since rumen is not functional in calves. when calves take excess of milk or milk replacers, they get abomasal bloat.
ruminal bloat is rare in calves but only occur when there is excess intake of milk or milk replacers in newly developed rumen... HOPE,, this ppt will help
Calf scours causes more financial losses to cow-calf producers than any health problem in their herds. Calf scours is not a single infection; it is a clinical signallied with several diseases characterized by diarrhea. Regardless of the cause, diarrhea prevents the absorption of fluids from the intestines; also, body fluids pass from the scouring calfs body into the intestines. A calf is about 70 percent water at birth.
The scouring calf loses fluids and rapidly dehydrates. In addition, dehydration is associated with loss of essential body chemicals (electrolytes)-sodium and potassium-and the buildup of acid. The scouring calf typically becomes dehydrated and suffers from electrolyte loss and acidosis. Infectious agents cause the prime damage to the intestine, but death from scours usually results from dehydration, acidosis, and loss of electrolytes. The identification of infectious agents which cause scours, is quiet essential for implementing effective preventive measures (Wenzel et al., 2009).
Calf scours causes more financial losses to cow-calf producers than any health problem in their herds. Calf scours is not a single infection; it is a clinical signallied with several diseases characterized by diarrhea. Regardless of the cause, diarrhea prevents the absorption of fluids from the intestines; also, body fluids pass from the scouring calfs body into the intestines. A calf is about 70 percent water at birth.
The scouring calf loses fluids and rapidly dehydrates. In addition, dehydration is associated with loss of essential body chemicals (electrolytes)-sodium and potassium-and the buildup of acid. The scouring calf typically becomes dehydrated and suffers from electrolyte loss and acidosis. Infectious agents cause the prime damage to the intestine, but death from scours usually results from dehydration, acidosis, and loss of electrolytes. The identification of infectious agents which cause scours, is quiet essential for implementing effective preventive measures (Wenzel et al., 2009).
Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
It is caused by the bacterium Mycobacterium avium subspecies paratuberculosis.
Infections normally affect ruminants (mammals that have four compartments of their stomachs, of which the rumen is one),
but have also been seen in a variety of non ruminant species, including rabbits, foxes, and birds. Horses, dogs, and nonhuman primates have been infected experimentally.
Paratuberculosis is found worldwide
Paratuberculosis is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
It is caused by the bacterium Mycobacterium avium subspecies paratuberculosis.
Infections normally affect ruminants (mammals that have four compartments of their stomachs, of which the rumen is one),
but have also been seen in a variety of non ruminant species, including rabbits, foxes, and birds. Horses, dogs, and nonhuman primates have been infected experimentally.
Paratuberculosis is found worldwide
Your website has out-of-control CSS bloat. You know your performance is being impacted, but how do you move from organic CSS with no particular architecture to something lighter, more logical, and easier to maintain? In this session, Nicole Sullivan and Stoyan Stefanov will show you how they improved the CSS at Facebook and Yahoo! Search. After this session you will know how to:
1. Use lint tools to automate and evaluate the efficiency of your CSS
2. Avoid the top 5 causes of CSS bloat, and
3. Speed up your site by making the UI code an order of magnitude smaller.
Grouping and nutritional strategies for dairy heifersJaylor
Jan Kleinschmidt explains how, in order for heifer rearing programs to be successful, these animals must be given the same time and consideration as the milking herd.
Jaylor: Forage Testing for Producers When, Where and HowJaylor
Many factors (variety, maturity, growing conditions, handling practices, etc.) affect forage quality prior to the time it is fed. As a result, predicting forage quality values from standard books often grossly overestimates or underestimates feeding value.
The internship of Final Professional Doctor of Veterinary Medicine
(D.V.M.), students was at early phase in “District Veterinary Hospital” and in final phase
at “Red sindhi cattle and breeding farm Tando Muhammad Khan”. In all institutions the
Veterinary practice with animal health and Breeding practices on scientific/ advance
technique were completed.
Such experiences as internee certificates were honoured by the
Professional head of the concern institution infavour of the internees. The detail report
was prepared and after thorough checking and correction, it was submitted for favoring
consideration and delivering of seminar and viva vice to complete the requirement of
internship in due time.
At Red Sindhi cattle & breeding farm different managemental procedures
were practiced. Such as management of feeding, management of housing and
management of animal health by monitor all managemental things which were under
farm schedule. The total farm animals are 383 and the average milk per Cow 4.14
Liters/day.
The second phases of internship in district veterinary hospital total
251animals were brought for clinical checkup. Among that 52 animal were infected by
parasitic problems, 18 animals suffer in wound, 16 animals were treated for dystocia, 82
cases of pneumonia, 48 cases of metabolic disorders and 35 cases of other disease.
In February and March 22 animal were castrated, 49 animals were
drenched. 550 animals were vaccinated for ETV, 320 animals for CPP and 26 animals
were vaccinated for rabies.
Not only has gentics and nutrition played a major role in maximizing milk production, but farm management, labor, and facilities all play a role as well. Jaylor's Ruminant Nutritionist, Janet Kleinschmidt, discusses how in PART 2 of this presentation.
This slide contains information regarding Protein Energy Malnutrition. This can be helpful for proficiency level and bachelor level nursing students. Your feedback is highly appreciated. Thank you!
Oxytocin is a peptide hormone that activates receptors on Uterine smooth muscle leading to the increased frequency, strength and duration of Uterine Contraction..
