Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
FLOW OF THE SEMINAR
1. Definition – antibiotic resistance, Multi-resistance, cross-resistance in antibiotics
2. Evolution of resistance
3. Impact of resistance
4. The scenario of resistance: Global, India
5. Factors causing resistance
6. Mechanisms of resistance: Intrinsic and Acquired
7. Acquired mechanism of resistance
8. Quorum sensing
9. Mechanism of resistance in commonly used antibiotics
10. Methods for determining the resistance
11. Strategies to contain resistance
12. Antibiotic stewardship
13. Role of Pharmacologist
14. Initiatives undertaken by India to control resistance
Introduction to bacterial resistance to antibiotics, types of resistance, brief explaining & examples
The lecture was presented at Al-Mahmoudiya General Hospital at Wed, 17th Nov. 2021
Represented & updated as part of the training course for fresh appointed pharmacist at 16/5/2023
To understand the mechanisms of antimicrobial action and the classification of antimicrobial drugs.
To explain the process of microbial resistance.
To understand the spread of resistant microbes.
Outlines the prevention of microbial resistance.
FLOW OF THE SEMINAR
1. Definition – antibiotic resistance, Multi-resistance, cross-resistance in antibiotics
2. Evolution of resistance
3. Impact of resistance
4. The scenario of resistance: Global, India
5. Factors causing resistance
6. Mechanisms of resistance: Intrinsic and Acquired
7. Acquired mechanism of resistance
8. Quorum sensing
9. Mechanism of resistance in commonly used antibiotics
10. Methods for determining the resistance
11. Strategies to contain resistance
12. Antibiotic stewardship
13. Role of Pharmacologist
14. Initiatives undertaken by India to control resistance
Introduction to bacterial resistance to antibiotics, types of resistance, brief explaining & examples
The lecture was presented at Al-Mahmoudiya General Hospital at Wed, 17th Nov. 2021
Represented & updated as part of the training course for fresh appointed pharmacist at 16/5/2023
To understand the mechanisms of antimicrobial action and the classification of antimicrobial drugs.
To explain the process of microbial resistance.
To understand the spread of resistant microbes.
Outlines the prevention of microbial resistance.
Rational Use of Antibiotics. Infection was a major cause of morbidity and mortality, before the development of antibiotics.
The treatment of infections faced a great challenge during those periods.
Later in 1928, the discovery of Penicillin, a beta-lactam antibiotic, by Alexander Fleming opened up the golden era of antibiotics.
It marked a revolution in the treatment of infectious diseases and stimulated new efforts to synthesize newer antibiotics.
The period between the 1950s and 1970s is considered the golden era of discovery of novel antibiotic classes, with very few classes discovered since then.
Values are enduring beliefs or attitudes about the worth of a person, object, idea, or action. Values are important because they influence decisions and actions, including
Nurses ethical decision making.
Nurses who understand how patients’ values and their own values shape nurse-patient interactions, and who continually develop sensitivity to the ethical dimensions of nursing practices, are best able to provide quality care and advocate for their patients.
Define the bio-medical waste.
List out the sources of bio-medical waste.
Tell the composition of biomedical waste.
Understood the classification of biomedical waste.
Discuss the category of waste for segregation.
Explain the steps in the management of biomedical waste.
Describe the role of nurse.
SCOPE OF NURSING , ROLES & RESPONSIBILITIES OF VARIOUS NURSING PERSONNEL, QUA...Krishna Gandhi
COMMUNITY HEALTH NURSE
TEACHING IN NURSING
SCOPE OF NURSING
ROLES & RESPONSIBILITIES OF VARIOUS NURSING PERSONNEL
QUALITIES OF A NURSE
INDUSTRIAL NURSE
MILITARY NURSE
NURSING SERVICE ABROAD
NURSING SERVICE ADMINISTRATIVE POSITION
NURSING AS A PROFESSION, CHARACTERISTICS OF NURSE,NURSING PRINCIPLES.pptxKrishna Gandhi
NURSING AS A PROFESSION, NURSING PRINCIPLES
Profession has been defined as that requires extensive education or a calling that requires special knowledge, skill and preparation.
Professional nurse is a health worker, a graduate from a recognized school who is identified by law as a registered nurse whether graduated from a baccalaureate (BSc) or a diploma program.
Specialized education is an important aspect of professional status. In modern times, the trend in education for the professions has shifted towards programs in colleges and universities.
