This document summarizes antipsychotic drugs used to treat psychosis and schizophrenia. It discusses the dopamine hypothesis for the pathophysiology of schizophrenia and how first-generation "typical" antipsychotics work by blocking dopamine D2 receptors, which can cause extrapyramidal side effects. Second-generation "atypical" antipsychotics have a lower risk of these side effects by also blocking serotonin receptors. Clozapine is reserved for treatment-resistant cases. Long term use of antipsychotics can cause neurological side effects like tardive dyskinesia. The document outlines the mechanisms of action, therapeutic uses, and adverse effects of antipsychotic drugs.
Schizophrenia A chronic mental disorder involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, inappropriate actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.
Antipsychotic Agents Antipsychotic drugs are able to reduce psychotic symptoms in a wide variety of conditions, including schizophrenia, bipolar disorder, psychotic depression and drug induced psychosis. They have also been termed neuroleptics, because they suppress motor activity and emotionalityClinical Efficacy of Antipsychotic Drugs
Antipsychotic drugs are effective in controlling symptoms of acute schizophrenia, when large doses may be needed.
Long-term antipsychotic treatment is often effective in preventing recurrence of schizophrenic attacks, and is a major factor in allowing schizophrenic patients to lead normal lives.
Classification of Antipsychotic Drugs Typical antipsychotics Phenothiazines (Chlorpromazine, Perphenazine, Fluphenazine, Thioridazine) Thioxanthenes (Flupenthixol, Clopenthixol) Butyrophenones (Haloperidol, Droperidol)
Atypical antipsychotics (Clozapine, Risperidone, Sulpiride, Olanzapine, Aripiprazole)
Depot preparations are often used for maintenance therapy.
Approximately 40% of chronic schizophrenic patients are poorly controlled by antipsychotic drugs; clozapine may be effective in some of these ‘antipsychotic-resistant’ cases.
This document discusses the treatment of psychotic disorders with antipsychotic drugs. It begins by defining psychotic disorders and their characteristics. It then describes major psychotic disorders and historical treatments prior to drugs such as shock therapy. It introduces the first antipsychotic drug, chlorpromazine, and describes the mechanisms and side effects of two classes of antipsychotic drugs: phenothiazines and butyrophenones. Finally, it discusses atypical antipsychotics which have fewer side effects, and current and future research directions for improving antipsychotic treatment.
There are three main points covered in the document:
1. Psychosis is a thought disorder characterized by disturbances in reality, perception, cognition, and affect. It encompasses several mental disorders including schizophrenia.
2. Schizophrenia is a type of psychosis characterized by severe personality changes and thought disorders. It has an onset in late teens to early twenties and has both genetic and environmental risk factors.
3. Antipsychotic drugs treat psychosis by blocking dopamine D2 receptors in the brain. Older "typical" antipsychotics are more likely to cause extrapyramidal side effects while newer "atypical" antipsychotics have fewer neurological side effects.
There are three main points covered in the document:
1. Psychosis is a thought disorder characterized by disturbances in reality, perception, cognition, and affect. It encompasses several mental disorders including schizophrenia.
2. Schizophrenia is a type of psychosis characterized by severe personality changes and thought disorders. It has an onset in late teens to early twenties and has both genetic and environmental risk factors.
3. Antipsychotic drugs treat psychosis by blocking dopamine D2 receptors in the brain. Older "typical" antipsychotics are more likely to cause extrapyramidal side effects while newer "atypical" antipsychotics have fewer neurological side effects.
Schizophrenia is a complex psychiatric disorder characterized by disorganized thoughts, delusions, hallucinations, inappropriate affect, and impaired social functioning. The exact causes are unknown but likely involve genetic, brain chemical, environmental, and family history factors. Brain imaging shows enlarged ventricles and decreased cortical size, particularly in the left temporal lobe. Symptoms include positive symptoms like hallucinations, negative symptoms like loss of interest, and mood symptoms. Treatment involves pharmacological therapy with antipsychotics and non-pharmacological approaches like therapy, social skills training, and vocational rehabilitation.
This document summarizes various psychopharmacological agents. It discusses anti-anxiety drugs like benzodiazepines which act by increasing GABA activity. Anti-psychotic drugs for treating schizophrenia are also covered, noting they work by blocking dopamine D2 receptors. Lithium is described as the standard treatment for bipolar disorder, stabilizing mood by inhibiting inositol monophosphate. Adverse effects of these classes of drugs are also briefly outlined.
Schizophrenia A chronic mental disorder involving a breakdown in the relation between thought, emotion, and behaviour, leading to faulty perception, inappropriate actions and feelings, withdrawal from reality and personal relationships into fantasy and delusion, and a sense of mental fragmentation.
