This ppt gives information about the introduction to asthma disease its causes, pathophysiology and classification of antiasthmetic drugs with its stucture , the ppt is made for basic knowledge of antiasthemetic drugs on medicinal chemistry point of veiw for B. pharmacy students.
this presentation gives the knowledge about the decongestants are a type of medication that can provide short relief for a blocked nose ................
this presentation gives the knowledge about the decongestants are a type of medication that can provide short relief for a blocked nose ................
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Dr. Jibachha Sah,M.V.Sc( Veterinary pharmacology, TU,Nepal),posted lecturer notes on AUTONOMIC AND SYSTEMIC PHARMACOLOGY for B.V.Sc & A.H. 6 th semester veterinary students of College of veterinary science,Nepal Polytechnique Institute, Bharatpur, Bhojard, Chitwan, Nepal.I hope this lecture notes may be beneficial for other Nepalese veterinary students. Please send your comment and suggestion .Email:jibachhashah@gmail.com,moble,00977-9845024121
Aminoglycosides(medicinal chemistry by p.ravisankar)Dr. Ravi Sankar
Aminoglycosides,Aminocyclitols,Source,Structures of streptomycin,Dihydrostreptomycin,A mention of other aminoglycoside antibiotics,Acid hydrolysis,Mechanism of action,SAR,Dihydrostreptomycin and its importance,therapeutic uses, toxicity.
My all and slides mostly try to simplify pharmacy knowledge. Any time you are free to connect me. It's my pleasure to help you to get simplified pharmacy concepts. You may suggest topics needs to simplify the terminolog
this will give brief about the peptic ulcer and give information about the drug used for peptic ulcer and classification of drugs including drugs and there use adverse effect.
Dr. Jibachha Sah,M.V.Sc( Veterinary pharmacology, TU,Nepal),posted lecturer notes on AUTONOMIC AND SYSTEMIC PHARMACOLOGY for B.V.Sc & A.H. 6 th semester veterinary students of College of veterinary science,Nepal Polytechnique Institute, Bharatpur, Bhojard, Chitwan, Nepal.I hope this lecture notes may be beneficial for other Nepalese veterinary students. Please send your comment and suggestion .Email:jibachhashah@gmail.com,moble,00977-9845024121
Aminoglycosides(medicinal chemistry by p.ravisankar)Dr. Ravi Sankar
Aminoglycosides,Aminocyclitols,Source,Structures of streptomycin,Dihydrostreptomycin,A mention of other aminoglycoside antibiotics,Acid hydrolysis,Mechanism of action,SAR,Dihydrostreptomycin and its importance,therapeutic uses, toxicity.
My all and slides mostly try to simplify pharmacy knowledge. Any time you are free to connect me. It's my pleasure to help you to get simplified pharmacy concepts. You may suggest topics needs to simplify the terminolog
this ppt gives information about COPD , Asthma(the respiratory disease)As stated before, diseases of the heart affect the lungs and diseases of the lungs affect the heart.
This is because of the peculiar characteristics of pulmonary vasculature. The pressure in the pulmonary arteries is much lower than in the systemic arteries.
The pulmonary arterial system is466 SECTION III Systemic Pathology thinner than the systemic arterial system.
They are thin elastic vessels which can be easily distinguished from thick-walled bronchial arteries supplying the large airways and the pleura.
General diseases of vascular origin occurring in the lungs such as pulmonary oedema, pulmonary congestion, pulmonary embolism and pulmonary infarction, have all been already discussed.
This is a PPT describing bronchial asthma, its clinical manifestations, differential diagnosis, Laboratory findings and treatment.
International European University
Kyiv, Ukraine
The small intestine and colon are parts of your digestive tract, which processes the foods you eat.
The intestines take nutrients from the foods. What isn't absorbed by the intestines continues along the digestive tract and is passed as stool during a bowel movement.
Intestinal obstruction is a blockage that keeps food or liquid from passing through your small intestine or large intestine (colon).
Causes of intestinal obstruction may include fibrous bands of tissue (adhesions) in the abdomen that form after surgery; hernias; colon cancer; certain medications; or strictures from an inflamed intestine caused by certain conditions, such as Crohn's disease or diverticulitis.
Without treatment, the blocked parts of the intestine can die, leading to serious problems. However, with prompt medical care, intestinal obstruction often can be successfully treated.
the presentation includes a definition of oral contraceptives, type of oral contraceptives, detail description of both types with its mode of action and potential beneficial and unwanted effects also include pharmacokinetics of oral contraceptives and knowledge of emergency contraceptives
the presentation give complete explanantion on OECD guideline 403 of acute toxicity study for inhalation and the test subject used in the studies. the presentation give complete explanation of the guideline 403 and also describe the observation result and data reporting of the guideline
the presentation is based on OECD guideline of chemical test on acute eye irritation guideline 403, it also give knowledge about why the guideline was updated and analgesic and anesthetic uses on the albino rabbit eye so to overcome the animal distress, and pain. the presentation explain the full guideline in detail
the above presentation contain the history of the thyroid disorder, including the definition of thyrotoxicosis, and its two main cause that are graves' disease and another toxic nodular goiter and the classification of drugs that are used in hyperthyroidism i.e. hormone sythesis inhibitor, hormone release inhibitors, destroy thyroid tissue, and inhibit ionic trapping with it's example including the adverse effect and side effect and marketted preparation of the same and the agents which cause hypothyroidism and the agents which are used to prescribe in the pregnancy
the presentation include the different type of mechanism used by cancer cells to protect them from anticancer agents lead to produce resistance. the slide include definition of cancer as per WHO, type of tumors, treatment of cancer, goal of treatment, problem associated with chemotherapeutic agents, need of studing mechanisms of resistance for anticancer agents, resistance, different mechanism of drug resistance, epigenetics, drug efflux, drug inactivation, DNA damage repair, drug target alteration and cell death inhibitiond
The above presentation consist of the definition of microarray, brief history, general principle of the same, the type of scanner that are used to read or to scan the microarray , type of DNA microarray and finally its various apliccation including the role of DNA microaarray in drug discovery.
the slideshare is been made to get knowledge about flow cytometry it's introduction, working, construction mainly components used in the flow cytometry and its application to use
This power point presentation include the definition of the peptic ulcer, formation of peptic ulcer, regulation of gastric acid secreation, sign and symptomes, etiology of chronic ulceration, acid- pepsin vs mucosal resistance, gastric hyper secreation, disease complication, infection and obstruction, different factors related to acid secreation, classification of drugs used in peptic ulcer animal models in experimental peptic ulcer in both in-vivo and in- vitro
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
2. INTRODUCTION:
The term asthma is derives from the greek
word aazein meaning to exhale with open
mouth.( Difficulty in breathing)
Asthma is a chronic inflammatory allergic
disease , the patients suffer with reversible
episodes of airways obstruction due to
bronchial hyper responsiveness.
In the early (acute)phase there are smooth
muscle spasm and excessive broncial
secretion of mucus.
3. In the late (chronic or delayed) phase,
inflamation continues accompaines by
fibrosis oedema and necrosis of broncial
epithelial cell.
4. SYMPTOMS:
Symptoms of asthma are breathlessness,
wheezing, cough and cheast tightness with
worsening of these symptoms at night.
In the acute asthma there are rapid
respiratory rate and tachycardia.
The majority of patients suffer with atopic
extrinsic asthma, which is associated with
expossure to specific allergen( pollen or
house dust, etc).
5. In nonatopic extrinsic asthma the attack may be
stimulated with some non specific stimulus ,Ex
chemical irritants, In such cases IgG and Ig
antibodies circulate in the blood but are not
attach to the mast cell or basophills.
Neutrophils destroy these antigen- antibody
complex as a result, the liberated lysosomal
enzymes can digest the remaining
mucoprotiens.
Many patients have no identifiable external
precipitating or immunological basis for
asthamatic attack this can be described as
intrinsic asthma.
6. Extrinsic asthma is episodic and less prone to
status asthmaticus.
Status asthmatics is a sever acute asthma,
which is a life threatening condition involving
exhaustion, cynosis, bradycardia,
hypotension, dehydratin and metabolic
acidosis.
7. [PATHOPHYSIOLOGY OF ASTHMA
Antigen (pollen and house dustmites) sensitive
patients by eliciting the production of IgE type of
antibodies.
They become attach to mast cells of nasal or
bronchial tissues and basophils.
On re exposure with same antigen, reulting
antigent- antibody reaction in the early phase
cause degranulation of lung mast cells and
releasing powerfull bronchoconstrictors
histamine, -HT, PGD2 AND Cysteinyl
leucotrienes( LTB4, LTC4, LTD4).
8. Lungs mast cells also release Ils( IL-4, IL-5 &
IL-13) in the late phase of asthma, these
mediator activate inflammatory cells,
eosinophils, basophils, alveolar,
macrophases) which also release LTs & ILs .
Other mediators of inflammation in delayed
phase are adenosine, neuropeptidases, etc.
9. Why asthma makes hard to
breath:
In an asthamatic person the broncial tubes
are tighten and thicken and the air passage
become inflammes and mucuos filled,
making it difficult for air to move, which
make patients hard to breath.
10. Classification of
Antiasthamatic drugs:
The drugs are classified into following
classes:
I . BRONCHODILATORS
a. Selective ß2- agonists
b. Nonselective ß-agonist
c. M- cholinolytics
II . ANTI INFLAMMATORY AGENTS
2. Mast cell stabilizers
3. Glucocorticoids
27. (a) Inhibit phosphodiasterase-III & IV
The two specific isoenzymes responsible for
degradation of Camp.
(b) Block the adenosine-1- receptors on airway
musle and adenosine-3 receptors, present
on mast cells
31. Cromolyn works by preventing the release of
mediators that would normally attract
inflammatory cell & becoz it stabilies the
inflammatory cells.
32. 3. GLUCOCORTICOIDS (GCS)
Provides long term stabilization of the symptoms
due to their Anti-inflammatory effects GCS
inhibit the release of PG 4 LTs thus block smooth
muscle contraction vascular permeability airway
mucus secretion.
GCS produces eiosinopenia which prevents
cytotoxicity of the merditors released from
eosinophills.
The anti-inflammatory actions of GCS are
mediated by simulation of synthesis of lipocortin
which inhibits pathway for production of PGs,
LTs & PAF.
This mediators normally increase vascular
permeability & subsequent change including
odema leucocyte and fibrin deposition.
40. 4. LEUKOTRIENE MODULATORS:
Metabolism of archidonic acid via 5-lipoxygenase
pathway yields the cysteinye LTs-C4, D4 & E4
which activate cysteinyl leukotriene receptors to
cause bronchoconstriction, stimulate mucus
sence & increase capillary permeability leading
to pulmonary oedema.
Zeleuton inhibit the 5- lipoxygenase &block
synthesis of LTs.
Zarfiralakust , Monolakust and pranulakust block
41. Cystiene LT- receptors and used with inhales
GCS in poorly respond asthmatic patient.
44. 5. MONOCLONAL ANTI-IgE
ANTIBODY:
Ex: Omalizumab is a recombinent humanized
monoclone antibody
1. It inhibit the binding of IgE to mast cell
2. It inhibit the binding of IgE to basophills
3. It inhibit activation of IgE to prevent mast
cell degranulation.