Week 22
 Genetic Changes




Ch. 11.3 pg 296
Mutation

Changes in the DNA sequence




A piece of                A piece of a chromosome     A broken piece attaches
chromosome                breaks off and reattaches   to a nonhomologous
breaks off and is lost.   in reverse order.           chromosome.
cancer
Diseases believed to be caused
  by changes in the genes that
  control the cell cycle
See pg 211
4 Mutations may occur during
• DNA replication (during interphase)

• Transcription (making mRNA)

• cell division (mitosis), or

• Exposure to external agents (mutagens)
Point mutation
Change in a single base pair in DNA, affects
 only one codon
frameshift mutation
When a single base is added or deleted
 from DNA, changes all following codons
Chromosomal
 _____________ mutation
When sections of chromosomes
 break and rejoin incorrectly or
 not at all




 A piece of                A piece of a chromosome     A broken piece attaches
 chromosome                breaks off and reattaches   to a nonhomologous
 breaks off and is lost.   in reverse order.           chromosome.
Mutagen
Any thing that may
 cause a change in
 the genetic code in
 DNA
3 causes of mutagens
• Radiation




• Chemical, and

• High temperature
And now the quiz
1
 _____________ mutation
When sections of chromosomes
 break and rejoin incorrectly or
 not at all




 A piece of                A piece of a chromosome     A broken piece attaches
 chromosome                breaks off and reattaches   to a nonhomologous
 breaks off and is lost.   in reverse order.           chromosome.
2 __________
Any thing that may cause a change in the
 genetic code in DNA
3 ________, ________
Two causes of mutations
4 ________
Diseases believed to be caused
  by changes in the genes that
  control the cell cycle
See pg 211
5 ________ mutation
Change in a single base pair in DNA, affects
 only one codon
6 _________

Changes in the DNA sequence




A piece of                A piece of a chromosome     A broken piece attaches
chromosome                breaks off and reattaches   to a nonhomologous
breaks off and is lost.   in reverse order.           chromosome.
7 ___________ mutation
When a single base is added or deleted
 from DNA, changing all following codons
8) When do mutations happen?
          2 examples
• errors in ___________ of DNA

• ___________ (making mRNA)

• cell division, or

• external agents (mutagens)
9 ______ RNA
• Supplies amino acids to the ribosomal
  RNA (rRNA)
10 ___________
• The assembly line for producing
  proteins, bonds amino acids together
11 ____________
When enzymes make an mRNA copy of a
 section of DNA (gene)




                          RNA

                         gene
Sections of gene that are expressed
    12 _____________
Sections of a gene that are NOT expressed

     Introns
   Not expressed




    expressed
13_______________
  proposed that DNA
  is composed of two
     strands twisted
      together in a
              helix
      double ____.
14 _________
     The two kinds of
      nucleic acids,
         DNA and RNA
     are made of these
They consist of 3 molecules bonded together

a phosphate group
a sugar,
and a nitrogenous base
codon / base / amino acid
                                base
• A group of three nitrogenous _____s in
                          amino
  a gene that code for an ______ acid is
           15
  called a ______
protein
                   Amino
16 _________       acid
                     tRNA

                             rRNA
A process which
 converts mRNA
 into a protein   mRNA
Mahalo!

B22 ppt genetic changes

  • 1.
    Week 22 GeneticChanges Ch. 11.3 pg 296
  • 2.
    Mutation Changes in theDNA sequence A piece of A piece of a chromosome A broken piece attaches chromosome breaks off and reattaches to a nonhomologous breaks off and is lost. in reverse order. chromosome.
  • 3.
    cancer Diseases believed tobe caused by changes in the genes that control the cell cycle See pg 211
  • 4.
    4 Mutations mayoccur during • DNA replication (during interphase) • Transcription (making mRNA) • cell division (mitosis), or • Exposure to external agents (mutagens)
  • 5.
    Point mutation Change ina single base pair in DNA, affects only one codon
  • 6.
    frameshift mutation When asingle base is added or deleted from DNA, changes all following codons
  • 7.
    Chromosomal _____________ mutation Whensections of chromosomes break and rejoin incorrectly or not at all A piece of A piece of a chromosome A broken piece attaches chromosome breaks off and reattaches to a nonhomologous breaks off and is lost. in reverse order. chromosome.
  • 8.
    Mutagen Any thing thatmay cause a change in the genetic code in DNA
  • 9.
    3 causes ofmutagens • Radiation • Chemical, and • High temperature
  • 10.
  • 11.
    1 _____________ mutation Whensections of chromosomes break and rejoin incorrectly or not at all A piece of A piece of a chromosome A broken piece attaches chromosome breaks off and reattaches to a nonhomologous breaks off and is lost. in reverse order. chromosome.
  • 12.
    2 __________ Any thingthat may cause a change in the genetic code in DNA
  • 13.
    3 ________, ________ Twocauses of mutations
  • 14.
    4 ________ Diseases believedto be caused by changes in the genes that control the cell cycle See pg 211
  • 15.
    5 ________ mutation Changein a single base pair in DNA, affects only one codon
  • 16.
    6 _________ Changes inthe DNA sequence A piece of A piece of a chromosome A broken piece attaches chromosome breaks off and reattaches to a nonhomologous breaks off and is lost. in reverse order. chromosome.
  • 17.
    7 ___________ mutation Whena single base is added or deleted from DNA, changing all following codons
  • 18.
    8) When domutations happen? 2 examples • errors in ___________ of DNA • ___________ (making mRNA) • cell division, or • external agents (mutagens)
  • 19.
    9 ______ RNA •Supplies amino acids to the ribosomal RNA (rRNA)
  • 20.
    10 ___________ • Theassembly line for producing proteins, bonds amino acids together
  • 21.
    11 ____________ When enzymesmake an mRNA copy of a section of DNA (gene) RNA gene
  • 22.
    Sections of genethat are expressed 12 _____________ Sections of a gene that are NOT expressed Introns Not expressed expressed
  • 23.
    13_______________ proposedthat DNA is composed of two strands twisted together in a helix double ____.
  • 24.
    14 _________ The two kinds of nucleic acids, DNA and RNA are made of these They consist of 3 molecules bonded together a phosphate group a sugar, and a nitrogenous base
  • 25.
    codon / base/ amino acid base • A group of three nitrogenous _____s in amino a gene that code for an ______ acid is 15 called a ______
  • 26.
    protein Amino 16 _________ acid tRNA rRNA A process which converts mRNA into a protein mRNA
  • 27.