This document discusses anisometropia, which is an unequal refractive error between the two eyes. A difference of 1 diopter causes a 2% difference in retinal image size, and a difference of 2.5-4 diopters is generally tolerated, whereas over 4 diopters is not. Anisometropia can lead to amblyopia, alternating vision, or strabismus. It has congenital, developmental, and acquired causes. Diagnosis involves retinoscopy and vision tests like the Worth Four Dot test. Treatment options include glasses, contact lenses, and keratoplasty.