Nursing is indeed an art and science.
Science helps to explain the work of a nurse, while art addresses the human connections, empathetic communication, and dedicated care and compassion that make nursing a critical element of healthcare.
HISTORY OF NURSING and NURSING AS A PROFESSION.pptxKrishna Gandhi
HISTORY OF NURSING and NURSING AS A PROFESSION
Knowledge of the profession‘s history increases the nurse‘s awareness and promotes an understanding of the social and intellectual origins.
From its earliest history nursing was a form of community service to protect and preserve the family.
definition
indication
purpose
articles
components:
====
Level of consciousness
Mental status examination
Sensory cerebral function
Cranial nerves
Reflexes
Motor system
Sensory system
Cerebellar function
---
role of nurse
Definitiom
indication
Explain the value of the Glasgow Coma Scale for patient care.
Outline the three areas the Glascow Coma Scales assesses.
Summarize the severity findings for each range of the Glascow Coma Scale.
Review how the interprofessional team can use the Glasgow Coma Scale to communicate regarding a patients condition.
case scenerio
FRACTURE
DEFINITION
CAUSES
TYPES
CLASSIFICATION
SIGN AND SYMPTOMS
5 P
CARE
NURSES ROLE
SPLINT
SLING
NONINVASIVE METHODS
PHARMACOLOGY METHOD
SURGERY
NURSING DIAGNOSIS
INTRODUCTION
TO DEFINE ICP
TO ENLIST FACTORS CAUSING INC ICP
TO ENLIST INDICATION ANDCONTRA INDICATION OF ICP MONITORING
TO BRIEF CONSIQUENCIES OF INC ICP
TO EXPLAIN ASSESSMENT OF INC ICP
TO BRIED WARNING SIGN OF ICPMONITORING
TO EXPLAIN VARIOUS INVASIVE AND NON INVASIVE METHOD OF ICP MONITORING
Struggling with intense fears that disrupt your life? At Renew Life Hypnosis, we offer specialized hypnosis to overcome fear. Phobias are exaggerated fears, often stemming from past traumas or learned behaviors. Hypnotherapy addresses these deep-seated fears by accessing the subconscious mind, helping you change your reactions to phobic triggers. Our expert therapists guide you into a state of deep relaxation, allowing you to transform your responses and reduce anxiety. Experience increased confidence and freedom from phobias with our personalized approach. Ready to live a fear-free life? Visit us at Renew Life Hypnosis..
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
How many patients does case series should have In comparison to case reports.pdfpubrica101
Pubrica’s team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
Navigating the Health Insurance Market_ Understanding Trends and Options.pdfEnterprise Wired
From navigating policy options to staying informed about industry trends, this comprehensive guide explores everything you need to know about the health insurance market.
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
According to TechSci Research report, "India Clinical Trials Market- By Region, Competition, Forecast & Opportunities, 2030F," the India Clinical Trials Market was valued at USD 2.05 billion in 2024 and is projected to grow at a compound annual growth rate (CAGR) of 8.64% through 2030. The market is driven by a variety of factors, making India an attractive destination for pharmaceutical companies and researchers. India's vast and diverse patient population, cost-effective operational environment, and a large pool of skilled medical professionals contribute significantly to the market's growth. Additionally, increasing government support in streamlining regulations and the growing prevalence of lifestyle diseases further propel the clinical trials market.
Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
2. What is an antibiotic?
“Antibiotic” is from antibiosis, meaning against life.
Substances derived from a microorganismor produce synthetically
(Sulfonamides & Quinolones) to kill or suppress the growth of
other microorganisms.
3. Classification of Antibiotics
Antibiotics are classified by several ways:
• On the basis of mechanism of action
• On the basis of spectrum of activity
• On the basis of mode of action
4. Mechanism of action of antimicrobial agents
1. Inhibition of cell wall synthesis:
• Penicillins, Cephalosporins, Bacitracin & Vancomycin
2. Inhibition of functions of cellular membrane:
• Polymyxins
3. Inhibition of protein synthesis:
• Chloramphenicol, Macrolides & Clindamycin
• Tetracyclines & Aminoglycosides
4. Inhibition of nucleic acid synthesis:
• Quinolones
• Rifampin
5. Inhibition of folic acid synthesis:
• Sulfonamides & trimethoprim
6. Antimicrobial Spectrum
Antimicrobial spectrum: the scope that a drug kills
or suppresses the growth of microorganisms.
