of
appetite and diarrhoea.
27. Good Lifestyle Choices Can Limit
Cancer Risk
-Avoid tobacco completely.
-Maintain a desirable weight; eat a low-fat
diet with plenty of fruits and vegetables.
-Avoid alcohol .
-Make sure your living and work
environment is safe from carcinogens.
-Protect your skin from the sun’s UV rays.
28. finally
. Remember you can’t inherit
cancer its just that you maybe
more susceptible to getting it. so
be careful and prevent your
self…….