Antipsychotic drugs, also known as neuroleptics, are used to treat psychotic disorders like schizophrenia. There are two main types - first generation "typical" antipsychotics that are associated with more extrapyramidal side effects, and second generation "atypical" antipsychotics that have fewer of these motor side effects. Antipsychotics work by blocking dopamine receptors in the brain, particularly in the mesolimbic pathway. They can have various adverse effects involving the cardiovascular, nervous, endocrine and other body systems. Proper management of these drugs requires monitoring for potential toxic reactions and drug interactions.
A compiled Power point presentation on "Antipsychotic drugs" suitable for Undergraduate level medical students and also PG students in the subject of Pharmacology.
Here is an overview of Antipsychotics,starting from basic pathophysiology of Psychosis and Schizophrenia,breifing the Neuropharmacology and lastly introduction of drugs with special reference to side effects and clincal uses.
A compiled Power point presentation on "Antipsychotic drugs" suitable for Undergraduate level medical students and also PG students in the subject of Pharmacology.
Here is an overview of Antipsychotics,starting from basic pathophysiology of Psychosis and Schizophrenia,breifing the Neuropharmacology and lastly introduction of drugs with special reference to side effects and clincal uses.
A simple presentation describing medications used in Psychosis.
In this file, you can have a better idea about psychosis, Schizophrenia and their treatment nowadays.
Pharmacology lecture for medical students in English.
Mood stabilizers is one of the treatment of bipolar disorder. however the effect require more than 2 weeks to action, thus need to adjuct with benzodiazepine for first 2 weeks. Not a choice for aggressive patient. The example of mood stabilizer are lithium, sodium valproate, carbamazepine and lamotrigine. it is suggestible to use mnemonic of "Lisa Very Commitment Lady"
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. • from the Greek "psyche", for mind/soul,
and "-osis", for abnormal condition or
derangement)
• Psychotic illnesses are characterized by
disordered thought processes
WHAT IS PSYCHOSIS
3. • The psychoses are among the most
severe psychiatric disorders
• Serious inability to think
• Symptoms of false beliefs (delusions)
• Abnormal sensations (hallucinations)
• Representative syndromes in this
category include schizophrenia brief
psychoses, and delusional disorders.
4. • Psychosis results from an overactivity of
dopamine function in the brain,
particularly in the mesolimbic pathway
• Substance induced
Pathophysiology
5. • The purpose of the brain is to collect
information from the body (pain, hunger,
etc.), and from the outside world, interpret it
to a coherent world view, and produce a
meaningful response. The information from
the senses enter the brain in the primary
sensory areas. They process the information
and send it to the secondary areas where
the information is interpreted. Spontaneous
activity in the primary sensory areas may
produce hallucinations which are
misinterpreted by the secondary areas as
information from the real world.
6. • Tertiary brain cortex collects the
interpretations from the secondary
cortexes and creates a coherent world
view of it. A study investigating structural
changes in the brains of people with
psychosis showed there was significant
grey matter reduction in the right medial
temporal, lateral temporal, and inferior
frontal gyrus, and in the cingulate cortex
bilaterally of people before and after
they became psychotic
7. • sensory deprivation have shown that the
brain is dependent on signals from the
outer world to function properly. If the
spontaneous activity in the brain is not
counterbalanced with information from
the senses, loss from reality and psychosis
may occur after some hours
10. • dopamine receptor antagonists
• 5-hydroxytryptamine (5-HT) receptors
antagonists
PHARMACOLOGICALLY, THEY ARE
CHARACTERISED AS
11. • Antischizophrenic drugs or major
tranquillisers-conventionally refers to
those used to treat schizophrenia, one of
the most common and debilitating forms
of mental illness.
ANTISCHIZOPHRENIC:
13. • Distinction between typical and atypical
groups is not clearly defined but rests on:
– Receptor profile
– Incidence of extrapyramidal side effects (less
in atypical group)
– Efficacy (specifically of clozapine ) in
'treatment-resistant' group of patients
– Efficacy against negative symptoms.