Narrow-spectrum: The drugs that only act on one
kind or one strain of bacteria.
(Isoniazide)
Broad-spectrum: The drugs that have a
wide antimicrobial scope.
(Tetracycline & Chloramphenicol)
10. Misuse of Antibiotics
Antibiotic misuse, sometimes called antibiotic abuse or antibiotic
overuse
The misuse or overuse of antibiotics, may produce serious effects on
health.
It is a contributing factor to the creation of multidrug- resistant bacteria,
informally called “super bugs”.
11. Antibiotic Resistancesand
Cross Resistances
Antibiotic resistance is the phenomenon that susceptibility of
pathogenic microorganisms
to antibiotic becomes lower or even loses after the microorganisms
contact with antibiotic many times.
When the bacteria show resistance to one antibiotic, they are
also resistant to some other antibiotics. This phenomenon is
called cross antibiotic resistance.
12. General Principles of Antimicrobial
Therapy
• Identification of the infecting organism should precede
antimicrobial therapy when possible.
• The pathogenic microorganism susceptibility to
antimicrobial agents should be determined, if a suitable
test exists.
• Factors that influence the choice of an antimicrobial agent
or its dosage for a patient include the age, renal & hepatic
function, pregnancy status and the site of infection, etc.
13. Selection of Antimicrobial Agent
• Empiric therapy - prior to identification of
Organism- critically ill patients
• Organism’s susceptibility to the antibiotic
• Patient factors - immune system,
renal/hepatic function
• Effect of site of infection on therapy - blood
brain barrier
• Safety of the agent
• Cost of therapy
14. Complications of Antibiotic Therapy
• Resistance due to inappropriate use of antibiotics
• Hypersensitivity (Penicillin)
• Direct toxicity (Aminoglycosides = ototoxicity)
• Super infections (broad spectrum antimicrobials
cause alteration of the normal flora; often
difficult to treat)
15. Classes of Antibiotics
The main classes of antibiotics are:
• Beta-Lactams
Penicillins
Cephalosporins
Carbapenems
Monobactams
• Macrolides & Ketolides
• Aminoglycosides
• Fluoroquinolones
• Tetracyclines,
Amphenicols
16. Penicillins
• The penicillins are the oldest class of antibiotics.
Penicillins have a common chemical structure
which they share with the Cephalosporins.
• Penicillins are generally bactericidal, inhibiting
formation of the cell wall.
17. Uses :
Penicillin's are
used to treat
• Skin infections,
• Dental infections,
• Ear infections,
• Respiratory tract infections,
• Urinary tract infections,
• Gonorrhea.
18. Types of penicillins
• The natural penicillins
Penicillin G
• Penicillinase-resistant
penicillins
Methicillin & Oxacillin
• Aminopenicillins
Ampicillin & Amoxicillin
19. Penicillin's Side Effects
• Diarrhea, nausea, vomiting, and upset
stomach
• In rare cases Penicillins can cause immediate
and delayed allergic reactions - specifically
skin rashes, fever & anaphylactic shock.
• Penicillins are classed as category B
during pregnancy.
20. Cephalosporins
• Cephalosporins have a mechanism of action
identical to that of the Penicillins.
• Interferes with synthesis of the bacterial cell wall
and so are bactericidal.
21. Cephalosporins are used to treat
pneumonia, staph infections, tonsillitis,
bronchitis, otitis media, various types of
skin infections, gonorrhea, urinary tract
infections.
Cephalosporins antibiotics are also
commonly used for surgical
prophylaxis.
Cephalexin can also be used to treat bone
infections.
1.
3.
2.
22. The first generation Cephalosporins
• They possess generally excellent coverage against
most Gram-positive pathogens and variable to poor
coverage against most Gram-negative pathogens.
• The first generation
includes: Cephradine
(Velosef) Cephalexin
(Ceporex) Cefadroxil
(Biodroxil, Duricef)
23. The second generation Cephalosporins
• In addition to the Gram-positive spectrum of the
first generation Cephalosporins, these agents have
expanded Gram-negative spectrum.
• Cefoxitin and Cefotetan also have good activity
against Bacteroides fragilis.
• The second generation
includes: Cefaclor
(Bacticlor) Cefuroxime
(Zinnat)
24. The third generation Cephalosporins
• They have much expanded gram negative activity. However,
some members of this group have decreased activity against
gram-positive organisms. They have the advantage of
convenient administration, but they are expensive.