Antipsychotic Agents Antipsychotic drugs are able to reduce psychotic symptoms in a wide variety of conditions, including schizophrenia, bipolar disorder, psychotic depression and drug induced psychosis. They have also been termed neuroleptics, because they suppress motor activity and emotionalityClinical Efficacy of Antipsychotic Drugs
Antipsychotic drugs are effective in controlling symptoms of acute schizophrenia, when large doses may be needed.
Long-term antipsychotic treatment is often effective in preventing recurrence of schizophrenic attacks, and is a major factor in allowing schizophrenic patients to lead normal lives.
Classification of Antipsychotic Drugs Typical antipsychotics Phenothiazines (Chlorpromazine, Perphenazine, Fluphenazine, Thioridazine) Thioxanthenes (Flupenthixol, Clopenthixol) Butyrophenones (Haloperidol, Droperidol)
Atypical antipsychotics (Clozapine, Risperidone, Sulpiride, Olanzapine, Aripiprazole)
Depot preparations are often used for maintenance therapy.
Approximately 40% of chronic schizophrenic patients are poorly controlled by antipsychotic drugs; clozapine may be effective in some of these ‘antipsychotic-resistant’ cases.
This document discusses the treatment of psychotic disorders with antipsychotic drugs. It begins by defining psychotic disorders and their characteristics. It then describes major psychotic disorders and historical treatments prior to drugs such as shock therapy. It introduces the first antipsychotic drug, chlorpromazine, and describes the mechanisms and side effects of two classes of antipsychotic drugs: phenothiazines and butyrophenones. Finally, it discusses atypical antipsychotics which have fewer side effects, and current and future research directions for improving antipsychotic treatment.
There are three main points covered in the document:
1. Psychosis is a thought disorder characterized by disturbances in reality, perception, cognition, and affect. It encompasses several mental disorders including schizophrenia.
2. Schizophrenia is a type of psychosis characterized by severe personality changes and thought disorders. It has an onset in late teens to early twenties and has both genetic and environmental risk factors.
3. Antipsychotic drugs treat psychosis by blocking dopamine D2 receptors in the brain. Older "typical" antipsychotics are more likely to cause extrapyramidal side effects while newer "atypical" antipsychotics have fewer neurological side effects.
There are three main points covered in the document:
1. Psychosis is a thought disorder characterized by disturbances in reality, perception, cognition, and affect. It encompasses several mental disorders including schizophrenia.
2. Schizophrenia is a type of psychosis characterized by severe personality changes and thought disorders. It has an onset in late teens to early twenties and has both genetic and environmental risk factors.
3. Antipsychotic drugs treat psychosis by blocking dopamine D2 receptors in the brain. Older "typical" antipsychotics are more likely to cause extrapyramidal side effects while newer "atypical" antipsychotics have fewer neurological side effects.
Schizophrenia is a complex psychiatric disorder characterized by disorganized thoughts, delusions, hallucinations, inappropriate affect, and impaired social functioning. The exact causes are unknown but likely involve genetic, brain chemical, environmental, and family history factors. Brain imaging shows enlarged ventricles and decreased cortical size, particularly in the left temporal lobe. Symptoms include positive symptoms like hallucinations, negative symptoms like loss of interest, and mood symptoms. Treatment involves pharmacological therapy with antipsychotics and non-pharmacological approaches like therapy, social skills training, and vocational rehabilitation.
This document summarizes various psychopharmacological agents. It discusses anti-anxiety drugs like benzodiazepines which act by increasing GABA activity. Anti-psychotic drugs for treating schizophrenia are also covered, noting they work by blocking dopamine D2 receptors. Lithium is described as the standard treatment for bipolar disorder, stabilizing mood by inhibiting inositol monophosphate. Adverse effects of these classes of drugs are also briefly outlined.
Schizophrenia is a chronic mental disorder involving breakdowns in thought, emotion and behavior. The document discusses antipsychotic drugs for treating schizophrenia, including typical and atypical drugs. Typical antipsychotics include phenothiazines and butyrophenones like haloperidol, while atypical drugs include clozapine, risperidone, olanzapine and aripiprazole. While both types can effectively treat schizophrenia, atypical drugs have fewer motor side effects but higher risks of weight gain and metabolic issues. The choice of drug depends on individual factors and side effect profiles.
This document summarizes schizophrenia and antipsychotic drugs. It describes schizophrenia as a mental disorder characterized by abnormal social behavior and difficulties determining what is real. It discusses the dopamine hypothesis of schizophrenia and evidence that excessive dopaminergic activity plays a role. It then categorizes and describes different classes of typical and atypical antipsychotic drugs, how they work, their indications, and common side effects like extrapyramidal symptoms.
