UAEU - CMHS - Hematology-Oncology Course - MMH 302 - HONC 320. Education material for medical students - It cover basic principles of hematology and oncology, including CAR-T and gene editing. It can be used for study and review. It illustrates main principles of hematology and oncology.
UAEU - CMHS - Hematology-Oncology Course - MMH 302 - HONC 320. Education material for medical students - It cover basic principles of hematology and oncology, including CAR-T and gene editing. It can be used for study and review. It illustrates main principles of hematology and oncology.
Megaloblastic anaemia is a red blood cell disorder due to the inhibition of DNA synthesis during erythropioesis.
Mitotically, the inhibition of the DNA synthesis impaires the progression of the cell cycle development from G2 to (M) stage.
causes of macrocytic anemia pathopysiology, sign and symptoms and the difference between macrocytic anemia megaloblastIc anemia. causes of hypersegmented neutrophils and its association between them. investigation and medical management plus pictures illustration.
1Es una alteración en la sangre del ser humano que hace que el glóbulo rojo se deforme y adquiera apariencia de hoz.
Es una enfermedad autosómico recesivo
Megaloblastic anaemia is a red blood cell disorder due to the inhibition of DNA synthesis during erythropioesis.
Mitotically, the inhibition of the DNA synthesis impaires the progression of the cell cycle development from G2 to (M) stage.
causes of macrocytic anemia pathopysiology, sign and symptoms and the difference between macrocytic anemia megaloblastIc anemia. causes of hypersegmented neutrophils and its association between them. investigation and medical management plus pictures illustration.
1Es una alteración en la sangre del ser humano que hace que el glóbulo rojo se deforme y adquiera apariencia de hoz.
Es una enfermedad autosómico recesivo
Es la expresión de un trastorno madurativo de los precursores eritroides y mieloides vitamina B12 o los folatos.
Afecta en la síntesis de ADN y varias metabolismos del cuerpo.
Eritrocitos inmaduros
A presentation made about Sickle cell disease by Yara Mostafa, Yasser Osama, Yaser Mostafa ,Ain shams university, Medicine faculty, first year students.
Daily minimum nutritional requirements of the critically illRalekeOkoye
Critically ill patients have nutritional needs that are essential in their management. This is a synopsis with specific calculable applications for the daily recommended components of nutrition in critical care.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
5. Transport
Transcobalamin I
(TC I)
Neutrophil granules
2/3 Saturated with cobalamin
Glycoprotein receptors
Cobalamin analogues
Transcobalamin II
(TC II)
Hepatic synthesis
20-60 ng / L plasma
controlled by a receptor endocytosis
6. FOLATE
Folic Acid
Folate precursor compound
Reduced to DHF or THF
Containing one carbon unit
Folate polyglutamates
Nutritional content: >100 pg/100 g
Western Food: 250 pg/día
Daily requirements: 100 pg
Body Reserves: 10 mg
16. DIAGNOSIS OF COBALAMIN
DEFICIENCIES
Intestinal Causes of
Cobalamin
Malabsorption
• Intestinal Stagnant Loop Syndrome
• Ileal resection
• Selective Malabsorption of Cobalamin with Proteinuria
• Tropical Sprue
• Fish Tapeworn Infestation
• Gluten-Induced Enteropathy
• Severe Chronic Pancreatitis
• HIV infection
• Zollinger-Ellison Syndrome
• Radiotherapy
• Graft-versus-Host Disease
• Drugs
17. CAUSES OF FOLATE DEFICIENCY
Nutritional
Malabsorption
Excess Utilization or Loss
• Pregnancy
• Prematurity
• Hematologic Disorders
• Inflamatory Conditions
• Homocystinuria
• Long-tern Dialysis
• Congestive Heart Failure, Liver Disease
Antifolate Drougs
Congenital Abnormalities of Folate Metabolism
18. DIAGNOSIS OF COBALAMIN
DEFICIENCES
Serum
ELISA
Cobalamin
160-200 ng/L to 1000 ng/L
100 and 200 ng/L are regarded as borderline
Serum Methyl
manolate and
Homocysteine
The serum MMA level is raised (Patients with cobalamin deficiency sufficient to cause anemia or neuropathy)
Serum MMA levels fluctuate in renal failure
30% Healthy volunters (350 ng/L)
15% Elderly subjects (>350 ng/L)
Serum Homocysteine (Cobalamin and Folate deficiency)
Cobalamin
Abosrption
Urinary excretion test
Patient is fasted ivernight
Cyanocobalamin oral
Radiactive Cyanocobalamin or Hydroxocobalamin (1mg)
24-hour urine specimen
After 48 hours with IF
19. DIAGNOSIS OF FOLATE DEFICIENCES
Serum
Folate
ELISA
2pg/L - 15pg/L
Serum folate rises in severe cobalamin deficiency
Intestinal stagnant loop syndrome
Red Cell
Folate
Less afected tan the serum assay by recent diet
160 – 640 pg/L
False normal results
21. TREATMENT OF COBALAMIN
DEFICIENCY
Borderline cobalamin levels
Hydroxocobalamin
Cyanocobalamin
Malabsorption of cobalamin
Rises in serum MMA levels
Indications for starting
cobalamin therapy
• Well-documented megaloblastic
anemia
• Hematologic abnormality
• Neuropathy due to the deficiency
Total gastrectomy or Ileal recection
Patients who have undergone gastric reduction for
control of obesity
Reciving long-term treatment with proton pump
inhibitors
22. Hydorxocobalamin
• Replenishment of body stores
Six 1000 µg IM/3-7 days
• Maintenance therapy
1000 µg IM / month for 3 months
Cyanocobalamin (Poorer retention)
Small fraction of cobalamin can be absorbed passively through mucous membranes
Large daily oral doses can be used in PA
Sublingual therapy
Oral therapy: Important to monitor compliance
2000 pg
23. TREATMENT OF FOLATE DEFICIENCY
5-15 mg
It is a customary ton continue therapy for -4 months
Cobalamin deficiency must be excluded
USA: Food fortification with folic acid
Long-term folic acid therapy
• Deficiency cannot be corrected
• Gluten-Inuduced enteropathy
• Important to measure the serum cobalamin
24. FOLINIC ACID
• Stable form of fully reduced folate
• Toxic efects of
• Methotrexate
• DHF reductasa inhibitors
25. PROPHYLACTIC FOLIC ACID
Chronic dialysis
Pregnancy
Parenteral feeds
• 400 µg daily
• 5 mg daily (previous fetus with a
neural tuve defects)
Reduce homocysteine levels
Cognitive function in the
elderly
Infancy and Childhood
• Smallest premature babies (first 6
weeks of life)
• Folic acid 1mg daily (< 1500 g)
• Normal premature babies
