This PPT is mainly oriented towards Bailey & Love - Topic on Skin & Sub-cutaneous tissue. Few common diseases has been added. Very useful to Final yr. MBBS Students
Seminar presentation by student under supervision of endocrinology specialist from HRPZ. References as mentioned in the slides. Mostly from Malaysia CPG.
This PPT is mainly oriented towards Bailey & Love - Topic on Skin & Sub-cutaneous tissue. Few common diseases has been added. Very useful to Final yr. MBBS Students
Seminar presentation by student under supervision of endocrinology specialist from HRPZ. References as mentioned in the slides. Mostly from Malaysia CPG.
Carcinoma of breast is the second common killer disease in women after carcinoma of cervix in developing countries like India whereas it is the number one killer in western world. It can also run in families associated with BRCA1 & BRCA2 genes. Early diagnosis is almost curative and that is why they are doing mass screening like mammogram to pick up this cancer early.
science has an evolving nature. what happened today may not be tomorrow, what is not today may happen tomorrow.
No one is complete so reading and thinking may open the door to the hidden ground.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
2. Anatomy
• Modified sweat gland – derived from the ectoderm
• Each breast consists of 15-20 lobules
3. • Breast extends from 2 – 6th rib
• Sternum to mid axillary line
• Lies in the superficial fascia, superficial to the pectoral fascia.
• Axillary tail of Spence - upper outer portion of the breast passes deep to the
deep fascia through the foramen of Langer.
4. Aberrations of Normal Development and
Involution of the Breast (ANDI)
• Breast in Females goes through various phases
• Early reproductive phase (Lobular development): 15 – 25 yrs
• Matured reproductive phase (Cyclical hormonal modification): 25 – 40 yrs
• Involution phase (Resorption of glandular structures): 40 – 55 yrs
• Presents as a spectrum of diseases at various stages of development
5. • Early reproductive age group:
• Fibroadenoma
• Giant
• Multiple
• Juvenile hypertrophy
• Mature reproductive age group:
• Caused due to cyclical hormonal effects
• Generalized enlargement
• Cyclical mastalgia with nodularity Fibroadenosis or fibrocystic disease
6. • Involution age group
• Lobular involution: Microcysts, fibrosis, adenosis, apocrine metaplasia
Macrocysts, cystic disease of breast, sclerosing adenosis
Ductal involution: Nipple discharge, periductal mastitis, bacterial infection,
nonlactational breast abscess, mammary duct fistula
7. Fibroadenoma
• Benign, encapsulated tumor occurring in younger patients 15- 25 yrs
• Presently considered as hyperplasia of single lobule.
• Most common lesion in patients < 30 yrs old
• Shows similar hormonal activity as normal breast tissue.
• Juvenile fibroadenoma:
• Adolescent girls with rapid growth (Epithelial & Stromal hyperplasia)
• May clinically mimic phyllodes tumor
8. • Giant Fibroadenoma:
• Size > 5 cm
• Multiple fibroadenoma
• Clinical features:
• Painless, smooth, nontender, well localized swelling
• Moves freely within the breast tissue
• No node enlargement
10. Fibrocystic disease of
breast/Fibrocystadenosis/ Mammary
dysplasia/ Cyclical mastalgia with nodularity
• Estrogen dependent condition.
• Most common breast condition
• Exaggerated response of breast stroma and epithelium to Hormones
and growth factors
• Stages
• Stromal proliferation
• Adenosis
• Cyst formation.
11. • Clinical features:
• Bilateral, painful, diffuse, granular, swelling
• Better palpated with the fingers than palm.
• Commonly in upper outer quadrant.
• Pain and tenderness >> just prior to menstruation
• Subsides during pregnancy, lactation and post menopause.
• Occasionally serous discharge may be present
12. • Treatment:
• Conservative management
• Oil of evening primrose – Linolenic acid + Linoleic acid
• Danazol – Interferes with FSH and LH decreases Est and Pro
• Bromocriptin – Lowers Prolactin
• Tamoxifen – Antiestrogenic drug.
• Vit E and B6
• NSAIDs
• Severe cases not subsiding with Medical management Subcutaneous
mastectomy or Cyst excision.
13. Sclerosing Adenosis
• 30 – 50 yrs of age
• Patient presents with mastalgia & Lump
• Palpation – Smooth, relatively mobile mass.
• Patho – Proliferative terminal ductules & acini, with proliferation of
stroma often with deposition of Ca.
• Treatment:??
14. PhyllodesTumor:
• Spectrum of disease.
• Benign Malignant
• Arises from the stromal element of the breast
• Microscopy:
• Contains cystic spaces with leaf like projections hence the name.