This document summarizes schizophrenia and antipsychotic drugs. It describes schizophrenia as a mental disorder characterized by abnormal social behavior and difficulties determining what is real. It discusses the dopamine hypothesis of schizophrenia and evidence that excessive dopaminergic activity plays a role. It then categorizes and describes different classes of typical and atypical antipsychotic drugs, how they work, their indications, and common side effects like extrapyramidal symptoms.
Antipsychotic drugs are primarily used to treat schizophrenia and other psychotic disorders by reducing hallucinations, delusions, and other positive symptoms. They are categorized into first-generation antipsychotics that are associated with movement disorders, and second-generation antipsychotics that have fewer extrapyramidal side effects but higher risks of metabolic adverse effects. While antipsychotics do not cure schizophrenia, they can help control symptoms and allow patients to function better with support. Long-term maintenance treatment is often required to prevent relapse of psychotic episodes.
Antipsychotic : Dr Rahul Kunkulol's Power point preparationsRahul Kunkulol
This document discusses the treatment of psychosis and schizophrenia with a focus on antipsychotic drugs. It begins by classifying psychiatric disorders and defining psychosis. Schizophrenia is described as a particular type of psychosis characterized by disturbances in thinking. The dopamine theory of schizophrenia is explained, which posits that psychosis is related to increased dopamine activity in the brain. Older antipsychotics are dopamine antagonists that can cause neurological side effects like tardive dyskinesia. Atypical antipsychotics have fewer side effects. Lithium is discussed as the drug of choice for treating mania in bipolar disorder.
This document discusses antipsychotic drugs, including their classification, mechanisms of action, uses, and side effects. It describes how antipsychotics are primarily used to treat schizophrenia and other psychotic disorders by blocking dopamine receptors. It distinguishes typical/first generation antipsychotics that are more likely to cause extrapyramidal side effects from atypical/second generation antipsychotics that have a lower risk of these motor side effects but a higher risk of metabolic adverse effects like weight gain and diabetes. The document provides details on various antipsychotics and their mechanisms, pharmacokinetics, therapeutic uses, and important adverse effects and cautions.
Antipsychotic drugs, also known as neuroleptics, are used to treat psychotic disorders like schizophrenia. There are two main types - first generation "typical" antipsychotics that are associated with more extrapyramidal side effects, and second generation "atypical" antipsychotics that have fewer of these motor side effects. Antipsychotics work by blocking dopamine receptors in the brain, particularly in the mesolimbic pathway. They can have various adverse effects involving the cardiovascular, nervous, endocrine and other body systems. Proper management of these drugs requires monitoring for potential toxic reactions and drug interactions.
pharmacology of Antipsychotic Agents & Lithium.pptNorhanKhaled15
This document discusses antipsychotic agents and lithium. It provides details on the types and mechanisms of action of antipsychotic drugs. The main points are:
1) Antipsychotic drugs work primarily by blocking dopamine D2 receptors in the brain. Newer "atypical" antipsychotics also block serotonin receptors.
2) Common types include phenothiazines, thioxanthenes, and butyrophenones. Newer drugs have varied chemical structures.
3) Antipsychotics are used mainly to treat schizophrenia but also other psychoses. They help control positive symptoms but are less effective for negative symptoms.
4) Side effects vary by drug but can include extra
This document provides a summary of typical antipsychotic drugs. It discusses the history of antipsychotics beginning with phenothiazines in the 1950s. It then classifies typical antipsychotics and describes their pharmacokinetics, mechanisms of action, indications, precautions, adverse reactions, and reviews several individual drugs including chlorpromazine, fluphenazine, haloperidol, and zuclopenthixol.
This document discusses antipsychotic/neuroleptic drugs used to treat psychosis and schizophrenia. It covers:
1. The etiology and symptoms of conditions treated, including schizophrenia, psychosis, and bipolar disorder. Positive symptoms respond to treatment while negative symptoms are less responsive.
2. The proposed neurochemical bases involving dopamine, serotonin, and glutamate systems. Antipsychotics work by blocking dopamine D2 receptors in the brain.
3. Details of typical antipsychotics including phenothiazines, butyrophenones, and thioxanthenes. Newer atypical antipsychotics like clozapine, risperidone, and olanzapine are also mentioned
Psychopharmacology is the scientific study of how drugs act on the mind and behavior. Antipsychotic drugs are used to treat psychotic disorders like schizophrenia. Typical or first-generation antipsychotics block dopamine receptors and have higher risks of side effects like extrapyramidal symptoms. Atypical or second-generation antipsychotics also block serotonin receptors and have lower risks of extrapyramidal symptoms but can cause weight gain. Long-term treatment and monitoring of side effects is often needed for chronic psychotic disorders.