14. • Delusions
• Hallucinations- Auditory, Visual, Olfactory,
and Tactile
• Losing Sense of Reality
• Disorganization of Thought
• Thought Blocking
SYMPTOMS :
16. Two main different types:
• Bipolar I
• Manic around 1 week
• Depressive around 2 weeks
• Bipolar II
• Depressive
• Hypomanic
Treatments:
Mood Stabilizers:
- Lithium
Antipsychotics
BIPOLAR DISORDER
17. Symptoms:
• Delusions
• Hallucinations
• Disorganized speech and behavior
• Negative Symptoms
• Blunted affect (lack of emotional reactivity)
• Alogia (poverty of speech)
• Avolition ( lack of drive, or motivation to
pursue meaningful goals)
21. • Prominent sedative effect
• Adverse autonomic and neurologic
effects, severe anxiety and restlessness
(akathisia)
• The risk of developing advers
extrapyramidal effects, including tardive
dyskinesia
PHARMACOLOGICAL PROPERTIES
22. • Auditory processing and attention, spatial
organization, verbal learning, verbal
memory, and executive functions, are
impaired in schizophrenia patients. Potent
d2-antagonist neuroleptics have very limited
beneficial effects on such functions. Some
atypical antipsychotic agents with mixed
D2/5-HT2A activity (including clozapine,
quetiapine, olanzapine, and risperidone), as
well as the D2 partial agonist aripiprazole,
seem to improve cognitive functioning in
psychotic patients.
1-EFFECTS ON COGNITIVE FUNCTION
23. • Antipsychotic drugs have inconsistent
effects on sleep patterns but tend to
normalize sleep disturbances
characteristic of many psychoses and
mania.
2-EFFECTS ON SLEEP
24. • Actions of antipsychotic agents are
based on their ability to antagonize the
actions of DA as a neurotransmitter in the
basal ganglia and limbic portions of the
forebrain.
3-EFFECTS ON SPECIFIC AREAS OF
THE NERVOUS SYSTEM
25. • Antipsychotic drugs interact with
dopaminergic projections to the
prefrontal and deep-temporal (limbic)
regions of the cerebral cortex, with
relative sparing of these areas from
adaptive changes in DA metabolism
4-CEREBRAL CORTEX
26. • Many neuroleptic drugs can lower the
seizure threshold and induce discharges in
the electroencephalogram (EEG) that are
associated with epileptic seizure disorders.
Clozapine, olanzapine, and aliphatic
phenothiazines with low potency (e.g.,
chlorpromazine) seem particularly able to do
this.
• while the more potent piperazine
phenothiazines and thioxanthenes
fluphenazine and thiothixene), risperidone,
and quetiapine are much less likely to have
this effect.
5-SEIZURE THRESHOLD
27. • Antagonism of DA-mediated synaptic
neurotransmission is an important action of
many antipsychotics,this prompted the
proposal that many adverse extrapyramidal
neurological and neuroendocrinological
effects of the neuroleptics are mediated by
antidopaminergic effects in the basal
ganglia and hypothalamic systems, whereas
the antipsychotic effects of neuroleptics are
mediated by modification of dopaminergic
neurotransmission in the limbic and
mesocortical systems
28. • Many antipsychotic drugs also block the
effects of agonists on DA-sensitive adenylyl
cyclase associated with D1/D5-receptors in
forebrain tissue
• Atypical antipsychotic drugs such as
clozapine and quetiapine are characterized
by low affinity or weak actions in such tests.
Initially, the standard antipsychotics increase
firing and metabolic activity in dopaminergic
neurons. These responses eventually are
replaced by diminished presynaptic activity
(“depolarization inactivation”) with reduced
firing and production of DA, particularly in
the extrapyramidal basal ganglia.
29.