• The third generation
includes: Ceftazidime
(Fortum) Cefixime
(Suprax) Cefoperazone
(Cefobid) Cefotaxime
(Claforan, Cefotax)
Ceftriaxone (Ceftriaxone,
Rociphen) Cefdinir (Omnicef)
25. The fourth generation Cephalosporins
• They are extended-spectrum agents with similar
activity against Gram-positive organisms as first-
generation cephalosporins. They also have a greater
resistance to beta- lactamases than the third generation
cephalosporins.
• Many fourth generation cephalosporins can cross
blood brain barrier and are effective in meningitis.
• The fourth generation
includes: Cefepime
(Maxipime)
26. The Fifth generation Cephalosporins
• Used to treat MRSA (methicillin-resistant
Staphylococcus aureus), penicillin-resistant
Streptococcus pneumoniae, Pseudomonas aeruginosa,
and enterococci.
• The fifth generation includes:
Ceftaroline (Teflaro)
Ceftobiprole (Zeftera)
27. Cephalosporins Side Effects
• Diarrhea, nausea, mild stomach upset
• Approximately 5–10% of patients with
allergic hypersensitivity to penicillins will
also have cross- reactivity with
cephalosporins.
• Cephalosporin antibiotics are classed as
pregnancy category B.
28. Carbapenems
• A class of β-Lactam antibiotics with a broad spectrum of
antibacterial activity.
• Highly resistant to most β-lactamases.
• Active against both Gram-positive and Gram-
negative bacteria, and anaerobes, with the exception of
intracellular bacteria (atypical), such as the Chlamydia.
• Agents:
Imipenem/Cilastatin (Tienem)
Meropenem (Meronem)
29. Adverse effects to Carbapenems include
• Headache
• Rash
• GI upset
• Phlebitis
• Hypotension
• Seizures in patients with renal dysfunction.
30. Monobactams
• They are β-lactam compounds.
• They work only against aerobic Gram
negative bacteria (Neisseria,
Pseudomonas).
• The only commercially available Monobactams
antibiotic is Aztreonam (Azactam).
• Adverse effects to Monobactams can include skin
rash and occasional abnormal liver functions.
31. Macrolides
• Macrolides are bacteriostatic, binding with bacterial
ribosomes to inhibit protein synthesis.
• Macrolides antibiotics are:
Erythromycin (Erythrocin)
Clarithromycin (Klacid)
Azithromycin (Zithromax)
Roxithromycin (Roxicin)
32. Macrolides antibiotics are used to treat
Respiratory tract infections (such as
pharyngitis, sinusitis, and bronchitis), genital,
gastrointestinal tract & skin infections.
33. Macrolides Side Effects
• Nausea, vomiting, diarrhea; infrequently, there may
be temporary auditory impairment.
• Oral Erythromycin may be highly irritating to the
stomach and when given by injection may cause severe
phlebitis.
• Macrolides antibiotics should be used with caution
in patients with liver dysfunction.
• Pregnancy category B: Azithromycin,
Erythromycin.
• Pregnancy category C: Clarithromycin
34. Ketolides
• Antibiotics belonging to the Macrolides group.
• Much broad spectrum than other Macrolides.
• Ketolides are effective against Macrolides-resistant
bacteria, due to their ability to bind at two sites at the
bacterial ribosome as well as having a structural
modification that makes them poor substrates for
efflux- pump mediated resistance.
• The only Ketolide on the market at this moment
is telithromycin, which is sold under the brand
name of Ketek.
35. Lincosamides (e.g. lincomycin, clindamycin)
• Lincosamides prevent bacteria replicating by
interfering with the synthesis of proteins.
• They are normally used to treat
staphylococci and streptococci, and have
proved useful in treating Bacteroides
fragilis and some other anaerobes.
36. • They are used in the treatment of Toxic Shock
Syndrome.
• Lincosamides antibiotics are one of the classes of
antibiotics most associated with pseudomembranous
colitis caused by C. difficile.
37. Aminoglycosides
• The Aminoglycosides are bactericidal and work by
stopping bacteria from making proteins.
• Aminoglycosides antibiotics are used to treat
infections caused by Gram-negative bacteria.
• Aminoglycosides may be used along with penicillins
or cephalosporins to give a two-pronged attack on
the bacteria.