First generation antipsychotics block dopamine receptors and were introduced in the 1950s-1970s. Second generation antipsychotics emerged in the 1980s and target multiple receptors with fewer side effects. Clozapine was the first second generation antipsychotic and has fewer extrapyramidal side effects but requires blood monitoring. Other second generation antipsychotics include risperidone, olanzapine, quetiapine, aripiprazole, and ziprasidone, which vary in their receptor profiles and side effect risks. Long-acting injectable antipsychotics provide consistent drug levels and can improve adherence compared to oral medications.
Antipsychotic drugs, also known as neuroleptics, are used to treat psychiatric disorders like psychosis, schizophrenia, bipolar disorder, and others. They work primarily by affecting neurotransmitters in the brain like dopamine and serotonin. Typical or first-generation antipsychotics are more likely to cause extrapyramidal side effects due to their strong dopamine receptor blockade, while atypical or second-generation antipsychotics have less risk of these motor side effects. Both types of antipsychotics can cause other adverse effects as well. The exact causes of psychiatric disorders like schizophrenia are still unclear but may involve an imbalance of neurotransmitters like dopamine and glutamate in the brain.
1. Parkinsonism is a progressive neurodegenerative disorder caused by loss of dopamine-producing neurons in the substantia nigra, leading to motor symptoms like bradykinesia, rigidity, resting tremor, and impaired balance.
2. Treatment aims to restore dopamine levels through levodopa or dopamine agonists to improve motor symptoms, and anticholinergics to reduce acetylcholine activity in the striatum.
3. Levodopa is most effective but side effects emerge with long term use, so combinations with carbidopa are used to sustain dopamine levels and minimize side effects.
Antipsychotic drugs, also called neuroleptics or major tranquilizers, are primarily used to treat schizophrenia and other psychotic states by decreasing the intensity of hallucinations, delusions, and permitting patients to function better. These drugs work by blocking dopamine receptors in the brain and have side effects like extrapyramidal symptoms and metabolic issues. Antipsychotics are classified based on their generation (first or second), chemical structure, and pharmacological properties.
This document discusses anti-psychotic medications. It describes how anti-psychotics work by inhibiting dopamine to treat psychosis symptoms. The document categorizes anti-psychotics as first-generation or typical, and second-generation or atypical. Typical anti-psychotics are further divided into basal and incisive, while atypical anti-psychotics have multi-receptor targets and include multi-acting receptor targeted antagonists, dopamine-serotonin antagonists, dopamine D2-D3 antagonists, and a dopamine partial agonist. The document notes the pharmacokinetics, side effects, and therapeutic strategies for using anti-psychotics.
M pharmacy (pharmacology) 2 - Psychosis pptxPriyashreeK1
This document provides information about the pharmacology of drugs used to treat psychosis. It begins with an introduction to antipsychotic drugs and schizophrenia. It then defines antipsychotics and describes their mechanisms of action, including dopamine antagonism and serotonin receptor blocking activity. The document classifies antipsychotics as first-generation or second-generation and discusses their mechanisms, actions, uses, and adverse effects. Key topics covered include the treatment of positive and negative schizophrenia symptoms, extrapyramidal side effects, and metabolic side effects. Examples of individual drug pharmacology are also provided.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
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Schizophrenia is a chronic mental disorder involving breakdowns in thought, emotion and behavior. The document discusses antipsychotic drugs for treating schizophrenia, including typical and atypical drugs. Typical antipsychotics include phenothiazines and butyrophenones like haloperidol, while atypical drugs include clozapine, risperidone, olanzapine and aripiprazole. While both types can effectively treat schizophrenia, atypical drugs have fewer motor side effects but higher risks of weight gain and metabolic issues. The choice of drug depends on individual factors and side effect profiles.
This document summarizes schizophrenia and antipsychotic drugs. It describes schizophrenia as a mental disorder characterized by abnormal social behavior and difficulties determining what is real. It discusses the dopamine hypothesis of schizophrenia and evidence that excessive dopaminergic activity plays a role. It then categorizes and describes different classes of typical and atypical antipsychotic drugs, how they work, their indications, and common side effects like extrapyramidal symptoms.
This document summarizes schizophrenia and antipsychotic drugs. It describes schizophrenia as a mental disorder characterized by abnormal social behavior and difficulties determining what is real. It discusses the dopamine hypothesis of schizophrenia and evidence that excessive dopaminergic activity plays a role. It then categorizes and describes different classes of typical and atypical antipsychotic drugs, how they work, their indications, and common side effects like extrapyramidal symptoms.
Antipsychotic drugs are primarily used to treat schizophrenia and other psychotic disorders by reducing hallucinations, delusions, and other positive symptoms. They are categorized into first-generation antipsychotics that are associated with movement disorders, and second-generation antipsychotics that have fewer extrapyramidal side effects but higher risks of metabolic adverse effects. While antipsychotics do not cure schizophrenia, they can help control symptoms and allow patients to function better with support. Long-term maintenance treatment is often required to prevent relapse of psychotic episodes.
Antipsychotic : Dr Rahul Kunkulol's Power point preparationsRahul Kunkulol
This document discusses the treatment of psychosis and schizophrenia with a focus on antipsychotic drugs. It begins by classifying psychiatric disorders and defining psychosis. Schizophrenia is described as a particular type of psychosis characterized by disturbances in thinking. The dopamine theory of schizophrenia is explained, which posits that psychosis is related to increased dopamine activity in the brain. Older antipsychotics are dopamine antagonists that can cause neurological side effects like tardive dyskinesia. Atypical antipsychotics have fewer side effects. Lithium is discussed as the drug of choice for treating mania in bipolar disorder.
This document discusses antipsychotic drugs, including their classification, mechanisms of action, uses, and side effects. It describes how antipsychotics are primarily used to treat schizophrenia and other psychotic disorders by blocking dopamine receptors. It distinguishes typical/first generation antipsychotics that are more likely to cause extrapyramidal side effects from atypical/second generation antipsychotics that have a lower risk of these motor side effects but a higher risk of metabolic adverse effects like weight gain and diabetes. The document provides details on various antipsychotics and their mechanisms, pharmacokinetics, therapeutic uses, and important adverse effects and cautions.
Antipsychotic drugs, also known as neuroleptics, are used to treat psychotic disorders like schizophrenia. There are two main types - first generation "typical" antipsychotics that are associated with more extrapyramidal side effects, and second generation "atypical" antipsychotics that have fewer of these motor side effects. Antipsychotics work by blocking dopamine receptors in the brain, particularly in the mesolimbic pathway. They can have various adverse effects involving the cardiovascular, nervous, endocrine and other body systems. Proper management of these drugs requires monitoring for potential toxic reactions and drug interactions.
pharmacology of Antipsychotic Agents & Lithium.pptNorhanKhaled15
This document discusses antipsychotic agents and lithium. It provides details on the types and mechanisms of action of antipsychotic drugs. The main points are:
1) Antipsychotic drugs work primarily by blocking dopamine D2 receptors in the brain. Newer "atypical" antipsychotics also block serotonin receptors.
2) Common types include phenothiazines, thioxanthenes, and butyrophenones. Newer drugs have varied chemical structures.
3) Antipsychotics are used mainly to treat schizophrenia but also other psychoses. They help control positive symptoms but are less effective for negative symptoms.
4) Side effects vary by drug but can include extra
This document provides a summary of typical antipsychotic drugs. It discusses the history of antipsychotics beginning with phenothiazines in the 1950s. It then classifies typical antipsychotics and describes their pharmacokinetics, mechanisms of action, indications, precautions, adverse reactions, and reviews several individual drugs including chlorpromazine, fluphenazine, haloperidol, and zuclopenthixol.
This document discusses antipsychotic/neuroleptic drugs used to treat psychosis and schizophrenia. It covers:
1. The etiology and symptoms of conditions treated, including schizophrenia, psychosis, and bipolar disorder. Positive symptoms respond to treatment while negative symptoms are less responsive.
2. The proposed neurochemical bases involving dopamine, serotonin, and glutamate systems. Antipsychotics work by blocking dopamine D2 receptors in the brain.
3. Details of typical antipsychotics including phenothiazines, butyrophenones, and thioxanthenes. Newer atypical antipsychotics like clozapine, risperidone, and olanzapine are also mentioned
Psychopharmacology is the scientific study of how drugs act on the mind and behavior. Antipsychotic drugs are used to treat psychotic disorders like schizophrenia. Typical or first-generation antipsychotics block dopamine receptors and have higher risks of side effects like extrapyramidal symptoms. Atypical or second-generation antipsychotics also block serotonin receptors and have lower risks of extrapyramidal symptoms but can cause weight gain. Long-term treatment and monitoring of side effects is often needed for chronic psychotic disorders.
First generation antipsychotics block dopamine receptors and were introduced in the 1950s-1970s. Second generation antipsychotics emerged in the 1980s and target multiple receptors with fewer side effects. Clozapine was the first second generation antipsychotic and has fewer extrapyramidal side effects but requires blood monitoring. Other second generation antipsychotics include risperidone, olanzapine, quetiapine, aripiprazole, and ziprasidone, which vary in their receptor profiles and side effect risks. Long-acting injectable antipsychotics provide consistent drug levels and can improve adherence compared to oral medications.
Antipsychotic drugs, also known as neuroleptics, are used to treat psychiatric disorders like psychosis, schizophrenia, bipolar disorder, and others. They work primarily by affecting neurotransmitters in the brain like dopamine and serotonin. Typical or first-generation antipsychotics are more likely to cause extrapyramidal side effects due to their strong dopamine receptor blockade, while atypical or second-generation antipsychotics have less risk of these motor side effects. Both types of antipsychotics can cause other adverse effects as well. The exact causes of psychiatric disorders like schizophrenia are still unclear but may involve an imbalance of neurotransmitters like dopamine and glutamate in the brain.
1. Parkinsonism is a progressive neurodegenerative disorder caused by loss of dopamine-producing neurons in the substantia nigra, leading to motor symptoms like bradykinesia, rigidity, resting tremor, and impaired balance.
2. Treatment aims to restore dopamine levels through levodopa or dopamine agonists to improve motor symptoms, and anticholinergics to reduce acetylcholine activity in the striatum.
3. Levodopa is most effective but side effects emerge with long term use, so combinations with carbidopa are used to sustain dopamine levels and minimize side effects.
Antipsychotic drugs, also called neuroleptics or major tranquilizers, are primarily used to treat schizophrenia and other psychotic states by decreasing the intensity of hallucinations, delusions, and permitting patients to function better. These drugs work by blocking dopamine receptors in the brain and have side effects like extrapyramidal symptoms and metabolic issues. Antipsychotics are classified based on their generation (first or second), chemical structure, and pharmacological properties.
This document discusses anti-psychotic medications. It describes how anti-psychotics work by inhibiting dopamine to treat psychosis symptoms. The document categorizes anti-psychotics as first-generation or typical, and second-generation or atypical. Typical anti-psychotics are further divided into basal and incisive, while atypical anti-psychotics have multi-receptor targets and include multi-acting receptor targeted antagonists, dopamine-serotonin antagonists, dopamine D2-D3 antagonists, and a dopamine partial agonist. The document notes the pharmacokinetics, side effects, and therapeutic strategies for using anti-psychotics.
M pharmacy (pharmacology) 2 - Psychosis pptxPriyashreeK1
This document provides information about the pharmacology of drugs used to treat psychosis. It begins with an introduction to antipsychotic drugs and schizophrenia. It then defines antipsychotics and describes their mechanisms of action, including dopamine antagonism and serotonin receptor blocking activity. The document classifies antipsychotics as first-generation or second-generation and discusses their mechanisms, actions, uses, and adverse effects. Key topics covered include the treatment of positive and negative schizophrenia symptoms, extrapyramidal side effects, and metabolic side effects. Examples of individual drug pharmacology are also provided.
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In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Pharmacology I, Antipsychotic (Neuroleptic) Drugs NK-Trimmed.pptx
1. Antipsychotic (Neuroleptic) Drugs
Pharmacology Team
Naim Kittana, Ansam Sawalha, Adham Abu Taha,
Suhaib Hattab, and Waleed Sweileh
An-Najah National University
Faculty of Medicine and Health Sciences
Department of Biomedical Sciences
1
2. Psychosis
• Psychosis is a thought disorder characterized by disturbances of reality and
perception, impaired cognitive functioning, and inappropriate or diminished
mood.
• Psychosis denotes many mental disorders.
• Schizophrenia is a particular kind of psychosis characterized mainly by a clear
sensorium but a marked thinking disturbance.
2
3. Schizophrenia
• Pathogenesis is unknown
• Onset of schizophrenia: late teens early twenties
• Genetic predisposition -- Familial incidence
• Multiple genes are involved
• Afflicts 1% of the population worldwide.
3
4. Schizophrenia
A. Positive Symptoms.
• They include:
– Delusions: strange belief
– Hallucinations: auditory (hear voices
inside their heads), visual, olfactory,
– Thought disorder: disorganized thinking,
word salad, neologisms
4
5. – When they talk, their voice can sound flat, like they have no emotions
Flat or blunted affect and emotion
– Poverty of speech (alogia)
– Inability to experience pleasure (anhedonia)
– Lack of motivation (avolition)
These symptoms are progressive
and non-responsive to medication.
Negative Symptoms of Schizophrenia
• They are considered to be the loss or absence of normal traits or abilities,
and include features such as:
5
6. The dopamine hypothesis of schizophrenia
• Proposes that the disorder is caused by a relative excess of functional
activity of the neurotransmitter dopamine in specific neuronal tracts in
the brain.