• Cells chow hyper cellularity and pleomorphism.
15. • Clinical Features:
• Premenopausal women,
• Usually unilateral, Rapid growth
• Smooth bossellated, overlying skin necrosis may be present
• Skin may be stretched, shiny, dilated veins + over the lesion.
• Recurrence is common.
• Investigation:???
• Treatment:???
16. Mastalgia:
• 45% of women present with mastalgia
• Predisposing conditions: ?? HRT, Caffeine, tobacco, large pendulous
breast
• Types:
• Cyclical (65%)
• Non cyclical (30 %)
• Chest wall pain (5%)
17. • Cyclical:
• Related to Menstrual cycle
• B/l diffuse pain with heavy feeling
• Patho Similar to ANDI
• Hence treatment similar to ANDI
• Non cyclical:
• Rule out other causes of breast pain
• Periductal mastitis, cervical root pain, malignancy,Teitz syndrome
• U/l C/c, burning or dragging in nature.
• Occurs in both pre and post menopausal age group
18. Traumatic fat necrosis:
• Caused d/t trauma
• PATHOGENESIS:
• Capillary ooze triglyceride in fat to dissociate into fatty acid Combines
with Ca Saponification Inflammatory reaction Swelling
• CLINICAL FEATURES:
• Painless swelling
• Hard, irregular and adherent to breasts tissue.
• INVESTIGATIONS:???
• TREATMENT:???
19. Galactocele:
• It is a retention cyst.
• Occurs in Lactating women and up to 10 months after lactation.
• The lactiferous duct gets blocked and large amount of milk gets
collected.
• Contents are milk and epithelial debris.
• CLINICAL FEATURES:
• Large, soft, fluctuant swelling usually in the lower quadrant.
• Untreated gets precipitated and calcified and mimics cancer.
• Usually gets infected Abscess
21. Mastitis:
• Types
• Sub areolar
• Intra mammary, a) Lactational abscess b) Non-lactational abscess
• Retro mammary
• Sub areolar:
• Infection developing d/t cracks in the nipple, infected Montgomerie glands
or a furuncle
• Can be caused by duct ectasia
• CLINICAL FINDINGS: Red, inflamed areola, tender, nipple retraction may be
present.
• TREATMENT: ???
22. Intra mammary mastitis
• Usually up to 6 months of feeding
• Predisposing factors:
• Cracked nipple
• Retracted nipple
• Improper cleaning
• Inadequate suckling by the baby stasis
• Infection from the mouth of the baby
Most common organism Staph. Aureus
23. • CLINICAL FEATURES:
• Fever with chills and rigors
• Throbbing pain, severe tenderness
• Redness, local rise in temperature, induration
• Purulent discharge from the nipple.
• Entire breast may be involved and may end up having fluctuation +ve.
• Treatment: ???
24. Retro mammary abscess:
• D/tTuberculosis of the internal mammary nodes, ribs, empyema
necessitans, hematoma
• Breast tissue per say is normal.
• Investigations:???
Treatment:???
25. Antibioma:
• If intra mammary mastitis Poorly treated with repeated with Abx
and/or inadequate drainage.
• Collection persists Surrounding inflammation settles with thick
fibrous septum formation Antibioma
• CLINICAL FEATURES: H/o Mastitis Rxed with Abx
• Lump, hard, non tender, smooth, fixed to surrounding breast tissue.
• INCESTIGATIONS AND MAMAGEMENT:
26. Duct Ectasia:
• It is dilatation of lactiferous ducts d/t relaxation of the myoepithelial
cells of the duct wall + Periductal mastitis.
• Hormones Duct wall relaxation + Ineffective reabsorption of
secretions Desquamation of epithelium in to the duct
• CLINICAL FEATURES:
• Greenish discharge or creamy discharge
• Indurated mass under the areola
• Retraction of the nipple at a later stage ( ??? )
• Eventually Abscess Fistula
• May be bilateral and multifocal
• Investigation and treatment: ???
27. Galactorrhoea
• Primary:
• Stress and other factors.
• Physiological during puberty or menopause.
• Secondary:
• Dopamine receptor blockers like haloperidol, methyl dopa, chlorpromazine,
metoclopramide
• Prolactin secreting pituitary tumors.
• Hypothyroidism
• Ectopic prolactin secreting tumors (like Bronchogenic Ca)
• CRF
• INVESTIGATION ANDTREATMENT
28. Duct Papilloma
• Epithelium lined papillae occurring in the lactiferous ducts.
• It is the most common cause of bloody discharge from the nipple.
• Usually < 1cm in size, fell as a mound in the retroareolar region.
• INVESTIGATION AND MANAGEMENT: