Azithromycin is an antibiotic used to treat various bacterial infections, including respiratory, skin, and sexually transmitted infections. It has a bioavailability of approximately 37% and is known for common side effects like nausea and diarrhea, as well as serious risks such as liver damage and heart rhythm changes. Drug interactions are considerable, with 327 other medications altering its effects, and it is contraindicated in patients with certain hypersensitivities and liver diseases.

1. P O W E R E D B Y ,
P O O J I T H A M O D E P A L L I
AZITHROMYCIN

2. Generic name : azithromycin
Brand name : azasite ,azithromycin 3 day
dose pack , azithromycin 5 day dose pack ,
zithromax , zithromax TRI-PAK , zithromax Z -
PAK , Z max
Drug class : macrolides

3. WHAT IS AZITHROMYCIN?
 Azithromycin is an antibiotic
 Azithromycin is used to treat different types of
infections caused by the bacteria , such as respiratory
infections , skin infections , ear infections, eye
infections and sexually transmitted diseases
 Azithromycin may also be used for purposes not
listed in medical guide
 Mech of action – inhibit RNA dependent protein
synthesis

4. PHARMACOKINETICS
 Route of administration – oral
 Bioavailability – approximately 37 %
 Metabolism – hepatic
 Excretion – biliary
 Drug elimination is biphasic with Half life – 5 days
 DOSE-
500mg a day for 3-10 days

5. SIDE EFFECTS
MOST COMMON EFFECTS
 Nausea ,Vomiting , Diarrhea ,Pain in abdomen
LESS COMMON EFFECTS
 Heart palpitations , acid reflux , dizziness , headache,
fatigue , vaginitis,skin rashes
SERIOUS EFFECTS
 Liver damage( in liver patients) , heart rhythm
changes ( people who take heart medications and low
blood potassium) , serious allergic conditions

6. DRUG INTERACTIONS
There are 327 drugs which interact with azithromycin
categorized as 71 major , 235 moderate and 21 minor
interactions
(you can check all these interactions in the website
https://www.drugs.com )
Most common interactions are nelfinavir , warfarin,
digoxin , colchicine , phenytoin , antacids that
contain magnesium or alluminium

7. CONTRA INDICATIONS and THERAPEUTIC USES
 Contraindicated in patients with known
hypersensitivity to azithromycin , or any other
macrolide and in hepatic diseases. Use with caution
in renal failure
 Therapeutic uses of azithromycin is bronchitis ,
pneumonia , std , lungs , sinuses , skin, throat and
reproductive organs

8. REFERENCES
https://www.drugs.com
https://www.medicalnewstoday.com
https://www.webmd.com
https://www.pediatriconcall.com
https://www.medlineplus.gov