6
7. Basis of dopamine hypothesis of schizophrenia
1. Many antipsychotic drugs block brain postsynaptic dopamine receptors
(especially D2 receptors) in the mesolimbic-frontal system in the CNS.
2. Dopamine agonist drugs (e.g., amphetamine, levodopa) exacerbate
schizophrenia.
3. An increased density of dopamine receptors has been detected in certain
brain regions of untreated schizophrenics.
7
8. • The dopamine hypothesis of schizophrenia is not fully satisfactory
because:
1. Antipsychotic drugs are only partly effective in most patients.
2. Many effective drugs have a much higher affinity for other receptors,
including serotonin receptors, than for D2 receptors.
3. Antagonists of the NMDA receptor such as phencyclidine, when
administered to nonpsychotic subjects, produce much more
"schizophrenia-like" symptoms than do dopamine agonists
8
9. • Serotonin hypothesis as an alternative to the dopamine hypothesis of the
nature of schizophrenia.
• Most of the atypical drugs cause less extrapyramidal dysfunction than
standard drugs.
• With the exception of haloperidol, all antipsychotic drugs block H1
receptors to some degree.
The Serotonin hypothesis of schizophrenia
9
11. Antipsychotics/Neuroleptics
• Antipsychotics are the drugs currently used in the prevention of psychosis.
• They have also been termed neuroleptics
** These drugs are not a cure **
SCHIZOPHRENIA IS FOR LIFE
There is no remission
• Schizophrenics must be treated with medications indefinitely, in as much
as the disease in lifelong and it is preferable to prevent the psychotic
episodes than to treat them.
11
12. Antipsychotics/Neuroleptics
Typical (Traditional) Atypical
- Chlorpromazine
- Fluphenazine
- Prochlorperazine
- Haloperidol
- Droperidol
- Clozapine
- Aripiprazole
- Olanzapine
- Resperidone
12
More likely to produce
extrapyramidal side
effects (EPS).
13. Typical “Traditional”, “1st generation”, “conventional”
• Competitive inhibitors at a variety of receptors
• Their antipsychotic reflects competitive blocking D2 receptors
• More likely to cause Extrapyramidal Side Effects (EPS)
• EPS correlates to the affinity towards D2 receptors, e.g. Haloperidole
highly likely to cause EPS, while it is much less with Chlorpromazine
• No one drug is clinically more effective than another.
13
14. Atypical “2nd generation”
• Lower incidence of EPS
• Associated with higher risk of metabolic side effects: diabetes,
hypercholesterolemia & weight gain
• Therapeutic activity is related to blockade of both serotonin and dopamine
receptors.
• First-line therapy for schizophrenia to avoid EPS
• Efficacy is comparable to that of 1st generation
14
15. Refractory patients
• 10-20% of schizophrenic patients do not respond to either typical or
atypical drugs
• Clozapine can be effective for these patients, with minimal risk of EPS.
• Serious Side effects of Clozapine:
- Bone marrow suppression
- Severe agranulocytosis (must monitor white blood cell counts)
- Seizures
- Cardiovascular side effects
15
16. Mechanism of action
• Dopamine antagonism:
All of the 1st and most of 2nd generation block D2 receptors in the brain
and periphery
• Serotonin receptor (5-HT2A) blocking activity:
Most of the 2nd generation exert part of their action via blocking 5-HT2A
receptors
• Many of these drugs also block cholinergic, adrenergic and histaminergic
receptors.
• It is not clear whether this contributes to the therapeutic action, but it is
clear to cause side-effects.
16
17. Therapeutic uses
1. Schizophrenia
Their antipsychotic effects include:
– Decreasing the positive symptoms: symptoms of thought disorders,
paranoid features, delusions, hostility, hallucinations
– to a lesser degree decreasing the negative symptoms: Decreased
withdrawal, apathy, and blunted affect, mainly by 2nd generation like
Clozapine.
– These drugs restrain acute psychotic attacks and delay subsequent
relapses.
17
18. 2. Prevention of severe nausea and vomiting:
• Conventional antipsychotic agents: they have strong antiemetic activity
due to dopamine D2-receptor blockade in the chemoreceptor trigger
zone of the medulla.
• The most commonly used:
– Prochlorperazine: marketed only as an antiemetic
– Promethazine: has no antipsychotic activity
18
19. 3. Other selected therapeutic uses:
a. Agitated and disruptive behavior, secondary to other disorders
b. Intractable hiccups: mainly Chlorpromazine
c. Pruritus: mainly Promethazine
d. Motor and phonic tics of Tourette disorder: Pimozide,
Risperidone and Haloperidol
19
20. Adverse effects and contraindications
• The adverse effects of antipsychotic agents are due to their antagonist
actions at receptors in:
CNS
– Dopamine D2-receptors
– Histamine H1-receptors
– (and possibly serotonin receptors)
Periphery
– Muscarinic cholinoceptors
– α-adrenoceptors
20
21. Central nervous system adverse effects
1. Extrapyramidal syndromes
• Related to dopamine-receptor blockade in the basal ganglia (and
elsewhere in the CNS)
• Leads to an imbalance in dopamine and acetylcholine actions in the
nigrostriatal pathway.