• Since Aminoglycosides are broken down easily in
the stomach, they can't be given by mouth and
must be injected.
38. Generally, Aminoglycosides are given for short time
periods.
Aminoglycosides group includes:
Amikacin (Amikin)
Gentamicin (Garamycin)
Neomycin (Neomycin)
Streptomycin (Streptomycin)
Tobramycin (Nebcin)
40. Fluoroquinolones
• They are synthetic antibiotics, not derived from bacteria.
• Fluoroquinolones are broad-spectrum bactericidal drugs
that are chemically unrelated to the penicillins or the
cephalosporins.
• Fluoroquinolones inhibit bacteria by interfering with their
ability to make DNA. This effect is bactericidal.
41. • Because of their excellent absorption Fluoroquinolones
can be administered not only by intravenous but orally
as well.
• Fluoroquinolones are used to treat most common
urinary tract infections, skin infections, and
respiratory infections (such as sinusitis, pneumonia).
• Fluoroquinolones group includes:
Ciprofloxacin (Ciprobay, Ciprocin)
Levofloxacin (Tavanic, Alfacef)
Norfloxacin (Noracin)
Ofloxacin (Tarivid)
Moxifloxacin(Avalox)
42. Fluoroquinolones Side Effects
• Nausea, vomiting, diarrhea, abdominal
pain
• Irreversible damage to central nervous
system (uncommon)
• Tendinosis (rare)
• Fluoroquinolones are classed as
pregnancy category C.
43. Trimethoprim/sulfamethoxazole or Co-
trimoxazole
• An antibiotic used in the treatment of a variety of
bacterial, fungal and protozoal infections.
• Co-trimoxazole is generally considered bactericidal,
although its components are individually
bacteriostatic.
• Its actions are antifolate in nature,
inhibiting both de novo folate biosynthesis and
metabolism.
44. Co-trimoxazole side effects
• Nausea, vomiting
• An allergic reaction and infection with Clostridium
difficile, a type of diarrhea
• Co-trimoxazole is classed as pregnancy category C.
• it should not be used during breastfeeding.
45. Tetracyclines
• Broad-spectrum bacteriostatic agents and work by
inhibiting the bacterial protein synthesis.
• Tetracyclines may be effective against a wide variety of
microorganisms, including Rickettsia and Amoebic
parasites.
• Tetracyclines are used in the treatment of infections of the
respiratory tract, sinuses, middle ear, urinary tract, skin,
intestines.
• Their most common current use is in the treatment of
moderately severe acne and rosacea.
46. • Tetracyclines also are used to treat Gonorrhea, Rocky
Mountain spotted fever, Lyme Disease, Typhus.
• Tetracycline antibiotics are:
Tetracycline
Doxycycline
(Vibramycin)
Minocycline
Oxytetracycline (Oxytetracid)
47. Tetracyclines side effects
• Cramps or burning of the stomach, diarrhea, sore mouth
or tongue
• Skin photosensitivity
• Allergic reactions
• Tetracycline antibiotics should not be used in children
under the age of 8 and specifically during periods of
tooth development.
• Tetracyclines are classed as pregnancy category D.
Use during pregnancy may cause alterations in
bone development.
48. Chloramphenicol
• It is a bacteriostatic.
• It is considered a prototypical broad-spectrum
antibiotic, alongside the tetracyclines, and as it is both
cheap and easy to manufacture, it is frequently an
antibiotic of choice in the developing world.
• Effective against a wide variety of Gram-positive and
Gram- negative bacteria, including most anaerobic
organisms.
49. • Due to resistance and safety concerns, it is no longer
a first- line agent for any infection in developed
nations, with the notable exception of topical
treatment of bacterial conjunctivitis.
50. Chloramphenicol side effects
• The most serious adverse effect associated with
chloramphenicol treatment is bone marrow toxicity.
• Use of intravenous chloramphenicol has also been
associated with gray baby syndrome.
• Other less serious reactions include fever, rashes,
headache, confusion.
51. Glycopeptides (e.g. vancomycin, teicoplanin)
• These antibiotics are effective principally against
Gram- positive cocci.
• This class of drugs inhibit the synthesis of cell walls
in susceptible microbes by inhibiting peptidoglycan
synthesis.
• Vancomycin is used if infection with
methicillin- resistant Staphylococcus aureus
(MRSA) is suspected.
