The document discusses the arterial blood supply and venous drainage of the heart. It notes that the heart receives its blood supply from two coronary arteries - the right and left coronary arteries. These arteries branch further to supply different regions of the heart. The venous drainage occurs primarily via the coronary sinus, which drains into the right atrium. A few small veins also drain directly into the right atrium. The document outlines the branches and territories supplied by the right and left coronary arteries in detail.
right ventricle internal and external features-
interior is divided into inflowing and outflowing parts (infundibulum)
inflowing part is rough due to trabeculae corneae, - ridges, bridges, pillars. Chordae tendineae- are attached to pillars and cusps of tricuspid valve.
outflowing part is smooth, semilunar valve guards opening of pulmonary valve
Right Atrium of human heart
This PPT help to understand the external and internal structures of right atrium.
sulcus terminalis on external surface of rt atrium,
crista terminalis on internal side of rt. atrium,
interior is divided into rough anterior part and smooth posterior part ( sinus venarum)
superior and inferior venae cavae drains deoxygenated blood into rt. atrim
there is Eustachian valve to guard the opening of IVC and Thebesian valve to guard the opening of coronary sinus
septal wall presents fossa ovalis with its border limbus fossa ovalis
right ventricle internal and external features-
interior is divided into inflowing and outflowing parts (infundibulum)
inflowing part is rough due to trabeculae corneae, - ridges, bridges, pillars. Chordae tendineae- are attached to pillars and cusps of tricuspid valve.
outflowing part is smooth, semilunar valve guards opening of pulmonary valve
Right Atrium of human heart
This PPT help to understand the external and internal structures of right atrium.
sulcus terminalis on external surface of rt atrium,
crista terminalis on internal side of rt. atrium,
interior is divided into rough anterior part and smooth posterior part ( sinus venarum)
superior and inferior venae cavae drains deoxygenated blood into rt. atrim
there is Eustachian valve to guard the opening of IVC and Thebesian valve to guard the opening of coronary sinus
septal wall presents fossa ovalis with its border limbus fossa ovalis
Cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat.
Cardiac events that occur from –
beginning of one heart beat to the beginning of the next are called the cardiac cycle.
Cardiac cycle refers to a complete heartbeat from its generation to the beginning of the next beat.
Cardiac events that occur from –
beginning of one heart beat to the beginning of the next are called the cardiac cycle.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
4. Arterial blood supply of heart
Arterial blood supply of heart
Heart is supplied by
coronary arteries.
Anatomically coronary
arteries are not end
arteries, but functionally
they behave like end
arteries.
Coronary is vasa vasorum
of ascending aorta.
5. Arterial blood supply of heart
Coronary arteries are
vasa vasorum arising from
aortic sinuses of Valsalva
of Ascending aorta
Right coronary artery
arises from right aortic
sinuses
Left coronary artery
arises from left aortic
sinuses.
6. Right coronary artery
Coronary arteries of heart
Right coronary artery
Arises from anterior
aortic sinus of ascending
aorta.
Right coronary artery is
smaller than the left
coronary
8. Courses of Right coronary artery
Passes forwards & to right between pulmonary trunk and right auricle.
Passes downwards to right in anterior atrioventricular groove and winds
round the inferior border to reach the diaphragmatic surface of heart.
Passes upwards to left in posterior part of atrioventricular groove & reach
crux of heart .
Ends by anastomosing with circumflex branch of left coronary artery.
9. Branches of right coronary artery
Right coronary artery branches
Small branches
Nodal in 60%
cases.
Right atrial
Infundibular
Terminal
branch
Right
ventricular
branch
Conus branch
10. Branches of right coronary artery
Branches of RCA
Large branches
Marginal.
Posterior
interventricular.
11. Area of distribution
1. Right atrium
2. Greater part of right ventricle
3. Small part of left ventricle adjoining inter ventricular groove
4. Posterior part of interventricular septum
5. Conducting system of heart in 40%
13. Left coronary artery
Left coronary artery
Arises from
left posterior
aortic sinus of
ascending aorta
Left coronary
artery is larger
than the right
coronary
14. Area of distribution
• Passes forwards & to left between pulmonary trunk and left auricle.