• These effects are a major cause of noncompliance.
21
22. Extrapyramidal effects
• Most likely occurs with typical drugs due to high affinity for
postjunctional dopamine D2-receptors in the basal ganglia.
• Can sometimes spontaneously remit.
• It includes:
Acute dystonia,
Akathisia,
Parkinson’s like syndrome and
Tardive dyskinesia.
22
23. Extrapyramidal syndromes include the following:
1. Acute dystonia
– is a neurological movement
disorder, in which sustained
muscle contractions cause
twisting and repetitive
movements or abnormal
postures
– This condition is often elicited
during the first week of
therapy.
23
24. Acute dystonia can be controlled with:
1. Centrally acting antimuscarinic drugs: e.g. benztropine
2. Antihistamine: diphenhydramine (which has central anticholinergic
activity)
3. By reducing the antipsychotic drug dose, which may lead to an increase
in psychotic symptoms.
24
25. 2. Akathisia:
Irresistible compulsion to be in motion.
• This condition can develop as early as the first 2 weeks of treatment or as
late as 60 days into therapy.
• Akathisia can be controlled by drugs:
1. with antimuscarinic activity
2. β-receptor antagonist propranolol.
25
26. 3. Parkinsonian-like syndrome
– Parkinsonian-like syndrome is characterized by tremors, bradykinesia,
rigidity, and other signs of parkinsonism.
– This syndrome can develop from 5 days to weeks into treatment.
– Parkinsonian-like syndrome can be controlled with:
• antimuscarinic drugs (e.g., benztropine, biperiden) or
• reducing the antipsychotic drug dose.
26
27. 4. Tardive dyskinesia (10—20%)
• CNS disorder characterized by:
- Twitching of the face and tongue
- Involuntary motor movements of the trunk and limbs
• More likely with conventional antipsychotic agents than atypical agents.
• Tardive dyskinesia: occurs after months to years of drug exposure
27
28. • more likely to occur in:
– the elderly or
– in institutionalized patients who receive long-term, high-dose therapy.
• The only effective treatment for tardive dyskinesia is the discontinuation
of treatment.
4. Tardive dyskinesia
28
29. Neuroleptic malignant syndrome
• Due to excessively rapid blockade of postsynaptic dopamine receptors.
• This syndrome is characterized by:
– Autonomic instability with altered blood pressure and heart rate.
– Muscle rigidity
– Diaphoresis
– Profound hyperthermia
– Myoglobinemia
• This condition occurs, often explosively, in 1% of patients; it is associated
with a 20% mortality rate.
29
30. Treatment of neuroleptic malignant syndrome
1. Discontinuing drug therapy
2. Initiating supportive measures, including the use of bromocriptine to
overcome the dopamine receptor blockade
3. Muscle relaxants such as dantrolene and diazepam to reduce muscle
rigidity.
30
31. Sedation
• Mechanism: Due to a central histamine H1-receptor blockade.
31
Confusional state with memory impairment
• This effect is likely with antipsychotic agents with pronounced antimuscarinic
activity.
Seizures
• Seizures are especially common with Chlorpromazine and Clozapine.
32. Autonomic Nervous system adverse effects
A. α-Adrenoceptor blockade: Manifests as postural hypotension
B. Atropine-like effects:
Dry mouth
Constipation
Urinary retention
Visual problems)
32
33. Endocrine and metabolic disturbances
A. Hyperprolactinemia: Due to dopamine (D2)-receptor antagonist
activity in the pituitary
- In women, these disturbances include:
Amenorrhea (absence of menstruation)
Galactorrhea (milky nipple discharge unrelated to the
normal milk production of breast-feeding)
Loss of libido
- In men, these disturbances include:
Gynecomastia (swelling of the breast tissue in males)
Infertility and erectile dysfunction
33
34. Other adverse effects
A. Withdrawal-like syndrome:
• Nausea, vomiting, insomnia, and headache
• These symptoms may persist for up to 2 weeks.
The symptoms can be minimized with a tapered reduction of drug
dosage.
B. Blood dyscrasias:
– Clozapine may induce agranulocytosis in up to 3% of patients
– Therefore it is used only when other drug groups prove ineffective.
34