52. • Due to their toxicity, use of glycopeptides antibiotics
is restricted to patients who are critically ill, who
have a demonstrated hypersensitivity to the β-
lactams, or who are infected with β-lactam-resistant
species.
• They exhibit a narrow spectrum of action,
and are bactericidal only against the
enterococci.
53. Vancomycin side effects
• Vancomycin is usually given intravenously, as an
infusion, and can cause tissue necrosis and phlebitis
at the injection site.
• Red man syndrome, an idiosyncratic reaction to bolus
dose caused by histamine release
• Nephrotoxicity including renal failure and
interstitial nephritis
• Blood disorders including neutropenia, and deafness,
which is reversible once therapy has stopped
• Risk of accumulation in patients with renal impairment
54. Streptogramins
• Effective in the treatment of vancomycin-
resistant Staphylococcus aureus (VRSA) and
vancomycin- resistant Enterococcus (VRE), two of the
most rapidly growing strains of multidrug-resistant
bacteria.
• Members include:
Quinupristin/dalfopristin
Pristinamycin
Virginiamycin
55. Adverse effects include:
Related to administration via peripheral vein
Inflammation, pain, edema, infusion site reaction,
thrombophlebitis
Non-venous adverse effects
• Nausea, vomiting, diarrhea
• Rash
• Headache
• Pain, ill-defined focal or generalized discomfort
• Pruritus
• Arthralgia, myalgia
• Asthenia
• Conjugated hyperbilirubinaemia
56. Oxazolidinones (e.g. linezolid)
• Linezolid inhibits ribosomal protein synthesis by inhibiting
formation of the initiation complex.
• It is used for the treatment of serious infections caused
by Gram-positive bacteria that are resistant to several other
antibiotics.
• Linezolid is active against most Gram-positive bacteria that
cause disease, including streptococci, vancomycin-resistant
enterococci (VRE), and methicillin-resistant Staphylococcus
aureus (MRSA).
57. • The main indications of linezolid are infections of the skin
& soft tissues and pneumonia (particularly hospital-
acquired pneumonia).
• Common adverse effects of short-term use
include headache, diarrhea & nausea.
Long-term use, however, has been associated with
serious adverse effects; linezolid can cause bone marrow
suppression and low platelet counts, particularly when
used for more than two weeks. If used for longer periods
still, it may cause sometimes irreversible chemotherapy-
induced peripheral neuropathy and optic nerve damage,
and lactic acidosis.
58. Metronidazole
• A nitroimidazole antibiotic medication used particularly
for anaerobic bacteria and protozoa.
• It is antibacterial against anaerobic organisms, an
amoebicide and an antiprotozoal.
• It inhibits nucleic acid synthesis by disrupting the DNA of
microbial cells. This function only occurs when
Metronidazole is partially reduced, and because this
reduction usually happens only in anaerobic cells, it has
relatively little effect upon human cells or aerobic bacteria.
59. Metronidazole is primarily used to treat:
• Bacterial vaginosis, pelvic inflammatory disease (along
with other antibacterials like ceftriaxone),
pseudomembranous colitis,
• Aspiration pneumonia,
• Rosacea (topical),
• Fungating wounds (topical),
• Intra-abdominal infections,
• Lung abscess,
• Gingivitis,
• Amoebiasis, giardiasis, trichomoniasis, and infections
caused by susceptible anaerobic organisms such as
Bacteroides.
60. • It is also often used to eradicate Helicobacter
pylori along with other drugs and to prevent
infection in people recovering from surgery.
• Adverse effects include:
Discolored urine, headache, metallic taste ,
nausea. Metronidazole is classed as
pregnancy category B.
61. 1. Brahmankar D.M, Biopharmaceutics And Pharmacokinetics, New Delhi,
Vallabh Publications, 2012.
2. Goodman L. S, Goodman & Gilman’s Pharmacological Basis Of Therapeutics,
13th Edition, New York; New Delhi, Tatamcgraw-hill Education, 2017.
3. Katzung B. G, Basic And Clinical Pharmacology, 14th Edition, New York; New
Delhi, Tatamcgraw-hill Education, 2017.
4. Tara V Shanbhaug “Pharmacology For Medical Graduates”(2014),elsevier
Publication,third Edition,2015
5. Tripathi K.D, Essentials Of Medical Pharmacology, 7th Edition, New Delhi,
Jaypee Brothers Publications, 2013.
BIBLIOGRAPHY