Divides into anterior interventricular artery & circumflex artery.
• Anterior interventricular artery – continuation of LCA descends in the
anterior interventricular groove up to the apex.
•Circumflex artery – passes to left in the left atrio ventricular groove.
Winds round the left border of heart & occupies posterior part atrio
ventricular groove – anatomises with RCA (crux)
15. Branches of left coronary artery
Branches of LCA
1. Anterior
interventricular
artery (left anterior
descending(LAD):
Also known as
widow maker artery
2. Circumflex artery
16. Branches of Circumflex artery
• Atrial & ventricular rami-LA & RA
• Sino-atrial nodal artery[in 35% people]
• Left marginal artery
• Circumflex artery- contd.. as Posterior interventricular artery [in 10%
people] .
• Atrial branch- communicate with similar branch of RCA (Kugels artery).
17. Branches of Left anterior descending (LAD)
LAD branches
Conal branch
Anterior ventricular
branches: right and left
Interventricular septal
branches: (anterior,
inferior) .
21. Area of distribution of LCA
1. Left atrium
2. Major part of left ventricle adjoining posterior interventricular groove
3. Small part of right ventricle adjoining anterior interventricular groove
4. Anterior part of interventricular septum
5. A part of left branch of AV bundle
22. Cardiac dominance
Mostly the right coronary artery gives posterior interventricular artery
branch . Such hearts are right dominant heart.
In about 10% of hearts, the right coronary is rather small and is not able to
give the posterior interventricular branch. In these cases the circumflex
artery(LCA) provides the posterior interventricular branch ,Such cases are
called left dominant.
70% cases post IV is a branch of RCA (Right coronary dominance)
23. Coronary artery that gives post IV branch is supposed to be dominant. Thus
the artery giving the posterior interventricular branch is the dominant artery.
In Left dominance heart a block in LCA affect entire Left ventricle and IV
septum, while in Right or balanced dominance a block in RCA at least spares
part (2/3) of septum and left ventricle.
26. Venous drainage of the heart
In heart most of the veins drain into the coronary sinus which opens in
right atrium.
The anterior cardiac veins and the venae cordis minimi open directly into
the right atrium.
The coronary sinus is the largest vein of the heart. It is situated in the left
posterior coronary Sulcus .It is about 3 cm long. Opens into Right atrium
b/between IVC and Tricuspid opening guarded by incomplete semicircular
“Thebesian valve”.
All veins of coronary sinus have valves except oblique Vein of left atrium
28. Tributaries of coronary sinus
1. Great Cardiac vein
2. Middle cardiac vein
3. Small cardiac vein
4. The posterior vein of the left ventricle
5. The oblique vein of the left atrium
6. The right marginal vein
30. Tributaries of coronary sinus
Great Cardiac vein begins first the anterior interventricular artery and
then the left coronary artery. It terminates at the left end of coronary
sinus.
Middle cardiac vein accompanies the posterior interventricular artery
and joins the middle part of coronary sinus.
The small cardiac vein accompanies the RCA in the right posterior
coronary Sulcus. It joins the right end of the coronary sinus. The right
marginal vein may drain into the small cardiac vein .
31. The posterior vein of the left ventricle runs on the diaphragmatic surface
of the left ventricle and it ends in the coronary sinus.
The oblique vein of the left atrium of Marshall is a small vein running on
the posterior surface of the left atrium .It terminates in the left end of the
coronary sinus.
The right marginal vein accompanies the marginal branch of the right
coronary artery. It may either drain into the small cardiac vein or may open
directly into the right atrium.
36. Veins emptying directly into the right atrium
Anterior cardiac veins are three or four small veins that drain the
infundibulum of right ventricle. These open directly into the right atrium
through its anterior wall.
Venae cordis minimi or Thebesian veins are numerous small valve less
veins present in all four chambers of the heart. These are more on the right
side of the heart rather than left.