The pulmonary trunk originates from the right ventricle and carries deoxygenated blood to the lungs. It divides into the left and right pulmonary arteries. The right pulmonary artery is longer, wider and passes behind the ascending aorta. The left pulmonary artery is shorter, narrower and passes along the upper border of the left atrium. Pulmonary artery catheterization involves passing a catheter through the jugular vein and right side of the heart into the pulmonary trunk to monitor cardiopulmonary functions.
Right Atrium of human heart
This PPT help to understand the external and internal structures of right atrium.
sulcus terminalis on external surface of rt atrium,
crista terminalis on internal side of rt. atrium,
interior is divided into rough anterior part and smooth posterior part ( sinus venarum)
superior and inferior venae cavae drains deoxygenated blood into rt. atrim
there is Eustachian valve to guard the opening of IVC and Thebesian valve to guard the opening of coronary sinus
septal wall presents fossa ovalis with its border limbus fossa ovalis
Right Atrium of human heart
This PPT help to understand the external and internal structures of right atrium.
sulcus terminalis on external surface of rt atrium,
crista terminalis on internal side of rt. atrium,
interior is divided into rough anterior part and smooth posterior part ( sinus venarum)
superior and inferior venae cavae drains deoxygenated blood into rt. atrim
there is Eustachian valve to guard the opening of IVC and Thebesian valve to guard the opening of coronary sinus
septal wall presents fossa ovalis with its border limbus fossa ovalis
venous drainage of the upper limb, median vein of forearm, deep veins, basilic vein, cephalic vein, median cubital vein, superficial vein, dorsal venous arch,
venous drainage of the upper limb, median vein of forearm, deep veins, basilic vein, cephalic vein, median cubital vein, superficial vein, dorsal venous arch,
The thoracic structure refers to the anatomical components of the thorax, which is the region of the body between the neck and the abdomen, also known as the chest. It includes the thoracic vertebrae, ribs, sternum (breastbone), and associated muscles, ligaments, and organs such as the heart and lungs. The thoracic structure plays a crucial role in protecting vital organs, supporting the upper body, and facilitating respiration.
The thoracic structure encompasses the anatomical elements of the chest region, including the thoracic vertebrae, ribs, sternum, associated muscles, and vital organs such as the heart and lungs. It provides protection, support, and facilitates respiration, highlighting its critical role in overall bodily function and health.The thoracic structure comprises the chest's anatomical components, including vertebrae, ribs, sternum, muscles, and vital organs like the heart and lungs, crucial for protection, support, and respiration..The thoracic structure includes the chest's bones, muscles, and organs, vital for breathing and protecting the heart and lungs.
1. **Thoracic Vertebrae:** The thoracic spine consists of twelve vertebrae (T1-T12) that form the posterior aspect of the thoracic structure. These vertebrae are larger than those in the cervical or lumbar regions and articulate with the ribs, providing stability and support for the upper body.
2. **Ribs:** There are twelve pairs of ribs that attach posteriorly to the thoracic vertebrae and curve anteriorly to meet the sternum. Ribs play a vital role in protecting the internal organs of the thoracic cavity, such as the heart and lungs. The upper seven pairs are true ribs, while the lower five pairs are false ribs (some of which do not directly attach to the sternum) or floating ribs.
3. **Sternum:** The sternum is a flat bone located in the center of the anterior thoracic wall. It consists of three parts: the manubrium, body, and xiphoid process. The sternum serves as an attachment point for the ribs and provides structural support to the chest.
4. **Muscles:** Several muscles surround the thoracic cavity, contributing to breathing and movement of the chest wall. These include the intercostal muscles (external, internal, and innermost), which are located between the ribs and aid in respiration, as well as muscles such as the diaphragm, which separates the thoracic and abdominal cavities and plays a primary role in breathing.
5. **Organs:** The thoracic cavity houses important organs such as the heart and lungs. The heart is situated in the mediastinum, a central compartment of the thoracic cavity, while the lungs occupy the lateral portions. The thoracic structure provides protection and support for these vital organs while allowing for their necessary movements during respiration and circulation.
Understanding the anatomy and function of the thoracic structure is essential for various medical disciplines, including anatomy, physiology, orthopedics, cardiology, and res
Embryology of heart, Anatomy of heart, Physiology of heart, Fetal circulation, Neonatal circulation, Congenital cyanotic and acyanotic heart diseases of children.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
3. The pulmonary trunk
• The pulmonary trunk and the ascending aorta lie with
in the fibrous pericardium.
• The pulmonary arteries receive deoxygenated blood
from the right ventricle, and deliver it to the lungs for
gas exchange to take place.
• The pumonary arteries begin as the pulmonary trunk, a
thick and short vessel, which is separated from the
right ventricle by the pulmonary valve.
• The trunk is located anteriorly and medially to the right
atrium. Behind them lies the transverse pericardium.
• It continues upwards, overlapping the root of the aorta
and passing posteriorly.
4.
5. The Pulmonary Trunk
• ORIGIN
•The Pulmonary Trunk is about 5 cm
long and originates from the upper
part (infundibulum) of the right
ventricle in the level of the sternal
end of left 3rd costal cartilage.
7. The Pulmonary Trunk
• COURSE
• After arising from infundibulum in the
middle mediastinum, it enters backwards
and to the left and ends below the arch
of aorta and in front of left principal
bronchus by dividing into left and
right pulmonary arteries at around the
level of T5-T6.
8. RELATIONS
ANTERIOR: A. Sternal end of left 2nd intercostal space.
B. Left lung and pleura.
POSTERIOR: A. Ascending aorta.
B. Commence of left coronary artery.
C. Transverse sinus of pericardium.
TO THE RIGHT: A. Ascending aorta.
B. Origin of right coronary artery.
C. Right auricle.
TO THE LEFT: A. Left coronary artery.
B. Left auricle.
The two pulmonary arteries lie in front of the bronchi and the
inferior trachiobronchial lymph nodes.
9.
10. The Pulmonary Trunk
• BRANCHES
• Left and right pulmonary arteries.
• The right pulmonary artery is larger
compared to the left and is located
somewhat at a lower level.
• The right and left pulmonary arteries lie
along the upper borders of the right and left
atria and of the upper pulmonary veins like
the transverse piece of the letter “T”.
11.
12. The right & left pulmonary artery
• The left pulmonary artery supplies blood
to the left lung, bifurcating into two
branches to supply each lobe of the lung.
• The right pulmonary artery is the thicker
and longer artery of the two, supplying
blood to the right lung. It also further
divides into two branches.
13. Pulmonary arteries
The right pulmonary
artery
The left pulmonary artery
Longer Shorter
Wider Narrower
Passes behind the
ascending aorta and
superior vena cava
Passes along the upper
border of the left atrium
Then passes in front of
right bronchus to reach
the hilum of the right lung.
Then passes in front of th
left bronchus and the
descending aorta to reach
the root of the left lung.
The left pulmonary artery is connected to the lower aspect of the ligamentum arteriosum.
14.
15. PULMONARY ARTERY CATHETERIZATION
• Different aspects of cardiopulmonary functions are
monitored by the cardiologists by pulmonary artery
catheterization.
• The catheter is passed successively as follows:
• Internal jugular vein/subclavian vein ► Right
atrium ► Right ventricle ► Pulmonary trunk ►
Pulmonary artery.
• Sudden occlusion of pulmonary trunk by an
embolus may be a sequel to the thrombosis of deep
veins of the calf. When the block is complete, death
ensues rapidly.