Physiology of Respiratory system bronchial asthma nasal decongestant antitissive agent Expectorant

1. Drug acting on
Respiratory System
Sujit Karpe
Principal,
Sojar college of pharmacy, khandvi

2. Respiratory System

3. Respiratory System

4. BRONCHIAL ASTHMA

5. ASTHMA

6. ETIOLOGY OF ASTHMA

7. BRONCHOSPASM

8. BRONCHOSPASM

9. CELLULAR MECHANISM OF BRONCHOSPASM

10. MUCOSAL OEDEMA

12. ASTHMA – EPISODIC FORM
 Cause is known as either by Allergy, or respiratory tract infection.
 Individual suffers from acute spasm attacks and responds nice to bronchodilators

13. ASTHMA – STATUS ASTHMATICUS
 It is severe and persistent attack, and is associated with respiratory failure or
insufficiency.
 Individual do not responds to bronchodilators.

14. ASTHMA – CHRONIC FORM
 Characterized by persistent dyspnea (difficult or laboured breathing) and wheeze (whistling
sound).
 It is due to inflammation and thickening of bronchial mucosa.
 It is correlated with excessive secretion of mucus, decreased elastic recoil of lung
tissue and bronchospasm.

15. BRONCHODILATOR - CLASSIFICATION
Class 1 Sympathomimetics
• Drug with alpha and beta effect -
Adrenaline, Ephedrine
• Drug with beta1 and beta2 effect -
Isoprenaline, orciprenaline
• Drug with beta2 effect – Salbutamol,
terbutaline
Class 2
Anticholinergic
drugs
• Atropine
• Ipratropine
Class 3
Phosphodiesterase
Inhibitors
• Theophylline
• Aminophylline

16. BRONCHODILATORS - PHARMACOLOGY
1. Sympathomimetics:
Smooth Muscle
relaxation –
Bronchodilation

17. BRONCHODILATORS - PHARMACOLOGY
1. Sympathomimetics:
Preparation:

18. BRONCHODILATORS - PHARMACOLOGY
2. Anticholinergics:
Preparation:
Ipratropium – Atrovent -40-80
microgram inhalation

19. BRONCHODILATORS - PHARMACOLOGY
3. Phosphodiesterase inhibitors:
Preparation:
 Aminophylline 250mg slow IV
 Choline theophyllinate 400mg oral

20. TREATMENT OF STATUS ASTHMATICUS

21. TREATMENT OF STATUS ASTHMATICUS

22. NASAL DECONGESTANT

23. NASAL DECONGESTANT

24. NASAL DECONGESTANT

25. ORAL DECONGESTANT

26. TOPICAL NASAL DECONGESTANT

27. TOPICAL NASAL DECONGESTANT

28. NASAL DECONGESTANT – MECHANISM OF ACTION

29. NASAL DECONGESTANT – MECHANISM OF ACTION

30. NASAL DECONGESTANT – THERAPEUTIC USES

31. NASAL DECONGESTANT – SIDE EFFECTS

32. ANTITISSIVES

33. COUGH PHYSIOLOGY

34. TWO BASIC TYPES OF COUGH

35. COUGHING

36. ANTITISSIVES

37. ANTITISSIVES – MECHANISM OF ACTION

38. ANTITISSIVES – MECHANISM OF ACTION

39. ANTITISSIVES – THERAPEUTIC USES

40. ANTITISSIVES – SIDE EFFECTS

41. EXPECTORANT

42. EXPECTORANT – MECHANISM OF ACTION

43. EXPECTORANT – MECHANISM OF ACTION

44. EXPECTORANT – MECHANISM OF ACTION

45. EXPECTORANT – DRUG EFFECT

46. EXPECTORANT – THERAPEUTIC USES

47. EXPECTORANT – SIDE EFFECTS