Introduction
• Pyloric stenosis is also known as pylorostenosis or infantile hypertrophic pyloric stenosis. It is the most common cause of intestinal obstruction in infants. It is a form of obstruction in the gastric outlet which means a blockage from stomach to intestine.
• It was First described by Hirschsprung in 1888
• Ramstedt described an operative procedure to alleviate the condition in 1907 – the procedure used to this day to treat pyloric stenosis.
Definition
• Hypertrophic pyloric stenosis is a marked and progressive outgrowth or enlargement of circular muscle fibers of pylorus causing partial or total obstruction of the stomach outlet due to narrowing of lumen.
Anatomy
The stomach sits in the upper abdomen on left side of the body. The top of the stomach connects to a valve called the esophageal sphincter (a muscle at the end of esophagus). The bottom of stomach connects to small intestine.
The stomach is divided into 5 regions:
• The cardia is the top part of the stomach. It contains the cardiac sphincter, which prevents food from traveling back up the esophagus.
• The fundus is a rounded section next to the cardia. It's below the diaphragm (the dome-shaped muscle that helps to breathe).
• The body (corpus) is the largest section of the stomach. In the body, stomach contracts and begins to mix food.
• The antrum lies below the body. It holds food until the stomach is ready to send it to your small intestine.
• The pylorus is the bottom part of the stomach. It includes the pyloric sphincter. This ring of tissue controls when and how stomach contents move to the small intestine.
Incidence
• It is more commonly seen in child with 2-5wks of age.
• 2-9 per 1000 livebirths can be born with this condition.
• Predominant sex: Male > Female (6:1). Males are more prone to get
• Genetic predisposition can be an underlying factor for disease causation.
• Full term babies especially first borne are most commonly affected.
• Death from infantile hypertrophic pyloric stenosis is rare and unexpected; the reported mortality rate is very low and usually results from delays in diagnosis with eventual dehydration and shock.
Etiology
• Idiopathic
• Other factors : *maternal stress especially in third trimester *elevated prostaglandin levels *deficiency of nitric acid *immature pyloric ganglion cells with abnormal muscle innervation.
• In adults, it can occur due to history of peptic ulcer in pylorus region and hypertrophic changes in muscle layer of pylorus.
Risk factors
• Sex. Pyloric stenosis is seen more often in boys — especially firstborn children — than in girls.
• Race. Pyloric stenosis is more common in whites of northern European ancestry, less common in Black people and rare in Asian
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. Abomasal Tympany
• RISK FACTORS
NO offering of water to calves
Poor milk hygiene/ intermittent feeding of large volumes of milk/cool
milk temperature
Dietary changes
Abomasal bezoar
3. Risk Factors
Organisms likeC.perfringens , Campylobacter, Sarcinia
Compromised immunity from inadequate colostrum
Ingestion of foreign bodies
Vitamin / mineral deficiency
4. PATHOPHYSIOLOGY
Large quantity of
milk replacerat
infrequent intervals
Proliferationof
lactobacilli, E.coli,
C.perfringens
Fermentation of
sugars produces CO2
5. Clinical Signs
• Colic
• Refusal to drink milk
• Restlessness & Depression
• Succusion of distended abdomen produces splashing & metallicsounds
• Passage of stomach tube fails to relieve distension
• Reduced fecal output & occasionally melena
• Metabolic alkalosisfollowed by metabolic acidosis
6. Treatment
• Prevent further suckling
• Don’t tube the calf
• Paracentesis- through right flank
• Right flank lapratomy
7. Treatment
• I/V fluids- correct dehydration electrolyte & metabolic derangement
• Earlierantibiotic Rx sometimes effective
• Addition of 0.1% formalin(37% formaldehyde) to milk replacer reduces
incidence
8. Recent Developments
• Length of tube to reach the stomach is typically length from mouth to last rib
on calf’s side
• After insertion, lift front end of calf up so that calf is sitting/standing in near
vertical plane
• Procaine penicillin (10 cc of 10,000 IU/ml solution) mixed in 2 cups of
mineral oil should be administered into the tube,
9. Recent Developments
• With a cup or two of warm water as a “chaser” to push the medication
out of the tube and into the stomach
• Subcutaneous administration of procaine penicillin (4 cc of 10,000 IU/ml
solution per 100 lbsofbodyweight, 1-2timesper day)
• Injection of 50-100 mg of intravenous or subcutaneous flunixin
meglumine
11. Management
• Monitor protein, energy, vitamin, and trace mineral
• Adequate colostral intake by newborn calves is must
• Monitor changes in the volume of milk ingested by a hungry calf
12. Management
• Prolonged interruption of suckling must be made time-efficient in order
to limit engorgement of the udder and subsequent ingestion by the
neonate of a larger than normal milk meal
• Sudden and severe changes in weather may cause dams and their
offspring to seek shelter or remain recumbent for prolonged periods of
time
16. Clinical signs
• Diarrhoea
• Poor development
• Rough hair coat
• Recurrent bloat
• Complication of severe bronchopneumonia
17. Management
• Reduction in the volume of milk fed per feeding
• Feeding from nipple rather than bucket
• Introduce calfstarter to promote rumen development
• Course of oral antibiotics(500 mg oxytetracycline) o.d help in killing of
putrefactive gut flora
• Placemantof fistula( buff’s screw trocar)