30. • Initially in antipsychotic treatment, DA
neurons activate and release more DA,
but following repeated treatment, they
enter a state of physiological
depolarization inactivation, with
diminished production and release of DA,
in addition to continued receptor
blockade. ER, endoplasmic reticulum.
31. 6-CHEMORECEPTOR TRIGGER
ZONE
• Most antipsychotics protect against the
nausea- and emesis-inducing effects of
apomorphine and certain ergot alkaloids,
all of which can interact with central
dopaminergic receptors in the
chemoreceptor trigger zone (CTZ) of the
medulla
32. 7-AUTONOMIC NERVOUS SYSTEM
• Chlorpromazine, clozapine, and
thioridazine have particularly significant
a-adrenergic antagonistic activity. The
potent piperazine tricyclic neuroleptics
(e.g., fluphenazine, trifluoperazine,
haloperidol, and risperidone) have
antipsychotic effects even when used in
low doses and show little antiadrenergic
activity.
33. 8-KIDNEY AND ELECTROLYTE
BALANCE
• Chlorpromazine may have weak diuretic
effects because of a depressant action
on the secretion of vasopressin
34. • Chlorpromazine and less potent antipsychotic
agents, as well as reserpine, risperidone, and
olanzapine, can cause orthostatic hypotension,
usually with rapid development of tolerance.
Thioridazine, mesoridazine, and other
phenothiazines with low potency, as well as
ziprasidone, droperidol, and perhaps high doses
of haloperidol, have a potentially clinically
significant direct negative inotropic action and a
quinidine-like effect on the heart (prolongation
of the QTc and PR intervals, blunting of T waves,
and depression of the ST segment)
9-CARDIOVASCULAR SYSTEM
35. • Many antipsychotics enhance the
turnover of acetylcholine Chlorpromazine
and low-potency antipsychotic agents,
including clozapine and quetiapine, have
antagonistic actions at histamine
receptors that probably contribute to
their sedative effects.
10-MISCELLANEOUS
PHARMACOLOGICAL EFFECTS
36. • The most important are those on the
cardiovascular,
• central and autonomic nervous systems,
and endocrine system. Other dangerous
• effects are seizures, agranulocytosis,
cardiac toxicity, and pigmentary
degeneration of the retina, all
• of which are rare
TOXIC REACTIONS AND ADVERSE
EFFECTS
37.
38. • Orthostatic hypotension, which may result
in syncope, falls, and injuries. Hypotension
is most likely to occur with administration
of the phenothiazine depress cardiac
repolarization, as reflected in the QT
interval corrected for heart rate (QTc)
Clozapine has rarely been associated
with myocarditis and cardiomyopathy.
risk of stroke among elderly patients
treated with risperidone and olanzapine
1-ADVERSE CARDIOVASCULAR
AND CEREBROVASCULAR EFFECTS
39. • Extrapyramidal motor system, occur by
high-potency D2-receptor antagonists
(tricyclic piperazines and
butyrophenones)
2-ADVERSE NEUROLOGICAL
EFFECTS
40. • Clozapine and olanzapine; somewhat less
with quetiapine; even less with fluphenazine,
haloperidol, and risperidone
3-WEIGHT GAIN AND METABOLIC
EFFECTS
41. • Mild leukocytosis, leukopenia, and
eosinophilia occurs with clozapine and
less often with phenothiazines
4-BLOOD DYSCRASIAS4-
44. • Chlorpromazine increases the miotic and
sedative effects of morphine and may
increase its analgesic actions.
• The antimuscarinic action of clozapine
and thioridazine can cause tachycardia
and enhance the peripheral and central
effects (confusion, delirium) of other
anticholinergic agents, such as the
tricyclic antidepressants and
antiparkinson agents.
7-INTERACTIONS WITH OTHER
DRUGS
45. • Potentiate the effect of medically
prescribed sedatives and analgesics,
alcohol, nonprescription sedatives and
hypnotics, antihistamines, and cold
remedies.
46. • Goodman and Gillman’s manual of
Pharmacology and Therapeutics
REFERENCES :